Dayclazide MP 80mg/15mg Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe hypoglycemia with confusion, seizures, or loss of consciousness
- Signs of heart failure such as shortness of breath, rapid weight gain, or swelling
- Yellowing of skin or eyes, dark urine, or severe abdominal pain
- Blood in urine or painful urination
- Severe allergic reaction with rash, itching, or swelling of face or throat
- Unusual bone pain or fractures
- Persistent nausea, vomiting, or loss of appetite
If experiencing severe symptoms, call emergency services immediately.
What is piozide m 80mg/15mg/500mg tablet used for?
This medicine is a combination of gliclazide and pioglitazone used to treat type 2 diabetes. It works by increasing insulin production and improving insulin sensitivity. It is taken orally with food, usually once daily. It can cause low blood sugar, weight gain, and swelling. Regular monitoring is required.
- Generic Name: Gliclazide (80mg) + Pioglitazone (15mg)
- Manufacturer: Placker Life Sciences
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 piozide m 80mg/15mg/500mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा ग्लिक्लाजाइड और पियोग्लिटाज़ोन का संयोजन है, जिसका उपयोग टाइप 2 मधुमेह के इलाज के लिए किया जाता है। यह रक्त शर्करा को नियंत्रित करने में मदद करती है जब अकेले आहार, व्यायाम और एक दवा से पर्याप्त नियंत्रण नहीं हो पाता। यह इंसुलिन का उत्पादन बढ़ाती है और शरीर की इंसुलिन के प्रति संवेदनशीलता में सुधार करती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में कम रक्त शर्करा (हाइपोग्लाइसीमिया), वजन बढ़ना, पैरों में सूजन, सिरदर्द और मतली शामिल हैं। गंभीर दुष्प्रभावों में गंभीर हाइपोग्लाइसीमिया, दिल की विफलता, जिगर की समस्या, मूत्राशय का कैंसर और हड्डियों का फ्रैक्चर शामिल हैं। कोई भी असामान्य लक्षण होने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को हमेशा भोजन के साथ लें ताकि कम रक्त शर्करा और पेट की परेशानी का खतरा कम हो। इस दवा को लेते समय भोजन न छोड़ें। कम रक्त शर्करा के इलाज के लिए तुरंत काम करने वाली शर्करा जैसे ग्लूकोज टैबलेट या कैंडी साथ रखें। शराब से बचें क्योंकि इससे हाइपोग्लाइसीमिया और जिगर की समस्या का खतरा बढ़ सकता है। अगर आपको दिल, जिगर या गुर्दे की बीमारी है तो अपने डॉक्टर को बताएं। गर्भावस्था या स्तनपान के दौरान इस दवा का उपयोग न करें।
💊 piozide m 80mg/15mg/500mg tablet Uses & Benefits
[{"condition":"Type 2 diabetes mellitus","description":"Used as an add-on therapy to improve glycemic control in adults whose blood sugar is not adequately controlled with metformin or other single agents.","evidence":"Well-established"}]
Off-label uses: []
Primary treatment for: Type 2 diabetes mellitus
Also treats: Obesity, Dyslipidemia, Hypertension
📋 Drug Information
| Generic Name(s) | Gliclazide (80mg) + Pioglitazone (15mg) |
| Brand Name | piozide m 80mg/15mg/500mg tablet |
| Manufacturer | Placker Life Sciences |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI DIABETIC |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place. Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antidiabetic agents with complementary mechanisms. Gliclazide stimulates insulin secretion from pancreatic beta cells by binding to sulfonylurea receptors and closing ATP-sensitive potassium channels. Pioglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-γ), which increases insulin sensitivity in peripheral tissues and decreases hepatic glucose production.
Mechanism Steps
💡 How to Take piozide m 80mg/15mg/500mg tablet
Strength: Tablet containing Gliclazide 80 mg and Pioglitazone 15 mg.
Dosage Information
| Adult Dosage | The usual starting dose is one tablet once daily with the first main meal. The dose may be adjusted by your doctor based on blood sugar levels and response. The maximum recommended dose is one tablet twice daily. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially hypoglycemia. Start with a lower dose and monitor closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Gliclazide should be used with caution in patients with kidney disease. Dose adjustment may be needed based on renal function. Pioglitazone does not require dose adjustment. Consult your doctor for personalized dosing. |
| Hepatic Impairment | Avoid in patients with severe liver disease. In mild to moderate liver disease, use with caution and monitor liver function. Dose adjustment may be needed. Consult your doctor. |
| Maximum Daily Dose | The maximum recommended daily dose is 160 mg gliclazide and 30 mg pioglitazone (two tablets of this strength). |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of piozide m 80mg/15mg/500mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Insulin | Major | |
| Warfarin | Major | |
| Gemfibrozil | Major | |
| Beta-blockers | Moderate | |
| Diuretics | Moderate | |
| Rifampicin | Moderate | |
| Antacids | Minor | |
| Corticosteroids | Minor | |
| Grapefruit juice | Moderate | |
| Alcohol | Major |
🚨 Major Interactions
- Insulin
- Warfarin
- Gemfibrozil
⚡ Moderate Interactions
- Beta-blockers
- Diuretics
- Rifampicin
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol can increase the risk of hypoglycemia and may worsen liver function. It can also interact with pioglitazone and increase the risk of side effects.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Type 1 diabetes mellitus","Diabetic ketoacidosis","Severe liver disease","Active bladder cancer","History of heart failure","Pregnancy and breastfeeding","Hypersensitivity to gliclazide, pioglitazone, or any component"]
⚠️ Warnings & Precautions
["May cause hypoglycemia, especially when combined with other antidiabetic drugs.","May cause weight gain and fluid retention.","May increase the risk of heart failure.","May increase the risk of bladder cancer with long-term use.","May increase the risk of bone fractures, especially in women.","Use with caution in elderly patients and those with kidney or liver disease.","Do not use during pregnancy or breastfeeding."]
🤱 Lactation Safety
Not recommended during breastfeeding. It is not known if this medicine passes into breast milk. Consult your doctor for alternative treatments.
💊 Overdose Management
Overdose may cause severe hypoglycemia. Symptoms include confusion, seizures, and loss of consciousness. Seek immediate medical attention. Treatment includes intravenous glucose and supportive care. Monitor blood sugar closely.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Always take this medicine with food to reduce the risk of low blood sugar and stomach upset. Do not skip meals while on this medicine. Carry a fast-acting sugar source like glucose tablets or candy to treat low blood sugar. Avoid alcohol as it can increase the risk of hypoglycemia and liver problems. Inform your doctor if you have heart, liver, or kidney disease. Do not use this medicine if you are pregnant or planning pregnancy. Regular monitoring of blood sugar, liver function, and weight is essential. Do not drive or operate heavy machinery if you feel dizzy or shaky. Keep this medicine out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of hypoglycemia and may be more sensitive to the side effects of this medicine. Start with a lower dose and monitor closely. Regular assessment of kidney and liver function is recommended.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy. If you are planning pregnancy, consult your doctor to switch to a safer alternative, usually insulin. Maintain good blood sugar control before conception.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. Blood sugar levels may need to be monitored closely during and after surgery. Your doctor may adjust the dose temporarily.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. Dental procedures can affect blood sugar levels. Monitor your blood sugar and take your medicine as prescribed. If you are unable to eat after the procedure, consult your doctor about dose adjustments.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise can lower blood sugar. Monitor your blood sugar before and after exercise, especially if you are on other antidiabetic medicines. Carry a fast-acting sugar source during exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or low blood sugar, which can affect your ability to drive or operate machinery. Avoid these activities if you feel unsteady. Inform your employer about your condition if necessary.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Stopping suddenly can cause blood sugar to rise. Your doctor may stop it if you develop serious side effects or if your treatment goals change.
📅 Long-Term Use Effects
Long-term use may increase the risk of heart failure, bladder cancer, and bone fractures. Regular monitoring of blood sugar, liver function, and weight is essential. Your doctor may adjust the dose or switch to another medicine if needed.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet and exercise are the foundation of diabetes management and can complement medicine.
Evidence: Well-establishedMetformin, DPP-4 inhibitors, SGLT2 inhibitors, or GLP-1 receptor agonists may be alternatives.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, people with diabetes are advised to receive routine vaccinations such as influenza and pneumococcal vaccines. Consult your doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid temperature extremes. If traveling across time zones, consult your doctor about adjusting the timing of your dose. Store at room temperature and protect from moisture. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within a few hours, but it may take several weeks to see the full effect on blood sugar control.
A: Yes, but only under your doctor's supervision. Combining with insulin or other antidiabetics may increase the risk of hypoglycemia.
A: Take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
🤔 Common Patient Concerns
🔄 Substitutes for piozide m 80mg/15mg/500mg tablet
View AllAlternative brands with exact same active ingredient:
-
glifid trio 80mg/15mg/500mg tabletFidelity Lifesciences Pvt Ltd ₹92.81 23.3% CHEAPER
-
dayclazide mp 80mg/15mg/500mg tabletDaylon Healthcare ₹110.63 8.5% CHEAPER
-
triclazone 80mg/15mg/500mg tabletSun Pharmaceutical Industries Ltd ₹149.00 23.2% COSTLIER
-
new triclazone 80 tabletSun Pharmaceutical Industries Ltd ₹157.50 30.2% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure diabetes.
Fact: This medicine helps control blood sugar but does not cure diabetes. Lifestyle changes and ongoing treatment are necessary. - Myth: I can stop taking this medicine once my sugar is normal.
Fact: Do not stop without consulting your doctor. Stopping suddenly can cause blood sugar to rise. - Myth: This medicine is safe for everyone with diabetes.
Fact: It is not for type 1 diabetes, pregnant women, or those with heart failure or liver disease.
🔄 Alternative Options
Generic Alternatives
- Gliclazide + Pioglitazone combination tablets from other manufacturers