oxymark-cd tablet - Paracetamol (650mg) + Codeine (30mg) medicine

Narcogin Forte Tablet: Comprehensive Medicine Guide

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🏭 Unimarck Pharma India Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026
⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for short-term pain management.
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Slow, shallow, or difficult breathing
  • Severe drowsiness or difficulty waking up
  • Yellowing of skin or eyes (jaundice)
  • Severe abdominal pain or vomiting blood
  • Swelling of face, lips, or throat
  • Seizures or convulsions
  • Decreased urine output

If experiencing severe symptoms, call emergency services immediately.

What is oxymark-cd tablet used for?

This medicine is a combination of Paracetamol 650 mg and Codeine 30 mg used for short-term relief of moderate to severe pain. It works by reducing pain signals in the brain and is available only by prescription.

  • Generic Name: Paracetamol (650mg) + Codeine (30mg)
  • Manufacturer: Unimarck Pharma India Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 oxymark-cd tablet के बारे में (Hindi Summary)

उपयोग: यह दवा पैरासिटामोल 650 मिलीग्राम और कोडीन 30 मिलीग्राम का संयोजन है। इसका उपयोग मध्यम से गंभीर दर्द के अल्पकालिक उपचार के लिए किया जाता है, जैसे सर्जरी के बाद का दर्द, दांत का दर्द, या चोट के कारण होने वाला दर्द। यह दवा केवल डॉक्टर के पर्चे पर ही मिलती है और इसे निर्धारित अवधि से अधिक नहीं लेना चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, मतली, उल्टी, कब्ज और सिर हल्का लगना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन सांस लेने में कठिनाई, गंभीर एलर्जी प्रतिक्रिया, या लीवर की क्षति हो सकती है। यदि कोई भी दुष्प्रभाव लंबे समय तक बना रहे तो डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। निर्धारित मात्रा से अधिक न लें। इस दवा के साथ शराब का सेवन न करें। जब तक आपको पता न चले कि यह दवा आप पर कैसे असर करती है, तब तक वाहन न चलाएं। यदि आपको सांस लेने में कठिनाई, अत्यधिक नींद, या आंखों या त्वचा का पीलापन दिखे तो तुरंत चिकित्सा सहायता लें।

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 oxymark-cd tablet Uses & Benefits

[{"condition":"Moderate to severe acute pain","description":"This medicine is used for short-term relief of moderate to severe pain that is not adequately controlled by non-opioid analgesics alone.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"It may be prescribed to manage pain following surgical procedures.","evidence":"Well-established"},{"condition":"Dental pain","description":"Used for relief of moderate to severe dental pain, such as after tooth extraction.","evidence":"Well-established"},{"condition":"Musculoskeletal pain","description":"May be used for short-term management of pain from injuries or musculoskeletal conditions.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Chronic pain","description":"Sometimes used off-label for chronic pain conditions, but this is not recommended due to risk of dependence.","evidence":"Limited"}]

Primary treatment for: Moderate to severe acute pain

Also treats: Post-operative pain, Dental pain, Musculoskeletal pain

📋 Drug Information

Generic Name(s)Paracetamol (650mg) + Codeine (30mg)
Brand Nameoxymark-cd tablet
ManufacturerUnimarck Pharma India Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action Class
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container, tightly closed.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Prescribe this medicine only for short-term use, typically not exceeding 3-5 days.
2
Assess patients for risk of opioid dependence before prescribing.
3
Advise patients to take the tablet with food to minimize gastrointestinal upset.
4
Warn patients about the risk of respiratory depression, especially when combined with other CNS depressants.
5
Instruct patients not to exceed the maximum daily dose of 6 tablets in 24 hours.
6
Monitor for signs of liver toxicity, especially in patients with hepatic impairment or alcohol use.
7
Consider alternative non-opioid analgesics for patients with a history of substance abuse.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Moderate to severe acute pain
This medicine is commonly prescribed for this.
Likely Use
❌
Mild pain
This medicine is not recommended for mild pain; use over-the-counter analgesics.
Not Primary
❌
Fever
This medicine contains paracetamol which reduces fever, but it is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionParacetamol is rapidly and almost completely absorbed from the gastrointestinal tract after oral administration. Codeine is also well absorbed orally. Food may delay the absorption of paracetamol slightly but does not significantly affect the extent of absorption.
DistributionParacetamol distributes widely into most body tissues, with a volume of distribution of about 0.9 L/kg. Codeine and its metabolites distribute into various tissues, including the central nervous system. Both drugs cross the placenta and are excreted in breast milk.
Protein BindingParacetamol is approximately 10-25% bound to plasma proteins. Codeine is about 25% bound to plasma proteins.
MetabolismParacetamol is primarily metabolized in the liver via glucuronidation and sulfation, with a small fraction metabolized by CYP2E1 to a toxic intermediate (NAPQI) that is normally detoxified by glutathione. Codeine is metabolized by CYP2D6 to morphine (active) and by CYP3A4 to norcodeine (inactive).
Half-LifeThe elimination half-life of paracetamol is approximately 2-3 hours. Codeine has a half-life of about 2.5-3 hours. In patients with hepatic or renal impairment, half-lives may be prolonged.
ExcretionParacetamol and its metabolites are excreted primarily in the urine. Codeine and its metabolites are also excreted mainly in the urine, with small amounts in feces.
BioavailabilityParacetamol has a high oral bioavailability of about 80-100%. Codeine's oral bioavailability is approximately 50-60% due to first-pass metabolism.
Onset of ActionPain relief typically begins within 30 to 60 minutes after oral administration.
Peak Plasma TimePeak plasma concentrations of paracetamol are reached within 0.5 to 2 hours. Codeine peaks at about 1 hour.
Duration of ActionThe analgesic effect usually lasts for 4 to 6 hours.

How It Works

This medicine combines two analgesics with different mechanisms. Paracetamol acts primarily in the central nervous system to reduce pain and fever, though its exact mechanism is not fully understood; it may inhibit prostaglandin synthesis in the brain. Codeine is a prodrug that is metabolized by the liver enzyme CYP2D6 to morphine, which then binds to mu-opioid receptors in the brain and spinal cord, inhibiting pain signal transmission. The combination provides additive pain relief.

Mechanism Steps

1
Paracetamol central action: Paracetamol reduces pain and fever primarily by inhibiting prostaglandin synthesis in the central nervous system.
2
Codeine metabolism: Codeine is metabolized by CYP2D6 in the liver to morphine, its active form.
3
Mu-opioid receptor activation: Morphine binds to mu-opioid receptors in the brain and spinal cord, inhibiting pain signal transmission.
4
Additive analgesia: The combined effects of paracetamol and codeine provide enhanced pain relief compared to either alone.

💡 How to Take oxymark-cd tablet

Strength: Each tablet contains Paracetamol 650 mg and Codeine Phosphate 30 mg.

1Take this medicine orally with a full glass of water.
2Take with food or milk to reduce stomach upset.
3Swallow the tablet whole; do not crush or chew.
4Take exactly as prescribed by your doctor.
5Do not exceed the recommended dose or duration of treatment.

Dosage Information

Adult DosageThe usual adult dose is one tablet taken orally every 4 to 6 hours as needed for pain. The maximum recommended dose is 6 tablets in 24 hours. Do not exceed the prescribed dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. This medicine is intended for short-term use only.
Pediatric DosagePediatric dosing is not established from available information. This medicine is contraindicated in children under 12 years of age. Consult a pediatrician for appropriate pain management in children.
Elderly DosageElderly patients (above 65 years) may be more sensitive to the effects of codeine, especially respiratory depression and constipation. Use with caution and consider lower initial doses. Dose must be individualized by a qualified clinician.
Renal ImpairmentIn patients with renal impairment, the elimination of codeine and its metabolites may be prolonged. Dose reduction or extended dosing intervals may be necessary. Consult a clinician for individualized dosing.
Hepatic ImpairmentIn patients with hepatic impairment, the metabolism of paracetamol and codeine may be altered. Use with caution and consider dose reduction. Avoid in severe hepatic impairment. Consult a clinician for individualized dosing.
Maximum Daily DoseThe maximum daily dose is 6 tablets (3900 mg paracetamol and 180 mg codeine) in 24 hours. Do not exceed this dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals or a snack
Reduces stomach upset and nausea.
Alcohol
Avoid
Increases risk of liver damage and respiratory depression.
High-fat meals
May delay absorption
Can slow the onset of pain relief.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of oxymark-cd tablet

✅ Common Side Effects

Drowsiness (Common (5-10%))
Avoid driving or operating machinery. Usually resolves with continued use.
Dizziness (Common (5-10%))
Rise slowly from sitting or lying position. Consult if persistent.
Nausea (Common (5-10%))
Take with food. Consult if severe or persistent.
Constipation (Common (5-10%))
Increase fluid and fiber intake. Consult if no bowel movement for 3 days.
Vomiting (Uncommon (1-5%))
Stay hydrated. Consult if persistent.

🚨 Serious Side Effects

Respiratory depression (Rare (<0.1%))
Seek immediate medical attention if breathing becomes slow or shallow.
Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Call emergency services if you experience swelling of face, lips, throat, or difficulty breathing.
Liver damage (Rare (<0.1%))
Seek medical attention if you notice yellowing of skin or eyes, dark urine, or severe abdominal pain.
Dependence and withdrawal (Uncommon with short-term use)
Do not stop abruptly after prolonged use; consult your doctor for a tapering plan.

⚠️ Rare Side Effects

Seizures
Seek immediate medical attention.
Severe skin reactions (Stevens-Johnson syndrome)
Stop the medicine and seek immediate medical attention if you develop a rash with blisters or peeling skin.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
MAOIs Major
Benzodiazepines Major
Fluoxetine Moderate
Rifampin Moderate
Anticholinergics Moderate
Antacids Minor
Cholestyramine Minor

🚨 Major Interactions

  • Monoamine oxidase inhibitors (MAOIs)
  • CNS depressants (e.g., benzodiazepines, alcohol)
  • Warfarin

⚡ Moderate Interactions

  • CYP2D6 inhibitors (e.g., fluoxetine, quinidine)
  • CYP3A4 inducers (e.g., rifampin, carbamazepine)
  • Anticholinergics

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol increases the risk of liver damage from paracetamol and enhances the sedative and respiratory depressant effects of codeine, which can be dangerous.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to paracetamol, codeine, or any component of the formulation","Severe respiratory depression or acute or severe bronchial asthma","Paralytic ileus or suspected gastrointestinal obstruction","Children under 12 years of age","Post-tonsillectomy or adenoidectomy in children under 18 years","Concurrent use with MAOIs or within 14 days of stopping MAOIs","Severe hepatic impairment"]

⚠️ Warnings & Precautions

["May cause respiratory depression; use with caution in elderly or debilitated patients.","Risk of dependence and withdrawal with prolonged use; use for the shortest duration possible.","Do not exceed the recommended dose of paracetamol; overdose can cause severe liver damage.","Avoid alcohol while taking this medicine.","May impair ability to drive or operate machinery; avoid until you know how it affects you.","Use with caution in patients with head injury, increased intracranial pressure, or seizure disorders.","Codeine may cause constipation; monitor and manage appropriately.","Not recommended for breastfeeding mothers due to risk of infant opioid toxicity."]

🤱 Lactation Safety

Codeine and paracetamol are excreted in breast milk. Codeine may cause serious adverse reactions in nursing infants, including excessive drowsiness and respiratory depression. Breastfeeding is not recommended while taking this medicine, especially for mothers who are ultra-rapid metabolizers of codeine.

💊 Overdose Management

Overdose of this medicine can cause severe liver damage from paracetamol and respiratory depression from codeine. Seek immediate medical attention. Treatment may include administration of N-acetylcysteine for paracetamol toxicity and naloxone for opioid toxicity. Supportive care and monitoring of vital signs are essential.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Avoid alcohol while taking this medicine, as it can increase the risk of liver damage and respiratory depression. Do not drive or operate heavy machinery until you know how this medicine affects you. Inform your doctor if you have a history of liver or kidney disease, breathing problems, or substance abuse. Do not use this medicine for longer than directed without medical supervision. Keep out of reach of children. Store at room temperature away from moisture and heat. If you experience difficulty breathing, severe drowsiness, or yellowing of the eyes or skin, seek immediate medical attention.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more sensitive to the effects of codeine, especially respiratory depression, constipation, and drowsiness. Lower doses and close monitoring are recommended. Avoid use in frail elderly patients if possible.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. Prolonged use during pregnancy can lead to neonatal opioid withdrawal syndrome. Use only if clearly needed and prescribed by a doctor.

🏥 Post-Surgery Considerations

This medicine may be prescribed for post-surgical pain. Take it exactly as directed and do not exceed the recommended dose. Inform your surgeon if you experience excessive drowsiness or difficulty breathing.

🦷 Dental Procedures

This medicine may be used for dental pain after procedures. Inform your dentist if you are taking this medicine before any dental work. Avoid alcohol-based mouthwashes as they may increase drowsiness.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce stress on joints and muscles.
🥗
Engage in regular low-impact exercise such as walking or swimming.
😴
Practice good posture to prevent musculoskeletal pain.
💧
Include anti-inflammatory foods in your diet, such as fruits and vegetables.
🧘
Get adequate sleep to aid recovery and pain management.
🌞
Stay well hydrated to prevent constipation.

🏋️ Exercise Considerations

Avoid strenuous exercise or activities that may worsen pain while taking this medicine. Gentle stretching and low-impact exercises may be beneficial, but consult your doctor before starting any exercise program.

🥗 Diet Recommendations

Include fiber-rich foods to prevent constipation.
Stay well hydrated by drinking plenty of water.
Avoid alcohol and caffeine, which can worsen side effects.
Eat small, frequent meals if you experience nausea.

💼 Impact on Daily Work & Life

This medicine may cause drowsiness and dizziness, which can impair your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also affect your ability to concentrate, so take precautions at work.

🛑 When to Stop This Medicine

Stop taking this medicine when your pain is controlled or as directed by your doctor. Do not stop abruptly after prolonged use without consulting your doctor, as withdrawal symptoms may occur. If you experience severe side effects, stop and seek medical attention.

📅 Long-Term Use Effects

Long-term use of this medicine can lead to physical dependence, tolerance, and withdrawal symptoms upon discontinuation. It may also cause chronic constipation, liver damage from paracetamol, and hormonal changes. Regular monitoring of liver function and pain control is recommended. Use for the shortest duration possible.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can help manage pain and improve function without medication.

Evidence: Well-established
Non-opioid analgesics

Medications like ibuprofen or naproxen may be sufficient for mild to moderate pain.

Evidence: Well-established
Mind-body techniques

Relaxation, meditation, and cognitive behavioral therapy can help manage chronic pain.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific interactions with vaccines are established. However, if you are scheduled for vaccination, inform your healthcare provider about this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✅ DO

Keep out of reach of children

❌ DON'T

Do not use after expiry date

✈️ Traveling with This Medicine

When traveling with this medicine, carry it in its original packaging along with a copy of your prescription. Check the laws of your destination country regarding opioid medications, as some countries have strict regulations. Store it in a cool, dry place away from direct sunlight. If crossing time zones, adjust dosing intervals as advised by your doctor. Never share this medicine with others.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old man with severe dental pain after tooth extraction
He was prescribed this medicine for 3 days. He took it with food as directed and experienced significant pain relief within 45 minutes. He reported mild drowsiness but was able to manage it by resting. He stopped the medicine after 3 days as instructed and had no withdrawal symptoms.
💡 Lesson: Short-term use as prescribed provides effective pain relief with minimal side effects.
👤 A 70-year-old woman with post-operative knee pain
She was prescribed this medicine but experienced excessive drowsiness and constipation. Her doctor reduced the dose and added a stool softener. She was advised to avoid driving and to increase fluid intake. Her pain was controlled with the adjusted dose.
💡 Lesson: Elderly patients may require lower doses and close monitoring for side effects.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts relieving pain within 30 to 60 minutes after taking it.

Q: How long can I take this medicine?

A: This medicine is intended for short-term use only, typically not more than 3-5 days. Prolonged use can lead to dependence.

Q: Can I take this medicine with alcohol?

A: No, alcohol should be avoided as it increases the risk of liver damage and respiratory depression.

Q: Is this medicine safe for children?

A: No, this medicine is contraindicated in children under 12 years of age.

Q: What should I do if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my liver?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?
  • Is it safe to take with other pain relievers?

🔄 Substitutes for oxymark-cd tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine is safe for long-term use.
    Fact: This medicine is intended for short-term use only. Prolonged use can lead to dependence and other serious side effects.
  • Myth: It is safe to take extra doses if pain is severe.
    Fact: Taking more than the recommended dose can cause severe liver damage and respiratory depression. Always follow the prescribed dose.
  • Myth: This medicine is safe for children.
    Fact: This medicine is contraindicated in children under 12 years due to risk of severe respiratory depression.

🔄 Alternative Options

Generic Alternatives

  • Paracetamol 650 mg + Codeine 30 mg tablet (generic)

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Paracetamol 650 mg + Codeine 30 mg","onset":"30-60 minutes","duration":"4-6 hours","notes":"Prescription only; risk of dependence."},{"medicine":"Paracetamol + Ibuprofen","composition":"Paracetamol 325 mg + Ibuprofen 200 mg","onset":"30-60 minutes","duration":"4-6 hours","notes":"Available over-the-counter; no opioid risk."}]

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