olmovin h 12.5mg/40mg tablet - Hydrochlorothiazide (12.5mg) + Olmesartan Medoxomil (40mg) medicine

Benitec H 40 Tablet: Comprehensive Guide to Uses, Side Effects, and Safety

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🏭 Shinto Organics (P) Limited 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026
⚠️ Nephrotoxicity Risk 🤰 Pregnancy Category This medicine is contraindicated in pregnancy. It can cause harm to the unborn baby, especially during the second and third trimesters. If you become pregnant while taking this medicine, contact your doctor immediately. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for hypertension.
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Swelling of face, lips, tongue, or throat
  • Difficulty breathing or swallowing
  • Severe dizziness or fainting
  • Decreased urine output or swelling in legs
  • Irregular heartbeat or palpitations
  • Severe abdominal pain with nausea and vomiting
  • Yellowing of skin or eyes
  • Persistent vomiting or diarrhea

If experiencing severe symptoms, call emergency services immediately.

What is olmovin h 12.5mg/40mg tablet used for?

This medicine is a combination of hydrochlorothiazide and olmesartan medoxomil used to treat high blood pressure. It works by reducing fluid volume and relaxing blood vessels. Take it once daily as prescribed.

  • Generic Name: Hydrochlorothiazide (12.5mg) + Olmesartan Medoxomil (40mg)
  • Manufacturer: Shinto Organics (P) Limited
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 olmovin h 12.5mg/40mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा उच्च रक्तचाप (हाई ब्लड प्रेशर) के इलाज के लिए इस्तेमाल की जाती है। इसमें हाइड्रोक्लोरोथियाजाइड और ओल्मेसार्टन मेडोक्सोमिल दो सक्रिय तत्व हैं। यह शरीर से अतिरिक्त नमक और पानी को बाहर निकालकर और रक्त वाहिकाओं को आराम देकर रक्तचाप को कम करती है। यह दवा उन वयस्कों के लिए है जिनका रक्तचाप एक दवा से नियंत्रित नहीं हो पाता। इसे डॉक्टर के निर्देशानुसार ही लें।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में चक्कर आना, सिरदर्द, थकान और मतली शामिल हैं। कुछ लोगों को पेशाब बार-बार आ सकता है। इलेक्ट्रोलाइट असंतुलन के कारण मांसपेशियों में ऐंठन या कमजोरी हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अगर चेहरे, होंठ या जीभ में सूजन, सांस लेने में कठिनाई, या पेशाब कम आना हो तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को गुर्दे, यकृत, हृदय रोग, मधुमेह या गाउट के बारे में बताएं। गर्भावस्था या स्तनपान के दौरान इस दवा का सेवन न करें। शराब से बचें क्योंकि इससे चक्कर और निम्न रक्तचाप बढ़ सकता है। पर्याप्त पानी पिएं। नियमित रूप से रक्तचाप, गुर्दे की कार्यप्रणाली और इलेक्ट्रोलाइट की जांच कराएं। डॉक्टर की सलाह के बिना दवा बंद न करें।

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 olmovin h 12.5mg/40mg tablet Uses & Benefits

  • [{"condition":"Hypertension","description":"This medicine is used to lower high blood pressure in adults when a single agent is insufficient.
  • It helps reduce the risk of stroke, heart attack, and kidney problems.","evidence":"Well-established"}]

Off-label uses: []

Primary treatment for: Hypertension

Also treats: Heart failure, Diabetic nephropathy, Stroke prevention

📋 Drug Information

Generic Name(s)Hydrochlorothiazide (12.5mg) + Olmesartan Medoxomil (40mg)
Brand Nameolmovin h 12.5mg/40mg tablet
ManufacturerShinto Organics (P) Limited
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassCARDIAC
Action Class
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F and 86°F). Keep in a dry place, away from direct sunlight and moisture.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine at the same time each day, preferably in the morning, to establish a routine.
2
Monitor your blood pressure regularly and keep a record to share with your doctor.
3
Stay hydrated, especially during hot weather or exercise, to prevent dehydration.
4
Avoid alcohol as it can increase dizziness and low blood pressure.
5
Do not stop taking this medicine abruptly without consulting your doctor.
6
Report any muscle cramps, weakness, or irregular heartbeat to your doctor promptly.
7
Follow a low-sodium diet and maintain a healthy weight to enhance the medicine's effect.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
High blood pressure
This medicine is commonly prescribed for this.
Likely Use
✅
Swelling due to fluid retention
The diuretic component helps reduce fluid retention.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionOlmesartan medoxomil is rapidly absorbed after oral administration and is hydrolyzed to olmesartan during absorption. The absolute bioavailability of olmesartan is approximately 26%. Hydrochlorothiazide is absorbed from the gastrointestinal tract, with a bioavailability of about 65-75%. Food does not significantly affect the absorption of olmesartan, but it may slightly affect hydrochlorothiazide absorption. Not established from the available information for specific values of this combination.
DistributionOlmesartan is highly protein-bound (99%) and has a volume of distribution of about 17 liters. Hydrochlorothiazide is distributed in extracellular fluid and has a volume of distribution of about 3-4 liters per kilogram. Hydrochlorothiazide crosses the placental barrier and is excreted in breast milk. Olmesartan is not known to cross the blood-brain barrier significantly.
Protein BindingOlmesartan is approximately 99% bound to plasma proteins, primarily albumin. Hydrochlorothiazide is about 40-68% bound to plasma proteins.
MetabolismOlmesartan medoxomil is a prodrug that is rapidly hydrolyzed to the active metabolite olmesartan during absorption, with no further significant metabolism. Hydrochlorothiazide is not metabolized in the body and is excreted unchanged in the urine.
Half-LifeThe elimination half-life of olmesartan is approximately 13 hours. The elimination half-life of hydrochlorothiazide is about 6-15 hours.
ExcretionOlmesartan is excreted primarily in the feces (about 50-60%) and in the urine (about 35-50%). Hydrochlorothiazide is excreted unchanged in the urine (about 95%).
BioavailabilityThe absolute bioavailability of olmesartan is about 26%. The bioavailability of hydrochlorothiazide is about 65-75%.
Onset of ActionThe antihypertensive effect of this medicine begins within 1-2 weeks of starting therapy, with maximum effect achieved after 4-8 weeks.
Peak Plasma TimeOlmesartan reaches peak plasma concentration in about 1-2 hours. Hydrochlorothiazide reaches peak plasma concentration in about 1-2 hours.
Duration of ActionThe antihypertensive effect of this medicine lasts for about 24 hours, allowing once-daily dosing.

How It Works

This medicine combines two antihypertensive agents with complementary mechanisms. Hydrochlorothiazide is a thiazide diuretic that inhibits the sodium-chloride symporter in the distal convoluted tubule of the kidney, increasing the excretion of sodium, chloride, and water. This reduces plasma volume and cardiac output initially, and later reduces peripheral vascular resistance. Olmesartan medoxomil is a prodrug that is hydrolyzed to olmesartan, an angiotensin II receptor blocker. Olmesartan selectively blocks the AT1 receptor subtype, preventing the vasoconstrictor and aldosterone-secreting effects of angiotensin II. This leads to vasodilation, reduced aldosterone secretion, and decreased sodium and water retention. The combination results in a more pronounced blood pressure reduction than either component alone.

Mechanism Steps

1
Hydrochlorothiazide inhibits sodium reabsorption: Hydrochlorothiazide acts on the distal convoluted tubule of the kidney to inhibit the sodium-chloride symporter, leading to increased excretion of sodium, chloride, and water.
2
Reduced plasma volume: The increased urinary output reduces plasma volume and extracellular fluid volume, which lowers blood pressure initially.
3
Olmesartan blocks AT1 receptors: Olmesartan medoxomil is converted to olmesartan, which selectively blocks angiotensin II at the AT1 receptor, preventing vasoconstriction and aldosterone secretion.
4
Vasodilation and reduced aldosterone: Blockade of AT1 receptors leads to relaxation of blood vessels and decreased aldosterone release, which reduces sodium and water retention.
5
Combined antihypertensive effect: The complementary actions of the diuretic and the ARB result in a greater reduction in blood pressure than either agent alone.

💡 How to Take olmovin h 12.5mg/40mg tablet

Strength: Tablet containing 12.5 mg hydrochlorothiazide and 40 mg olmesartan medoxomil.

1Take this medicine exactly as prescribed by your doctor.
2Swallow the tablet whole with a glass of water.
3Take it at the same time each day, preferably in the morning.
4You can take it with or without food, but taking it with food may reduce stomach upset.
5Do not crush, chew, or break the tablet unless instructed by your doctor.
6If you miss a dose, follow the missed dose instructions.
7Do not stop taking this medicine without consulting your doctor.

Dosage Information

Adult DosageThe usual adult dose of this medicine is one tablet taken orally once daily, with or without food. The dose may be adjusted by your doctor based on your blood pressure response and tolerability. The maximum recommended dose is one tablet of 12.5 mg hydrochlorothiazide and 40 mg olmesartan medoxomil per day. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of this medicine, especially dizziness and electrolyte imbalances. Start with a lower dose and monitor closely. Dose must be individualized by a qualified clinician.
Renal ImpairmentIn patients with mild to moderate renal impairment (eGFR 30-60 mL/min), no dose adjustment is usually needed, but monitoring is recommended. This medicine is contraindicated in severe renal impairment (eGFR <30 mL/min). Dose must be individualized by a qualified clinician.
Hepatic ImpairmentIn patients with mild to moderate hepatic impairment, no dose adjustment is usually needed. This medicine is contraindicated in severe hepatic impairment. Dose must be individualized by a qualified clinician.
Maximum Daily DoseOne tablet of 12.5 mg hydrochlorothiazide and 40 mg olmesartan medoxomil per day.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset and improves absorption.
Grapefruit
Avoid
May increase drug levels and side effects.
High-sodium foods
Limit
Can counteract blood pressure-lowering effect.

⏰ What to Do If You Miss a Dose

📌 Less than 12 hours have passed since the missed dose
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than 12 hours have passed since the missed dose
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of olmovin h 12.5mg/40mg tablet

✅ Common Side Effects

Dizziness (Common (5-10%))
Get up slowly from sitting or lying position. Avoid driving if dizzy. Consult doctor if persistent.
Headache (Common (5-10%))
Usually resolves on its own. Take rest and stay hydrated. Consult doctor if severe.
Fatigue (Common (5-10%))
Ensure adequate sleep and hydration. Consult doctor if it interferes with daily activities.
Nausea (Common (5-10%))
Take with food to reduce nausea. Consult doctor if vomiting occurs.
Increased urination (Common (5-10%))
Take the medicine in the morning to avoid nighttime urination. Consult doctor if excessive.

🚨 Serious Side Effects

Severe allergic reaction (angioedema) (Rare (<0.1%))
Seek immediate medical attention if you experience swelling of face, lips, tongue, or throat, or difficulty breathing.
Kidney problems (Rare (<0.1%))
Report decreased urine output, swelling in legs, or fatigue. Your doctor may monitor kidney function.
Severe electrolyte imbalance (Uncommon (0.1-1%))
Seek medical attention if you experience muscle cramps, weakness, irregular heartbeat, or confusion.
Severe low blood pressure (Uncommon (0.1-1%))
Lie down and elevate legs if you feel faint. Seek immediate medical help if you faint or have chest pain.

⚠️ Rare Side Effects

Rhabdomyolysis
Seek immediate medical attention if you experience muscle pain, tenderness, or dark urine.
Pancreatitis
Seek immediate medical attention if you have severe abdominal pain radiating to the back, with nausea and vomiting.
Severe skin reactions
Seek immediate medical attention if you develop a rash, blisters, or peeling skin.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Lithium Major
NSAIDs Major
Potassium-sparing diuretics Major
ACE inhibitors Major
Corticosteroids Moderate
Diabetes medications Moderate
Cholestyramine Moderate
Digoxin Moderate
Antacids Minor
Carbamazepine Minor

🚨 Major Interactions

  • Lithium
  • Potassium-sparing diuretics (e.g., spironolactone)
  • NSAIDs (e.g., ibuprofen, naproxen)
  • ACE inhibitors (e.g., lisinopril)

⚡ Moderate Interactions

  • Corticosteroids
  • Diabetes medications (e.g., metformin, insulin)
  • Cholestyramine and colestipol
  • Digoxin

🍷 Alcohol Interaction

Alcohol may increase the blood pressure-lowering effect of this medicine, leading to dizziness, lightheadedness, and fainting. It is advisable to avoid alcohol or limit consumption while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Pregnancy","Breastfeeding","Severe kidney disease (eGFR

⚠️ Warnings & Precautions

["This medicine can cause fetal harm; avoid in pregnancy.","May cause symptomatic low blood pressure, especially in volume-depleted patients.","Monitor kidney function and electrolytes regularly.","May worsen gout or lupus.","Can cause allergic reactions; discontinue if angioedema occurs.","May increase blood sugar levels in diabetics.","Avoid in patients with severe liver disease.","Use with caution in elderly patients due to increased risk of electrolyte imbalance."]

🤱 Lactation Safety

Hydrochlorothiazide is excreted in breast milk and may cause side effects in the nursing infant. Olmesartan is also excreted in breast milk. This medicine is not recommended during breastfeeding. Consult your doctor for alternative treatments.

💊 Overdose Management

Overdose of this medicine may cause severe low blood pressure, electrolyte imbalances, and dehydration. If overdose is suspected, seek immediate medical attention. Treatment is supportive and symptomatic, including intravenous fluids and electrolyte correction. Hemodialysis may be considered for hydrochlorothiazide removal, but not for olmesartan.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time.

Additional Safety Advice

General Safety

Before taking this medicine, inform your doctor if you have kidney disease, liver disease, heart failure, diabetes, or gout. Do not take this medicine if you are pregnant or planning to become pregnant, as it can harm the unborn baby. Avoid alcohol while taking this medicine, as it can increase dizziness and low blood pressure. Drink adequate fluids to prevent dehydration, especially in hot weather or during exercise. Your doctor may monitor your blood pressure, kidney function, and electrolyte levels regularly. Do not stop taking this medicine suddenly without consulting your doctor, as this can cause a rebound increase in blood pressure. Keep all appointments for monitoring. If you experience severe dizziness, fainting, or persistent vomiting, contact your doctor immediately. This medicine may interact with other medications, so always inform your healthcare provider about all the medicines you are taking.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more prone to dizziness, electrolyte imbalances, and kidney problems. Start with a lower dose and monitor closely. Regular check-ups are important.

🤰 Pregnancy Planning (TTC)

This medicine is contraindicated during pregnancy. If you are planning to become pregnant, consult your doctor to switch to a safer alternative before conception.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist that you are taking this medicine. It may need to be stopped temporarily before surgery to avoid low blood pressure during the procedure. Follow your doctor's instructions.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine. It may cause dry mouth or low blood pressure during dental procedures. Take your medicine as usual unless advised otherwise.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to help control blood pressure.
🥗
Follow a low-sodium diet rich in fruits and vegetables.
😴
Engage in regular physical activity like walking or swimming.
💧
Limit alcohol and avoid smoking.
🧘
Manage stress through relaxation techniques like yoga or meditation.
🌞
Get adequate sleep to support overall health.

🏋️ Exercise Considerations

Exercise is generally safe while taking this medicine, but avoid strenuous activities in hot weather to prevent dehydration. If you feel dizzy or faint during exercise, stop and rest. Stay hydrated.

🥗 Diet Recommendations

Reduce salt intake to less than 5 grams per day.
Include potassium-rich foods like bananas, oranges, and spinach.
Limit processed and fried foods.
Stay well hydrated with water.
Avoid excessive caffeine.

💼 Impact on Daily Work & Life

This medicine may cause dizziness, especially when standing up quickly. Avoid driving or operating heavy machinery until you know how it affects you. Take it in the morning to minimize nighttime urination. Most people can continue their daily activities with minor adjustments.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. If you experience severe side effects like angioedema, kidney problems, or severe low blood pressure, seek immediate medical attention. Your doctor may adjust the dose or switch to another medicine.

📅 Long-Term Use Effects

Long-term use of this medicine may lead to electrolyte imbalances, kidney function changes, and increased blood sugar levels. Regular monitoring of blood pressure, kidney function, and electrolytes is essential. Your doctor may adjust the dose or add supplements as needed. Do not stop the medicine without medical advice.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Lifestyle modifications

Diet, exercise, and weight loss can help control blood pressure and may reduce the need for medication.

Evidence: Well-established
Other antihypertensive classes

ACE inhibitors, calcium channel blockers, or beta-blockers may be alternatives if this medicine is not suitable.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions are known. However, consult your doctor before receiving any vaccine while on this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or moisture. If crossing time zones, continue taking your dose at the same local time as much as possible. Consult your doctor if you need to adjust timing. Check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 55-year-old man with a history of hypertension
He was prescribed this medicine after his blood pressure remained high on a single drug. Within a month, his blood pressure was well controlled. He experienced mild dizziness initially but it subsided after a few days. He emphasizes taking the medicine in the morning to avoid nighttime urination.
💡 Lesson: Combination therapy can be effective when single agents fail. Taking the medicine in the morning helps manage diuretic effects.
👤 A 62-year-old woman with diabetes and hypertension
She started this medicine and noticed improved blood pressure control. However, she developed muscle cramps due to low potassium. Her doctor adjusted her diet and added a potassium supplement. She now monitors her electrolytes regularly.
💡 Lesson: Regular monitoring of electrolytes is crucial, especially in patients on diuretics. Dietary adjustments can help manage side effects.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine starts lowering blood pressure within 1-2 weeks, with maximum effect after 4-8 weeks.

Q: Can I take this medicine with other blood pressure medicines?

A: Only if prescribed by your doctor. Combining with other antihypertensives may increase the risk of low blood pressure and kidney problems.

Q: What should I do if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Q: Is this medicine safe during pregnancy?

A: No, this medicine is contraindicated during pregnancy as it can harm the unborn baby. Consult your doctor for alternative treatment.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for olmovin h 12.5mg/40mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be stopped once blood pressure is normal.
    Fact: High blood pressure often has no symptoms, and stopping treatment can lead to dangerous complications. Continue as prescribed.
  • Myth: This medicine causes kidney damage in everyone.
    Fact: While it can affect kidney function, regular monitoring helps prevent problems. Benefits usually outweigh risks.
  • Myth: You can take this medicine without any dietary changes.
    Fact: A low-sodium diet and healthy lifestyle enhance the effectiveness of this medicine.

🔄 Alternative Options

Generic Alternatives

  • Hydrochlorothiazide + Olmesartan Medoxomil generic tablets

Brand Alternatives

  • Benitec H 40 Tablet

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Hydrochlorothiazide 12.5 mg + Olmesartan Medoxomil 40 mg","frequency":"Once daily","notes":"Combination therapy for hypertension."},{"medicine":"Olmesartan Medoxomil + Amlodipine","composition":"Olmesartan Medoxomil 40 mg + Amlodipine 5 mg","frequency":"Once daily","notes":"Alternative combination without diuretic."}]

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