Lupi-FSH 75 Injection: A Comprehensive Guide to Urofollitropin
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe abdominal pain or bloating
- Rapid weight gain (more than 2 kg in 24 hours)
- Difficulty breathing or shortness of breath
- Decreased urine output
- Severe headache with visual disturbances
- Swelling of face, lips, or throat
- Chest pain or leg swelling
If experiencing severe symptoms, call emergency services immediately.
What is ovitropin fsh 75iu injection used for?
This medicine is a purified follicle-stimulating hormone (FSH) used to stimulate ovulation and multiple follicle development in women undergoing fertility treatment, and to stimulate sperm production in men with certain hormonal disorders. It is given by injection under the supervision of a fertility specialist.
- Generic Name: Urofollitropin (75IU)
- Manufacturer: Shree Venkatesh International Limited
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ovitropin fsh 75iu injection के बारे में (Hindi Summary)
उपयोग: यह दवा मुख्य रूप से महिलाओं में ओव्यूलेशन को उत्तेजित करने और आईवीएफ जैसी सहायक प्रजनन तकनीकों में अंडों के विकास के लिए उपयोग की जाती है। यह पुरुषों में शुक्राणु उत्पादन को बढ़ाने के लिए भी इस्तेमाल की जा सकती है। यह एक इंजेक्शन है जो डॉक्टर की देखरेख में दिया जाता है।
साइड इफेक्ट्स: आम दुष्प्रभावों में इंजेक्शन स्थल पर दर्द, सूजन, सिरदर्द, पेट दर्द, मतली और मूड में बदलाव शामिल हैं। गंभीर दुष्प्रभावों में ओवेरियन हाइपरस्टिमुलेशन सिंड्रोम (OHSS), ओवेरियन टॉर्शन, और थ्रोम्बोएम्बोलिक घटनाएं शामिल हैं। कोई भी गंभीर लक्षण होने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा का उपयोग केवल प्रजनन विशेषज्ञ की देखरेख में ही करें। बिना प्रशिक्षण के स्वयं इंजेक्शन न लगाएं। निर्धारित खुराक और समय का पालन करें। नियमित अल्ट्रासाउंड और रक्त परीक्षण करवाएं। OHSS के लक्षण जैसे गंभीर पेट दर्द, सूजन, तेजी से वजन बढ़ना या सांस लेने में कठिनाई हो तो तुरंत डॉक्टर को बताएं। धूम्रपान और शराब से बचें।
💊 ovitropin fsh 75iu injection Uses & Benefits
[{"condition":"Ovulation induction in anovulatory infertility","description":"Used to stimulate ovulation in women who do not ovulate regularly, particularly those with polycystic ovary syndrome (PCOS) who do not respond to first-line treatments.","evidence":"Well-established"},{"condition":"Controlled ovarian hyperstimulation for assisted reproductive technologies (ART)","description":"Used to stimulate the development of multiple follicles in women undergoing IVF, ICSI, or other ART procedures.","evidence":"Well-established"},{"condition":"Hypogonadotropic hypogonadism in men","description":"Used to stimulate spermatogenesis in men with low gonadotropin levels, often in combination with human chorionic gonadotropin (hCG).","evidence":"Established"}]
Off-label uses: [{"condition":"Luteal phase support","description":"Sometimes used off-label to support the luteal phase in ART cycles, although evidence is limited.","evidence":"Limited"}]
Primary treatment for: Infertility
Also treats: Polycystic ovary syndrome (PCOS), Hypogonadotropic hypogonadism
📋 Drug Information
| Generic Name(s) | Urofollitropin (75IU) |
| Brand Name | ovitropin fsh 75iu injection |
| Manufacturer | Shree Venkatesh International Limited |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GYNAECOLOGICAL |
| Action Class | Gonadotropins |
| Route of Administration | Parenteral (subcutaneous or intramuscular injection) |
| Storage | Store the lyophilized powder at 2-8°C (36-46°F) in the refrigerator. Do not freeze. After reconstitution, the solution should be used immediately or stored as directed by the manufacturer. Protect from light. |
| Shelf Life | Refer to the expiry date on the package. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Urofollitropin is a purified form of follicle-stimulating hormone (FSH) that binds to FSH receptors on granulosa cells in the ovary. This binding activates intracellular signaling pathways, primarily the cAMP/protein kinase A pathway, leading to follicular growth, granulosa cell proliferation, and increased estrogen production. In men, FSH acts on Sertoli cells in the testes to promote spermatogenesis. The effects are dose-dependent and require the presence of functional ovaries or testes.
Mechanism Steps
💡 How to Take ovitropin fsh 75iu injection
Strength: Lyophilized powder for injection, 75 IU per vial
Dosage Information
| Adult Dosage | The dose of this medicine is individualized based on the patient's response, indication, and treatment protocol. For ovulation induction, a typical starting dose is 75 IU to 150 IU daily, administered subcutaneously or intramuscularly, with adjustments based on ovarian response monitored by ultrasound and estradiol levels. For controlled ovarian hyperstimulation in ART, doses may range from 150 IU to 300 IU daily, often in combination with a GnRH agonist or antagonist. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | This medicine is not intended for use in elderly patients. Safety and efficacy have not been established in this population. |
| Renal Impairment | No specific dose adjustments are established for renal impairment. Use with caution and monitor closely. |
| Hepatic Impairment | No specific dose adjustments are established for hepatic impairment. Use with caution and monitor closely. |
| Maximum Daily Dose | The maximum daily dose is determined by the clinician based on individual response and should not exceed the prescribed amount. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ovitropin fsh 75iu injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| GnRH antagonists | Major | |
| GnRH agonists | Major | |
| Clomiphene citrate | Moderate |
🚨 Major Interactions
- Gonadotropin-releasing hormone (GnRH) antagonists
- Gonadotropin-releasing hormone (GnRH) agonists
⚡ Moderate Interactions
- Clomiphene citrate
🍷 Alcohol Interaction
Alcohol may reduce fertility and should be avoided during treatment with this medicine. It can also worsen side effects such as mood swings and abdominal discomfort.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to urofollitropin or any excipient","Primary ovarian failure","Primary testicular failure","Uncontrolled thyroid or adrenal dysfunction","Ovarian cysts or enlargement not due to PCOS","Abnormal uterine bleeding of unknown cause","Pregnancy","Breastfeeding"]
⚠️ Warnings & Precautions
["This medicine should only be prescribed by a fertility specialist.","Ovarian hyperstimulation syndrome (OHSS) can occur; monitor closely.","Multiple pregnancies are a risk with ovulation induction.","Ectopic pregnancy should be ruled out early.","Thromboembolic events have been reported rarely.","Injection site reactions may occur; rotate sites.","Do not use if the solution is cloudy or contains particles.","Keep out of reach of children."]
🤱 Lactation Safety
It is not known whether urofollitropin is excreted in human breast milk. Because many drugs are excreted in human milk, caution should be exercised when this medicine is administered to a nursing woman. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose may lead to ovarian hyperstimulation syndrome (OHSS). If overdose is suspected, seek immediate medical attention. Treatment is symptomatic and supportive, with close monitoring of ovarian response and fluid balance. There is no specific antidote.
⏰ Missed Dose
If you miss a dose, contact your fertility specialist for guidance. Do not double the dose to make up for a missed one. The dosing schedule is critical for treatment success.
Additional Safety Advice
This medicine must only be used under the supervision of a qualified fertility specialist. Do not self-administer unless you have been properly trained. Follow the prescribed dose and schedule exactly. Regular monitoring with ultrasound and blood tests is essential to assess ovarian response and adjust the dose. Report any signs of ovarian hyperstimulation syndrome, such as severe abdominal pain, bloating, rapid weight gain, or shortness of breath, immediately. Avoid alcohol and smoking during treatment as they can affect fertility outcomes. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Store the medication as directed and never use it beyond the expiry date. Keep all appointments for monitoring and follow-up.
👴 Special Considerations for Elderly
💡 For Patients Above 65
This medicine is not intended for use in elderly patients. Safety and efficacy have not been established in this population.
🤰 Pregnancy Planning (TTC)
This medicine is used to help achieve pregnancy. If you become pregnant during treatment, discontinue the medicine and consult your doctor immediately. It is important to have a pregnancy test as advised by your doctor.
🏥 Post-Surgery Considerations
If you undergo surgery while on this medicine, inform your surgeon and anesthesiologist. There are no specific restrictions, but your fertility specialist should be consulted.
🦷 Dental Procedures
No specific precautions for dental procedures. However, inform your dentist about your medication.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe, but avoid high-impact activities that may cause ovarian torsion if you have enlarged ovaries. Consult your doctor before starting any exercise program during treatment.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue in some patients. Avoid driving or operating heavy machinery if you experience these effects. Treatment requires frequent monitoring appointments, which may affect work schedules. Discuss with your employer for flexibility.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your fertility specialist. If you experience severe side effects or suspect pregnancy, contact your doctor immediately. Treatment is typically stopped after the trigger shot or if OHSS develops.
📅 Long-Term Use Effects
Long-term use of this medicine is generally limited to the duration of fertility treatment cycles. There is no established evidence of long-term adverse effects, but some studies suggest a possible increased risk of ovarian tumors with prolonged use of fertility drugs. Regular follow-up with your doctor is recommended.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Oral medication for ovulation induction, often used as first-line treatment.
Evidence: Well-establishedOral aromatase inhibitor used for ovulation induction, especially in PCOS.
Evidence: Well-establishedWeight loss, diet, and exercise can improve fertility in some women.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are known. However, consult your doctor before receiving any vaccine during fertility treatment.
📦 Storage Guide
✅ DO
Store in the refrigerator at 2-8°C
❌ DON'T
Do not freeze
✅ DO
Keep in original packaging to protect from light
❌ DON'T
Do not use if the solution is cloudy or contains particles
✅ DO
Use reconstituted solution immediately or as directed
❌ DON'T
Do not store reconstituted solution for extended periods
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with the prescription label. Keep it refrigerated (2-8°C) during travel using a cooler bag with ice packs. Do not freeze. Carry a copy of your prescription and a doctor's letter explaining the medical need. Check airline regulations for carrying injectables and sharps. If traveling across time zones, consult your doctor for schedule adjustments.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Ovarian response usually occurs within 7-14 days of starting treatment, but this varies by individual. Your doctor will monitor your response with ultrasound and blood tests.
A: It is not known if this medicine passes into breast milk. Consult your doctor before using it while breastfeeding.
A: Contact your fertility specialist for guidance. Do not double the dose.
A: No specific food restrictions are known. However, avoid alcohol and maintain a healthy diet.
🤔 Common Patient Concerns
🔄 Substitutes for ovitropin fsh 75iu injection
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Foliton 75IU InjectionInga Laboratories Pvt Ltd ₹682.50 45.4% CHEAPER
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utrova 75iu injectionGlenmark Pharmaceuticals Ltd ₹750.00 40% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine guarantees pregnancy.
Fact: This medicine increases the chance of ovulation and follicle development, but pregnancy depends on many factors including egg quality, sperm quality, and uterine receptivity. - Myth: This medicine is safe to take without monitoring.
Fact: This medicine requires close monitoring by a fertility specialist to avoid serious complications such as ovarian hyperstimulation syndrome.
🔄 Alternative Options
Generic Alternatives
- Urofollitropin
Brand Alternatives
- Lupi-FSH 75 Injection