Novodol 37.5 Mg/325 Mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or slow, shallow breathing
- Seizures or convulsions
- Severe allergic reaction (rash, swelling, difficulty breathing)
- Yellowing of skin or eyes, dark urine
- Severe abdominal pain or vomiting blood
- Confusion, hallucinations, or extreme drowsiness
If experiencing severe symptoms, call emergency services immediately.
What is novodol 37.5 mg/325 mg tablet used for?
This medicine is a combination of tramadol and paracetamol used for moderate to severe pain. It works by blocking pain signals in the brain and reducing fever. It should be taken exactly as prescribed and is not for children under 12.
- Generic Name: Tramadol (37.5 mg) + Paracetamol (325 mg)
- Manufacturer: UniOrange Life Care Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 novodol 37.5 mg/325 mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा ट्रामाडोल और पैरासिटामोल का संयोजन है, जिसका उपयोग मध्यम से गंभीर दर्द के इलाज के लिए किया जाता है। यह सर्जरी, दांत दर्द, या मस्कुलोस्केलेटल चोट के बाद होने वाले दर्द में प्रभावी है। यह दवा केवल डॉक्टर के पर्चे पर ही लेनी चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, चक्कर आना, नींद आना, कब्ज, सिरदर्द और मुंह सूखना शामिल हैं। गंभीर दुष्प्रभावों में सांस लेने में कठिनाई, दौरे, सेरोटोनिन सिंड्रोम, और लीवर की क्षति शामिल हैं। यदि आपको कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। शराब और अन्य नींद लाने वाली दवाओं से बचें। गाड़ी चलाने या मशीन चलाने से बचें जब तक आपको पता न चले कि यह दवा आप पर कैसे असर करती है। दीर्घकालिक उपयोग के बाद अचानक बंद न करें।
💊 novodol 37.5 mg/325 mg tablet Uses & Benefits
[{"condition":"Acute moderate to severe pain","description":"Used for short-term relief of moderate to severe pain, such as post-operative pain, dental pain, or musculoskeletal pain.","evidence":"Well-established"},{"condition":"Chronic pain","description":"May be used for chronic pain conditions like osteoarthritis or low back pain when other treatments are inadequate.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Neuropathic pain","description":"Sometimes prescribed off-label for neuropathic pain, though evidence is limited.","evidence":"Limited"}]
Primary treatment for: Moderate to severe acute pain
Also treats: Chronic pain, Post-operative pain, Dental pain
📋 Drug Information
| Generic Name(s) | Tramadol (37.5 mg) + Paracetamol (325 mg) |
| Brand Name | novodol 37.5 mg/325 mg tablet |
| Manufacturer | UniOrange Life Care Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) away from moisture and heat. Keep in original container. |
| Shelf Life | 24 months from date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two analgesics with complementary mechanisms. Tramadol is a centrally acting opioid analgesic that binds to mu-opioid receptors and inhibits the reuptake of norepinephrine and serotonin, enhancing descending inhibitory pain pathways. Paracetamol acts primarily in the central nervous system to reduce pain and fever, though its exact mechanism is not fully understood; it may inhibit prostaglandin synthesis in the brain and modulate pain perception.
Mechanism Steps
💡 How to Take novodol 37.5 mg/325 mg tablet
Strength: Tablet containing tramadol 37.5 mg and paracetamol 325 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet every 4 to 6 hours as needed for pain. Do not exceed 8 tablets in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects. Start with a lower dose and monitor closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Dose adjustment may be needed in renal impairment. Consult your doctor. |
| Hepatic Impairment | Dose adjustment may be needed in hepatic impairment. Consult your doctor. |
| Maximum Daily Dose | Maximum 8 tablets in 24 hours (tramadol 300 mg and paracetamol 2600 mg). |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of novodol 37.5 mg/325 mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAO inhibitors | Major | |
| SSRIs | Major | |
| Warfarin | Major | |
| Benzodiazepines | Moderate | |
| Carbamazepine | Moderate |
🚨 Major Interactions
- MAO inhibitors
- SSRIs, SNRIs, tricyclic antidepressants
- Warfarin
⚡ Moderate Interactions
- CNS depressants (benzodiazepines, alcohol)
- Carbamazepine
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of drowsiness, respiratory depression, and liver damage.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Children under 12 years of age","Severe respiratory depression","Acute or severe asthma","Known hypersensitivity to tramadol or paracetamol","Concurrent use of MAO inhibitors","Severe liver or kidney impairment"]
⚠️ Warnings & Precautions
["Risk of dependence and withdrawal","Risk of seizures, especially with high doses or predisposing factors","Risk of serotonin syndrome with serotonergic drugs","Risk of respiratory depression","Avoid in patients with head injury or increased intracranial pressure","Use with caution in elderly and debilitated patients"]
🤱 Lactation Safety
Tramadol and paracetamol are excreted in breast milk. Consult your doctor before use. Monitor infant for drowsiness or poor feeding.
💊 Overdose Management
Seek emergency medical help immediately. Overdose can cause respiratory depression, seizures, liver damage, and coma. Treatment is supportive and may include naloxone for opioid effects and N-acetylcysteine for paracetamol toxicity.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Avoid alcohol and other central nervous system depressants while taking this medicine. Do not drive or operate heavy machinery until you know how this medicine affects you. Inform your doctor about all other medications you are taking, especially antidepressants, anticonvulsants, and blood thinners. Do not stop this medicine abruptly after long-term use; your doctor may taper the dose gradually. Keep this medicine out of reach of children and pets. Store at room temperature away from moisture and heat. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of side effects like drowsiness, dizziness, and respiratory depression. Use with caution and lower doses may be needed.
🤰 Pregnancy Planning (TTC)
Consult your doctor if you are planning pregnancy or are pregnant. This medicine may not be safe during pregnancy.
🏥 Post-Surgery Considerations
This medicine may be prescribed for post-operative pain. Follow your surgeon's instructions carefully.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities that may increase pain. Consult your doctor before starting any exercise program while on this medicine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness and dizziness. Avoid driving or operating heavy machinery until you know how it affects you. It may affect your ability to perform tasks requiring alertness.
🛑 When to Stop This Medicine
Do not stop this medicine abruptly without consulting your doctor, especially after long-term use. Your doctor will gradually reduce the dose to prevent withdrawal symptoms.
📅 Long-Term Use Effects
Long-term use may lead to dependence, tolerance, and withdrawal symptoms. Regular monitoring of liver and kidney function is advised. Do not use for extended periods without medical supervision.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain management.
Evidence: Well-establishedMay help with certain types of pain.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information. Consult your doctor regarding vaccinations while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and avoid extreme heat. If traveling across time zones, adjust dosing schedule as advised by your doctor. Check local customs regulations for controlled substances.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Pain relief typically begins within 30-60 minutes after taking the tablet.
A: Consult your doctor before combining with other pain relievers, especially those containing paracetamol, to avoid overdose.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine is safe for everyone.
Fact: It is not safe for children under 12, pregnant women, or those with certain medical conditions. - Myth: You can stop this medicine anytime.
Fact: Abrupt discontinuation after long-term use can cause withdrawal symptoms.
🔄 Alternative Options
Generic Alternatives
- Tramadol and Paracetamol Tablet
Brand Alternatives
- Ultracet
- Tramazac
- Zydol