Aceclofenac 100mg + Paracetamol 325mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is nutrafenac p 100mg/325mg tablet used for?
This medicine is a combination of aceclofenac and paracetamol used for pain relief and fever. It works by reducing inflammation and acting on the brain to relieve pain. Take it with food and avoid alcohol.
- Generic Name: Information coming soon
- Manufacturer: Multiple manufacturers
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nutrafenac p 100mg/325mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एसिटामिनोफेन और एसिटाइलसैलिसिलिक एसिड का संयोजन है, जिसका उपयोग दर्द और सूजन को कम करने के लिए किया जाता है। यह मुख्य रूप से गठिया, मांसपेशियों के दर्द, सिरदर्द, दांत दर्द और बुखार के इलाज में उपयोग की जाती है। यह दवा शरीर में प्रोस्टाग्लैंडिन नामक रसायन को कम करके काम करती है, जो दर्द और सूजन का कारण बनता है। इसे भोजन के साथ लेना चाहिए ताकि पेट में जलन न हो। इसका उपयोग डॉक्टर की सलाह के अनुसार ही करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, अपच, सिरदर्द, चक्कर आना और त्वचा पर दाने शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन इनमें पेट में रक्तस्राव, अल्सर, गुर्दे की समस्या, यकृत की क्षति और एलर्जी प्रतिक्रियाएं शामिल हो सकती हैं। यदि आपको काला मल, उल्टी में खून, गंभीर पेट दर्द, सांस लेने में कठिनाई, चेहरे या गले में सूजन, या आंखों या त्वचा का पीलापन दिखाई दे, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक से अधिक न लें। इसे भोजन या दूध के साथ लें ताकि पेट में जलन न हो। इस दवा के साथ शराब का सेवन न करें क्योंकि इससे पेट में रक्तस्राव और यकृत की क्षति का खतरा बढ़ सकता है। यदि आपको पेट के अल्सर, गुर्दे या यकृत की बीमारी, हृदय की विफलता, उच्च रक्तचाप या अस्थमा है, तो अपने डॉक्टर को बताएं। गर्भावस्था और स्तनपान के दौरान इस दवा का उपयोग न करें। इसे बच्चों की पहुंच से दूर रखें।
💊 nutrafenac p 100mg/325mg tablet Uses & Benefits
[{"condition":"Osteoarthritis","description":"Relieves pain and improves joint mobility in knee, hip, and hand osteoarthritis.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Reduces joint pain, inflammation" class="semantic-link" title="Medicines for swelling">swelling, and stiffness in rheumatoid arthritis.","evidence":"Well-established"},{"condition":"Ankylosing spondylitis","description":"Helps alleviate pain and inflammation in the spine and sacroiliac joints.","evidence":"Well-established"},{"condition":"Acute musculoskeletal pain","description":"Used for short-term relief of pain from sprains, strains, and sports injuries.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Provides effective analgesia after surgical procedures.","evidence":"Well-established"},{"condition":"Dental pain","description":"Relieves pain following dental extraction or other dental procedures.","evidence":"Well-established"},{"condition":"Fever","description":"Reduces fever due to the paracetamol component.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks, but evidence is limited.","evidence":"Limited"},{"condition":"Dysmenorrhea","description":"May be used off-label for menstrual pain, but not a first-line choice.","evidence":"Limited"}]
Primary treatment for: Pain and inflammation associated with musculoskeletal conditions
Also treats: Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis, Acute musculoskeletal pain, Post-operative pain, Dental pain, Fever
📋 Drug Information
| Generic Name(s) | Information coming soon |
| Brand Name | nutrafenac p 100mg/325mg tablet |
| Manufacturer | Multiple manufacturers |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a cool, dry place, away from direct sunlight and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Aceclofenac, an NSAID, inhibits the cyclooxygenase (COX) enzymes, particularly COX-2, leading to decreased synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. Paracetamol acts primarily in the central nervous system by inhibiting prostaglandin synthesis and possibly activating descending serotonergic pathways, resulting in analgesia and antipyresis. The combination provides enhanced pain relief through both peripheral anti-inflammatory and central analgesic actions.
Mechanism Steps
💡 How to Take nutrafenac p 100mg/325mg tablet
Strength: Each tablet contains aceclofenac 100 mg and paracetamol 325 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally two to three times daily, preferably after meals. The dose may be adjusted by your doctor based on the severity of your condition and your response to treatment. Do not exceed the recommended dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially gastrointestinal bleeding and kidney impairment. Use with caution and lower doses may be appropriate. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with kidney impairment. Dose reduction may be necessary. Consult your doctor for appropriate dosing. |
| Hepatic Impairment | Use with caution in patients with liver impairment. Dose reduction may be necessary. Consult your doctor for appropriate dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is 3 tablets in 24 hours. Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nutrafenac p 100mg/325mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Corticosteroids | Major | |
| Methotrexate | Major | |
| Lithium | Major | |
| ACE inhibitors | Major | |
| Diuretics | Major | |
| SSRIs | Moderate | |
| Anticonvulsants | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., ibuprofen, naproxen)
- Corticosteroids
- Methotrexate
- Lithium
- ACE inhibitors
- Diuretics
⚡ Moderate Interactions
- Antihypertensives (beta-blockers, calcium channel blockers)
- SSRIs
- Anticonvulsants (phenytoin, carbamazepine)
- Probenecid
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding, ulceration, and liver damage, especially with paracetamol. It can also enhance the sedative effects of the medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to aceclofenac, paracetamol, or any component of the formulation.","History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.","Active peptic ulcer or history of recurrent peptic ulcer.","Severe heart failure.","Severe kidney impairment.","Severe liver impairment.","Pregnancy, especially third trimester.","Breastfeeding.","Children under 12 years of age (unless specifically prescribed)."]
⚠️ Warnings & Precautions
["Take with food or milk to reduce stomach upset.","Avoid alcohol while taking this medicine.","Do not exceed the recommended dose or duration.","Use with caution in the elderly.","Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, heart failure, high blood pressure, or asthma.","Do not take other NSAIDs or paracetamol-containing products simultaneously.","Discontinue and consult doctor if you experience signs of gastrointestinal bleeding, allergic reactions, or liver problems.","May cause dizziness or drowsiness; avoid driving or operating machinery until you know how it affects you."]
🤱 Lactation Safety
Not established from the available information. Aceclofenac and paracetamol are excreted in breast milk. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose of this medicine can cause severe liver damage due to paracetamol, and gastrointestinal bleeding, kidney failure, and central nervous system effects due to aceclofenac. Seek immediate medical attention. Treatment includes gastric lavage, activated charcoal, and administration of N-acetylcysteine for paracetamol toxicity. Supportive care for other symptoms.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine as it can increase the risk of gastrointestinal bleeding and liver damage. Do not take other NSAIDs or paracetamol-containing products simultaneously to avoid overdose. Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, heart failure, high blood pressure, or asthma. Use with caution in the elderly, as they are more prone to side effects. Do not use this medicine during pregnancy, especially in the third trimester, or while breastfeeding unless advised by a doctor. Store in a cool, dry place away from direct sunlight and out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use with caution, at the lowest effective dose, and monitor closely.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. NSAIDs like aceclofenac may affect ovulation and are generally avoided during pregnancy.
🏥 Post-Surgery Considerations
This medicine may be used for post-operative pain, but consult your surgeon before taking it, especially if you are on other medications or have underlying conditions.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure, as it may increase bleeding risk.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may experience dizziness or drowsiness. Avoid strenuous exercise or activities that require alertness until you know how the medicine affects you. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It is generally safe to continue desk work, but take breaks and stay hydrated.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if you experience any serious side effects, such as gastrointestinal bleeding, allergic reactions, or signs of liver or kidney problems. Do not stop abruptly if you are on long-term therapy without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of gastrointestinal bleeding, ulcers, kidney impairment, liver toxicity, and cardiovascular events. Regular monitoring of kidney and liver function, blood counts, and blood pressure is recommended. Use the lowest effective dose for the shortest duration possible.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve mobility.
Evidence: Well-establishedApplying heat or cold packs can help reduce pain and inflammation.
Evidence: Well-establishedMay provide pain relief for some individuals.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information. Consult your doctor regarding vaccination while taking this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it in a cool, dry place away from direct sunlight. If crossing time zones, adjust your dosing schedule accordingly, but do not take a double dose. Check customs regulations for carrying prescription medicines. Keep it in your carry-on luggage to avoid loss.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 30 to 60 minutes after taking it.
A: It is best taken with food or milk to reduce the risk of stomach upset.
A: No, you should not take other NSAIDs or paracetamol-containing products without consulting your doctor, as it can increase the risk of side effects.
A: This medicine is generally avoided during pregnancy, especially in the third trimester. Consult your doctor for safer alternatives.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can be taken on an empty stomach.
Fact: It should be taken with food to reduce stomach upset. - Myth: This medicine is safe to take with other painkillers.
Fact: Taking it with other NSAIDs or paracetamol can increase the risk of side effects. - Myth: This medicine is safe during pregnancy.
Fact: It is generally avoided during pregnancy, especially in the third trimester.
🔄 Alternative Options
Generic Alternatives
- Aceclofenac 100 mg + Paracetamol 325 mg tablet