Nuroclas P 1500mcg/75mg Capsule: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of the face, lips, or throat, or difficulty breathing
- Suicidal thoughts or self-harm
- Severe muscle pain, tenderness, or dark urine
- Signs of heart failure such as shortness of breath, fatigue, or swelling
- Severe abdominal pain radiating to the back
- Unusual bruising or bleeding
- Yellowing of the skin or eyes
- Decreased urine output
- Severe dizziness or fainting
- Confusion or hallucinations
If experiencing severe symptoms, call emergency services immediately.
What is nuroclas p 1500mcg/75mg capsule used for?
This medicine is a combination of methylcobalamin (1500 mcg) and pregabalin (75 mg) used to treat neuropathic pain and vitamin B12 deficiency. It works by reducing abnormal nerve signals and supporting nerve repair. It is taken orally, usually once or twice daily, and should not be stopped suddenly.
- Generic Name: Information coming soon
- Manufacturer: Multiple manufacturers
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nuroclas p 1500mcg/75mg capsule के बारे में (Hindi Summary)
उपयोग: यह दवा मेथिलकोबालामिन 1500 माइक्रोग्राम और प्रेगाबालिन 75 मिलीग्राम का संयोजन है। इसका उपयोग नसों के दर्द (न्यूरोपैथिक दर्द), जैसे डायबिटिक न्यूरोपैथी और दाद के बाद होने वाले दर्द के इलाज में किया जाता है। यह विटामिन बी12 की कमी को भी पूरा करती है और नसों की मरम्मत में मदद करती है। यह दवा दर्द को कम करने और नसों के कार्य को बेहतर बनाने में सहायक है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में चक्कर आना, नींद आना, थकान, मुँह सूखना, हाथ-पैरों में सूजन और वजन बढ़ना शामिल हैं। कुछ लोगों को धुंधली दृष्टि, एकाग्रता में कमी या अस्थिरता महसूस हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन चेहरे, होंठ या गले में सूजन, सांस लेने में कठिनाई, या आत्महत्या के विचार हो सकते हैं। यदि कोई भी दुष्प्रभाव परेशान करे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। इसे अचानक बंद न करें, क्योंकि इससे withdrawal के लक्षण हो सकते हैं। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन न चलाएँ और मशीनरी न चलाएँ। शराब का सेवन न करें। यदि आपको गुर्दे, यकृत या हृदय की समस्या है, तो अपने डॉक्टर को बताएं। गर्भावस्था या स्तनपान के दौरान इस दवा का उपयोग डॉक्टर की सलाह के बिना न करें।
💊 nuroclas p 1500mcg/75mg capsule Uses & Benefits
[{"condition":"Diabetic peripheral neuropathy","description":"This medicine helps relieve burning, tingling, and shooting pain in the feet and hands caused by diabetes-related nerve damage.","evidence":"Well-established"},{"condition":"Postherpetic neuralgia","description":"It reduces persistent nerve pain that can occur after a shingles infection.","evidence":"Well-established"},{"condition":"Vitamin B12 deficiency neuropathy","description":"Methylcobalamin in this medicine helps repair nerve damage and improve symptoms of B12 deficiency, such as numbness and weakness.","evidence":"Well-established"},{"condition":"Fibromyalgia","description":"Pregabalin is approved for fibromyalgia in some regions and may reduce widespread muscle pain and improve sleep.","evidence":"Moderate"},{"condition":"Partial-onset seizures","description":"Pregabalin is used as an add-on treatment for certain types of epilepsy, though this combination is not primarily for seizures.","evidence":"Well-established for pregabalin alone"}]
Off-label uses: [{"condition":"Generalized anxiety disorder","description":"Pregabalin is sometimes prescribed off-label for anxiety when other treatments are not effective.","evidence":"Limited"},{"condition":"Chronic low back pain with neuropathic features","description":"May be used off-label when nerve involvement is suspected.","evidence":"Limited"},{"condition":"Restless legs syndrome","description":"Pregabalin has been studied off-label for reducing symptoms of restless legs syndrome.","evidence":"Limited"}]
Primary treatment for: Peripheral neuropathic pain
Also treats: Diabetic neuropathy, Postherpetic neuralgia, Fibromyalgia, Vitamin B12 deficiency
📋 Drug Information
| Generic Name(s) | Information coming soon |
| Brand Name | nuroclas p 1500mcg/75mg capsule |
| Manufacturer | Multiple manufacturers |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container, tightly closed. Do not refrigerate unless specified by the manufacturer. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary actions. Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, reducing the release of excitatory neurotransmitters such as glutamate, norepinephrine, and substance P. This decreases abnormal nerve firing and pain signaling. Methylcobalamin is a coenzyme for methionine synthase, which is essential for DNA synthesis and myelin formation. It supports the repair and maintenance of the myelin sheath that insulates nerve fibers, improving nerve conduction and reducing symptoms of neuropathy.
Mechanism Steps
💡 How to Take nuroclas p 1500mcg/75mg capsule
Strength: Each capsule contains methylcobalamin 1500 mcg and pregabalin 75 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one capsule taken orally once or twice daily, or as directed by your physician. The dose depends on the indication, severity of symptoms, and renal function. For neuropathic pain, the typical starting dose is one capsule daily, which may be increased gradually based on response and tolerability. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially dizziness, drowsiness, and peripheral edema. Dose reduction may be necessary based on renal function. Start with a low dose and titrate slowly. Regular monitoring of renal function and mental status is advised. |
| Renal Impairment | Pregabalin is primarily excreted by the kidneys, so dose adjustment is required in patients with renal impairment. For creatinine clearance 30-60 mL/min, the dose may be reduced by 50%. For creatinine clearance 15-30 mL/min, the dose may be reduced by 75%. For creatinine clearance less than 15 mL/min, the dose should be reduced to once daily or as directed by a nephrologist. Methylcobalamin does not require dose adjustment in renal impairment. |
| Hepatic Impairment | Pregabalin is not metabolized by the liver, so no dose adjustment is required for hepatic impairment. Methylcobalamin is metabolized in the liver, but dose adjustment is not typically necessary. However, caution is advised in severe hepatic impairment. |
| Maximum Daily Dose | The maximum recommended daily dose of pregabalin is 600 mg per day, but in this fixed-dose combination, the maximum daily dose is usually limited by the pregabalin content. For this specific strength (75 mg), the maximum daily dose is typically 300 mg (4 capsules) per day, but must be individualized by a clinician. Methylcobalamin 1500 mcg per day is the maximum in this combination. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nuroclas p 1500mcg/75mg capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Moderate | |
| Opioids | Major | |
| Benzodiazepines | Major | |
| ACE inhibitors | Major | |
| Thiazolidinediones | Moderate | |
| Loop diuretics | Moderate | |
| Metformin | Minor | |
| Antacids | Minor | |
| Oral contraceptives | Minor | |
| Antihypertensives | Moderate |
🚨 Major Interactions
- CNS depressants (e.g., opioids, benzodiazepines, alcohol)
- Angiotensin-converting enzyme (ACE) inhibitors
- Thiazolidinediones (e.g., pioglitazone)
⚡ Moderate Interactions
- Loop diuretics (e.g., furosemide)
- Antihypertensives
- Oral contraceptives
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can increase drowsiness, dizziness, and difficulty concentrating. It may also worsen the sedative effects of pregabalin and increase the risk of central nervous system depression.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to pregabalin, methylcobalamin, or any component of the formulation","Concurrent use with strong opioids or benzodiazepines without close monitoring","Severe renal impairment (creatinine clearance
⚠️ Warnings & Precautions
["May cause dizziness and drowsiness; avoid driving or operating machinery until effects are known.","Do not stop abruptly; taper gradually to avoid withdrawal symptoms.","May cause peripheral edema; monitor for swelling and weight gain.","May increase risk of suicidal thoughts; monitor mood closely.","Use with caution in patients with renal impairment; dose adjustment required.","May cause angioedema; discontinue immediately if swelling of face, lips, or throat occurs.","Avoid alcohol and other CNS depressants.","May cause blurred vision; caution while driving.","Not recommended for children under 18 years unless prescribed by a specialist.","May cause weight gain; monitor weight and diet."]
🤱 Lactation Safety
Pregabalin is excreted in human breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Methylcobalamin is also excreted in breast milk but is considered safe.
💊 Overdose Management
Overdose of this medicine may cause excessive drowsiness, confusion, agitation, and in severe cases, respiratory depression, coma, or death. There is no specific antidote for pregabalin. Treatment should be supportive and symptomatic, including monitoring of vital signs and airway management. Hemodialysis may be considered in severe cases, especially in patients with renal impairment. Methylcobalamin is generally non-toxic even at high doses. Seek emergency medical attention immediately if overdose is suspected.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it suddenly, as this can cause withdrawal symptoms such as anxiety, insomnia, and sweating. Avoid driving or operating heavy machinery until you know how this medicine affects you. Do not drink alcohol while taking this medicine, as it can increase drowsiness and dizziness. Inform your doctor if you have kidney problems, liver disease, heart failure, or a history of substance abuse. This medicine may cause swelling of the feet and hands; if this occurs, elevate your legs and inform your doctor. Do not take this medicine if you are pregnant or planning to become pregnant without consulting your doctor. Keep this medicine out of the reach of children and store it in a cool, dry place.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of side effects such as dizziness, drowsiness, and peripheral edema. Dose reduction may be necessary based on renal function. Regular monitoring of renal function, mental status, and fall risk is advised. Start with a low dose and titrate slowly.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Pregabalin may harm the unborn baby. Your doctor may switch you to a safer alternative or adjust the dose. Use effective contraception while taking this medicine.
🏥 Post-Surgery Considerations
If you are undergoing surgery, inform your surgeon and anesthesiologist that you are taking this medicine. Pregabalin may interact with anesthetic agents and increase sedation. Your doctor may advise you to stop the medicine temporarily before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. Pregabalin may interact with sedatives or anesthetics used during dental work. Your dentist may need to adjust the medications used.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may experience dizziness and drowsiness. Avoid activities that require high alertness, such as heavy lifting, running on uneven surfaces, or operating machinery. Gentle exercises like walking or stretching are generally safe. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and dizziness, which may affect your ability to drive or operate machinery. It is advisable to avoid such activities until you know how the medicine affects you. If your job requires high alertness, discuss with your doctor about adjusting the dose or timing. Most people can continue their daily activities with caution.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as angioedema, suicidal thoughts, or severe muscle pain, seek immediate medical attention and your doctor may advise stopping the medicine. Otherwise, your doctor will gradually taper the dose to prevent withdrawal symptoms.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to physical dependence on pregabalin, requiring gradual tapering to avoid withdrawal symptoms. It may also cause weight gain, peripheral edema, and cognitive effects such as memory problems. Regular monitoring of renal function, mood, and weight is advised. Methylcobalamin is generally safe for long-term use. Periodic review with your doctor is necessary to assess the continued need for this medicine.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve mobility.
Evidence: Well-establishedMay provide additional pain relief for some patients.
Evidence: ModerateHelps manage chronic pain and improve coping skills.
Evidence: ModerateSome patients report pain relief with acupuncture.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for any vaccination, inform your healthcare provider about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, adjust dosing times gradually under medical advice. Check local customs regulations for controlled substances, as pregabalin may be regulated in some countries.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling some relief within a few days, but it can take 2 to 4 weeks for the full effect. Continue taking it as prescribed.
A: No, do not stop suddenly. Your doctor will gradually reduce the dose to prevent withdrawal symptoms.
A: Take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: Inform your doctor about all medicines you take. Some combinations may increase side effects. Do not start any new medicine without consulting your doctor.
A: Pregabalin has a potential for abuse and dependence. Take it exactly as prescribed and do not increase the dose on your own.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine is a painkiller like paracetamol.
Fact: This medicine is not a simple painkiller; it is specifically for nerve pain and works differently. - Myth: I can stop this medicine once my pain improves.
Fact: You should not stop this medicine abruptly; it must be tapered gradually under medical supervision. - Myth: This medicine is safe to take during pregnancy.
Fact: This medicine may harm the unborn baby; consult your doctor before taking it during pregnancy. - Myth: This medicine can be taken with alcohol.
Fact: Alcohol increases the sedative effects and should be avoided.
🔄 Alternative Options
Generic Alternatives
- Methylcobalamin 1500 mcg + Pregabalin 75 mg capsule (generic)
Brand Alternatives
- Nuroclas P 1500mcg/75mg capsule