nortas cr 15 tablet - Norethisterone (15mg) medicine

Ethione CR 15 Tablet: Complete Medicine Guide

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🏭 Intas Pharmaceuticals Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 21, 2026
⚠️ Hepatotoxicity Risk 🤰 Pregnancy Category Norethisterone is contraindicated during pregnancy. It is classified as Pregnancy Category D by the FDA (there is evidence of human fetal risk). 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for menstrual disorders; moderate for other uses.
Reviewed by
SaathiMed Expert Panel | Oct 21, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Sudden severe headache, vision changes, or confusion
  • Chest pain, shortness of breath, or coughing up blood
  • Swelling, pain, or redness in one leg
  • Severe abdominal pain, especially with nausea and vomiting
  • Yellowing of the skin or eyes, dark urine, or pale stools
  • Unusual vaginal bleeding that is heavy or prolonged
  • Signs of allergic reaction: rash, itching, swelling of face or throat

If experiencing severe symptoms, call emergency services immediately.

What is nortas cr 15 tablet used for?

This medicine contains Norethisterone 15 mg, a progestogen used to treat heavy menstrual bleeding, endometriosis, and to delay periods. It works by regulating the uterine lining and suppressing ovulation. It is not a contraceptive and should be taken only as prescribed.

  • Generic Name: Norethisterone (15mg)
  • Manufacturer: Intas Pharmaceuticals Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 nortas cr 15 tablet के बारे में (Hindi Summary)

उपयोग: यह दवा नोरेथिस्टेरोन 15 मिलीग्राम युक्त एक प्रोजेस्टोजन है, जिसका उपयोग भारी मासिक धर्म, एंडोमेट्रियोसिस और मासिक धर्म को स्थगित करने के लिए किया जाता है। यह गर्भनिरोधक नहीं है और इसे डॉक्टर की सलाह के बिना नहीं लेना चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, मतली, स्तन में कोमलता और अनियमित रक्तस्राव शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन रक्त के थक्के, यकृत की समस्या और एलर्जी प्रतिक्रिया हो सकती है। यदि आपको सीने में दर्द, सांस लेने में कठिनाई या त्वचा का पीलापन हो तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। गर्भावस्था के दौरान न लें। धूम्रपान से बचें क्योंकि इससे रक्त के थक्के बनने का खतरा बढ़ सकता है। नियमित जांच के लिए डॉक्टर से मिलते रहें।

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 nortas cr 15 tablet Uses & Benefits

[{"condition":"Heavy menstrual bleeding (menorrhagia)","description":"This medicine helps reduce heavy menstrual bleeding by thinning the uterine lining and stabilizing the endometrium.","evidence":"Well-established"},{"condition":"Endometriosis","description":"It is used to suppress endometrial tissue growth and relieve pain associated with endometriosis.","evidence":"Well-established"},{"condition":"Menstrual cycle delay","description":"Short-term use to postpone menstruation for convenience or medical reasons.","evidence":"Well-established"},{"condition":"Hormone replacement therapy","description":"Used in combination with estrogen to protect the uterus in postmenopausal women.","evidence":"Well-established"},{"condition":"Breast cancer","description":"Sometimes used as a second-line hormonal treatment in certain types of breast cancer.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Catamenial epilepsy","description":"May be used to reduce seizure frequency related to menstrual cycles.","evidence":"Limited"},{"condition":"Premenstrual syndrome (PMS)","description":"Occasionally prescribed to alleviate severe PMS symptoms.","evidence":"Limited"}]

Primary treatment for: Heavy menstrual bleeding

Also treats: Endometriosis, Menstrual cycle delay, Hormone replacement therapy

📋 Drug Information

Generic Name(s)Norethisterone (15mg)
Brand Namenortas cr 15 tablet
ManufacturerIntas Pharmaceuticals Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGYNAECOLOGICAL
Action ClassProgestins (First generation)
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine at the same time each day to maintain consistent hormone levels.
2
Use a backup non-hormonal contraceptive method while taking this medicine, as it is not a contraceptive.
3
Inform your doctor immediately if you experience leg pain, swelling, or shortness of breath, as these may be signs of a blood clot.
4
Avoid smoking while taking this medicine, as it significantly increases the risk of cardiovascular events.
5
Keep all follow-up appointments to monitor your response and check for any adverse effects.
6
Do not stop this medicine abruptly without consulting your doctor, as it may cause withdrawal bleeding.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Heavy menstrual bleeding
This medicine is commonly prescribed for this.
Likely Use
✅
Pelvic pain due to endometriosis
This medicine can help relieve pain.
Likely Use
❌
Fever
This medicine is not a fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionNorethisterone is rapidly absorbed from the gastrointestinal tract after oral administration. The bioavailability is approximately 64% due to first-pass metabolism.
DistributionNorethisterone is widely distributed in the body. It is highly protein-bound, primarily to albumin and sex hormone-binding globulin (SHBG).
Protein BindingApproximately 97% bound to plasma proteins, mainly albumin and SHBG.
MetabolismNorethisterone is extensively metabolized in the liver, primarily by reduction and conjugation. The main metabolites are 5α-dihydro-norethisterone and 5β-dihydro-norethisterone, which are excreted as glucuronide and sulfate conjugates.
Half-LifeThe elimination half-life of norethisterone is approximately 8-10 hours.
ExcretionNorethisterone and its metabolites are excreted mainly in the urine, with a small amount in feces.
BioavailabilityApproximately 64%
Onset of ActionThe onset of action for menstrual bleeding control is within 1-3 days of starting treatment. For ovulation inhibition, it may take up to 7 days.
Peak Plasma Time1-2 hours after oral administration.
Duration of ActionThe duration of action depends on the indication and dose. For menstrual bleeding, effects last as long as the drug is taken. For ovulation inhibition, it lasts for about 24 hours after a dose.

How It Works

Norethisterone is a synthetic progestogen that binds to progesterone receptors in target tissues such as the endometrium, breast, and pituitary. This binding leads to changes in gene expression that inhibit ovulation, thicken cervical mucus, and alter the endometrium. It also has weak androgenic and estrogenic effects. By suppressing gonadotropin release, it reduces estrogen production and endometrial proliferation.

Mechanism Steps

1
Binding to progesterone receptors: Norethisterone binds to progesterone receptors in the cytoplasm of target cells.
2
Receptor translocation: The drug-receptor complex moves into the nucleus and binds to DNA response elements.
3
Gene transcription modulation: This alters the transcription of specific genes, leading to changes in protein synthesis.
4
Endometrial effects: The endometrium becomes secretory, and its growth is suppressed, reducing bleeding.
5
Ovulation inhibition: At higher doses, norethisterone inhibits the midcycle surge of luteinizing hormone, preventing ovulation.

💡 How to Take nortas cr 15 tablet

Strength: Norethisterone 15 mg immediate-release tablet

1Take this medicine by mouth with a glass of water.
2Swallow the tablet whole; do not crush or chew.
3Take with food to reduce stomach upset.
4Take at the same time each day to maintain consistent levels.
5Follow your doctor's instructions exactly.

Dosage Information

Adult DosageThe dose of this medicine varies depending on the condition being treated. For heavy menstrual bleeding, a common dose is 5 mg three times daily for 10 days. For endometriosis, doses may range from 10-15 mg daily. For menstrual delay, 5 mg three times daily may be used. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of this medicine. Use with caution and monitor for adverse effects.
Renal ImpairmentNo specific dose adjustment is provided in the literature. Use with caution in patients with renal impairment.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose reduction may be necessary.
Maximum Daily DoseThe maximum daily dose depends on the indication and should not exceed 15 mg per day unless otherwise directed by a clinician.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset and nausea.
Grapefruit
Avoid
May increase drug levels by inhibiting CYP3A4.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of nortas cr 15 tablet

✅ Common Side Effects

Headache (Common (5-10%))
Usually resolves on its own. Consult doctor if persistent or severe.
Nausea (Common (5-10%))
Take with food to reduce nausea. Consult doctor if vomiting occurs.
Breast tenderness (Common (5-10%))
Wear a supportive bra. Consult doctor if severe or persistent.
Irregular vaginal bleeding (Common (5-10%))
Usually settles after a few cycles. Consult doctor if heavy or prolonged.
Mood swings (Common (5-10%))
Discuss with doctor if affecting daily life.

🚨 Serious Side Effects

Blood clots (thrombosis) (Rare (<0.1%))
Seek immediate medical attention if you experience chest pain, shortness of breath, leg swelling, or severe headache.
Liver problems (Rare (<0.1%))
Report yellowing of skin or eyes, dark urine, or severe abdominal pain immediately.
Severe allergic reaction (Rare (<0.1%))
Seek emergency care if you develop rash, itching, swelling of face or throat, or difficulty breathing.

⚠️ Rare Side Effects

Visual disturbances
Consult an ophthalmologist if you experience blurred vision or loss of vision.
Cholestatic jaundice
Seek medical attention if you notice yellowing of skin or eyes.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Rifampicin Major
Carbamazepine Major
Phenytoin Moderate
St. John's wort Moderate

🚨 Major Interactions

  • Warfarin
  • Rifampicin
  • Carbamazepine

⚡ Moderate Interactions

  • Phenytoin
  • St. John's wort

🍷 Alcohol Interaction

Alcohol may increase the risk of liver problems and can worsen side effects such as dizziness. It is advisable to limit or avoid alcohol while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Pregnancy","History of or active thromboembolic disorders","Severe liver disease","Undiagnosed vaginal bleeding","Known hypersensitivity to norethisterone"]

⚠️ Warnings & Precautions

["Use with caution in patients with a history of blood clots.","May cause fluid retention; caution in hypertension and heart failure.","May affect glucose tolerance; monitor in diabetics.","Avoid in patients with a history of migraine with aura.","Not for use as a contraceptive."]

🤱 Lactation Safety

Norethisterone is excreted in breast milk in small amounts. It may reduce milk production. Consult your doctor before using this medicine while breastfeeding.

💊 Overdose Management

Overdose may cause nausea, vomiting, and withdrawal bleeding. There is no specific antidote. Treatment is supportive and symptomatic. Contact a poison control center or emergency department if overdose is suspected.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration. Inform your doctor if you have a history of blood clots, liver disease, migraines, or high blood pressure. Use effective non-hormonal contraception if you are sexually active and not planning pregnancy, as this medicine is not a contraceptive. Avoid smoking while taking this medicine, as it increases the risk of blood clots. Regular follow-up with your doctor is important to monitor for any adverse effects.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more susceptible to cardiovascular side effects. Use with caution and monitor blood pressure and signs of thromboembolism.

🤰 Pregnancy Planning (TTC)

This medicine is contraindicated during pregnancy. If you are planning to become pregnant, stop this medicine and consult your doctor for alternative treatments.

🏥 Post-Surgery Considerations

Inform your surgeon if you are taking this medicine, as it may increase the risk of blood clots after surgery. Your doctor may advise you to stop it temporarily before surgery.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine, as it may affect bleeding during dental procedures. No specific precautions are usually needed, but your dentist may consult your doctor.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce the risk of blood clots.
🥗
Exercise regularly, but avoid strenuous activities if you feel dizzy.
😴
Eat a balanced diet rich in fruits and vegetables.
💧
Avoid smoking and limit alcohol consumption.
🧘
Get adequate sleep to help manage mood swings.

🏋️ Exercise Considerations

This medicine may cause dizziness or fatigue. Avoid heavy lifting or high-impact exercises if you experience these symptoms. Consult your doctor before starting any new exercise regimen.

🥗 Diet Recommendations

Include calcium-rich foods to support bone health.
Reduce salt intake to minimize fluid retention.
Stay well hydrated.
Avoid grapefruit and grapefruit juice.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or mood changes that could affect your ability to drive or operate machinery. Avoid driving if you feel dizzy or drowsy. Take breaks if you have a desk job to reduce the risk of blood clots.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. Stopping abruptly may cause withdrawal bleeding or worsening of symptoms. Your doctor will advise you on the appropriate duration of treatment.

📅 Long-Term Use Effects

Long-term use of this medicine may increase the risk of blood clots, liver problems, and bone density loss. Regular monitoring of liver function and blood pressure is recommended. Discuss with your doctor if you need to use it for more than a few months.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Non-hormonal treatments

Tranexamic acid or NSAIDs for heavy bleeding.

Evidence: Well-established
Lifestyle modifications

Weight loss, exercise, and stress reduction can help manage menstrual disorders.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions are known. However, inform your doctor if you are due for any vaccinations.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from extreme heat or moisture. If traveling across time zones, adjust the timing of your doses gradually to maintain consistent intervals. Check local regulations regarding prescription medicines before traveling internationally.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 38-year-old woman with heavy menstrual bleeding
She was prescribed this medicine for 10 days to control excessive bleeding. After starting treatment, her bleeding reduced significantly within 2 days. She experienced mild nausea, which was managed by taking the tablet with food. She completed the course and her hemoglobin levels improved.
💡 Lesson: Taking this medicine with food can reduce nausea, and adherence to the prescribed duration is crucial for optimal results.
👤 A 29-year-old woman needing to delay her period for a wedding
She consulted her doctor to postpone her period for a week. She was prescribed this medicine to start 3 days before the expected date. Her period was successfully delayed without significant side effects. She was advised not to use this method frequently.
💡 Lesson: This medicine can effectively delay menstruation for short periods, but it should only be used under medical supervision and not as a routine practice.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: For heavy bleeding, you may notice a reduction within 1-3 days. For other uses, it may take longer.

Q: Can I take this medicine if I am pregnant?

A: No, this medicine is contraindicated during pregnancy as it may harm the fetus.

Q: Is this medicine a contraceptive?

A: No, this medicine is not a contraceptive. Use a reliable non-hormonal contraceptive method if you are sexually active.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my fertility?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for nortas cr 15 tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine is a contraceptive.
    Fact: This medicine is not a contraceptive and does not prevent pregnancy.
  • Myth: This medicine can be taken without a prescription.
    Fact: This medicine is a prescription drug and should only be taken under medical supervision.

🔄 Alternative Options

Generic Alternatives

  • Norethisterone 15 mg tablet

Brand Alternatives

  • Ethione CR 15 Tablet

📊 Comparison with Similar Medicines

[{"medicine":"Norethisterone","class":"Progestogen","primary_use":"Heavy menstrual bleeding","half_life":"8-10 hours"},{"medicine":"Medroxyprogesterone acetate","class":"Progestogen","primary_use":"Menstrual disorders","half_life":"12-17 hours"}]

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