Govit-K Injection (Phytomenadione 1mg): Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or shortness of breath after injection
- Swelling of the face, lips, tongue, or throat
- Severe dizziness or fainting
- Chest pain or palpitations
- Signs of severe allergic reaction such as hives or widespread rash
- Bleeding that does not stop or worsens despite treatment
- Yellowing of the skin or eyes (jaundice) in newborns
If experiencing severe symptoms, call emergency services immediately.
What is phyto k1 1mg injection used for?
This medicine is a vitamin K1 injection used to treat and prevent bleeding caused by vitamin K deficiency or blood thinners like warfarin. It works by helping the liver make clotting factors. It is given by a healthcare professional.
- Generic Name: Phytomenadione (1mg)
- Manufacturer: Delvin Formulations Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 phyto k1 1mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा फाइटोमेनाडियोन का इंजेक्शन है, जिसे विटामिन K1 भी कहा जाता है। इसका उपयोग विटामिन K की कमी या खून पतला करने वाली दवाओं (जैसे वारफेरिन) के कारण होने वाले रक्तस्राव के इलाज और रोकथाम के लिए किया जाता है। यह नवजात शिशुओं में रक्तस्राव की बीमारी को रोकने के लिए भी दी जाती है। यह दवा लीवर को खून का थक्का बनाने वाले कारक बनाने में मदद करती है। यह इंजेक्शन के रूप में डॉक्टर या नर्स द्वारा अस्पताल या क्लिनिक में दी जाती है। इसे घर पर स्वयं नहीं लगाया जाना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में इंजेक्शन लगाने की जगह पर दर्द, लालिमा या सूजन शामिल है। कुछ लोगों को हल्की खुजली या दाने हो सकते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी की प्रतिक्रिया, सांस लेने में कठिनाई, चेहरे या गले में सूजन, या रक्तचाप में अचानक गिरावट हो सकती है। अगर आपको कोई असामान्य लक्षण दिखे तो तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल डॉक्टर या नर्स द्वारा अस्पताल या क्लिनिक में दी जाती है। इसे स्वयं न लगाएं। इस दवा को लेने से पहले अपने डॉक्टर को बताएं कि आपको किसी भी दवा से एलर्जी है, आपको लीवर की बीमारी है, या आप G6PD की कमी से पीड़ित हैं। यदि आप गर्भवती हैं, गर्भवती होने की योजना बना रही हैं, या स्तनपान करा रही हैं, तो भी डॉक्टर को बताएं। इस दवा को लेते समय शराब न पिएं। अपने सभी फॉलो-अप और ब्लड टेस्ट समय पर कराएं।
💊 phyto k1 1mg injection Uses & Benefits
[{"condition":"Vitamin K deficiency bleeding","description":"This medicine is used to treat and prevent bleeding due to low levels of vitamin K, which can occur in newborns, people with poor nutrition, or those with liver disease.","evidence":"Well-established"},{"condition":"Warfarin overdose or excessive anticoagulation","description":"This medicine is used to reverse the blood-thinning effects of warfarin when the INR is too high or when bleeding occurs.","evidence":"Well-established"},{"condition":"Hemorrhagic disease of the newborn","description":"This medicine is given to newborns to prevent and treat a serious bleeding disorder caused by vitamin K deficiency.","evidence":"Well-established"},{"condition":"Prevention of bleeding in patients with malabsorption","description":"This medicine may be used in patients with conditions that impair vitamin K absorption, such as cystic fibrosis or biliary obstruction.","evidence":"Established"}]
Off-label uses: [{"condition":"Prevention of bleeding in patients with liver disease","description":"Sometimes used off-label to correct prolonged prothrombin time in patients with chronic liver disease, though its effectiveness is variable.","evidence":"Limited"},{"condition":"Management of bleeding in patients on direct oral anticoagulants","description":"Rarely used off-label for bleeding associated with direct oral anticoagulants, but it is not a specific antidote and evidence is limited.","evidence":"Limited"}]
Primary treatment for: Vitamin K deficiency bleeding
Also treats: Warfarin overdose, Hemorrhagic disease of the newborn, Malabsorption syndromes, Liver disease with coagulopathy
📋 Drug Information
| Generic Name(s) | Phytomenadione (1mg) |
| Brand Name | phyto k1 1mg injection |
| Manufacturer | Delvin Formulations Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | BLOOD RELATED |
| Action Class | Vitamins |
| Route of Administration | Parenteral (intramuscular or intravenous injection) |
| Storage | Store in a refrigerator at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light by keeping the ampoule or vial in its original carton until use. |
| Shelf Life | The shelf life is typically 24 to 36 months from the date of manufacture, depending on the manufacturer. Check the expiry date on the packaging. |
| WHO Guideline | The World Health Organization recommends the use of vitamin K1 for the prevention of hemorrhagic disease of the newborn. It is also included in the WHO Model List of Essential Medicines. |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) recognizes phytomenadione as an essential medicine for the treatment of vitamin K deficiency bleeding and for reversal of warfarin overdose. Guidelines recommend its use in appropriate clinical settings. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine provides a synthetic form of vitamin K1, which is essential for the synthesis of active clotting factors II, VII, IX, and X in the liver. These clotting factors require vitamin K as a cofactor for gamma-carboxylation, a process that enables them to bind calcium and function properly in the coagulation cascade. By supplying vitamin K1, this medicine restores the liver's ability to produce these functional clotting factors, thereby improving blood clotting and reducing bleeding.
Mechanism Steps
💡 How to Take phyto k1 1mg injection
Strength: Injection: 1 mg in 0.5 mL (or as per manufacturer)
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on the indication, the patient's INR, and clinical condition. For reversal of warfarin, a common dose is 1 to 10 mg given by slow intravenous injection, but the exact dose must be determined by the doctor. For vitamin K deficiency bleeding, the dose may range from 1 to 10 mg. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. In newborns, the dose is typically 0.5 to 1 mg intramuscularly at birth to prevent hemorrhagic disease of the newborn, but this must be determined by a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially if they have liver or kidney disease. The dose should be individualized by a clinician based on the patient's condition and response. |
| Renal Impairment | No specific dose adjustment is recommended for renal impairment, but this medicine should be used with caution in patients with severe kidney disease. Individualize dose based on clinical response. |
| Hepatic Impairment | In patients with hepatic impairment, the effectiveness of this medicine may be reduced because the liver's ability to synthesize clotting factors is impaired. The dose may need to be adjusted, and close monitoring of INR is required. Individualize dose based on clinical response. |
| Maximum Daily Dose | The maximum daily dose is not firmly established and depends on the indication. In general, doses above 10 mg are rarely needed. The dose must be individualized by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of phyto k1 1mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Cefoperazone | Moderate | |
| Cefotetan | Moderate | |
| Cholestyramine | Minor | |
| Orlistat | Minor |
🚨 Major Interactions
- Warfarin
- Cephalosporins with NMTT side chain (e.g., cefoperazone, cefotetan)
⚡ Moderate Interactions
- Antibiotics (broad-spectrum)
- Bile acid sequestrants (e.g., cholestyramine)
🍷 Alcohol Interaction
Alcohol can impair liver function and reduce the liver's ability to synthesize clotting factors. Drinking alcohol while receiving this medicine may increase the risk of bleeding and reduce the effectiveness of the treatment. It is best to avoid alcohol during treatment with this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to phytomenadione or any component of the formulation.","Severe liver disease with impaired clotting factor synthesis, unless specifically indicated.","Use with caution in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency due to risk of hemolysis.","Not for use in patients with known allergy to vitamin K1."]
⚠️ Warnings & Precautions
["This medicine should be administered only by a healthcare professional.","Rapid intravenous injection may cause severe reactions; administer slowly.","Use with caution in patients with liver disease; monitor INR closely.","In newborns, use the appropriate formulation and dose to avoid kernicterus.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.","Avoid alcohol while receiving this medicine.","Tell your doctor about all other medicines you are taking, especially blood thinners."]
🤱 Lactation Safety
Phytomenadione is excreted in breast milk, but it is considered safe for use during breastfeeding. It is often given to newborns to prevent vitamin K deficiency bleeding, and maternal supplementation is not typically required unless the mother is deficient.
💊 Overdose Management
Overdose of this medicine is unlikely to cause serious harm because vitamin K1 has a wide safety margin. However, excessive doses may lead to hypercoagulability in some patients, especially those with certain risk factors. Treatment is supportive and symptomatic. In case of accidental overdose, contact a healthcare professional immediately.
⏰ Missed Dose
This medicine is given by a healthcare professional, so missed doses are unlikely. If you miss a scheduled dose, contact your doctor or clinic for instructions. Do not attempt to self-administer.
Additional Safety Advice
This medicine is given only by a healthcare professional in a hospital or clinic. Do not attempt to inject it yourself. Before receiving this medicine, tell your doctor if you are allergic to vitamin K or any other medicines, if you have liver disease, or if you have a condition called glucose-6-phosphate dehydrogenase deficiency. Also, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. This medicine can interact with blood thinners like warfarin, so your doctor will monitor your blood clotting tests closely. Avoid alcohol while receiving this medicine, as it can affect liver function and increase the risk of bleeding. If you miss a dose, contact your doctor for advice; do not try to catch up on your own. Keep all follow-up appointments and blood tests as scheduled.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced liver function, which can affect the effectiveness of this medicine. They may also be more sensitive to its effects. Close monitoring of INR and clinical response is recommended.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor. This medicine is considered safe during pregnancy when used as directed. It is often given to newborns to prevent bleeding.
🏥 Post-Surgery Considerations
This medicine may be used after surgery to reverse anticoagulation or treat bleeding. Inform your surgeon if you have received this medicine recently, as it may affect clotting.
🦷 Dental Procedures
If you are scheduled for a dental procedure and are on warfarin, your dentist may coordinate with your doctor. This medicine may be used to reverse anticoagulation before the procedure if needed.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid contact sports or activities that can cause bleeding or bruising while you are at risk of bleeding. Consult your doctor before starting any new exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a healthcare setting, so it may require a visit to a clinic or hospital. After receiving the injection, you may feel dizzy or tired; avoid driving or operating heavy machinery until you feel normal. Most people can resume normal activities the same day.
🛑 When to Stop This Medicine
This medicine is given as a single dose or a short course, so stopping is not usually a concern. If you are receiving it for a chronic condition, your doctor will determine when to stop based on your INR and clinical condition. Do not stop without consulting your doctor.
📅 Long-Term Use Effects
Long-term effects of this medicine are not a concern because it is typically used for short-term treatment. However, repeated use may be necessary in patients with chronic vitamin K deficiency. In such cases, regular monitoring of INR and liver function is important. Prolonged use may lead to excessive clotting in some patients, but this is rare. Always follow your doctor's guidance.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Oral vitamin K may be used for mild deficiency or maintenance, but it is not suitable for emergency reversal of warfarin.
Evidence: Well-establishedThese blood products can rapidly reverse anticoagulation in emergencies, but they carry risks and are used when vitamin K alone is insufficient.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for a vaccination, inform your healthcare provider that you have received this medicine.
📦 Storage Guide
✅ DO
Store in a refrigerator at 2-8°C
❌ DON'T
Do not freeze
✅ DO
Keep in original carton to protect from light
❌ DON'T
Do not expose to direct sunlight
✅ DO
Check expiry date before use
❌ DON'T
Do not use if expired or if solution is discolored
✈️ Traveling with This Medicine
This medicine is given in a healthcare setting, so travel advice is limited. If you are prescribed this medicine for home use (rare), carry it in its original packaging with the prescription. Keep it refrigerated (2-8°C) during travel using a cool pack. Inform airport security about the medication and carry a doctor's letter. Check customs regulations for injectable medicines before traveling internationally.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine is given as an injection into a muscle or vein by a healthcare professional in a hospital or clinic.
A: It usually starts working within 6 to 12 hours, but the full effect may take up to 24 hours.
A: Common side effects include pain, redness, or swelling at the injection site. Serious allergic reactions are rare.
A: This medicine may cause dizziness in some people. It is best to avoid driving until you know how it affects you.
A: It is considered safe when used as directed by a doctor. It is commonly used to prevent bleeding in newborns.
🤔 Common Patient Concerns
🔄 Substitutes for phyto k1 1mg injection
View AllAlternative brands with exact same active ingredient:
-
injek 1mg injectionNeon Laboratories Ltd ₹15.19 80.3% CHEAPER
-
vit k 1mg injectionSuncure Lifescience Pvt Ltd ₹15.54 79.9% CHEAPER
-
kvi 1mg injectionDewcare Concept Pvt.Ltd. ₹16.00 79.3% CHEAPER
-
kip 1mg injectionDWD Pharmaceuticals Ltd ₹16.50 78.6% CHEAPER
-
weldion 1mg injectionWelgenic Pharma ₹16.78 78.3% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken orally as a pill.
Fact: This medicine is an injection and must be given by a healthcare professional. Oral forms of vitamin K exist but are different products. - Myth: This medicine is a blood thinner.
Fact: This medicine actually helps blood clot by providing vitamin K, which is the opposite of a blood thinner. - Myth: This medicine can be used to treat all types of bleeding.
Fact: This medicine is only effective for bleeding caused by vitamin K deficiency or warfarin. It does not reverse other blood thinners or treat bleeding from other causes.
🔄 Alternative Options
Generic Alternatives
- Phytomenadione injection
Brand Alternatives
- Govit-K Injection