phyto k1 1mg injection - Phytomenadione (1mg) medicine

Govit-K Injection (Phytomenadione 1mg): Complete Medicine Guide

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🏭 Delvin Formulations Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: High
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

When to Call Your Doctor IMMEDIATELY

  • Difficulty breathing or shortness of breath after injection
  • Swelling of the face, lips, tongue, or throat
  • Severe dizziness or fainting
  • Chest pain or palpitations
  • Signs of severe allergic reaction such as hives or widespread rash
  • Bleeding that does not stop or worsens despite treatment
  • Yellowing of the skin or eyes (jaundice) in newborns

If experiencing severe symptoms, call emergency services immediately.

What is phyto k1 1mg injection used for?

This medicine is a vitamin K1 injection used to treat and prevent bleeding caused by vitamin K deficiency or blood thinners like warfarin. It works by helping the liver make clotting factors. It is given by a healthcare professional.

  • Generic Name: Phytomenadione (1mg)
  • Manufacturer: Delvin Formulations Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 phyto k1 1mg injection के बारे में (Hindi Summary)

उपयोग: यह दवा फाइटोमेनाडियोन का इंजेक्शन है, जिसे विटामिन K1 भी कहा जाता है। इसका उपयोग विटामिन K की कमी या खून पतला करने वाली दवाओं (जैसे वारफेरिन) के कारण होने वाले रक्तस्राव के इलाज और रोकथाम के लिए किया जाता है। यह नवजात शिशुओं में रक्तस्राव की बीमारी को रोकने के लिए भी दी जाती है। यह दवा लीवर को खून का थक्का बनाने वाले कारक बनाने में मदद करती है। यह इंजेक्शन के रूप में डॉक्टर या नर्स द्वारा अस्पताल या क्लिनिक में दी जाती है। इसे घर पर स्वयं नहीं लगाया जाना चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में इंजेक्शन लगाने की जगह पर दर्द, लालिमा या सूजन शामिल है। कुछ लोगों को हल्की खुजली या दाने हो सकते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी की प्रतिक्रिया, सांस लेने में कठिनाई, चेहरे या गले में सूजन, या रक्तचाप में अचानक गिरावट हो सकती है। अगर आपको कोई असामान्य लक्षण दिखे तो तुरंत डॉक्टर को बताएं।

सुरक्षा सलाह: यह दवा केवल डॉक्टर या नर्स द्वारा अस्पताल या क्लिनिक में दी जाती है। इसे स्वयं न लगाएं। इस दवा को लेने से पहले अपने डॉक्टर को बताएं कि आपको किसी भी दवा से एलर्जी है, आपको लीवर की बीमारी है, या आप G6PD की कमी से पीड़ित हैं। यदि आप गर्भवती हैं, गर्भवती होने की योजना बना रही हैं, या स्तनपान करा रही हैं, तो भी डॉक्टर को बताएं। इस दवा को लेते समय शराब न पिएं। अपने सभी फॉलो-अप और ब्लड टेस्ट समय पर कराएं।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 phyto k1 1mg injection Uses & Benefits

[{"condition":"Vitamin K deficiency bleeding","description":"This medicine is used to treat and prevent bleeding due to low levels of vitamin K, which can occur in newborns, people with poor nutrition, or those with liver disease.","evidence":"Well-established"},{"condition":"Warfarin overdose or excessive anticoagulation","description":"This medicine is used to reverse the blood-thinning effects of warfarin when the INR is too high or when bleeding occurs.","evidence":"Well-established"},{"condition":"Hemorrhagic disease of the newborn","description":"This medicine is given to newborns to prevent and treat a serious bleeding disorder caused by vitamin K deficiency.","evidence":"Well-established"},{"condition":"Prevention of bleeding in patients with malabsorption","description":"This medicine may be used in patients with conditions that impair vitamin K absorption, such as cystic fibrosis or biliary obstruction.","evidence":"Established"}]

Off-label uses: [{"condition":"Prevention of bleeding in patients with liver disease","description":"Sometimes used off-label to correct prolonged prothrombin time in patients with chronic liver disease, though its effectiveness is variable.","evidence":"Limited"},{"condition":"Management of bleeding in patients on direct oral anticoagulants","description":"Rarely used off-label for bleeding associated with direct oral anticoagulants, but it is not a specific antidote and evidence is limited.","evidence":"Limited"}]

Primary treatment for: Vitamin K deficiency bleeding

Also treats: Warfarin overdose, Hemorrhagic disease of the newborn, Malabsorption syndromes, Liver disease with coagulopathy

📋 Drug Information

Generic Name(s)Phytomenadione (1mg)
Brand Namephyto k1 1mg injection
ManufacturerDelvin Formulations Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassBLOOD RELATED
Action ClassVitamins
Route of AdministrationParenteral (intramuscular or intravenous injection)
StorageStore in a refrigerator at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light by keeping the ampoule or vial in its original carton until use.
Shelf LifeThe shelf life is typically 24 to 36 months from the date of manufacture, depending on the manufacturer. Check the expiry date on the packaging.
WHO GuidelineThe World Health Organization recommends the use of vitamin K1 for the prevention of hemorrhagic disease of the newborn. It is also included in the WHO Model List of Essential Medicines.
ICMR GuidelineThe Indian Council of Medical Research (ICMR) recognizes phytomenadione as an essential medicine for the treatment of vitamin K deficiency bleeding and for reversal of warfarin overdose. Guidelines recommend its use in appropriate clinical settings.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always administer this medicine slowly intravenously to avoid severe reactions such as flushing and hypotension.
2
Monitor INR closely after administration to determine the need for additional doses.
3
For warfarin reversal, use the lowest effective dose to avoid overcorrection and potential clotting.
4
In newborns, use the appropriate formulation and dose to prevent kernicterus.
5
Assess for signs of allergic reactions during and after injection, and have emergency equipment ready.
6
Consider alternative treatments if the patient has a history of severe allergic reactions to vitamin K.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Unexplained bleeding or bruising
This medicine is used to treat bleeding due to vitamin K deficiency or warfarin.
Likely Use
Nosebleeds that won't stop
May be used if caused by excessive anticoagulation.
Likely Use
Bleeding in a newborn
This medicine is used to prevent and treat hemorrhagic disease of the newborn.
Likely Use
Fever
This medicine is not a fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionThis medicine is administered by injection, so it is directly introduced into the bloodstream or muscle tissue. After intramuscular injection, phytomenadione is absorbed from the injection site into the bloodstream. The absorption rate may be influenced by blood flow at the injection site and the formulation.
DistributionPhytomenadione is highly lipophilic and is distributed primarily to the liver, where it is used for clotting factor synthesis. It is also distributed to other tissues, including the spleen, lungs, and bone marrow. It crosses the placenta and is excreted in breast milk.
Protein BindingPhytomenadione is highly bound to plasma proteins, primarily to beta-lipoproteins.
MetabolismPhytomenadione is metabolized in the liver to more polar metabolites, including vitamin K1 2,3-epoxide, which is subsequently reduced back to the active form by vitamin K epoxide reductase. The metabolites are excreted in bile and urine.
Half-LifeThe elimination half-life of phytomenadione is approximately 1.5 to 3 hours, but the clinical effect on clotting factors lasts longer, typically 6 to 24 hours.
ExcretionPhytomenadione and its metabolites are excreted primarily in the bile and feces, with a small amount excreted in urine.
BioavailabilityBioavailability is not applicable for intravenous administration, as it is 100% bioavailable. For intramuscular administration, bioavailability is high but may be slightly lower than intravenous.
Onset of ActionThe onset of action for this medicine is typically 6 to 12 hours after injection, as it takes time for the liver to synthesize new clotting factors. In cases of severe bleeding, the effect may be seen within 1 to 2 hours if given intravenously, but full correction of INR may take up to 24 hours.
Peak Plasma TimePeak plasma concentrations are reached within 1 to 2 hours after intramuscular injection and immediately after intravenous injection.
Duration of ActionThe duration of action of this medicine is approximately 6 to 24 hours, depending on the dose and the patient's liver function. The effect on clotting factors may last for several days after a single dose.

How It Works

This medicine provides a synthetic form of vitamin K1, which is essential for the synthesis of active clotting factors II, VII, IX, and X in the liver. These clotting factors require vitamin K as a cofactor for gamma-carboxylation, a process that enables them to bind calcium and function properly in the coagulation cascade. By supplying vitamin K1, this medicine restores the liver's ability to produce these functional clotting factors, thereby improving blood clotting and reducing bleeding.

Mechanism Steps

1
Provision of vitamin K1: This medicine delivers phytomenadione, a fat-soluble vitamin that is taken up by the liver.
2
Activation of vitamin K-dependent carboxylase: In the liver, phytomenadione is reduced to its active form, which acts as a cofactor for the enzyme gamma-glutamyl carboxylase.
3
Gamma-carboxylation of clotting factors: The activated enzyme carboxylates specific glutamic acid residues on clotting factors II, VII, IX, and X, allowing them to bind calcium.
4
Restoration of coagulation: The carboxylated clotting factors become functional and participate in the coagulation cascade, leading to improved clot formation and reduced bleeding.

💡 How to Take phyto k1 1mg injection

Strength: Injection: 1 mg in 0.5 mL (or as per manufacturer)

1This medicine is given by a healthcare professional in a hospital or clinic setting.
2It is administered as an intramuscular or intravenous injection.
3For intravenous use, it is given slowly to avoid reactions.
4Do not attempt to self-administer this medicine.
5After injection, you will be monitored for any immediate reactions.
6Follow your doctor's instructions for follow-up blood tests.

Dosage Information

Adult DosageThe dose of this medicine is individualized by a qualified clinician based on the indication, the patient's INR, and clinical condition. For reversal of warfarin, a common dose is 1 to 10 mg given by slow intravenous injection, but the exact dose must be determined by the doctor. For vitamin K deficiency bleeding, the dose may range from 1 to 10 mg. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician. In newborns, the dose is typically 0.5 to 1 mg intramuscularly at birth to prevent hemorrhagic disease of the newborn, but this must be determined by a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of this medicine, especially if they have liver or kidney disease. The dose should be individualized by a clinician based on the patient's condition and response.
Renal ImpairmentNo specific dose adjustment is recommended for renal impairment, but this medicine should be used with caution in patients with severe kidney disease. Individualize dose based on clinical response.
Hepatic ImpairmentIn patients with hepatic impairment, the effectiveness of this medicine may be reduced because the liver's ability to synthesize clotting factors is impaired. The dose may need to be adjusted, and close monitoring of INR is required. Individualize dose based on clinical response.
Maximum Daily DoseThe maximum daily dose is not firmly established and depends on the indication. In general, doses above 10 mg are rarely needed. The dose must be individualized by a qualified clinician.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

No specific food interactions
No restrictions
This medicine is given by injection, so food does not affect its absorption.
Alcohol
Avoid
Alcohol can impair liver function and increase bleeding risk.

⏰ What to Do If You Miss a Dose

📌 If you miss a scheduled dose at the clinic
→ Contact your doctor or clinic as soon as possible to reschedule.
💡 Do not attempt to self-administer.
📌 If you forget to follow up for monitoring
→ Schedule the blood test as soon as you remember.
💡 Monitoring is important to ensure the medicine is working and to adjust the dose.

⚠️ Side Effects of phyto k1 1mg injection

✅ Common Side Effects

Injection site pain (Common (1-10%))
Apply a cold compress to the site. It usually resolves within a day.
Injection site redness or swelling (Common (1-10%))
Keep the area clean and avoid rubbing. Consult a doctor if it worsens.
Mild rash or itching (Uncommon (0.1-1%))
Inform your doctor. Antihistamines may help if prescribed.
Feeling of warmth (Uncommon (0.1-1%))
This usually passes quickly. Report if it persists.

🚨 Serious Side Effects

Anaphylaxis (Rare (<0.1%))
Seek emergency medical help immediately if you experience difficulty breathing, swelling of the face or throat, or a sudden drop in blood pressure.
Severe allergic reaction (Rare (<0.1%))
Get immediate medical attention if you develop hives, severe itching, or swelling.
Hemolysis in G6PD deficiency (Rare (<0.1%))
Inform your doctor if you have G6PD deficiency. Seek care if you notice dark urine, jaundice, or fatigue.
Kernicterus in premature infants (Rare (<0.1%))
This is a risk in premature infants. Healthcare providers should monitor bilirubin levels and use appropriate doses.

⚠️ Rare Side Effects

Bluish discoloration of skin
Report to your doctor. It is usually reversible.
Hypersensitivity reactions
Seek immediate medical attention if you experience any signs of an allergic reaction.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Cefoperazone Moderate
Cefotetan Moderate
Cholestyramine Minor
Orlistat Minor

🚨 Major Interactions

  • Warfarin
  • Cephalosporins with NMTT side chain (e.g., cefoperazone, cefotetan)

⚡ Moderate Interactions

  • Antibiotics (broad-spectrum)
  • Bile acid sequestrants (e.g., cholestyramine)

🍷 Alcohol Interaction

Alcohol can impair liver function and reduce the liver's ability to synthesize clotting factors. Drinking alcohol while receiving this medicine may increase the risk of bleeding and reduce the effectiveness of the treatment. It is best to avoid alcohol during treatment with this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to phytomenadione or any component of the formulation.","Severe liver disease with impaired clotting factor synthesis, unless specifically indicated.","Use with caution in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency due to risk of hemolysis.","Not for use in patients with known allergy to vitamin K1."]

⚠️ Warnings & Precautions

["This medicine should be administered only by a healthcare professional.","Rapid intravenous injection may cause severe reactions; administer slowly.","Use with caution in patients with liver disease; monitor INR closely.","In newborns, use the appropriate formulation and dose to avoid kernicterus.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.","Avoid alcohol while receiving this medicine.","Tell your doctor about all other medicines you are taking, especially blood thinners."]

🤱 Lactation Safety

Phytomenadione is excreted in breast milk, but it is considered safe for use during breastfeeding. It is often given to newborns to prevent vitamin K deficiency bleeding, and maternal supplementation is not typically required unless the mother is deficient.

💊 Overdose Management

Overdose of this medicine is unlikely to cause serious harm because vitamin K1 has a wide safety margin. However, excessive doses may lead to hypercoagulability in some patients, especially those with certain risk factors. Treatment is supportive and symptomatic. In case of accidental overdose, contact a healthcare professional immediately.

⏰ Missed Dose

This medicine is given by a healthcare professional, so missed doses are unlikely. If you miss a scheduled dose, contact your doctor or clinic for instructions. Do not attempt to self-administer.

Additional Safety Advice

General Safety

This medicine is given only by a healthcare professional in a hospital or clinic. Do not attempt to inject it yourself. Before receiving this medicine, tell your doctor if you are allergic to vitamin K or any other medicines, if you have liver disease, or if you have a condition called glucose-6-phosphate dehydrogenase deficiency. Also, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. This medicine can interact with blood thinners like warfarin, so your doctor will monitor your blood clotting tests closely. Avoid alcohol while receiving this medicine, as it can affect liver function and increase the risk of bleeding. If you miss a dose, contact your doctor for advice; do not try to catch up on your own. Keep all follow-up appointments and blood tests as scheduled.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may have reduced liver function, which can affect the effectiveness of this medicine. They may also be more sensitive to its effects. Close monitoring of INR and clinical response is recommended.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, discuss with your doctor. This medicine is considered safe during pregnancy when used as directed. It is often given to newborns to prevent bleeding.

🏥 Post-Surgery Considerations

This medicine may be used after surgery to reverse anticoagulation or treat bleeding. Inform your surgeon if you have received this medicine recently, as it may affect clotting.

🦷 Dental Procedures

If you are scheduled for a dental procedure and are on warfarin, your dentist may coordinate with your doctor. This medicine may be used to reverse anticoagulation before the procedure if needed.

💚 Lifestyle Tips for Better Results

🏃
Maintain a consistent intake of vitamin K-rich foods if you are on warfarin.
🥗
Avoid alcohol to protect your liver and reduce bleeding risk.
😴
Follow up regularly with your doctor for blood tests.
💧
Inform all healthcare providers about this medicine before any procedure.
🧘
Eat a balanced diet to support overall health and liver function.
🌞
Exercise regularly, but avoid activities that may cause injury or bleeding.

🏋️ Exercise Considerations

Avoid contact sports or activities that can cause bleeding or bruising while you are at risk of bleeding. Consult your doctor before starting any new exercise routine.

🥗 Diet Recommendations

Maintain a consistent intake of vitamin K-rich foods such as leafy greens if you are on warfarin.
Avoid alcohol.
Stay well hydrated.
Eat a balanced diet to support liver health.

💼 Impact on Daily Work & Life

This medicine is given in a healthcare setting, so it may require a visit to a clinic or hospital. After receiving the injection, you may feel dizzy or tired; avoid driving or operating heavy machinery until you feel normal. Most people can resume normal activities the same day.

🛑 When to Stop This Medicine

This medicine is given as a single dose or a short course, so stopping is not usually a concern. If you are receiving it for a chronic condition, your doctor will determine when to stop based on your INR and clinical condition. Do not stop without consulting your doctor.

📅 Long-Term Use Effects

Long-term effects of this medicine are not a concern because it is typically used for short-term treatment. However, repeated use may be necessary in patients with chronic vitamin K deficiency. In such cases, regular monitoring of INR and liver function is important. Prolonged use may lead to excessive clotting in some patients, but this is rare. Always follow your doctor's guidance.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Oral vitamin K supplements

Oral vitamin K may be used for mild deficiency or maintenance, but it is not suitable for emergency reversal of warfarin.

Evidence: Well-established
Fresh frozen plasma (FFP) or prothrombin complex concentrate (PCC)

These blood products can rapidly reverse anticoagulation in emergencies, but they carry risks and are used when vitamin K alone is insufficient.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, if you are scheduled for a vaccination, inform your healthcare provider that you have received this medicine.

📦 Storage Guide

✅ DO

Store in a refrigerator at 2-8°C

❌ DON'T

Do not freeze

✅ DO

Keep in original carton to protect from light

❌ DON'T

Do not expose to direct sunlight

✅ DO

Check expiry date before use

❌ DON'T

Do not use if expired or if solution is discolored

✈️ Traveling with This Medicine

This medicine is given in a healthcare setting, so travel advice is limited. If you are prescribed this medicine for home use (rare), carry it in its original packaging with the prescription. Keep it refrigerated (2-8°C) during travel using a cool pack. Inform airport security about the medication and carry a doctor&#039;s letter. Check customs regulations for injectable medicines before traveling internationally.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 65-year-old man on warfarin for atrial fibrillation
He was brought to the emergency room with nosebleeds and bruising. His INR was 8.5. He received an injection of this medicine, and within 12 hours his INR dropped to 2.5, and the bleeding stopped. He was advised to continue warfarin at a lower dose and to have regular INR checks.
💡 Lesson: This medicine effectively reverses excessive anticoagulation from warfarin, but close monitoring is essential to avoid re-bleeding or clotting.
👤 A newborn baby born at home without vitamin K prophylaxis
The baby developed bleeding from the umbilical stump on day 5 of life. The baby was taken to the hospital and received an intramuscular injection of this medicine. The bleeding stopped within a few hours, and the baby recovered fully. The parents were educated about the importance of vitamin K prophylaxis for future pregnancies.
💡 Lesson: Vitamin K injection at birth is crucial to prevent hemorrhagic disease of the newborn, which can be life-threatening.

💬 Questions Patients Often Ask

Q: How is this medicine given?

A: This medicine is given as an injection into a muscle or vein by a healthcare professional in a hospital or clinic.

Q: How long does it take to work?

A: It usually starts working within 6 to 12 hours, but the full effect may take up to 24 hours.

Q: What are the common side effects?

A: Common side effects include pain, redness, or swelling at the injection site. Serious allergic reactions are rare.

Q: Can I drive after receiving this medicine?

A: This medicine may cause dizziness in some people. It is best to avoid driving until you know how it affects you.

Q: Is this medicine safe during pregnancy?

A: It is considered safe when used as directed by a doctor. It is commonly used to prevent bleeding in newborns.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can this medicine be given at home?
  • How long does the effect last?
  • What are the signs of an allergic reaction?
  • Can I take this medicine if I am pregnant?
  • Does this medicine interact with my other medications?
  • What should I do if I miss a dose?

🔄 Substitutes for phyto k1 1mg injection

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken orally as a pill.
    Fact: This medicine is an injection and must be given by a healthcare professional. Oral forms of vitamin K exist but are different products.
  • Myth: This medicine is a blood thinner.
    Fact: This medicine actually helps blood clot by providing vitamin K, which is the opposite of a blood thinner.
  • Myth: This medicine can be used to treat all types of bleeding.
    Fact: This medicine is only effective for bleeding caused by vitamin K deficiency or warfarin. It does not reverse other blood thinners or treat bleeding from other causes.

🔄 Alternative Options

Generic Alternatives

  • Phytomenadione injection

Brand Alternatives

  • Govit-K Injection

📊 Comparison with Similar Medicines

[{"medicine":"Phytomenadione (this medicine)","active_ingredient":"Phytomenadione","route":"Parenteral","primary_use":"Vitamin K deficiency bleeding, warfarin reversal"},{"medicine":"Menadione","active_ingredient":"Menadione","route":"Oral, Parenteral","primary_use":"Vitamin K deficiency (less commonly used)"}]

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