osynac gel - Diclofenac (1.16% w/w) medicine

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Diclofenac (1.16% w/w)
🏭 Pharmasynth Formulations Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for topical diclofenac in localized musculoskeletal pain.
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026

When to Call Your Doctor IMMEDIATELY

  • Severe allergic reaction: swelling of face, lips, tongue, or throat, difficulty breathing.
  • Severe skin reaction: blistering, peeling, or widespread rash.
  • Signs of gastrointestinal bleeding: black, tarry stools, vomiting blood, or severe abdominal pain.
  • Chest pain, shortness of breath, or irregular heartbeat.
  • Decreased urine output or swelling in the legs.
  • Yellowing of the skin or eyes (jaundice).
  • Persistent or worsening pain despite using the gel as directed.

If experiencing severe symptoms, call emergency services immediately.

What is osynac gel used for?

This medicine is a topical gel containing diclofenac 1.16% w/w, an NSAID used to relieve pain and inflammation in conditions like osteoarthritis and soft tissue injuries. It is applied directly to the skin over the affected area 3 to 4 times daily.

  • Generic Name: Diclofenac (1.16% w/w)
  • Manufacturer: Pharmasynth Formulations Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 osynac gel के बारे में (Hindi Summary)

उपयोग: यह दवा एक टॉपिकल जेल है जिसमें डाइक्लोफेनाक 1.16% w/w सक्रिय घटक के रूप में मौजूद है। यह मुख्य रूप से जोड़ों के दर्द, सूजन और अकड़न के इलाज के लिए उपयोग की जाती है, जैसे कि घुटनों का ऑस्टियोआर्थराइटिस, कमर दर्द, मोच और खेल-कूद से जुड़ी चोटें। इसे प्रभावित त्वचा पर पतली परत में लगाया जाता है और धीरे-धीरे मला जाता है। यह दर्द और सूजन को कम करने में मदद करती है।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में त्वचा पर हल्की जलन, लालिमा, खुजली या दाने शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। कभी-कभी गंभीर एलर्जी प्रतिक्रिया हो सकती है जैसे चेहरे, होंठ या गले में सूजन, जिसके लिए तुरंत डॉक्टर से संपर्क करना चाहिए।

सुरक्षा सलाह: इस दवा को लगाने के बाद हाथ धो लें, जब तक कि हाथ ही इलाज वाला हिस्सा न हो। इसे टूटी हुई त्वचा, आंखों, नाक या मुंह के पास न लगाएं। अगर दर्द 7 दिनों से ज्यादा बना रहे तो डॉक्टर से सलाह लें। गर्भावस्था या स्तनपान के दौरान उपयोग से पहले डॉक्टर से परामर्श करें। बच्चों पर बिना डॉक्टर की सलाह के उपयोग न करें।

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 osynac gel Uses & Benefits

[{"condition":"Osteoarthritis of the knee","description":"This medicine is applied to the affected knee to reduce pain and improve joint function in patients with knee osteoarthritis.","evidence":"Well-established"},{"condition":"Osteoarthritis of the hand","description":"Topical application to the hands can relieve pain and stiffness associated with hand osteoarthritis.","evidence":"Well-established"},{"condition":"Soft tissue injuries","description":"Used for localized pain and inflammation" class="semantic-link" title="Medicines for swelling">swelling from sprains, strains, and sports injuries.","evidence":"Well-established"},{"condition":"Localized musculoskeletal pain","description":"Provides relief for acute musculoskeletal pain such as back pain or neck pain when applied to the affected area.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Localized neuropathic pain","description":"Sometimes used off-label for localized neuropathic pain, though evidence is limited.","evidence":"Limited"}]

Primary treatment for: Osteoarthritis

Also treats: Soft tissue injuries, Musculoskeletal pain, Sprains and strains

📋 Drug Information

Generic Name(s)Diclofenac (1.16% w/w)
Brand Nameosynac gel
ManufacturerPharmasynth Formulations Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action ClassNSAID's- Non-Selective COX 1&2 Inhibitors (acetic acid)
Route of AdministrationTopical
StorageStore at room temperature (15-30°C). Protect from direct sunlight and moisture. Keep the tube tightly closed when not in use.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Apply this medicine only to intact skin and avoid broken or irritated areas.
2
Wash your hands thoroughly after each application to prevent accidental contact with eyes or mouth.
3
Do not use a heating pad or occlusive dressing over the treated area unless advised by your doctor.
4
If you experience skin irritation, stop using the gel and consult your doctor.
5
Use the gel consistently for the best results, but do not exceed the recommended frequency or duration.
6
Inform your doctor if you are taking oral NSAIDs or blood thinners, as interactions may occur.
7
Keep the gel away from children and pets.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Chronic joint pain
This medicine is commonly prescribed for this.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary
✅
Muscle sprain
This medicine can help relieve pain and swelling from sprains.
Likely Use

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionDiclofenac is absorbed through the skin when applied topically. The extent of absorption depends on the amount applied, the size of the treated area, and the condition of the skin. Typically, only a small fraction of the applied dose reaches the systemic circulation, resulting in low plasma concentrations compared to oral dosing.
DistributionAfter absorption, diclofenac is distributed into the underlying tissues, including synovial fluid, where it exerts its local effects. It is highly bound to plasma proteins, primarily albumin. The distribution volume is relatively small due to its high protein binding.
Protein BindingDiclofenac is approximately 99% bound to plasma proteins, mainly albumin.
MetabolismDiclofenac is metabolized in the liver by cytochrome P450 enzymes, primarily CYP2C9, into several metabolites, including 4'-hydroxydiclofenac and 5-hydroxydiclofenac. Some of these metabolites may have weak anti-inflammatory activity.
Half-LifeThe elimination half-life of diclofenac from plasma is approximately 1 to 2 hours after topical application, although the local tissue effects may last longer.
ExcretionDiclofenac and its metabolites are excreted primarily in the urine (about 65%) and in the bile and feces (about 35%).
BioavailabilityThe systemic bioavailability of diclofenac after topical application is low, typically less than 10% of the applied dose, depending on the formulation and application site.
Onset of ActionPain relief typically begins within 1 to 2 hours after application of the gel.
Peak Plasma TimePeak plasma concentrations after topical application are usually reached within 2 to 4 hours, but levels are much lower than those achieved with oral dosing.
Duration of ActionThe pain-relieving effect of this medicine can last for several hours, and it is usually applied 3 to 4 times daily as needed.

How It Works

This medicine works by inhibiting the cyclooxygenase enzymes, specifically COX-1 and COX-2, which are involved in the production of prostaglandins. Prostaglandins are chemicals that promote inflammation, pain, and fever. By blocking these enzymes, diclofenac reduces the formation of prostaglandins at the site of application, thereby decreasing inflammation and pain. Because the gel is applied topically, the effect is largely localized to the underlying tissues, with less systemic absorption compared to oral formulations.

Mechanism Steps

1
Absorption through the skin: After application, diclofenac penetrates the skin and reaches the underlying inflamed tissues.
2
Inhibition of cyclooxygenase enzymes: Diclofenac binds to and inhibits the COX-1 and COX-2 enzymes, blocking the conversion of arachidonic acid to prostaglandins.
3
Reduction of prostaglandin synthesis: With the enzymes inhibited, the production of prostaglandins, which are mediators of pain and inflammation, is reduced.
4
Decreased inflammation and pain: The lower levels of prostaglandins lead to less inflammation, swelling, and pain at the site of application.

💡 How to Take osynac gel

Strength: Topical gel containing diclofenac 1.16% w/w.

1Wash your hands before and after applying the gel, unless your hands are the treated area.
2Clean and dry the affected area.
3Squeeze the required amount of gel onto your fingertips or directly onto the affected area.
4Gently rub the gel into the skin until it is absorbed.
5Do not cover the area with a bandage or dressing unless instructed by your doctor.
6Wash your hands immediately after applying, unless your hands are the treated area.
7Avoid touching your eyes, mouth, or nose until your hands are washed.

Dosage Information

Adult DosageThe usual adult dose of this medicine is to apply a thin layer of the gel to the affected area 3 to 4 times daily, gently rubbing it into the skin. The amount needed depends on the size of the painful area; typically, 2 to 4 grams of gel (about 4 to 8 cm of gel) is used per application. The maximum daily dose should not exceed 16 grams of gel. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not use for more than 7 days without medical advice.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may use this medicine at the same adult dose, but they should be monitored for side effects as they may be more susceptible to skin reactions and systemic effects. Dose must be individualized by a qualified clinician.
Renal ImpairmentNo dosage adjustment is typically required for topical diclofenac in patients with renal impairment, as systemic absorption is low. However, caution is advised in severe renal impairment, and use should be under medical supervision.
Hepatic ImpairmentNo dosage adjustment is typically required for topical diclofenac in patients with hepatic impairment, as systemic absorption is low. However, caution is advised in severe hepatic impairment.
Maximum Daily DoseThe maximum recommended daily dose is 16 grams of gel per day, which corresponds to 185.6 mg of diclofenac.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Apply the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not apply a double dose to catch up.

⚠️ Side Effects of osynac gel

✅ Common Side Effects

Application site irritation (Common (1-10%))
Usually resolves on its own. If irritation persists or worsens, consult your doctor.
Redness or rash (Common (1-10%))
Discontinue use if rash becomes severe or spreads. Consult a doctor if concerned.
Itching (Common (1-10%))
Avoid scratching. If itching is severe, stop using and consult a doctor.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek emergency medical help immediately if you experience swelling of the face, lips, throat, or difficulty breathing.
Severe skin reactions (e.g., Stevens-Johnson syndrome) (Rare (<0.1%))
Stop using the medicine and seek immediate medical attention if you notice blistering, peeling, or a widespread rash.
Gastrointestinal bleeding (Rare (<0.1%))
Although rare with topical use, seek medical attention if you notice black stools, vomiting blood, or severe abdominal pain.

⚠️ Rare Side Effects

Photosensitivity reaction
Avoid sun exposure to treated areas. If a reaction occurs, stop using and consult a doctor.
Contact dermatitis
Discontinue use and consult a doctor if you develop a persistent rash or skin inflammation.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Ibuprofen Major
Naproxen Major
Methotrexate Major
ACE inhibitors Moderate
Diuretics Moderate
Corticosteroids Moderate
Aspirin Moderate
Clopidogrel Moderate
Topical corticosteroids Minor

🚨 Major Interactions

  • Oral NSAIDs (e.g., ibuprofen, naproxen)
  • Anticoagulants (e.g., warfarin)
  • Methotrexate

⚡ Moderate Interactions

  • Antihypertensives (e.g., ACE inhibitors, diuretics)
  • Corticosteroids

🍷 Alcohol Interaction

No specific interaction is established between alcohol and topically applied diclofenac. However, alcohol may increase the risk of gastrointestinal bleeding if diclofenac is absorbed systemically. It is advisable to limit alcohol consumption while using this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to diclofenac or any other component of the gel.","History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.","Application on broken, irritated, or infected skin.","Use in the eyes or on mucous membranes.","Third trimester of pregnancy."]

⚠️ Warnings & Precautions

["For external use only. Do not ingest.","Avoid contact with eyes, nose, and mouth.","Do not apply to large areas of skin or use under occlusive dressings without medical advice.","Wash hands after application unless hands are the treated area.","Avoid exposure of treated skin to sunlight or tanning beds.","Consult a doctor if pain persists or worsens after 7 days of use.","Use with caution in patients with a history of gastrointestinal ulcers or bleeding.","Use with caution in elderly patients who may be more susceptible to side effects."]

🤱 Lactation Safety

It is not known whether diclofenac applied topically is excreted in human milk. Because systemic absorption is low, the risk to a nursing infant is likely minimal, but caution is advised. Consult a doctor before using this medicine while breastfeeding.

💊 Overdose Management

Overdose with topical diclofenac is unlikely due to low systemic absorption. If accidental ingestion occurs, seek medical attention immediately. Symptoms of overdose may include nausea, vomiting, abdominal pain, and gastrointestinal bleeding. Treatment is supportive and symptomatic.

⏰ Missed Dose

If you miss a dose, apply it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Always wash your hands thoroughly after applying this medicine, unless your hands are the treated area. Avoid applying the gel to broken, irritated, or infected skin, and do not cover the treated area with airtight dressings unless instructed by your doctor. Keep this medicine away from your eyes, nose, and mouth. If accidental contact occurs, rinse thoroughly with water. Do not use this medicine for more than the recommended duration without consulting a healthcare professional. If your pain persists or worsens after a few days of use, or if you notice any signs of an allergic reaction, stop using the gel and speak to your doctor. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding before using this medicine. Do not use this medicine on children without medical advice. Avoid exposure of the treated area to sunlight or tanning beds, as this may increase the risk of skin reactions.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the effects of this medicine. They should use it with caution and monitor for skin reactions or systemic symptoms. It is advisable to use the lowest effective dose for the shortest duration.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before using this medicine. Topical diclofenac should be used only if clearly needed, and its use should be avoided in the third trimester.

🏥 Post-Surgery Considerations

After surgery, use this medicine only if prescribed by your surgeon. It can help with localized pain and inflammation, but ensure the surgical wound is fully closed before applying the gel near the incision site.

🦷 Dental Procedures

This medicine is not typically used for dental pain. If you have dental procedures, inform your dentist about all medications you are using, including this gel.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce stress on your joints.
🥗
Engage in low-impact exercises like swimming or cycling to improve joint mobility.
😴
Practice good posture to prevent unnecessary strain on muscles and joints.
💧
Include anti-inflammatory foods such as fruits, vegetables, and omega-3 rich fish in your diet.
🧘
Get adequate rest and sleep to help your body recover.
🌞
Apply heat or cold packs as recommended by your doctor to complement the gel's effects.

🏋️ Exercise Considerations

While using this medicine, you can continue with your regular exercise routine as tolerated. However, avoid strenuous activities that may worsen your pain or cause injury. If you experience increased pain or swelling after exercise, rest and consult your doctor.

🥗 Diet Recommendations

Include omega-3 rich foods like salmon, flaxseeds, and walnuts.
Reduce intake of processed foods and refined sugars.
Stay well hydrated by drinking plenty of water.
Eat a balanced diet rich in fruits and vegetables to support overall health.

💼 Impact on Daily Work & Life

This medicine is applied topically and is unlikely to affect your ability to drive or operate machinery. However, if you experience any dizziness or drowsiness, avoid these activities until you feel alert. You can continue your normal work and daily activities as tolerated.

🛑 When to Stop This Medicine

Stop using this medicine and consult your doctor if your pain does not improve after 7 days of use, if it worsens, or if you experience any skin irritation or allergic reaction. Do not stop prescribed treatment without talking to your doctor.

📅 Long-Term Use Effects

Long-term use of this medicine is generally safe when used as directed. However, prolonged use over large areas may increase the risk of systemic side effects such as gastrointestinal or kidney problems. It is advisable to use the lowest effective dose for the shortest duration necessary. Regular monitoring by a healthcare professional is recommended if you need to use it for more than a few weeks.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain and improve joint function.

Evidence: Well-established
Hot and cold therapy

Applying heat or cold packs can help reduce pain and inflammation.

Evidence: Well-established
Acupuncture

May provide pain relief for some individuals with musculoskeletal pain.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. You can receive vaccinations while using this gel.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it in a cool, dry place away from direct sunlight. If you are flying, keep it in your carry-on luggage if you need it during the flight. There are no specific time zone adjustments required for topical application, but maintain your regular schedule as much as possible. Check customs regulations for carrying medications across borders.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 58-year-old woman with knee osteoarthritis
She had been suffering from chronic knee pain that limited her daily activities. Her doctor prescribed this medicine to be applied three times a day. After two weeks of regular use, she noticed significant reduction in pain and stiffness, allowing her to walk more comfortably. She made sure to wash her hands after each application and avoided using it on any cuts.
💡 Lesson: Consistent application and proper technique can lead to meaningful pain relief in osteoarthritis.
👤 A 35-year-old man with a sports injury
He sprained his ankle while playing football. His doctor recommended this medicine along with rest and ice. He applied the gel four times daily and found that the swelling and pain decreased within a few days. He was careful not to apply it on broken skin and kept the area clean.
💡 Lesson: Topical NSAIDs can be effective for acute soft tissue injuries when used as directed.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine typically starts relieving pain within 1 to 2 hours after application, but the full effect may take a few days of regular use.

Q: Can I use this gel on my face?

A: No, this medicine is not recommended for use on the face or mucous membranes. It is intended for application on the body and limbs.

Q: Is it safe to use during pregnancy?

A: Consult your doctor before using this medicine during pregnancy. Topical NSAIDs are generally avoided in the third trimester.

Q: Can I use this gel with oral painkillers?

A: Using this gel with oral NSAIDs may increase the risk of side effects. Consult your doctor before combining them.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for osynac gel

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This gel works instantly.
    Fact: It may take 1 to 2 hours to start relieving pain, and regular use is needed for best results.
  • Myth: More gel means faster relief.
    Fact: Using more than the recommended amount does not improve efficacy and may increase the risk of side effects.
  • Myth: This gel is completely free of side effects because it is topical.
    Fact: Although side effects are less common than with oral NSAIDs, skin reactions and, rarely, systemic effects can occur.

🔄 Alternative Options

Generic Alternatives

  • Diclofenac topical gel 1.16% w/w

Brand Alternatives

  • Aeran X Gel

📊 Comparison with Similar Medicines

[{"medicine":"This medicine (Diclofenac 1.16% gel)","active_ingredient":"Diclofenac","strength":"1.16% w/w","route":"Topical","common_use":"Osteoarthritis, soft tissue injuries"},{"medicine":"Ibuprofen gel","active_ingredient":"Ibuprofen","strength":"5% w/w","route":"Topical","common_use":"Muscle pain, sprains"},{"medicine":"Ketoprofen gel","active_ingredient":"Ketoprofen","strength":"2.5% w/w","route":"Topical","common_use":"Localized pain and inflammation"}]

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