Nojbac Mr 100mg/325mg/250mg Tablet: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in vomit or black, tarry stools
- Severe abdominal pain or persistent vomiting
- Yellowing of skin or eyes (jaundice)
- Decreased urine output or swelling in legs
- Severe allergic reaction: rash, swelling of face, lips, or throat, difficulty breathing
- Chest pain or shortness of breath
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is nojbac mr 100mg/325mg/250mg tablet used for?
This medicine is a combination of nimesulide, paracetamol, and magnesium trisilicate used for short-term relief of acute pain, inflammation, and fever. It works by reducing pain and inflammation while protecting the stomach. It should be taken as prescribed, usually with food, and not for more than 7 days without medical advice.
- Generic Name: Information coming soon
- Manufacturer: Multiple manufacturers
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nojbac mr 100mg/325mg/250mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा निमेसुलाइड, पैरासिटामोल और मैग्नीशियम ट्राइसिलिकेट का संयोजन है, जिसका उपयोग तीव्र दर्द, सूजन और बुखार से राहत के लिए किया जाता है। यह मांसपेशियों और जोड़ों के दर्द, दांत दर्द, ऑपरेशन के बाद के दर्द और मासिक धर्म के दर्द में प्रभावी है। यह दवा दर्द और सूजन को कम करने के साथ-साथ पेट की परत की रक्षा भी करती है। इसे डॉक्टर के निर्देशानुसार ही लें और 7 दिनों से अधिक न लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, जलन, दस्त और चक्कर आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें पेट के अल्सर, गैस्ट्रोइंटेस्टाइनल रक्तस्राव, गुर्दे की समस्या, यकृत की क्षति और एलर्जी प्रतिक्रियाएं शामिल हो सकती हैं। यदि आपको काला मल, खून की उल्टी, त्वचा या आंखों का पीलापन, या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक या अवधि से अधिक न लें। इसे भोजन या दूध के साथ लें ताकि पेट की जलन कम हो। इस दवा के साथ शराब न लें क्योंकि इससे पेट में रक्तस्राव और यकृत की क्षति का खतरा बढ़ सकता है। अन्य दर्द निवारक दवाओं या पैरासिटामोल युक्त उत्पादों के साथ इसका सेवन न करें। यदि आप गर्भवती हैं, स्तनपान करा रही हैं, या आपको गुर्दे या यकृत की बीमारी है, तो डॉक्टर से परामर्श लें।
💊 nojbac mr 100mg/325mg/250mg tablet Uses & Benefits
[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in muscles, joints, and soft tissues due to sprains, strains, or injuries.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides relief from toothache and pain following dental procedures.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of pain after minor surgeries.","evidence":"Moderate"},{"condition":"Fever","description":"Reduces fever due to its paracetamol content.","evidence":"Well-established"},{"condition":"Dysmenorrhea","description":"Relieves menstrual cramps and associated pain.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks, but not first-line.","evidence":"Limited"},{"condition":"Osteoarthritis flare-ups","description":"May be used short-term for pain relief during flare-ups, but not for long-term management.","evidence":"Limited"}]
Primary treatment for: Acute pain and inflammation
Also treats: Musculoskeletal pain, Dental pain, Post-operative pain, Fever, Dysmenorrhea
📋 Drug Information
| Generic Name(s) | Information coming soon |
| Brand Name | nojbac mr 100mg/325mg/250mg tablet |
| Manufacturer | Multiple manufacturers |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a cool, dry place, away from direct sunlight and moisture. Keep in the original container, tightly closed. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines three active ingredients with complementary actions. Nimesulide is a non-steroidal anti-inflammatory drug that selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, reducing the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. Paracetamol acts primarily in the central nervous system to produce analgesia and antipyresis, possibly by inhibiting prostaglandin synthesis in the brain and interfering with pain pathways. Magnesium trisilicate is an antacid that neutralizes gastric acid, thereby reducing the risk of stomach irritation caused by nimesulide. Together, these ingredients provide relief from pain, inflammation, and fever while offering some protection to the stomach lining.
Mechanism Steps
💡 How to Take nojbac mr 100mg/325mg/250mg tablet
Strength: Each tablet contains nimesulide 100 mg, paracetamol 325 mg, and magnesium trisilicate 250 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally 1 to 3 times daily, as prescribed by a doctor. The dose and frequency depend on the severity of pain and the patient's condition. Do not exceed the recommended dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. The maximum duration of use without medical advice is typically 5-7 days. |
| Pediatric Dosage | Pediatric dosing is not established from available information. This medicine is not recommended for children under 12 years. Consult a pediatrician for appropriate pain relief in children. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the side effects of this medicine, especially gastrointestinal bleeding and kidney impairment. Use with caution and at the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with kidney impairment. Dose reduction or avoidance may be necessary. Consult a doctor for individualized dosing. Not recommended in severe kidney impairment. |
| Hepatic Impairment | Use with caution in patients with liver impairment. Dose reduction or avoidance may be necessary. Consult a doctor for individualized dosing. Contraindicated in severe liver impairment. |
| Maximum Daily Dose | The maximum daily dose should not exceed 3 tablets in 24 hours, unless otherwise prescribed by a doctor. Do not exceed the recommended dose due to risk of liver and kidney toxicity. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nojbac mr 100mg/325mg/250mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Ibuprofen | Major | |
| Methotrexate | Major | |
| ACE inhibitors | Major | |
| Diuretics | Major | |
| Corticosteroids | Moderate | |
| SSRIs | Moderate | |
| Lithium | Moderate | |
| Antacids | Minor | |
| Cholestyramine | Minor |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., ibuprofen, aspirin)
- Methotrexate
- ACE inhibitors and ARBs
- Diuretics
⚡ Moderate Interactions
- Corticosteroids
- SSRIs
- Lithium
- Anticoagulants (e.g., heparin)
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding, ulcers, and liver damage, especially when combined with nimesulide and paracetamol.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to nimesulide, paracetamol, magnesium trisilicate, or any other ingredients","History of gastrointestinal bleeding or perforation related to NSAID use","Active or history of peptic ulcer disease","Severe liver impairment","Severe kidney impairment","Severe heart failure","Children under 12 years of age","Pregnancy (especially third trimester)","Breastfeeding"]
⚠️ Warnings & Precautions
["Take with food or milk to reduce stomach upset.","Do not exceed the recommended dose or duration.","Avoid alcohol while taking this medicine.","Do not use with other NSAIDs or paracetamol-containing products.","Use with caution in elderly patients and those with kidney or liver disease.","Discontinue and consult a doctor if you experience signs of gastrointestinal bleeding, liver problems, or allergic reactions.","Do not drive or operate machinery if you feel dizzy.","Inform your doctor if you have a history of asthma, especially aspirin-sensitive asthma."]
🤱 Lactation Safety
Not recommended during breastfeeding. Nimesulide may pass into breast milk and could harm the infant. Paracetamol is considered safe during breastfeeding, but the combination should be avoided. Consult your doctor for alternative pain relief.
💊 Overdose Management
Overdose of this medicine can cause severe liver damage, kidney failure, and gastrointestinal bleeding. Symptoms of overdose include nausea, vomiting, abdominal pain, confusion, and drowsiness. If you suspect an overdose, seek immediate medical attention. Treatment may include activated charcoal, gastric lavage, and administration of acetylcysteine for paracetamol toxicity. Supportive care and monitoring of liver and kidney function are essential.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not take more than the recommended dose or for longer than the prescribed duration. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine as it can increase the risk of stomach bleeding and liver damage. Do not take other medicines containing paracetamol or other NSAIDs without consulting your doctor, as this can lead to overdose or increased side effects. If you have a history of stomach ulcers, kidney disease, liver disease, or bleeding disorders, inform your doctor before taking this medicine. Do not use this medicine for self-medication of chronic pain. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine. Keep out of reach of children. Store in a cool, dry place away from direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor kidney and liver function regularly. Avoid if possible in those with multiple comorbidities.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended for women planning pregnancy or who are pregnant. Nimesulide may interfere with ovulation and is contraindicated in the third trimester. Consult your doctor for safe alternatives for pain relief.
🏥 Post-Surgery Considerations
This medicine may be used for short-term post-operative pain relief, but it can increase the risk of bleeding and interfere with wound healing. Consult your surgeon before taking it after surgery.
🦷 Dental Procedures
This medicine can provide short-term relief for dental pain, but it should not replace dental treatment. Inform your dentist if you are taking this medicine before any dental procedure, as it may increase bleeding risk.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting while taking this medicine, especially if you have musculoskeletal pain. Gentle stretching and low-impact activities are generally safe. Listen to your body and stop if pain worsens.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue desk work, but take breaks and stay hydrated.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if you experience severe side effects such as stomach pain, black stools, vomiting blood, yellowing of eyes, decreased urine output, or allergic reactions. Do not stop abruptly if you are on a prescribed course without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended due to the risk of serious side effects such as gastrointestinal bleeding, ulcers, kidney impairment, and liver damage. If long-term pain management is needed, consult your doctor for safer alternatives and regular monitoring of liver and kidney function.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve mobility.
Evidence: Well-establishedApplying heat or cold packs can help reduce localized pain and inflammation.
Evidence: ModerateMay provide pain relief for some individuals.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are known. However, if you are scheduled for vaccination, inform your doctor about this medicine. It is generally safe to continue, but your doctor may advise temporary discontinuation if you have an acute illness.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it in a cool, dry place away from direct sunlight. If crossing time zones, continue taking it at the same intervals as prescribed, but consult your doctor for specific advice. Check customs regulations for carrying prescription medicines. Always keep it in your carry-on luggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 30-60 minutes after taking it.
A: No, it should be taken with food or milk to reduce the risk of stomach upset.
A: No, do not take it with other NSAIDs or paracetamol-containing products without consulting your doctor.
A: It is not recommended during pregnancy, especially in the third trimester. Consult your doctor for alternatives.
A: If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine is safe for long-term use.
Fact: This medicine is only for short-term use. Long-term use can cause serious side effects like stomach ulcers, kidney problems, and liver damage. - Myth: It can be taken on an empty stomach.
Fact: It should be taken with food or milk to reduce the risk of stomach upset and ulcers. - Myth: It is safe to take with other painkillers.
Fact: Taking it with other NSAIDs or paracetamol-containing products can increase the risk of toxicity. Always consult a doctor.