Etodolac 400mg + Paracetamol 325mg Tablet: Complete Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is orthoriv p 400mg/325mg tablet used for?
This medicine is a combination of Etodolac 400 mg and Paracetamol 325 mg used for short-term relief of moderate to severe pain and inflammation. It works by reducing prostaglandins that cause pain and fever. Take it with food to avoid stomach upset and do not exceed the prescribed dose.
- Generic Name: Etodolac (400mg) + Paracetamol (325mg)
- Manufacturer: Fedley Healthcare Private Limited
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 orthoriv p 400mg/325mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एटोडोलैक 400 मिलीग्राम और पैरासिटामोल 325 मिलीग्राम का संयोजन है। इसका उपयोग मध्यम से गंभीर दर्द और सूजन के अल्पकालिक उपचार के लिए किया जाता है, जैसे कि जोड़ों का दर्द, दांत का दर्द, ऑपरेशन के बाद का दर्द, और बुखार। यह दर्द और सूजन को कम करने के लिए प्रोस्टाग्लैंडिन के उत्पादन को रोकता है। इसे भोजन के साथ लें ताकि पेट में जलन न हो।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, पेट दर्द, सिरदर्द, चक्कर आना और नींद आना शामिल हैं। गंभीर दुष्प्रभावों में पेट में रक्तस्राव, गुर्दे की समस्या, यकृत विषाक्तता, और गंभीर एलर्जी प्रतिक्रिया शामिल हो सकती है। यदि आपको काला मल, खून की उल्टी, गंभीर पेट दर्द, सांस लेने में कठिनाई, चेहरे या गले में सूजन, या पेशाब कम आना जैसे लक्षण दिखें तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को हमेशा भोजन या दूध के साथ लें ताकि पेट में जलन न हो। निर्धारित खुराक से अधिक न लें। शराब और अन्य दर्द निवारक दवाओं से बचें। यदि आपको अल्सर, गुर्दे या यकृत की बीमारी, उच्च रक्तचाप, या हृदय की समस्या है तो अपने डॉक्टर को बताएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। बच्चों की पहुंच से दूर रखें।
💊 orthoriv p 400mg/325mg tablet Uses & Benefits
[{"condition":"Osteoarthritis","description":"Relieves pain and improves joint mobility in knee, hip, and hand osteoarthritis.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Reduces joint pain, inflammation" class="semantic-link" title="Medicines for swelling">swelling, and stiffness in rheumatoid arthritis.","evidence":"Well-established"},{"condition":"Acute musculoskeletal pain","description":"Provides short-term relief from pain due to sprains, strains, and sports injuries.","evidence":"Well-established"},{"condition":"Dental pain","description":"Effective for managing post-extraction pain and other dental procedures.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of moderate to severe post-surgical pain.","evidence":"Well-established"},{"condition":"Fever","description":"Reduces fever due to its paracetamol component.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks, but evidence is limited.","evidence":"Limited"},{"condition":"Dysmenorrhea","description":"May be used off-label for menstrual cramps, but not first-line.","evidence":"Limited"}]
Primary treatment for: Pain and inflammation
Also treats: Osteoarthritis, Rheumatoid arthritis, Dental pain, Post-operative pain, Fever
📋 Drug Information
| Generic Name(s) | Etodolac (400mg) + Paracetamol (325mg) |
| Brand Name | orthoriv p 400mg/325mg tablet |
| Manufacturer | Fedley Healthcare Private Limited |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Etodolac is a nonsteroidal anti-inflammatory drug that selectively inhibits cyclooxygenase-2 (COX-2), reducing the production of prostaglandins that mediate pain, inflammation, and fever. Paracetamol acts primarily in the central nervous system to produce analgesia and antipyresis, possibly through inhibition of prostaglandin synthesis in the brain and modulation of descending serotonergic pathways. Together, they provide enhanced pain relief and anti-inflammatory effects.
Mechanism Steps
💡 How to Take orthoriv p 400mg/325mg tablet
Strength: Tablet containing Etodolac 400 mg and Paracetamol 325 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet (Etodolac 400 mg + Paracetamol 325 mg) taken orally two to three times daily, preferably with food. The maximum daily dose should not exceed 3 tablets in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially gastrointestinal and kidney effects. Use the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with kidney impairment. Dose reduction may be necessary. Consult a doctor for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with liver impairment. Dose reduction may be necessary. Consult a doctor for individualized dosing. |
| Maximum Daily Dose | Maximum daily dose: Etodolac 1200 mg and Paracetamol 1950 mg (3 tablets) in 24 hours. Do not exceed. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of orthoriv p 400mg/325mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| ACE inhibitors | Major | |
| Diuretics | Major | |
| Lithium | Major | |
| Corticosteroids | Moderate | |
| Methotrexate | Moderate | |
| SSRIs | Moderate | |
| Antacids | Minor | |
| Cholestyramine | Minor |
🚨 Major Interactions
- Warfarin
- Other NSAIDs
- ACE inhibitors
- Diuretics
- Lithium
⚡ Moderate Interactions
- Corticosteroids
- Methotrexate
- SSRIs
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of liver toxicity from paracetamol and gastrointestinal bleeding from etodolac.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to etodolac, paracetamol, or any component of the formulation","History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs","Active peptic ulcer disease or history of recurrent ulcers","Severe kidney impairment (eGFR
⚠️ Warnings & Precautions
["Take with food to reduce gastrointestinal irritation.","Avoid alcohol and other NSAIDs.","Use with caution in elderly patients due to increased risk of GI bleeding and kidney impairment.","Monitor liver and kidney function with prolonged use.","Do not exceed recommended dose of paracetamol from all sources.","May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Consult doctor if symptoms persist beyond 7 days."]
🤱 Lactation Safety
Etodolac and paracetamol are excreted in breast milk in small amounts. Consult your doctor before use. Generally considered compatible with breastfeeding but monitor infant for adverse effects.
💊 Overdose Management
Overdose can cause severe liver damage from paracetamol and gastrointestinal bleeding from etodolac. Seek immediate medical attention. Treatment includes activated charcoal, N-acetylcysteine for paracetamol toxicity, and supportive care. Do not induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
Additional Safety Advice
Always take this medicine with food or milk to reduce stomach irritation. Do not exceed the prescribed dose or duration. Avoid alcohol and other NSAIDs while taking this medicine. Inform your doctor if you have a history of ulcers, kidney or liver disease, high blood pressure, or heart failure. Do not use this medicine for more than 10 days for pain or 3 days for fever without consulting a doctor. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before use. Keep out of reach of children. Store at room temperature away from moisture and sunlight. Do not drive or operate heavy machinery if you feel dizzy or drowsy.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration and monitor closely.
🤰 Pregnancy Planning (TTC)
Consult your doctor before taking this medicine if you are planning pregnancy. Avoid use in the third trimester.
🏥 Post-Surgery Considerations
This medicine may be used for post-operative pain but should be used with caution due to risk of bleeding and kidney impairment. Follow your surgeon's instructions.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure, as it may increase bleeding risk.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities that may increase pain or risk of injury while taking this medicine. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how it affects you. It may also cause stomach upset; take with food.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if you experience severe side effects, or if your symptoms do not improve within 7 days. Do not stop abruptly if you have been taking it for a long time without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of gastrointestinal bleeding, kidney impairment, liver toxicity, and cardiovascular events. Regular monitoring of liver and kidney function is recommended. Use the lowest effective dose for the shortest duration.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain.
Evidence: Well-establishedMay help relieve localized pain and inflammation.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are known. However, consult your doctor before vaccination if you are taking this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. If traveling across time zones, adjust dosing schedule as advised by your doctor. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 30-60 minutes after taking it.
A: It is best taken with food or milk to reduce stomach upset.
A: Do not take with other NSAIDs or paracetamol-containing products without consulting your doctor.
🤔 Common Patient Concerns
🔄 Substitutes for orthoriv p 400mg/325mg tablet
View AllAlternative brands with exact same active ingredient:
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orthokind p tabletMankind Pharma Ltd ₹74.87 20.9% CHEAPER
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toldin p 400mg/325mg tabletTorrent Pharmaceuticals Ltd ₹75.80 19.9% CHEAPER
-
etosma p 400 mg/325 mg tabletMolekule India Pvt Ltd ₹80.35 15.1% CHEAPER
-
etodenz-xt tabletDenzai Innovations & Therapeutics Pvt Ltd ₹81.09 14.4% CHEAPER
-
etova-p 400 tabletIpca Laboratories Ltd ₹84.38 10.9% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken on an empty stomach.
Fact: It should be taken with food to reduce stomach irritation. - Myth: It is safe to take this medicine for long periods without monitoring.
Fact: Prolonged use requires monitoring of liver and kidney function. - Myth: This medicine is safe during pregnancy.
Fact: Consult a doctor before use; avoid in third trimester.
🔄 Alternative Options
Generic Alternatives
- Etodolac + Paracetamol combination tablets from other manufacturers