Agward-O Dry Syrup: Complete Information
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, or throat
- Severe or bloody diarrhea
- Sudden joint pain or inability to move a limb
- Seizures or convulsions
- Yellowing of the skin or eyes
- Decreased urine output or swelling
- Unusual bruising or bleeding
If experiencing severe symptoms, call emergency services immediately.
What is p-cef-o 50mg/50mg dry syrup used for?
This medicine is a combination antibiotic dry syrup containing cefixime and ofloxacin, used to treat bacterial infections in children. It works by killing bacteria through two different mechanisms. It should be used only under a doctor's supervision.
- Generic Name: Cefixime (50mg) + Ofloxacin (50mg)
- Manufacturer: MaxQure Labs
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 p-cef-o 50mg/50mg dry syrup के बारे में (Hindi Summary)
उपयोग: यह दवा सेफिक्साइम और ऑफ्लोक्सासिन का संयोजन है, जिसका उपयोग बच्चों में बैक्टीरियल संक्रमण के इलाज के लिए किया जाता है। यह श्वसन तंत्र, मूत्र मार्ग, कान और त्वचा के संक्रमण में प्रभावी है। यह दवा केवल डॉक्टर के निर्देशानुसार ही दी जानी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में दस्त, जी मिचलाना, उल्टी, पेट दर्द और दाने शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी, टेंडन टूटना, दौरे और आंतों का गंभीर संक्रमण हो सकता है। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही दें। खुराक न बदलें और न ही बीच में बंद करें। देने से पहले बोतल को अच्छी तरह हिलाएं। सही मापने वाले कप का उपयोग करें। दवा को भोजन के साथ या बिना भोजन के दिया जा सकता है। एंटासिड या आयरन की खुराक के साथ 2 घंटे का अंतराल रखें। बच्चे को पर्याप्त तरल पदार्थ दें।
💊 p-cef-o 50mg/50mg dry syrup Uses & Benefits
[{"condition":"Respiratory tract infections","description":"Used to treat bacterial infections of the throat, tonsils, sinuses, and lungs, such as pharyngitis, tonsillitis, sinusitis, and pneumonia.","evidence":"Well-established"},{"condition":"Urinary tract infections","description":"Effective against many bacteria that cause bladder and kidney infections.","evidence":"Well-established"},{"condition":"Ear infections","description":"Used for middle ear infections (otitis media) caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Can be used for certain bacterial skin infections, but only when the bacteria are known to be susceptible.","evidence":"Limited"}]
Off-label uses: [{"condition":"Typhoid fever","description":"Sometimes used off-label for enteric fever caused by Salmonella typhi, but resistance is common and other antibiotics are preferred.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Respiratory tract infections, Urinary tract infections, Otitis media, Skin infections
📋 Drug Information
| Generic Name(s) | Cefixime (50mg) + Ofloxacin (50mg) |
| Brand Name | p-cef-o 50mg/50mg dry syrup |
| Manufacturer | MaxQure Labs |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store the dry powder at room temperature (15-30°C) in a dry place, away from direct sunlight. After reconstitution, store the syrup in the refrigerator (2-8°C) and use within 7-14 days as directed on the label. Do not freeze. |
| Shelf Life | 24 months from the date of manufacture for the dry powder. After reconstitution, use within 7-14 days if refrigerated. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antibiotics with different mechanisms of action. Cefixime, a third-generation cephalosporin, binds to penicillin-binding proteins (PBPs) on the bacterial cell wall, inhibiting the final step of peptidoglycan synthesis. This weakens the cell wall and leads to bacterial cell lysis and death. Ofloxacin, a fluoroquinolone, inhibits DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination. This leads to inhibition of bacterial DNA synthesis and cell death. The combination provides broad-spectrum coverage and may be synergistic against some bacteria.
Mechanism Steps
💡 How to Take p-cef-o 50mg/50mg dry syrup
Strength: Dry syrup containing cefixime 50 mg and ofloxacin 50 mg per 5 mL after reconstitution.
Dosage Information
| Adult Dosage | This medicine is a pediatric dry syrup and is not typically prescribed for adults. Adult dosing of cefixime and ofloxacin combinations varies widely based on the infection being treated, its severity, and the patient's kidney and liver function. A qualified clinician must individualize the dose. Do not self-medicate. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. The dose is usually calculated based on the child's weight and the severity of the infection. The dry syrup must be reconstituted with the specified amount of water before use. Shake well before each dose. Use a proper measuring device. |
| Elderly Dosage | This medicine is not intended for elderly patients as it is a pediatric formulation. Elderly patients may be more sensitive to the effects of fluoroquinolones, especially tendon rupture and central nervous system effects. Dose adjustment may be needed based on renal function. |
| Renal Impairment | Dose adjustment is required in patients with renal impairment. For cefixime, the dose may need to be reduced if creatinine clearance is below 20 mL/min. For ofloxacin, the dose should be adjusted based on creatinine clearance. Consult a doctor for specific dosing. |
| Hepatic Impairment | No specific dose adjustment is established for hepatic impairment. Use with caution and monitor liver function. |
| Maximum Daily Dose | Not established from the available information. The maximum daily dose must be determined by a qualified clinician based on the patient's condition and renal function. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of p-cef-o 50mg/50mg dry syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Antacids | Major | |
| Iron supplements | Major | |
| Warfarin | Major | |
| Theophylline | Major | |
| NSAIDs | Major | |
| Corticosteroids | Moderate | |
| Sulfonylureas | Moderate | |
| Probenecid | Moderate | |
| Cimetidine | Moderate | |
| Cyclosporine | Minor |
🚨 Major Interactions
- Antacids containing aluminum or magnesium
- Iron supplements
- Warfarin
- Theophylline
- NSAIDs (e.g., ibuprofen)
⚡ Moderate Interactions
- Corticosteroids
- Antidiabetic drugs (sulfonylureas)
- Probenecid
- Cimetidine
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine, as it can increase the risk of stomach upset, dizziness, and liver problems. Alcohol may also worsen the side effects of ofloxacin, such as drowsiness and dizziness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to cefixime, other cephalosporins, ofloxacin, or other fluoroquinolones.","History of tendon disorders associated with fluoroquinolone use.","Children under 18 years of age (except for specific indications where benefits outweigh risks, as fluoroquinolones can affect cartilage development).","Pregnancy and breastfeeding, unless clearly needed.","Patients with myasthenia gravis (fluoroquinolones may worsen muscle weakness)."]
⚠️ Warnings & Precautions
["Serious allergic reactions, including anaphylaxis, can occur. Stop the medicine and seek emergency help if signs occur.","Clostridium difficile-associated diarrhea can occur during or after treatment. Do not treat with anti-diarrheal drugs without consulting a doctor.","Fluoroquinolones, including ofloxacin, can cause tendon inflammation and rupture, especially in children and the elderly. Report any joint pain immediately.","May cause dizziness and drowsiness. Avoid driving or operating machinery until you know how the medicine affects you.","May cause photosensitivity. Avoid prolonged sun exposure and use sunscreen.","Use with caution in patients with kidney or liver impairment. Dose adjustment may be needed.","May worsen symptoms of myasthenia gravis.","Prolonged use may lead to overgrowth of non-susceptible organisms, including fungi."]
🤱 Lactation Safety
Both cefixime and ofloxacin are excreted in breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Consult a doctor before use.
💊 Overdose Management
Overdose of this medicine may cause nausea, vomiting, diarrhea, and abdominal pain. In severe cases, seizures, confusion, and kidney problems may occur. There is no specific antidote. Treatment is supportive and symptomatic. If overdose is suspected, contact a poison control center or emergency room immediately. Gastric lavage may be considered if the overdose is recent. Maintain adequate hydration and monitor renal function.
⏰ Missed Dose
If a dose is missed, give it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Always give this medicine exactly as prescribed by your child's doctor. Do not change the dose or stop the medicine early, even if your child seems better. Shake the bottle well before each dose. Use a proper measuring device to ensure the correct amount. This medicine can be given with or without food, but giving it with food may reduce stomach upset. Avoid giving antacids or iron supplements within two hours of this medicine, as they can reduce its absorption. Make sure your child drinks plenty of fluids. Do not share this medicine with anyone else. Keep it out of reach of children. If your child develops a rash, difficulty breathing, or swelling of the face, stop the medicine and seek emergency help. Inform your doctor if your child has kidney or liver problems, or a history of seizures.
👴 Special Considerations for Elderly
💡 For Patients Above 65
This medicine is not intended for elderly patients as it is a pediatric formulation. Elderly patients are at higher risk of tendon rupture, kidney problems, and central nervous system effects from fluoroquinolones.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy, especially ofloxacin, due to potential risk to the developing fetus. Consult a doctor for alternative antibiotics if you are pregnant or planning pregnancy.
🏥 Post-Surgery Considerations
If the child has recently undergone surgery, inform the surgeon about this medicine. It may interact with other medications used during surgery.
🦷 Dental Procedures
Inform the dentist about this medicine before any dental procedure. Antibiotics may affect the oral flora and increase the risk of fungal infections.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Children should avoid strenuous physical activity while taking this medicine, especially if they experience joint pain or tendon discomfort. If any joint pain occurs, stop exercise and consult a doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some children. They should avoid activities that require alertness, such as riding a bicycle or playing sports, until they know how the medicine affects them.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting the doctor. Complete the full course as prescribed, even if the child feels better. If serious side effects occur, stop the medicine and seek medical advice immediately.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to antibiotic resistance and may increase the risk of serious side effects such as tendon rupture, peripheral neuropathy, and Clostridium difficile infection. It should only be used for the prescribed duration. Regular monitoring of kidney and liver function may be needed if used for prolonged periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
May help prevent antibiotic-associated diarrhea.
Evidence: ModerateHelps flush out the infection and supports recovery.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Antibiotics may reduce the effectiveness of live bacterial vaccines such as the typhoid vaccine. Consult the doctor about vaccination timing.
📦 Storage Guide
✅ DO
Store dry powder at room temperature (15-30°C)
❌ DON'T
Do not refrigerate the dry powder
✅ DO
After reconstitution, store in refrigerator (2-8°C)
❌ DON'T
Do not freeze the reconstituted syrup
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging with the prescription label intact. Keep the dry powder at room temperature and protect it from extreme heat or moisture. If the syrup is already reconstituted, carry it in a cool bag and refrigerate upon arrival. Carry a copy of the prescription to avoid issues at customs. If crossing time zones, adjust dosing times gradually, but do not double up on doses. Consult your doctor for specific advice.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Improvement in symptoms is usually seen within 24-48 hours, but the full course must be completed.
A: It is better to separate milk by 2 hours because calcium can reduce absorption.
A: Give the missed dose as soon as you remember, but if it is almost time for the next dose, skip it and continue with the regular schedule.
A: Avoid giving antacids, iron supplements, or dairy products within 2 hours of this medicine.
🤔 Common Patient Concerns
🔄 Substitutes for p-cef-o 50mg/50mg dry syrup
View AllAlternative brands with exact same active ingredient:
-
cefizime o dry syrupBluepipes Healthcare Private Limited ₹37.00 50.7% CHEAPER
-
mahacef plus syrupMankind Pharma Ltd ₹37.41 50.1% CHEAPER
-
cefo plus 50 mg/50 mg suspensionMedley Pharmaceuticals ₹40.78 45.6% CHEAPER
-
agward-o dry syrupAcekinetics Healthcare Pvt Ltd ₹45.00 40% CHEAPER
-
hifen plus 50 mg/50 mg dry syrupHetero Drugs Ltd ₹45.85 38.9% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Antibiotics can cure the common cold.
Fact: The common cold is usually caused by viruses, and antibiotics like this medicine do not work against viruses. - Myth: You can stop taking antibiotics once you feel better.
Fact: You must complete the full course as prescribed to prevent the infection from returning and to avoid antibiotic resistance. - Myth: This medicine can be used for any infection.
Fact: This medicine is only effective against certain bacterial infections. Using it for viral infections is not helpful and can cause side effects.
🔄 Alternative Options
Generic Alternatives
- Cefixime + Ofloxacin dry syrup (generic)
Brand Alternatives
- Agward-O Dry Syrup