Aelxim-OF Dry Syrup: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe allergic reaction: swelling of face, lips, throat, difficulty breathing.
- Bloody or severe diarrhea, abdominal cramps, fever.
- Sudden tendon pain, swelling, or inability to move a joint.
- Numbness, tingling, or weakness in hands or feet.
- Seizures or severe dizziness.
- Irregular heartbeat or fainting.
- Yellowing of skin or eyes, dark urine.
If experiencing severe symptoms, call emergency services immediately.
What is cefo plus 50 mg/50 mg suspension used for?
This medicine is a combination antibiotic dry syrup containing cefixime and ofloxacin. It is used to treat certain bacterial infections when a doctor decides that both antibiotics are needed. It is not for viral infections and should be taken exactly as prescribed.
- Generic Name: Cefixime + Ofloxacin
- Manufacturer: Medley Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cefo plus 50 mg/50 mg suspension के बारे में (Hindi Summary)
उपयोग: यह दवा सेफिक्साइम और ओफ्लोक्सासिन का संयोजन है, जिसका उपयोग कुछ जीवाणु संक्रमणों के इलाज के लिए किया जाता है। यह मूत्र मार्ग संक्रमण, श्वसन तंत्र संक्रमण और टाइफाइड बुखार जैसी स्थितियों में डॉक्टर द्वारा निर्धारित की जा सकती है। यह वायरल संक्रमण जैसे सर्दी-जुकाम के लिए प्रभावी नहीं है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, दस्त, पेट दर्द, सिरदर्द और चक्कर आना शामिल हैं। कुछ रोगियों में त्वचा पर चकत्ते, खुजली या धूप के प्रति संवेदनशीलता हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी, टेंडन टूटना, तंत्रिका क्षति और दौरे जैसी समस्याएं हो सकती हैं।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। एंटासिड, आयरन या जिंक सप्लीमेंट के साथ लेने से बचें, क्योंकि ये दवा के अवशोषण को कम कर सकते हैं। पर्याप्त पानी पिएं। धूप में जाने से बचें और सनस्क्रीन का उपयोग करें। दस्त, टेंडन दर्द या एलर्जी के लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
💊 cefo plus 50 mg/50 mg suspension Uses & Benefits
[{"condition":"Complicated urinary tract infections","description":"Used when a doctor determines that a combination of antibiotics is needed to cover multiple bacteria.","evidence":"Limited"},{"condition":"Respiratory tract infections","description":"May be prescribed for certain lower respiratory tract infections, but not as first-line therapy.","evidence":"Limited"},{"condition":"Typhoid fever","description":"Sometimes used in areas where resistance patterns make other antibiotics less effective.","evidence":"Limited"}]
Off-label uses: []
Primary treatment for: Bacterial infections
Also treats: Urinary tract infections, Respiratory tract infections, Typhoid fever
📋 Drug Information
| Generic Name(s) | Cefixime + Ofloxacin |
| Brand Name | Abixim O Tablet |
| Manufacturer | Medley Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Antibiotic (Cephalosporin + Fluoroquinolone) |
| Route of Administration | Oral |
| Storage | Store the dry powder at room temperature (15-30°C) in a dry place, away from direct sunlight. After reconstitution, store the suspension in the refrigerator (2-8°C) and discard any unused portion after 14 days. Do not freeze. |
| Shelf Life | The dry powder has a shelf life of 24 months from the date of manufacture. After reconstitution, the suspension should be used within 14 days if stored in the refrigerator. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine contains two antibiotics with different mechanisms. Cefixime, a cephalosporin, binds to penicillin-binding proteins and inhibits bacterial cell wall synthesis, leading to cell lysis. Ofloxacin, a fluoroquinolone, inhibits DNA gyrase and topoisomerase IV, enzymes required for bacterial DNA replication, transcription, repair, and recombination. The combination provides broad-spectrum antibacterial activity.
Mechanism Steps
💡 How to Take cefo plus 50 mg/50 mg suspension
Strength: Each 5 mL of reconstituted suspension contains cefixime 50 mg and ofloxacin 50 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 5-10 mL of the reconstituted suspension orally every 12 hours, or as directed by your doctor. The dose may vary depending on the type and severity of infection, your kidney function, and other factors. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. This combination is generally not recommended for children under 18 years due to the ofloxacin component. |
| Elderly Dosage | Elderly patients may require dose adjustment based on renal function. Ofloxacin can increase the risk of tendon rupture and central nervous system effects in older adults. Use with caution and monitor closely. |
| Renal Impairment | Dose adjustment is required in patients with renal impairment. For creatinine clearance less than 50 mL/min, the dose of ofloxacin should be reduced. Cefixime dose may also need adjustment. Consult your doctor for specific dosing. |
| Hepatic Impairment | No specific dose adjustment is established for hepatic impairment, but caution is advised. Monitor liver function if used in patients with liver disease. |
| Maximum Daily Dose | The maximum daily dose should not exceed 20 mL of the reconstituted suspension per day, but this must be confirmed by your doctor. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cefo plus 50 mg/50 mg suspension
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Antacids | Major | |
| NSAIDs | Major | |
| Theophylline | Major | |
| Corticosteroids | Major | |
| Probenecid | Moderate | |
| Cimetidine | Moderate | |
| Oral hypoglycemics | Moderate | |
| Phenytoin | Moderate | |
| Cyclosporine | Minor |
🚨 Major Interactions
- Antacids, sucralfate, iron, zinc
- Warfarin
- Theophylline
- NSAIDs
- Corticosteroids
⚡ Moderate Interactions
- Probenecid
- Cimetidine
- Oral hypoglycemics
- Phenytoin
🍷 Alcohol Interaction
Alcohol may increase the risk of central nervous system side effects such as dizziness, drowsiness, and seizures. It is advisable to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to cephalosporins or fluoroquinolones","History of tendon disorders with fluoroquinolones","Myasthenia gravis","Pregnancy (especially first trimester)","Breastfeeding","Children under 18 years (for ofloxacin component)","Severe renal impairment (dose adjustment required)"]
⚠️ Warnings & Precautions
["This medicine can cause severe allergic reactions. Stop use and seek emergency help if you experience rash, swelling, or difficulty breathing.","Fluoroquinolones, including ofloxacin, can cause tendon rupture, especially in older adults, those with kidney disease, or those taking corticosteroids. Stop use and rest if you experience tendon pain.","Ofloxacin can cause peripheral neuropathy. Report numbness, tingling, or weakness.","This medicine can cause dizziness and seizures. Avoid driving or operating machinery until you know how it affects you.","Prolonged use may lead to bacterial or fungal superinfections. Report new symptoms.","Avoid excessive sunlight and use sunscreen, as this medicine can cause photosensitivity.","Do not use this medicine for viral infections like colds or flu.","Take with food to reduce stomach upset.","Complete the full course as prescribed, even if you feel better.","Inform your doctor if you have kidney or liver disease, diabetes, or heart conditions."]
🤱 Lactation Safety
Both cefixime and ofloxacin are excreted in breast milk. Ofloxacin may cause serious adverse effects in a nursing infant, so this combination is not recommended during breastfeeding. Consult your doctor for alternative options.
💊 Overdose Management
Overdose of this medicine may cause nausea, vomiting, diarrhea, and seizures. There is no specific antidote. Treatment is supportive and symptomatic. In case of overdose, seek immediate medical attention. Hemodialysis may be considered for ofloxacin overdose but is not effective for cefixime.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at once to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop treatment early, even if you feel better, as this can lead to antibiotic resistance. Complete the full course as directed. Avoid taking antacids, iron supplements, or multivitamins containing zinc within 2 hours before or after this medicine, as they can reduce absorption. Drink plenty of fluids to stay hydrated. Avoid excessive sunlight and use sunscreen, as this medicine can make your skin more sensitive to sunlight. Do not share this medicine with others. If you experience severe diarrhea, tendon pain, or any signs of an allergic reaction, seek medical help immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of tendon rupture, kidney problems, and central nervous system effects. Dose adjustment may be needed based on kidney function. Monitor closely.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy, especially in the first trimester, due to the ofloxacin component. If you are planning pregnancy, consult your doctor for alternative antibiotics.
🏥 Post-Surgery Considerations
This medicine may be used to treat or prevent infections after surgery, but it is not routinely recommended. Follow your surgeon's instructions.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine. It may interact with other medications used during dental procedures. No specific precautions are established.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities that could cause tendon injury while taking this medicine, especially if you are older or have kidney disease. If you experience joint pain, stop exercising and consult your doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause dizziness and seizures, so avoid driving or operating heavy machinery until you know how it affects you. It may also cause photosensitivity, so take precautions if you work outdoors. Most people can continue their usual activities with caution.
🛑 When to Stop This Medicine
Stop taking this medicine and seek immediate medical attention if you experience signs of a severe allergic reaction, tendon pain, severe diarrhea, seizures, or irregular heartbeat. Do not stop the medicine without consulting your doctor unless instructed to do so.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to antibiotic resistance, superinfections, and rare but serious effects such as tendon damage, peripheral neuropathy, and liver or kidney problems. It should only be used for the shortest duration necessary. Regular monitoring of kidney and liver function may be required if used for prolonged periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
In many cases, a single antibiotic may be sufficient and reduces the risk of side effects and resistance.
Evidence: Well-establishedMay help prevent antibiotic-associated diarrhea.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Antibiotics may reduce the effectiveness of live bacterial vaccines such as typhoid vaccine. Complete the antibiotic course before receiving live vaccines, or consult your doctor for timing.
📦 Storage Guide
✅ DO
Store dry powder at room temperature (15-30°C)
❌ DON'T
Do not refrigerate the dry powder
✅ DO
After reconstitution, store in refrigerator (2-8°C)
❌ DON'T
Do not freeze the suspension
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Discard unused suspension after 14 days
❌ DON'T
Do not use beyond the expiry date
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription and a doctor's note if traveling internationally. Keep the dry powder at room temperature and protect it from moisture and direct sunlight. If you need to reconstitute it during travel, use clean water and store the suspension in a refrigerator if available; otherwise, keep it cool and use within 14 days. Be aware of customs regulations regarding prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start to feel better within 24-48 hours, but you must complete the full course as prescribed.
A: Yes, take it with food to reduce stomach upset.
A: Take it as soon as you remember if less than 6 hours have passed. If more than 6 hours, skip it and continue with your regular schedule. Do not double dose.
A: This combination is generally not recommended for children under 18 years due to the ofloxacin component. Consult a pediatrician.
A: No, you must complete the full course to prevent resistance and ensure the infection is fully treated.
🤔 Common Patient Concerns
🔄 Substitutes for cefo plus 50 mg/50 mg suspension
View AllAlternative brands with exact same active ingredient:
-
cefizime o dry syrupBluepipes Healthcare Private Limited ₹37.00 9.3% CHEAPER
-
mahacef plus syrupMankind Pharma Ltd ₹37.41 8.3% CHEAPER
-
agward-o dry syrupAcekinetics Healthcare Pvt Ltd ₹45.00 10.3% COSTLIER
-
hifen plus 50 mg/50 mg dry syrupHetero Drugs Ltd ₹45.85 12.4% COSTLIER
-
Fixal O Dry SyrupShalman Pharma Pvt Ltd ₹46.88 15% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any infection.
Fact: This medicine only works for specific bacterial infections and is not effective against viruses. - Myth: I can stop taking this medicine once I feel better.
Fact: You must complete the full course to prevent resistance and ensure the infection is fully treated. - Myth: This medicine is safe for children.
Fact: This combination is generally not recommended for children under 18 years due to the ofloxacin component.
🔄 Alternative Options
Generic Alternatives
- Cefixime + Ofloxacin dry syrup (generic)