nurosig gb 100mg/500mcg tablet - Gabapentin (100mg) + Methylcobalamin (500mcg) medicine

Gabaneuron 100 Tablet: Complete Guide to Uses, Side Effects, and Safety

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🏭 Signova Pharma Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 26, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
12 min read
Evidence: Well-established for neuropathic pain and epilepsy.
Reviewed by
SaathiMed Expert Panel | Sep 26, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Severe allergic reaction with swelling of face, lips, or throat, or difficulty breathing.
  • New or worsening depression, anxiety, or suicidal thoughts.
  • Severe skin rash with blisters, peeling skin, or sores in the mouth.
  • Decreased urine output or swelling in the legs.
  • Severe abdominal pain radiating to the back.
  • Muscle pain, weakness, or dark urine.
  • Unusual bruising or bleeding.

If experiencing severe symptoms, call emergency services immediately.

What is nurosig gb 100mg/500mcg tablet used for?

This medicine is a combination of Gabapentin and Methylcobalamin used to treat neuropathic pain. Gabapentin reduces abnormal nerve signals, while Methylcobalamin supports nerve repair. It is taken orally, usually one to three times daily, as prescribed by a doctor.

  • Generic Name: Gabapentin (100mg) + Methylcobalamin (500mcg)
  • Manufacturer: Signova Pharma Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 nurosig gb 100mg/500mcg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा गैबापेंटिन 100 मिलीग्राम और मिथाइलकोबालामिन 500 माइक्रोग्राम का संयोजन है। इसका उपयोग न्यूरोपैथिक दर्द (नसों का दर्द) के इलाज के लिए किया जाता है, जिसमें जलन, झुनझुनी, सुन्नपन या बिजली के झटके जैसा दर्द शामिल है। यह मधुमेह न्यूरोपैथी, दाद के बाद होने वाले दर्द, और मिर्गी के दौरों में भी मदद करती है। गैबापेंटिन नसों के असामान्य संकेतों को कम करता है, जबकि मिथाइलकोबालामिन नसों की मरम्मत और मजबूती में सहायता करता है। यह दवा डॉक्टर के निर्देशानुसार ही लेनी चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में चक्कर आना, नींद आना, थकान, और अस्थिरता शामिल हैं। कुछ लोगों को मतली, उल्टी, या पेट में हल्की परेशानी हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी, त्वचा पर चकत्ते, सूजन, या सांस लेने में कठिनाई हो सकती है। यदि आपको कोई असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। दवा की खुराक खुद से न बदलें और न ही अचानक बंद करें। इस दवा से चक्कर और नींद आ सकती है, इसलिए वाहन चलाने या मशीनरी चलाने से बचें। शराब का सेवन न करें। गुर्दे या लीवर की बीमारी हो तो डॉक्टर को बताएं। दवा को बच्चों की पहुंच से दूर रखें।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 nurosig gb 100mg/500mcg tablet Uses & Benefits

  • [{"condition":"Neuropathic pain","description":"This medicine is used to relieve burning, tingling, and shooting pain caused by nerve damage.
  • It is commonly prescribed for diabetic neuropathy and postherpetic neuralgia.","evidence":"Well-established"},{"condition":"Epilepsy (partial seizures)","description":"Gabapentin is used as an add-on therapy for partial seizures in adults and children above 12 years.
  • Methylcobalamin supports overall nerve health.","evidence":"Well-established"},{"condition":"Postherpetic neuralgia","description":"This medicine helps reduce the persistent pain that can occur after a shingles infection.","evidence":"Well-established"},{"condition":"Diabetic neuropathy","description":"It helps manage nerve pain associated with diabetes and supports nerve repair with Methylcobalamin.","evidence":"Well-established"},{"condition":"Spinal cord injury pain","description":"Sometimes prescribed to manage chronic nerve pain following spinal cord injury.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Restless legs syndrome","description":"Gabapentin is sometimes used off-label to reduce symptoms of restless legs syndrome.","evidence":"Limited"},{"condition":"Anxiety disorders","description":"In some cases, Gabapentin is prescribed off-label for anxiety, but this is not a first-line treatment.","evidence":"Limited"},{"condition":"Migraine prophylaxis","description":"Gabapentin may be used off-label to prevent migraines in some patients.","evidence":"Limited"}]

Primary treatment for: Neuropathic pain

Also treats: Epilepsy, Postherpetic neuralgia, Diabetic neuropathy, Spinal cord injury pain

📋 Drug Information

Generic Name(s)Gabapentin (100mg) + Methylcobalamin (500mcg)
Brand Namenurosig gb 100mg/500mcg tablet
ManufacturerSignova Pharma Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassNEURO CNS
Action Class
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture and direct sunlight. Do not refrigerate.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine at the same time each day to maintain consistent blood levels.
2
Start with a low dose and increase gradually as advised by your doctor to minimize side effects.
3
Avoid driving or operating heavy machinery until you know how this medicine affects you.
4
Do not stop this medicine abruptly; always taper under medical supervision.
5
Inform your doctor if you have kidney problems, as dose adjustment may be needed.
6
Avoid alcohol while taking this medicine to prevent increased drowsiness and respiratory depression.
7
If you miss a dose, take it as soon as you remember, but do not double the dose.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Burning or tingling in hands and feet
This medicine is commonly prescribed for neuropathic pain.
Likely Use
✅
Shooting or electric shock-like pain
This medicine helps reduce abnormal nerve signals.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary
❌
Headache
This medicine is not typically used for headaches.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionGabapentin is absorbed from the gastrointestinal tract via a saturable transport mechanism. Bioavailability is dose-dependent and decreases as the dose increases. Methylcobalamin is absorbed in the ileum with the help of intrinsic factor.
DistributionGabapentin distributes widely in the body, including the brain and cerebrospinal fluid. It does not bind significantly to plasma proteins. Methylcobalamin is transported in the blood bound to transcobalamin II and is taken up by tissues, especially the liver, bone marrow, and nervous system.
Protein BindingGabapentin is less than 3% bound to plasma proteins. Methylcobalamin is highly bound to transcobalamin II.
MetabolismGabapentin is not metabolized in humans and is excreted unchanged. Methylcobalamin is metabolized in the liver to some extent, but mostly stored and used as a coenzyme.
Half-LifeThe elimination half-life of Gabapentin is approximately 5 to 7 hours in patients with normal renal function. The half-life of Methylcobalamin is not well established but is generally considered to be several days due to tissue storage.
ExcretionGabapentin is excreted unchanged in the urine by renal filtration. Methylcobalamin is excreted in bile and urine, with some enterohepatic circulation.
BioavailabilityThe bioavailability of Gabapentin is approximately 60% at a 100 mg dose, but it decreases at higher doses. The bioavailability of Methylcobalamin is variable but generally good when taken orally.
Onset of ActionThe onset of action for neuropathic pain relief with Gabapentin can take several days to weeks. Some patients may experience improvement within a few days, but full effect may take longer. Methylcobalamin's effects on nerve health are gradual and may take weeks to months.
Peak Plasma TimeGabapentin reaches peak plasma concentrations within 2 to 3 hours after oral administration. Methylcobalamin reaches peak plasma levels within 3 to 6 hours.
Duration of ActionThe duration of action of Gabapentin is typically 6 to 8 hours, requiring multiple daily doses. Methylcobalamin's effects are long-lasting due to tissue storage.

How It Works

This medicine combines two active ingredients with complementary actions. Gabapentin is a structural analogue of the neurotransmitter GABA, but it does not bind to GABA receptors. Instead, it binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This binding reduces the release of excitatory neurotransmitters such as glutamate, substance P, and noradrenaline, which are involved in pain signaling. By stabilizing neuronal membranes, Gabapentin reduces abnormal electrical activity and alleviates neuropathic pain. Methylcobalamin is a coenzyme form of vitamin B12. It plays a crucial role in the synthesis of myelin, the protective sheath around nerves, and in the metabolism of fatty acids and amino acids. It supports nerve regeneration and improves nerve conduction. Together, these ingredients help reduce nerve pain and promote nerve health.

Mechanism Steps

1
Binding to calcium channels: Gabapentin binds to the alpha-2-delta subunit of voltage-gated calcium channels on presynaptic neurons.
2
Reduced neurotransmitter release: This binding reduces the influx of calcium into the neuron, leading to decreased release of excitatory neurotransmitters like glutamate and substance P.
3
Stabilization of neuronal activity: The reduced excitation stabilizes neuronal membranes and reduces abnormal pain signals.
4
Methylcobalamin supports myelin: Methylcobalamin acts as a coenzyme in methionine synthase, which is essential for myelin synthesis and nerve cell maintenance.
5
Enhanced nerve repair: Methylcobalamin promotes regeneration of damaged nerves and improves nerve conduction velocity.

💡 How to Take nurosig gb 100mg/500mcg tablet

Strength: Each tablet contains Gabapentin 100 mg and Methylcobalamin 500 mcg.

1Take this medicine orally with a glass of water.
2You can take it with or without food, but taking it with food may reduce stomach upset.
3Swallow the tablet whole. Do not crush, chew, or break it.
4Take it at the same time each day to maintain consistent blood levels.
5If you are taking antacids, take this medicine at least 2 hours before or after antacids.
6Do not stop taking this medicine suddenly without consulting your doctor.

Dosage Information

Adult DosageThe usual adult dose of this medicine is one tablet taken orally one to three times a day, depending on the indication and your doctor's prescription. The dose may be started low and gradually increased to minimize side effects. The maximum daily dose of Gabapentin is typically 3600 mg, but in this combination, the dose is individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may require a lower dose due to reduced renal function. Dose adjustment is based on creatinine clearance. Close monitoring for side effects such as dizziness, drowsiness, and falls is recommended.
Renal ImpairmentDose adjustment is required in patients with renal impairment. For creatinine clearance 30-59 mL/min, the dose may be reduced. For creatinine clearance 15-29 mL/min, further reduction is needed. For creatinine clearance <15 mL/min, the dose should be reduced proportionally to creatinine clearance. Consult your doctor for precise dosing.
Hepatic ImpairmentNo dose adjustment is typically required for hepatic impairment, as Gabapentin is not metabolized by the liver. However, caution is advised in patients with severe liver disease.
Maximum Daily DoseThe maximum daily dose of Gabapentin in this combination is not fixed and depends on the indication. The maximum recommended daily dose of Gabapentin alone is 3600 mg. Methylcobalamin maximum daily dose is not established. Always follow your doctor's prescription.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset and improves absorption.
Grapefruit juice
Avoid
May increase drug levels and side effects.
High-fat meals
Take with caution
May increase Gabapentin absorption.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of nurosig gb 100mg/500mcg tablet

✅ Common Side Effects

Dizziness (Common (10-20%))
Avoid sudden movements. If dizziness persists, consult your doctor.
Drowsiness (Common (10-20%))
Avoid driving or operating machinery. Take the medicine at bedtime if advised.
Fatigue (Common (5-10%))
Get adequate rest. If fatigue interferes with daily activities, consult your doctor.
Nausea (Common (5-10%))
Take with food to reduce nausea. If it persists, consult your doctor.
Unsteadiness (Common (5-10%))
Use caution when walking or climbing stairs. Report to your doctor if it worsens.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical attention if you experience rash, itching, swelling of the face, lips, or throat, or difficulty breathing.
Stevens-Johnson syndrome (Very rare (<0.01%))
Seek immediate medical help if you develop a severe skin rash with blisters, peeling skin, or sores in the mouth.
Mood changes or suicidal thoughts (Rare (<0.1%))
Contact your doctor immediately if you experience new or worsening depression, anxiety, or thoughts of self-harm.
Kidney problems (Rare (<0.1%))
Report decreased urine output, swelling in legs, or fatigue to your doctor.

⚠️ Rare Side Effects

Blood dyscrasias
Report unusual bruising, bleeding, or infections to your doctor.
Pancreatitis
Seek medical attention if you experience severe abdominal pain radiating to the back.
Rhabdomyolysis
Report muscle pain, weakness, or dark urine to your doctor immediately.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Morphine Major
Oxycodone Major
Alcohol Major
Aluminum/magnesium antacids Moderate
Cimetidine Moderate
Naproxen Moderate
Oral contraceptives Minor
Antihistamines Minor

🚨 Major Interactions

  • Opioid analgesics (e.g., morphine, oxycodone)
  • Alcohol
  • Antacids containing aluminum or magnesium

⚡ Moderate Interactions

  • Morphine
  • Cimetidine
  • Naproxen

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol can increase drowsiness, dizziness, and the risk of respiratory depression. It may also worsen the side effects of Gabapentin.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity or allergy to Gabapentin, Methylcobalamin, or any component of the formulation.","Severe renal impairment (creatinine clearance

⚠️ Warnings & Precautions

["This medicine may cause dizziness and drowsiness. Avoid driving or operating machinery until you know how it affects you.","Do not stop this medicine abruptly, as it can cause withdrawal symptoms. Taper gradually under medical supervision.","Use with caution in elderly patients due to increased risk of side effects and falls.","Inform your doctor if you have kidney disease, liver disease, or a history of substance abuse.","This medicine may increase the risk of suicidal thoughts. Monitor mood closely.","Avoid alcohol while taking this medicine.","Do not share this medicine with others."]

🤱 Lactation Safety

Gabapentin is excreted in human breast milk. Breastfeeding is not recommended while taking this medicine unless the potential benefit outweighs the risk. Methylcobalamin is safe during breastfeeding. Consult your doctor before breastfeeding.

💊 Overdose Management

Overdose of this medicine may cause severe drowsiness, dizziness, double vision, slurred speech, and difficulty breathing. If you suspect an overdose, seek immediate medical attention. Treatment is supportive and symptomatic. Hemodialysis may be considered in severe cases of Gabapentin overdose, especially in patients with renal failure.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without consulting your doctor. This medicine can cause dizziness and drowsiness, so avoid driving, operating machinery, or doing activities that require alertness until you know how it affects you. Avoid drinking alcohol while taking this medicine, as it can increase drowsiness and other side effects. Inform your doctor if you have kidney disease, liver disease, or a history of drug or alcohol abuse. Do not share this medicine with others, even if they have similar symptoms. Keep this medicine out of reach of children. Store it at room temperature, away from moisture and direct sunlight. If you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up. If you experience any serious side effects or allergic reactions, seek immediate medical help.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of side effects such as dizziness, drowsiness, and falls. Dose adjustment based on renal function is often necessary. Close monitoring is recommended.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. Gabapentin may harm the fetus. Effective contraception should be used during treatment.

🏥 Post-Surgery Considerations

This medicine may be continued after surgery if prescribed for neuropathic pain. Inform your surgeon and anesthesiologist about all medicines you are taking.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine. It may interact with anesthetics or other medications used during dental procedures.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce nerve pressure.
🥗
Engage in regular low-impact exercise like walking or swimming.
😴
Practice good posture to avoid nerve compression.
💧
Include foods rich in vitamin B12, such as eggs, fish, and dairy.
🧘
Get adequate sleep to support nerve health.
🌞
Manage stress through relaxation techniques like yoga or meditation.

🏋️ Exercise Considerations

Avoid high-impact exercises that may worsen nerve pain. Consult your doctor before starting any new exercise routine. If you experience dizziness or drowsiness, avoid activities that require balance.

🥗 Diet Recommendations

Include omega-3 rich foods like flaxseeds and walnuts.
Reduce processed and sugary foods.
Stay well hydrated.
Eat a balanced diet rich in fruits and vegetables.
Limit alcohol and caffeine.

💼 Impact on Daily Work & Life

This medicine may cause dizziness and drowsiness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. Inform your employer if your job requires alertness.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. If you experience serious side effects or your condition improves, your doctor may gradually reduce the dose. Abrupt discontinuation can cause withdrawal symptoms.

📅 Long-Term Use Effects

Long-term use of this medicine may require periodic monitoring of kidney function, especially in elderly patients. Gabapentin can cause dependence and withdrawal symptoms if stopped abruptly. Methylcobalamin is generally safe for long-term use. Regular follow-up with your doctor is recommended to assess efficacy and adjust the dose.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain and improve mobility.

Evidence: Well-established
Acupuncture

May help reduce neuropathic pain in some patients.

Evidence: Limited
Transcutaneous electrical nerve stimulation (TENS)

May provide symptomatic relief for nerve pain.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions are known. However, inform your doctor about your vaccination status before starting this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, consult your doctor about adjusting the dosing schedule. Do not pack it in checked baggage. Check local customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 55-year-old man with diabetic neuropathy
He had been experiencing burning and tingling in his feet for over a year. His doctor prescribed this medicine. After 3 weeks, he noticed a significant reduction in the burning sensation. He took it regularly with food and avoided alcohol. He also monitored his blood sugar levels.
💡 Lesson: Consistent use and lifestyle modifications can greatly improve outcomes in diabetic neuropathy.
👤 A 62-year-old woman with postherpetic neuralgia
After a bout of shingles, she was left with severe shooting pain in her chest. This medicine was prescribed. It took about 4 weeks for the pain to subside. She experienced mild dizziness initially, which improved after a few days. She was advised not to drive during the initial period.
💡 Lesson: Patience is key; neuropathic pain relief may take several weeks. Report side effects to your doctor.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: It may take several days to weeks to notice improvement in neuropathic pain. Full effects may take longer.

Q: Can I stop taking this medicine suddenly?

A: No, stopping suddenly can cause withdrawal symptoms. Always taper under medical supervision.

Q: Is it safe to take with other painkillers?

A: Consult your doctor before taking any other painkillers, as interactions may occur.

Q: Does it cause weight gain?

A: Weight gain is not a common side effect, but some people may experience increased appetite.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for nurosig gb 100mg/500mcg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: Gabaneuron 100 Tablet is a simple painkiller.
    Fact: It is not a simple painkiller. It works on nerve pain by stabilizing nerve activity and supporting nerve health.
  • Myth: You can stop taking it as soon as you feel better.
    Fact: Stopping suddenly can cause withdrawal symptoms. Always taper under medical supervision.
  • Myth: It is safe to take with alcohol.
    Fact: Alcohol increases the risk of drowsiness and respiratory depression. Avoid alcohol.
  • Myth: It is addictive.
    Fact: Gabapentin has a low potential for abuse but can cause dependence. It should be used only as prescribed.

🔄 Alternative Options

Generic Alternatives

  • Gabapentin + Methylcobalamin

Brand Alternatives

  • Gabaneuron 100 Tablet

📊 Comparison with Similar Medicines

[{"medicine":"Gabaneuron 100 Tablet","active_ingredients":"Gabapentin 100 mg + Methylcobalamin 500 mcg","primary_use":"Neuropathic pain","route":"Oral"},{"medicine":"Pregabalin + Methylcobalamin","active_ingredients":"Pregabalin 75 mg + Methylcobalamin 750 mcg","primary_use":"Neuropathic pain","route":"Oral"},{"medicine":"Gabapentin alone","active_ingredients":"Gabapentin 100 mg","primary_use":"Neuropathic pain, epilepsy","route":"Oral"}]

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