Nuroclas Pn 75mg/10mg/1500mcg Tablet Sr: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of face, lips, or throat, or difficulty breathing
- Suicidal thoughts or self-harm behavior
- Severe skin rash with blisters or peeling
- Irregular heartbeat or palpitations
- Severe abdominal pain or blood in vomit/stool
- Yellowing of skin or eyes
- Decreased urine output or severe swelling
If experiencing severe symptoms, call emergency services immediately.
What is nuroclas pn 75mg/10mg/1500mcg tablet sr used for?
This medicine is a combination of pregabalin, nortriptyline, and methylcobalamin used to treat neuropathic pain. It works by reducing nerve pain signals and supporting nerve health. Take it exactly as prescribed, usually once daily at bedtime.
- Generic Name: Information coming soon
- Manufacturer: Multiple manufacturers
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nuroclas pn 75mg/10mg/1500mcg tablet sr के बारे में (Hindi Summary)
उपयोग: यह दवा न्यूरोपैथिक दर्द (नसों से जुड़ा दर्द) के इलाज के लिए इस्तेमाल की जाती है। इसमें प्रेगाबालिन, नॉर्ट्रिप्टिलीन और मिथाइलकोबालामिन तीन सक्रिय तत्व होते हैं। यह दवा नसों में दर्द के संकेतों को कम करने, नसों को आराम देने और नसों की मरम्मत में मदद करती है। यह आमतौर पर डायबिटीज के कारण होने वाले न्यूरोपैथी, दाद के बाद होने वाले दर्द, और रीढ़ की हड्डी की चोट के बाद होने वाले दर्द में उपयोग की जाती है। इसे डॉक्टर के निर्देशानुसार ही लें।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में चक्कर आना, नींद आना, मुँह सूखना, धुंधली दृष्टि, वजन बढ़ना और हाथ-पैरों में सूजन शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में कम हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अगर आपको सांस लेने में कठिनाई, चेहरे या गले में सूजन, या आत्महत्या के विचार आते हैं, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। गोली को चबाएं या तोड़ें नहीं, पूरा निगल लें। शराब न पिएं क्योंकि इससे नींद और चक्कर बढ़ सकते हैं। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन न चलाएं। अचानक दवा बंद न करें, इससे withdrawal symptoms हो सकते हैं। इसे बच्चों की पहुंच से दूर रखें।
💊 nuroclas pn 75mg/10mg/1500mcg tablet sr Uses & Benefits
[{"condition":"Diabetic peripheral neuropathy","description":"Reduces burning, tingling, and shooting pain in the feet and hands caused by diabetes-related nerve damage.","evidence":"Well-established"},{"condition":"Postherpetic neuralgia","description":"Relieves persistent nerve pain that can occur after a shingles infection.","evidence":"Well-established"},{"condition":"Neuropathic pain due to spinal cord injury","description":"May help alleviate chronic nerve pain following spinal cord injury.","evidence":"Moderate"},{"condition":"Fibromyalgia","description":"Can reduce widespread musculoskeletal pain and improve sleep in some patients.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Migraine prophylaxis","description":"Sometimes prescribed off-label to prevent migraines, especially when other treatments fail.","evidence":"Limited"},{"condition":"Generalized anxiety disorder","description":"Pregabalin component may be used off-label for anxiety, but this combination is not standard.","evidence":"Limited"}]
Primary treatment for: Neuropathic pain
Also treats: Diabetic peripheral neuropathy, Postherpetic neuralgia, Fibromyalgia, Spinal cord injury pain
📋 Drug Information
| Generic Name(s) | Information coming soon |
| Brand Name | nuroclas pn 75mg/10mg/1500mcg tablet sr |
| Manufacturer | Multiple manufacturers |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines three active ingredients with complementary mechanisms. Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, reducing the release of excitatory neurotransmitters such as glutamate, norepinephrine, and substance P, which decreases nerve pain signaling. Nortriptyline, a tricyclic antidepressant, inhibits the reuptake of serotonin and norepinephrine, enhancing descending inhibitory pain pathways in the brain and spinal cord. Methylcobalamin is a coenzyme form of vitamin B12 that supports myelin synthesis and nerve cell metabolism, aiding in nerve repair and function.
Mechanism Steps
💡 How to Take nuroclas pn 75mg/10mg/1500mcg tablet sr
Strength: Sustained-release tablet containing pregabalin 75 mg, nortriptyline 10 mg, and methylcobalamin 1500 mcg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally once daily, preferably at bedtime, or as directed by your physician. The dose may be adjusted based on your response and tolerability. Do not exceed the prescribed dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects, especially dizziness, drowsiness, and confusion. Start with a lower dose and titrate slowly. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Pregabalin requires dose reduction in renal impairment. For creatinine clearance 30-60 mL/min, reduce dose by 50%; for 15-30 mL/min, reduce to 25% of normal dose; for <15 mL/min, use 25 mg once daily. Consult your doctor for precise dosing. |
| Hepatic Impairment | Nortriptyline should be used with caution in hepatic impairment. Dose reduction may be necessary. Consult your doctor. |
| Maximum Daily Dose | The maximum recommended daily dose is one tablet (75 mg pregabalin, 10 mg nortriptyline, 1500 mcg methylcobalamin). Do not exceed this without medical advice. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nuroclas pn 75mg/10mg/1500mcg tablet sr
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Moderate | |
| Tramadol | Major | |
| SSRIs | Major | |
| MAO inhibitors | Major | |
| Opioids | Major | |
| Benzodiazepines | Moderate | |
| Anticholinergics | Moderate | |
| Diuretics | Moderate | |
| CYP2D6 inhibitors | Moderate | |
| CYP1A2 inducers | Moderate |
🚨 Major Interactions
- MAO inhibitors
- CNS depressants (opioids, benzodiazepines, alcohol)
- Anticholinergic drugs
⚡ Moderate Interactions
- CYP2D6 inhibitors (fluoxetine, paroxetine, quinidine)
- CYP1A2 inducers (smoking, rifampin)
- Diuretics
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can enhance the sedative effects of pregabalin and nortriptyline, leading to increased drowsiness, dizziness, and impaired motor skills. It may also increase the risk of respiratory depression and other central nervous system effects.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to pregabalin, nortriptyline, or methylcobalamin","Concurrent use of MAO inhibitors","Recent myocardial infarction","Uncontrolled narrow-angle glaucoma","Severe renal impairment (creatinine clearance
⚠️ Warnings & Precautions
["May cause dizziness and drowsiness; avoid driving or operating machinery until you know how it affects you.","Do not stop abruptly; taper gradually to avoid withdrawal symptoms.","May increase suicidal thoughts; monitor mood closely.","Use with caution in elderly due to increased risk of falls and confusion.","May cause peripheral edema; monitor for swelling.","Avoid alcohol and other CNS depressants.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding."]
🤱 Lactation Safety
This medicine may pass into breast milk and could cause drowsiness in the infant. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose may cause severe drowsiness, confusion, dizziness, blurred vision, seizures, and cardiac arrhythmias. Seek emergency medical attention immediately. Treatment is supportive and symptomatic. Gastric lavage may be considered if within 1-2 hours of ingestion. Monitor vital signs and cardiac rhythm.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed. Do not crush, chew, or break the sustained-release tablet; swallow it whole. Avoid alcohol as it can increase drowsiness and dizziness. Do not drive or operate heavy machinery until you know how this medicine affects you. Inform your doctor if you have kidney problems, heart disease, or a history of substance abuse. Do not stop taking this medicine suddenly, as it can cause withdrawal symptoms. Keep out of reach of children. Store at room temperature away from moisture and heat.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more prone to side effects like dizziness, drowsiness, confusion, and falls. Start with a lower dose and monitor closely. Renal function should be assessed before starting.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. It should be used during pregnancy only if clearly needed. Discuss potential risks and benefits.
🏥 Post-Surgery Considerations
This medicine may be continued after surgery if prescribed for neuropathic pain. Inform your surgeon and anesthesiologist about all medicines you are taking. It may interact with anesthetic agents.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may interact with certain dental anesthetics or medications. It may also cause dry mouth, which can affect oral health.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid high-impact exercises that may worsen nerve pain. Consult your doctor before starting any new exercise regimen. If you experience increased pain or dizziness during exercise, stop and rest.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and dizziness, which may affect your ability to drive or operate machinery. It is best to avoid these activities until you know how the medicine affects you. Inform your employer if your job involves such tasks.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience serious side effects or no improvement after several weeks, your doctor may decide to stop or change the medicine. Always taper gradually to avoid withdrawal symptoms.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to tolerance, dependence, and withdrawal symptoms if stopped abruptly. Regular monitoring of renal function, liver function, and mood is recommended. Weight gain and peripheral edema may persist. Periodic review by your doctor is necessary to assess continued benefit and adjust the dose.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve mobility.
Evidence: Well-establishedHelps manage chronic pain and associated distress.
Evidence: ModerateMay provide pain relief for some patients with neuropathic pain.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are known. However, consult your doctor before any vaccination while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, consult your doctor about adjusting the timing. Carry enough supply for the entire trip. Check customs regulations for controlled substances.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start to feel some relief within a few days, but full effect for neuropathic pain can take 2-4 weeks.
A: This medicine should be used during pregnancy only if clearly needed. Consult your doctor to discuss risks and benefits.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, you should not stop suddenly as it can cause withdrawal symptoms. Consult your doctor for a gradual taper.
A: This medicine may cause drowsiness and dizziness. Avoid driving until you know how it affects you.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine is a painkiller like paracetamol.
Fact: This medicine is not a simple painkiller; it is specifically for nerve pain and works differently. - Myth: I can stop taking this medicine once I feel better.
Fact: You should not stop suddenly; it must be tapered gradually under medical supervision. - Myth: This medicine is addictive.
Fact: It can cause dependence, but addiction is rare when taken as prescribed. Do not increase the dose on your own.
🔄 Alternative Options
Generic Alternatives
- Pregabalin 75 mg + Nortriptyline 10 mg + Methylcobalamin 1500 mcg sustained-release tablets (various manufacturers)
Brand Alternatives
- Nuroclas PN 75mg/10mg/1500mcg Tablet SR