Intaxel 260mg Injection: Comprehensive Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing, rash, or swelling during infusion
- Fever, chills, or signs of infection
- Unusual bleeding or bruising
- Chest pain or palpitations
- Severe numbness or weakness in hands or feet
- Yellowing of skin or eyes
- Severe abdominal pain or vomiting
If experiencing severe symptoms, call emergency services immediately.
What is paclitero 260 mg injection used for?
This medicine is a chemotherapy injection containing paclitaxel 260 mg, used to treat breast, ovarian, lung, and other cancers. It works by stopping cancer cell division and is given intravenously by a healthcare professional.
- Generic Name: Paclitaxel (260mg)
- Manufacturer: Hetero Drugs Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 paclitero 260 mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा पैक्लिटैक्सेल 260 मिलीग्राम इंजेक्शन के रूप में एक कीमोथेरेपी दवा है, जिसका उपयोग स्तन कैंसर, डिम्बग्रंथि कैंसर, फेफड़ों के कैंसर और कपोसी सारकोमा के इलाज के लिए किया जाता है। यह कैंसर कोशिकाओं के विभाजन को रोककर उन्हें नष्ट करती है। यह दवा केवल अस्पताल या कैंसर केंद्र में डॉक्टर द्वारा नस के माध्यम से दी जाती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में बालों का झड़ना, मतली, उल्टी, दस्त, मुंह के छाले, जोड़ों और मांसपेशियों में दर्द, और हाथ-पैरों में झुनझुनी शामिल हैं। गंभीर दुष्प्रभावों में एलर्जी, संक्रमण, रक्तस्राव और हृदय संबंधी समस्याएं हो सकती हैं।
सुरक्षा सलाह: यह दवा केवल योग्य डॉक्टर की देखरेख में ही दी जानी चाहिए। उपचार के दौरान गर्भधारण से बचें और स्तनपान न कराएं। संक्रमण, असामान्य रक्तस्राव या लगातार सुन्नपन की स्थिति में तुरंत डॉक्टर से संपर्क करें। नियमित रक्त परीक्षण आवश्यक हैं।
💊 paclitero 260 mg injection Uses & Benefits
[{"condition":"Metastatic breast cancer","description":"Used as first-line or subsequent therapy, often in combination with other agents, to shrink tumors and prolong survival.","evidence":"Well-established"},{"condition":"Advanced ovarian cancer","description":"Used after failure of platinum-based chemotherapy or as part of initial therapy in combination with platinum drugs.","evidence":"Well-established"},{"condition":"Non-small cell lung cancer","description":"Used in combination with platinum-based chemotherapy for advanced or metastatic disease.","evidence":"Well-established"},{"condition":"AIDS-related Kaposi's sarcoma","description":"Used as second-line therapy for patients who have failed other treatments.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Gastric cancer","description":"Sometimes used in combination regimens for advanced gastric cancer.","evidence":"Limited"},{"condition":"Head and neck cancer","description":"Investigated in clinical trials for recurrent or metastatic disease.","evidence":"Limited"},{"condition":"Bladder cancer","description":"Used in some combination regimens for advanced bladder cancer.","evidence":"Limited"}]
Primary treatment for: Cancer (breast, ovarian, lung, Kaposi's sarcoma)
Also treats: Metastatic breast cancer, Advanced ovarian cancer, Non-small cell lung cancer, AIDS-related Kaposi's sarcoma
📋 Drug Information
| Generic Name(s) | Paclitaxel (260mg) |
| Brand Name | paclitero 260 mg injection |
| Manufacturer | Hetero Drugs Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Antimicrotubule agents- Taxanes |
| Route of Administration | Intravenous infusion |
| Storage | Store vials in a refrigerator at 2°C to 8°C (36°F to 46°F) in the original carton to protect from light. Do not freeze. Once diluted, the solution should be used immediately or stored as per institutional guidelines. |
| Shelf Life | Refer to the manufacturer's packaging for the expiration date. Do not use after the expiry date. |
| WHO Guideline | Paclitaxel is included in the WHO Model List of Essential Medicines for the treatment of breast cancer, ovarian cancer, and Kaposi's sarcoma. |
| ICMR Guideline | ICMR guidelines recommend paclitaxel as part of chemotherapy regimens for breast, ovarian, and lung cancers, based on stage and patient factors. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Paclitaxel binds to the beta-tubulin subunit of microtubules and stabilizes them, preventing their disassembly. This disrupts the dynamic reorganization of the microtubule network that is essential for cell division, leading to cell cycle arrest in the G2/M phase and subsequent cell death. It also affects other microtubule-dependent processes such as intracellular transport and cell signaling.
Mechanism Steps
💡 How to Take paclitero 260 mg injection
Strength: 260 mg per vial (injection)
Dosage Information
| Adult Dosage | The dose of this medicine varies depending on the type of cancer, stage, prior treatments, and patient factors. Common regimens include 175 mg/m² given as a 3-hour intravenous infusion every 3 weeks, or 135 mg/m² every 3 weeks in combination with other agents. For some indications, a dose of 260 mg/m² may be used. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and blood counts. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric oncologist. |
| Elderly Dosage | Elderly patients may be more susceptible to side effects such as neuropathy and myelosuppression. Dose adjustments may be necessary based on renal and hepatic function and overall health status. Individualized dosing by a clinician is essential. |
| Renal Impairment | No specific dose adjustment is recommended for renal impairment, but caution is advised. Monitor renal function closely. |
| Hepatic Impairment | In patients with hepatic impairment, dose reduction is recommended. For mild to moderate impairment, a reduced dose may be used. For severe impairment, paclitaxel should not be used. Consult a clinician for individualized dosing. |
| Maximum Daily Dose | The maximum tolerated dose varies by regimen. Common single-agent doses range from 135 mg/m² to 260 mg/m² per cycle. Do not exceed the dose prescribed by your oncologist. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of paclitero 260 mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Ritonavir | Major | |
| Gemfibrozil | Major | |
| Warfarin | Moderate | |
| Rifampin | Moderate | |
| Carbamazepine | Moderate | |
| Doxorubicin | Moderate | |
| Grapefruit juice | Minor | |
| St. John's wort | Minor |
🚨 Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
- CYP2C8 inhibitors (e.g., gemfibrozil)
- Live vaccines
⚡ Moderate Interactions
- Warfarin
- CYP3A4 inducers (e.g., rifampin, carbamazepine)
- Doxorubicin
🍷 Alcohol Interaction
Alcohol may increase the risk of liver toxicity and worsen side effects such as nausea and dizziness. It is advisable to avoid alcohol during treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to paclitaxel or other taxanes","Baseline neutrophil count less than 1,500 cells/mm³","Severe hepatic impairment","Pregnancy","Breastfeeding"]
⚠️ Warnings & Precautions
["Administer only under the supervision of a qualified oncologist.","Premedicate with corticosteroids, antihistamines, and H2 antagonists to prevent hypersensitivity reactions.","Monitor for bone marrow suppression; adjust dose based on blood counts.","Avoid live vaccines during treatment.","Use effective contraception during and after treatment.","Exercise caution in patients with pre-existing neuropathy.","Monitor liver function in patients with hepatic impairment."]
🤱 Lactation Safety
It is not known if paclitaxel is excreted in human milk. Because of the potential for serious adverse reactions in nursing infants, breastfeeding should be discontinued during treatment and for at least 2 weeks after the last dose.
💊 Overdose Management
Overdose of paclitaxel may cause severe bone marrow suppression, peripheral neuropathy, and mucositis. There is no specific antidote. Treatment is supportive and symptomatic. Patients should be monitored closely, and blood counts should be checked frequently. In case of overdose, contact a poison control center or emergency room immediately.
⏰ Missed Dose
This medicine is administered by a healthcare professional in a clinical setting. If you miss an appointment for your infusion, contact your doctor or clinic as soon as possible to reschedule. Do not attempt to self-administer.
Additional Safety Advice
This medicine must only be given by a qualified healthcare professional in a setting equipped to manage severe allergic reactions. Inform your doctor about all medications, supplements, and herbal products you are taking, as many can interact with this medicine. Avoid live vaccines during treatment. Use effective contraception to prevent pregnancy during and for some time after treatment, as this medicine can harm a developing fetus. Do not breastfeed while receiving this medicine. Report any signs of infection, unusual bleeding, or persistent numbness promptly. Regular blood tests are required to monitor blood counts, liver function, and kidney function.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of neuropathy, myelosuppression, and cardiac toxicity. Dose adjustments and close monitoring are recommended.
🤰 Pregnancy Planning (TTC)
This medicine can harm a fetus. Women should use effective contraception during treatment and for at least 6 months after the last dose. Men should use condoms during treatment and for 3 months after. Consult your doctor if you are planning pregnancy.
🏥 Post-Surgery Considerations
If you have recently had surgery, inform your doctor. Paclitaxel may affect wound healing and increase infection risk. Timing of treatment after surgery should be determined by your oncologist.
🦷 Dental Procedures
Inform your dentist that you are receiving this medicine. It can increase the risk of bleeding and infection. Dental procedures may need to be timed around your chemotherapy cycles.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise may be beneficial, but avoid strenuous activities if you have fatigue, neuropathy, or low blood counts. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
You may need to take time off work for infusions and recovery. Fatigue and neuropathy can affect your ability to perform certain tasks. Discuss work accommodations with your employer.
🛑 When to Stop This Medicine
Do not stop treatment without consulting your oncologist. Treatment may be stopped or modified based on disease progression, severe side effects, or other medical reasons.
📅 Long-Term Use Effects
Long-term effects may include persistent peripheral neuropathy, secondary cancers, and cardiac issues. Regular follow-up with your oncologist is essential to monitor for recurrence and late effects.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the cancer type, other drugs like docetaxel or platinum agents may be used.
Evidence: Well-establishedFor certain cancers, targeted therapies may be an option.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided during treatment. Inactivated vaccines may be given, but response may be reduced. Consult your doctor before any vaccination.
📦 Storage Guide
✅ DO
Store in refrigerator at 2°C to 8°C
❌ DON'T
Do not freeze
✅ DO
Keep in original carton to protect from light
❌ DON'T
Do not expose to direct sunlight
✅ DO
Use aseptic technique when handling
❌ DON'T
Do not use if solution is discolored or contains particles
✈️ Traveling with This Medicine
This medicine is administered in a healthcare setting, so travel is not applicable for self-administration. If you need to travel for treatment, carry your prescription and medical records. Ensure the clinic can store and handle the medicine properly. For international travel, check customs regulations regarding chemotherapy drugs.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The effects on cancer cells begin soon after infusion, but clinical response may take weeks to months to become evident.
A: You may experience dizziness or fatigue; avoid driving until you know how this medicine affects you.
A: Avoid live vaccines, grapefruit, St. John's wort, and alcohol. Use contraception and avoid breastfeeding.
🤔 Common Patient Concerns
🔄 Substitutes for paclitero 260 mg injection
View AllAlternative brands with exact same active ingredient:
-
dutaxel 260mg injectionSamarth Life Sciences Pvt Ltd ₹1,128.00 89.6% CHEAPER
-
taxeleon 260mg injectionNeon Laboratories Ltd ₹1,440.00 86.7% CHEAPER
-
paclicad 260mg injectionCadila Pharmaceuticals Ltd ₹2,601.56 76% CHEAPER
-
paclistar 260mg injectionLupin Ltd ₹3,146.52 71% CHEAPER
-
maclitaxel 260mg injectionMacleods Pharmaceuticals Pvt Ltd ₹3,678.75 66.1% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Paclitaxel can be taken orally.
Fact: Paclitaxel is not effective orally and must be given intravenously. - Myth: Paclitaxel is safe during pregnancy.
Fact: Paclitaxel can harm the fetus and is contraindicated in pregnancy. - Myth: Hair loss from paclitaxel is permanent.
Fact: Hair loss is usually temporary and hair regrows after treatment ends.
🔄 Alternative Options
Generic Alternatives
- Paclitaxel injection (generic)
Brand Alternatives
- Intaxel 260mg injection