Isolin 2mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Chest pain or pressure that lasts more than a few minutes
- Severe irregular heartbeat or palpitations
- Sudden difficulty breathing or wheezing that worsens
- Fainting or loss of consciousness
- Swelling of the face, lips, tongue, or throat
- Severe headache with blurred vision
- Decreased urine output or swelling in the legs
If experiencing severe symptoms, call emergency services immediately.
What is pacemak 2mg injection used for?
This medicine is an injectable beta-agonist used in hospitals to treat dangerously slow heart rates and severe asthma attacks. It works quickly to stimulate the heart and open the airways, but it requires continuous monitoring because it can cause serious heart rhythm problems.
- Generic Name: Isoprenaline (2mg)
- Manufacturer: Molekule India Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 pacemak 2mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा अस्पताल में डॉक्टर द्वारा इंजेक्शन के रूप में दी जाती है। इसका उपयोग दिल की धड़कन बहुत धीमी होने, गंभीर दमा के दौरे, और कुछ आपातकालीन स्थितियों में किया जाता है। यह दिल को तेज़ और मजबूत धड़कन के लिए उत्तेजित करती है और फेफड़ों की नलियों को खोलती है। यह दवा केवल डॉक्टर की निगरानी में ही दी जाती है, घर पर नहीं।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में दिल की धड़कन तेज़ होना, हाथ-पैर कांपना, घबराहट, सिरदर्द, चेहरे पर गर्मी लगना और पसीना आना शामिल हैं। गंभीर दुष्प्रभावों में अनियमित दिल की धड़कन, सीने में दर्द, और ब्लड प्रेशर में अचानक गिरावट हो सकती है। इन्हें तुरंत डॉक्टर को बताना चाहिए।
सुरक्षा सलाह: यह दवा केवल अस्पताल में डॉक्टर या नर्स द्वारा ही दी जानी चाहिए। घर पर खुद से इंजेक्शन न लगाएं। इस दवा को लेने से पहले अपने सभी स्वास्थ्य संबंधी जानकारी डॉक्टर को बताएं, खासकर दिल, थायरॉइड, और पोटैशियम की समस्या। दवा लेते समय आपकी दिल की धड़कन और ब्लड प्रेशर की लगातार निगरानी की जाएगी।
💊 pacemak 2mg injection Uses & Benefits
[{"condition":"Severe bradycardia or heart block","description":"Used as a temporary measure to increase heart rate in patients with dangerously slow heartbeats until a pacemaker can be placed.","evidence":"Well-established"},{"condition":"Cardiac arrest","description":"May be used during resuscitation efforts to stimulate the heart when other measures have failed, though it is not a first-line drug.","evidence":"Limited"},{"condition":"Acute severe asthma or bronchospasm","description":"Given by injection to rapidly open airways in life-threatening asthma attacks when inhaled therapy is not effective or not possible.","evidence":"Well-established"},{"condition":"Anaphylaxis","description":"Occasionally used as an adjunct in severe allergic reactions to support blood pressure and breathing, but adrenaline is preferred.","evidence":"Limited"},{"condition":"Diagnostic testing for cardiac stress","description":"Rarely used during certain cardiac stress tests to increase heart rate when exercise is not possible.","evidence":"Limited"}]
Off-label uses: [{"condition":"Hyperkalemia","description":"Sometimes given to temporarily shift potassium into cells in severe high-potassium emergencies, though other agents are more commonly used.","evidence":"Limited"},{"condition":"Beta-blocker overdose","description":"May be used to counteract dangerously slow heart rate and low blood pressure caused by beta-blocker poisoning.","evidence":"Limited"}]
Primary treatment for: Severe bradycardia or heart block
Also treats: Acute severe asthma, Cardiac arrest, Anaphylaxis, Beta-blocker overdose
📋 Drug Information
| Generic Name(s) | Isoprenaline (2mg) |
| Brand Name | pacemak 2mg injection |
| Manufacturer | Molekule India Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | Sympathomimetics agonist-Inotropes |
| Route of Administration | Parenteral (intravenous injection or infusion) |
| Storage | Store in a refrigerator at 2°C to 8°C. Do not freeze. Protect from light. Keep in the original carton until use. Once diluted for infusion, use promptly as directed by the hospital pharmacy. |
| Shelf Life | Refer to the product label for the exact shelf life. Typically 18 to 24 months from the date of manufacture when stored properly. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is a non-selective beta-adrenergic agonist. It binds to beta-1 receptors on the heart, increasing heart rate, conduction speed, and the force of heart muscle contraction. It also binds to beta-2 receptors in the lungs, causing relaxation of bronchial smooth muscle and widening of the airways. Additionally, it stimulates beta-2 receptors in blood vessels, leading to vasodilation and a fall in diastolic blood pressure. At higher doses, it can also stimulate alpha receptors, but its primary effects are on beta receptors.
Mechanism Steps
💡 How to Take pacemak 2mg injection
Strength: Injection: 2 mg in a suitable volume for parenteral use.
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on the patient's condition, response, and monitoring parameters. For severe bradycardia or heart block, a typical initial intravenous dose is 0.2 mg to 1 mg, given slowly, followed by a continuous infusion titrated to heart rate. For acute severe asthma, 0.1 mg to 0.5 mg may be given intravenously, but inhaled therapy is preferred. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially on the heart. Doses should be started low and titrated carefully with close monitoring. Dose must be individualized by a qualified clinician. |
| Renal Impairment | No specific dose adjustment guidelines are established from the available information. Use with caution in patients with kidney disease and monitor closely. |
| Hepatic Impairment | No specific dose adjustment guidelines are established from the available information. Use with caution in patients with liver disease and monitor closely. |
| Maximum Daily Dose | The maximum daily dose is not fixed and depends on the clinical situation. It is determined by the treating clinician based on continuous monitoring of heart rate, blood pressure, and clinical response. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of pacemak 2mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Propranolol | Major | |
| Amitriptyline | Major | |
| Phenelzine (MAOI) | Major | |
| Halothane | Major | |
| Digoxin | Major | |
| Furosemide | Moderate | |
| Prednisone | Moderate | |
| Theophylline | Moderate | |
| Diphenhydramine | Moderate | |
| Levothyroxine | Moderate |
🚨 Major Interactions
- Beta-blockers (e.g., propranolol, metoprolol)
- Tricyclic antidepressants (e.g., amitriptyline)
- Monoamine oxidase inhibitors (MAOIs)
- General anesthetics (e.g., halothane)
- Digoxin
⚡ Moderate Interactions
- Diuretics (e.g., furosemide)
- Corticosteroids
- Theophylline
- Antihistamines (e.g., diphenhydramine)
- Thyroid hormones
🍷 Alcohol Interaction
Alcohol should be avoided while receiving this medicine. Alcohol can lower blood pressure and increase the risk of irregular heartbeats, which may be dangerous in patients already receiving a powerful heart stimulant.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to isoprenaline or any component of the formulation","Ventricular fibrillation","Severe coronary artery disease","Untreated hyperthyroidism","Severe hypokalemia (low potassium)","Use with caution in patients with diabetes, glaucoma, or prostate enlargement"]
⚠️ Warnings & Precautions
["This medicine should only be used in a hospital setting with continuous cardiac monitoring.","It can cause dangerous irregular heart rhythms; use with extreme caution in patients with heart disease.","It may lower potassium levels; monitor and replace as needed.","It can increase blood sugar; monitor in diabetic patients.","It may cause tremor and nervousness; avoid driving or operating machinery until effects wear off.","Use with caution in elderly patients who may be more sensitive to its effects.","Do not use if the solution is discolored or contains particles."]
🤱 Lactation Safety
It is not known whether this medicine passes into breast milk. Because of the potential for serious adverse reactions in a nursing infant, breastfeeding is not recommended while receiving this medicine. Consult your doctor.
💊 Overdose Management
Overdose of this medicine can cause severe fast heart rate, irregular heart rhythms, high blood pressure, chest pain, and cardiac arrest. Treatment is supportive and symptomatic. Stop the infusion immediately. Administer a beta-blocker (such as propranolol) with caution to counteract cardiac effects, but be aware that beta-blockers can cause bronchospasm. Monitor heart rhythm, blood pressure, and electrolytes closely. Seek emergency medical attention.
⏰ Missed Dose
This medicine is given by a healthcare professional in a controlled setting. Missed doses are not applicable for home use. If you miss a scheduled hospital dose, inform your nurse or doctor immediately. Do not attempt to self-administer.
Additional Safety Advice
This medicine must only be given by a qualified healthcare professional in a hospital or emergency setting. Do not attempt to use it at home. Before receiving this medicine, tell your doctor about all your medical conditions, especially heart problems, high blood pressure, thyroid disease, diabetes, or low potassium levels. Also inform them about all other medicines you take, including over-the-counter drugs and herbal supplements. While receiving this medicine, you will be monitored closely for changes in heart rate, blood pressure, and heart rhythm. Do not drive or operate heavy machinery immediately after treatment, as you may feel dizzy or shaky. If you are pregnant or breastfeeding, discuss the risks and benefits with your doctor before this medicine is given.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the effects of this medicine, especially on the heart. They may experience more pronounced increases in heart rate and blood pressure changes. Doses should be started low and titrated carefully with close monitoring.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss with your doctor before receiving this medicine. It should be used during pregnancy only if clearly needed. Effective contraception is recommended during treatment unless otherwise advised.
🏥 Post-Surgery Considerations
This medicine may be used during or after surgery to manage severe bradycardia or bronchospasm. It requires continuous monitoring in the postoperative period. Inform your surgeon and anesthesiologist if you have received this medicine recently.
🦷 Dental Procedures
Inform your dentist if you have received this medicine recently, as it can interact with certain anesthetics and affect heart rate. Your dentist may need to consult your doctor before proceeding.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting immediately after receiving this medicine, as it can cause dizziness, rapid heartbeat, and low blood pressure. Gradually resume activities as advised by your doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital setting, so it does not directly affect your work life at home. However, after treatment, you may feel tired, shaky, or dizzy for a short time. Do not drive or operate machinery until you feel fully alert and your doctor approves.
🛑 When to Stop This Medicine
This medicine is stopped by your healthcare provider when your condition stabilizes or when the risks outweigh the benefits. Do not stop or adjust the dose yourself. If you experience severe side effects, inform your doctor immediately; they will decide whether to stop the medicine.
📅 Long-Term Use Effects
This medicine is typically used for short periods in emergency settings. Long-term use is not common. Prolonged infusions can lead to tolerance, increased heart rate, and electrolyte imbalances. If used for extended periods, regular monitoring of heart function, potassium levels, and blood sugar is necessary. The need for continued use should be reviewed frequently by the treating clinician.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A permanent solution for severe bradycardia or heart block.
Evidence: Well-establishedFirst-line treatment for asthma and bronchospasm.
Evidence: Well-establishedAlternative emergency drug for anaphylaxis and cardiac arrest.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are established from the available information. However, inform your doctor about your vaccination status before receiving this medicine.
📦 Storage Guide
✅ DO
Store in refrigerator at 2°C to 8°C
❌ DON'T
Do not freeze
✅ DO
Keep in original carton to protect from light
❌ DON'T
Do not use if solution is discolored or contains particles
✅ DO
Use promptly after dilution
❌ DON'T
Do not store diluted solution for long periods
✈️ Traveling with This Medicine
This medicine is given only in a hospital setting, so travel advice is not applicable for self-administration. If you are traveling after receiving this medicine, ensure you are cleared by your doctor. Carry a copy of your prescription and medical records. If you have a portable infusion pump, check with the airline and customs about carrying medical devices and medications. Store the medicine as directed by your pharmacist.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 1 to 5 minutes after intravenous injection.
A: A single dose lasts about 10 to 30 minutes, but an infusion can maintain the effect as long as needed.
A: It should be used during pregnancy only if clearly needed and under strict medical supervision. Discuss the risks and benefits with your doctor.
A: Fast heartbeat, trembling, headache, flushing, and sweating are common. These usually lessen with dose adjustment.
A: Yes, your doctor may check potassium and blood sugar levels, and monitor your heart continuously.
🤔 Common Patient Concerns
🔄 Substitutes for pacemak 2mg injection
View AllAlternative brands with exact same active ingredient:
-
isuprin 2mg injectionLemery ₹29.00 27.5% CHEAPER
-
isolin 2mg injectionSamarth Life Sciences Pvt Ltd ₹63.58 59% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be used at home for asthma attacks.
Fact: This medicine is given only by healthcare professionals in a hospital setting because it requires continuous heart monitoring. - Myth: This medicine is safe for everyone with a slow heart rate.
Fact: It is contraindicated in certain heart conditions and must be used with caution in others. Only a doctor can decide if it is appropriate. - Myth: This medicine has no serious side effects.
Fact: It can cause dangerous irregular heart rhythms, chest pain, and low blood pressure. Close monitoring is essential.
🔄 Alternative Options
Generic Alternatives
- Isoprenaline injection
Brand Alternatives
- Isolin 2mg injection