Activid 400mg Tablet (Ofloxacin): Complete Uses, Dosage, Side Effects, and Safety Guide

[{"condition":"Urinary tract infections","description":"Used to treat uncomplicated and complicated urinary tract infections caused by susceptible bacteria, including cystitis and pyelonephritis.","evidence":"Well-established"},{"condition":"Respiratory tract infections","description":"Prescribed for certain bacterial respiratory infections such as acute exacerbations of chronic bronchitis and some pneumonias when susceptible organisms are involved.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Used for bacterial skin infections and soft tissue infections caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Sexually transmitted infections","description":"Used in the treatment of gonorrhoea and chlamydia, often as part of a broader management plan.","evidence":"Well-established"},{"condition":"Gastrointestinal infections","description":"Prescribed for certain bacterial diarrhoeal illnesses and other gastrointestinal infections caused by susceptible bacteria.","evidence":"Established"},{"condition":"Drug-resistant tuberculosis","description":"Used as part of combination regimens for multidrug-resistant tuberculosis under specialist supervision.","evidence":"Established in specialist settings"}]

Off-label uses: [{"condition":"Prostatitis","description":"Sometimes used for chronic bacterial prostatitis when cultures show susceptible organisms, although this is not a primary approved indication.","evidence":"Limited"},{"condition":"Epididymitis","description":"May be used in selected cases of epididymitis caused by susceptible bacteria, usually alongside other antibiotics.","evidence":"Limited"}]

Primary treatment for: Bacterial infections

Also treats: Urinary tract infections, Respiratory tract infections, Skin and soft tissue infections, Gonorrhoea, Chlamydia, Bacterial gastroenteritis, Drug-resistant tuberculosis (as part of combination therapy)

Generic Name(s)	Ofloxacin (400mg)
Brand Name	offey 400mg tablet
Manufacturer	Pray Healthcare
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	ANTI INFECTIVES
Action Class	Quinolones/ Fluroquinolones
Route of Administration	Oral
Storage	Store this medicine at room temperature between 15°C and 30°C, away from direct sunlight, heat, and moisture. Keep the tablets in their original blister pack or container until it is time to take them. Do not store this medicine in the bathroom or near the kitchen sink.
Shelf Life	The shelf life is typically 24 to 36 months from the date of manufacture, depending on the manufacturer and pack. Always check the expiry date printed on the pack and do not use the medicine after that date.
WHO Guideline	Not established from the available information. Always follow national and local treatment guidelines for the specific infection being treated.
ICMR Guideline	Not established from the available information. In India, antibiotic use should follow the Indian Council of Medical Research (ICMR) treatment guidelines for the specific infection and local resistance patterns.

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

Drug	Severity	Effect
Antacids (aluminium/magnesium)	Major
Iron supplements	Major
Zinc supplements	Major
Sucralfate	Major
Warfarin	Major
Class IA/III antiarrhythmics	Major
Theophylline	Moderate
Caffeine	Moderate
NSAIDs	Moderate
Probenecid	Moderate

🚫 Contraindications

["Known allergy or hypersensitivity to ofloxacin, other fluoroquinolones, or any ingredient in this tablet.","History of tendon disorders or tendon rupture associated with fluoroquinolone use.","Myasthenia gravis, because fluoroquinolones can worsen muscle weakness.","Children and adolescents in most situations, because of the risk of cartilage and tendon damage during growth.","Pregnancy and breastfeeding, unless a specialist decides the benefit clearly outweighs the risk.","Known QT interval prolongation or a history of serious heart rhythm problems, unless clearly necessary and supervised.","Severe kidney impairment without appropriate dose adjustment."]

⚠️ Warnings & Precautions

["This medicine can cause tendon inflammation and rupture, especially in people over 60, those taking corticosteroids, and those with kidney, heart, or lung transplants. Stop the medicine and seek medical help if you develop tendon pain or swelling.","Fluoroquinolones can cause peripheral neuropathy. Report tingling, burning, numbness, or weakness in the hands or feet promptly.","This medicine can cause central nervous system effects such as dizziness, confusion, tremors, and seizures. Avoid driving or operating machinery until you know how it affects you.","Serious allergic reactions, including anaphylaxis, can occur. Seek emergency care for swelling of the face or throat, difficulty breathing, or a widespread rash.","Clostridioides difficile-associated diarrhoea can occur during or after treatment. Do not treat diarrhoea with over-the-counter medicines without consulting your doctor.","This medicine can make your skin more sensitive to sunlight. Avoid excessive sun exposure and use sunscreen.","Do not take this medicine with antacids, iron, zinc, or sucralfate within 2 hours, as they reduce its absorption.","Tell your doctor about all other medicines you take, especially blood thinners, diabetes medicines, and heart rhythm medicines.","Complete the full course as prescribed, even if you feel better, to reduce the risk of resistance and relapse.","Keep this medicine out of reach of children and do not share it with others."]

🤱 Lactation Safety

This medicine passes into breast milk in small amounts. Because of the potential risk of cartilage and tendon problems in infants, breastfeeding is generally not recommended while taking this medicine. If treatment is essential, your doctor may advise temporarily stopping breastfeeding or using an alternative antibiotic. Discuss this with your doctor before starting treatment.

Additional Safety Advice

If you are trying to conceive or planning a pregnancy, tell your doctor before taking this medicine. Fluoroquinolones are generally avoided during pregnancy unless there is no safer alternative and the benefit clearly outweighs the risk. If you become pregnant while taking this medicine, contact your doctor immediately for advice. Do not start or stop any medicine without medical guidance when planning pregnancy.

If you are scheduled for surgery or have recently had surgery, tell your surgeon and anaesthetist that you are taking this medicine. It can interact with other medicines used during surgery and may affect heart rhythm, kidney function, and tendon health. Your surgical team may adjust the dose or timing, or choose an alternative antibiotic. Do not stop the medicine without speaking to your prescriber, especially if you are being treated for a surgical site infection.

Tell your dentist that you are taking this medicine before any dental procedure. Antibiotics can affect the balance of bacteria in the mouth and may interact with other medicines used during dental work. If you need a dental procedure while taking this medicine, your dentist may coordinate with your doctor. Do not stop the antibiotic before a dental visit unless your prescriber advises it.

You can usually continue light exercise while taking this medicine, but avoid strenuous or high-impact activities if you feel dizzy, tired, or have joint or tendon pain. Stop exercising and seek medical advice if you develop sudden pain, swelling, or difficulty moving a tendon, especially in the heel or shoulder. Drink enough water before, during, and after exercise to stay hydrated.

This medicine may cause dizziness, drowsiness, or confusion in some people. Avoid driving, operating heavy machinery, or working at heights until you know how it affects you. If your job involves close contact with others, follow hygiene measures to prevent spreading infection. Most people can continue their usual daily activities, but take extra rest if you feel tired or unwell. Tell your employer or supervisor if you need to take time off for treatment or recovery.

Stop this medicine and seek medical advice immediately if you develop tendon pain or swelling, tingling or numbness in the hands or feet, severe diarrhoea, signs of an allergic reaction, yellowing of the skin or eyes, palpitations, fainting, confusion, or seizures. Otherwise, do not stop the medicine early just because you feel better. Complete the full course prescribed by your doctor. If you need to stop for any other reason, speak to your prescriber first.

Long-term use of this medicine is not usually recommended unless a specialist is treating a serious infection such as drug-resistant tuberculosis. Prolonged use can increase the risk of tendon damage, nerve symptoms, heart rhythm problems, liver injury, kidney problems, and the development of antibiotic resistance. If long-term treatment is needed, your doctor will monitor your kidney and liver function, heart rhythm, and symptoms regularly. Do not continue this medicine beyond the prescribed duration without medical review.

🔄 Substitutes for offey 400mg tablet

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[{"medicine":"This medicine (Ofloxacin 400 mg)","class":"Fluoroquinolone","route":"Oral","common_uses":"Urinary, respiratory, skin, and sexually transmitted infections","key_note":"Requires dose adjustment in kidney impairment."},{"medicine":"Ciprofloxacin","class":"Fluoroquinolone","route":"Oral or intravenous","common_uses":"Urinary, gastrointestinal, and some respiratory infections","key_note":"Similar spectrum but different dosing and interaction profile."},{"medicine":"Levofloxacin","class":"Fluoroquinolone","route":"Oral or intravenous","common_uses":"Respiratory, urinary, and skin infections","key_note":"Once-daily dosing is common; active against more Gram-positive bacteria."},{"medicine":"Azithromycin","class":"Macrolide","route":"Oral or intravenous","common_uses":"Respiratory infections, chlamydia, and some skin infections","key_note":"Different mechanism and side effect profile."}]