Nocoril 5mg/10mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe dizziness, fainting, or a sudden drop in blood pressure
- Painful mouth ulcers or sores that do not heal
- Non-healing skin ulcers or sores
- Severe abdominal pain, black stools, or vomiting blood
- Swelling of the face, lips, tongue, or throat, or difficulty breathing
- Chest pain that is not relieved by your usual angina medicine
- Irregular heartbeat or palpitations
If experiencing severe symptoms, call emergency services immediately.
What is nocoril 5mg/10mg tablet used for?
This medicine is a prescription tablet containing nicorandil 5 mg and 10 mg, used to prevent angina attacks by relaxing blood vessels and improving blood flow to the heart. It is taken twice daily and is not for immediate relief of acute chest pain.
- Generic Name: Information coming soon
- Manufacturer: Multiple manufacturers
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nocoril 5mg/10mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एंजाइना पेक्टोरिस (सीने में दर्द) को रोकने और इलाज के लिए इस्तेमाल की जाती है। यह रक्त वाहिकाओं को फैलाकर दिल तक रक्त का प्रवाह बढ़ाती है और दिल पर दबाव कम करती है। यह दवा तीव्र एंजाइना हमले के तत्काल राहत के लिए नहीं है। इसका उपयोग केवल डॉक्टर के परामर्श से ही करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, चेहरे पर लालिमा, चक्कर आना, मतली और कमजोरी शामिल हैं। कुछ लोगों को मुँह के छाले भी हो सकते हैं। यदि आपको गंभीर चक्कर आना, बेहोशी, या मुँह के छाले होते हैं, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे अचानक बंद न करें। शराब और सिल्डेनाफिल जैसी दवाओं के साथ इसका सेवन न करें। अगर आपको चक्कर आते हैं तो गाड़ी चलाने से बचें। नियमित रूप से रक्तचाप की जांच कराएं।
💊 nocoril 5mg/10mg tablet Uses & Benefits
[{"condition":"Chronic stable angina","description":"This medicine is used to reduce the frequency and severity of angina attacks in adults with chronic stable angina who remain symptomatic despite treatment with beta-blockers or calcium channel blockers.","evidence":"Well-established"},{"condition":"Unstable angina","description":"This medicine may be used in the management of unstable angina as part of a comprehensive treatment plan, but it is not for immediate relief of acute attacks.","evidence":"Moderate"},{"condition":"Vasospastic angina","description":"This medicine can help prevent coronary artery spasms that cause chest pain in people with vasospastic angina.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Prevention of contrast-induced nephropathy","description":"Some studies have explored the use of nicorandil to protect kidney function in patients undergoing procedures with contrast dye, but this is not an approved indication.","evidence":"Limited"},{"condition":"Heart failure with preserved ejection fraction","description":"Nicorandil has been studied as an add-on therapy in some patients with heart failure, but its role remains investigational.","evidence":"Limited"}]
Primary treatment for: Angina pectoris
Also treats: Coronary artery disease, Vasospastic angina, Chronic stable angina
📋 Drug Information
| Generic Name(s) | Information coming soon |
| Brand Name | nocoril 5mg/10mg tablet |
| Manufacturer | Multiple manufacturers |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store this medicine at room temperature between 15°C and 30°C (59°F to 86°F). Keep it in the original container, tightly closed, away from moisture, heat, and direct sunlight. Do not refrigerate unless specified by the manufacturer. |
| Shelf Life | The shelf life of this medicine is typically 24 months from the date of manufacture. Check the expiry date on the packaging before use. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by activating adenosine triphosphate-sensitive potassium channels in the smooth muscle cells of blood vessels. When these channels open, potassium ions flow out of the cells, causing the cell membrane to become less excitable. This leads to relaxation of the blood vessel walls, a process known as vasodilation. As a result, both arteries and veins widen, which reduces the workload on the heart and improves blood flow to the heart muscle. Additionally, this medicine has a nitrate-like effect that further dilates veins and reduces preload. Together, these actions help to prevent angina attacks by balancing the heart's oxygen supply and demand.
Mechanism Steps
💡 How to Take nocoril 5mg/10mg tablet
Strength: This medicine is available as an immediate-release tablet containing 5 mg and 10 mg of nicorandil, for a total of 15 mg per tablet.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken twice daily, approximately 12 hours apart. The dose may be adjusted by your doctor based on your response and tolerance. The maximum recommended daily dose is 30 mg (two 15 mg tablets). Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the blood pressure-lowering effects of this medicine. Start with a lower dose and monitor blood pressure closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with severe renal impairment, the dose of this medicine may need to be reduced. Consult your doctor for individualized dosing. |
| Hepatic Impairment | In patients with severe hepatic impairment, the dose of this medicine may need to be reduced. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose of this medicine is 30 mg (two 15 mg tablets). |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nocoril 5mg/10mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Sildenafil | Major | |
| Nitroglycerin | Major | |
| Riociguat | Major | |
| Alcohol | Moderate | |
| Lisinopril | Moderate | |
| Metoprolol | Moderate | |
| Amlodipine | Moderate | |
| Furosemide | Moderate | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- Phosphodiesterase-5 inhibitors (e.g., sildenafil, tadalafil, vardenafil)
- Nitrates (e.g., nitroglycerin, isosorbide mononitrate)
- Riociguat
⚡ Moderate Interactions
- Alcohol
- Antihypertensive drugs (e.g., ACE inhibitors, beta-blockers, calcium channel blockers)
- Diuretics
🍷 Alcohol Interaction
Alcohol can enhance the blood pressure-lowering effect of this medicine and increase the risk of dizziness, fainting, and falls. It is best to avoid alcohol or limit its intake while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Allergy to nicorandil or any component of the tablet","Cardiogenic shock","Severe hypotension (low blood pressure)","Heart failure with low filling pressures","Concomitant use with phosphodiesterase-5 inhibitors (e.g., sildenafil)","Concomitant use with riociguat","Severe dehydration","Acute myocardial infarction with low blood pressure"]
⚠️ Warnings & Precautions
["This medicine can cause severe hypotension, especially when used with other blood pressure-lowering drugs or alcohol. Monitor blood pressure regularly.","Mouth ulcers are a common side effect. If they occur, stop the medicine and consult your doctor. Dose reduction or discontinuation may be necessary.","Skin and gastrointestinal ulcers have been reported. Report any non-healing sores or severe abdominal pain to your doctor.","Use with caution in elderly patients, who may be more sensitive to the blood pressure-lowering effects.","Do not use this medicine for immediate relief of an acute angina attack. Use a fast-acting nitrate as prescribed.","Inform your doctor if you have liver or kidney disease, as dose adjustment may be needed.","Avoid driving or operating machinery until you know how this medicine affects you."]
🤱 Lactation Safety
It is not known whether this medicine is excreted in human breast milk. Because many drugs are excreted in human milk, caution should be exercised when this medicine is administered to a nursing woman. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose of this medicine can cause severe hypotension, dizziness, fainting, and reflex tachycardia. If you suspect an overdose, seek emergency medical attention immediately. Treatment is supportive and symptomatic, including intravenous fluids and vasopressors if needed. There is no specific antidote.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without medical advice. This medicine can cause dizziness or lightheadedness, especially when you stand up quickly, so rise slowly from sitting or lying positions. Avoid driving or operating heavy machinery until you know how this medicine affects you. Do not take this medicine with erectile dysfunction medicines such as sildenafil, tadalafil, or vardenafil, as this can cause a dangerous drop in blood pressure. Inform your doctor if you have low blood pressure, heart failure, or kidney or liver problems. Keep all follow-up appointments so your doctor can monitor your blood pressure and heart function. Store this medicine at room temperature, away from moisture and heat.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the blood pressure-lowering effects of this medicine. Start with a lower dose and monitor blood pressure closely. Falls due to dizziness are a concern, so advise patients to rise slowly and use support when needed.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. The safety of this medicine during pregnancy is not well established, and your doctor will weigh the benefits and risks.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may need to be temporarily stopped before certain procedures to avoid interactions with anesthetic agents. Follow your doctor's instructions regarding when to resume.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may interact with certain local anesthetics or medications used during dental work. Your dentist may consult your doctor to determine if any precautions are needed.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe while taking this medicine, but avoid sudden strenuous activities that could trigger angina. Always warm up and cool down. If you experience chest pain, dizziness, or shortness of breath during exercise, stop and rest. Consult your doctor before starting any new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or lightheadedness, especially when you first start taking it. Avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their normal daily activities, but take precautions when standing up quickly. Inform your employer if your job involves operating machinery or driving.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as severe hypotension, persistent mouth ulcers, or skin ulcers, contact your doctor immediately. Your doctor may reduce the dose or switch you to a different medicine. In case of an acute angina attack, use your fast-acting nitrate as prescribed, and seek emergency care if the pain persists.
📅 Long-Term Use Effects
Long-term use of this medicine is generally well tolerated. However, regular monitoring of blood pressure, heart rate, and symptoms is recommended. Some patients may develop mouth ulcers or skin ulcers, which may require dose reduction or discontinuation. Liver and kidney function should be monitored in patients with pre-existing disease. The medicine should be reviewed periodically to ensure it remains appropriate for your condition.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Heart-healthy diet, regular exercise, smoking cessation, and stress management can complement medicine for angina.
Evidence: Well-establishedA structured program of exercise and education can improve heart health and reduce angina symptoms.
Evidence: Well-establishedAngioplasty or bypass surgery may be considered for certain patients with severe coronary artery disease.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, always inform your healthcare provider about all medicines you are taking before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store it at room temperature and protect it from extreme heat or cold. If you are crossing time zones, adjust your dosing schedule gradually in consultation with your doctor. Check the customs regulations of your destination country regarding prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 30 to 60 minutes after taking a dose, but its full benefits in preventing angina may take a few days to become noticeable.
A: Yes, you can take this medicine with or without food. Taking it with food may help reduce stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: The safety of this medicine during pregnancy is not well established. Consult your doctor if you are pregnant or planning to become pregnant.
A: No, do not stop taking this medicine without consulting your doctor. Stopping suddenly may increase your risk of angina attacks.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can be used to relieve an acute angina attack.
Fact: This medicine is for prevention of angina attacks. For immediate relief, a fast-acting nitrate such as sublingual nitroglycerin is used. - Myth: This medicine is safe to take with erectile dysfunction drugs.
Fact: Combining this medicine with phosphodiesterase-5 inhibitors like sildenafil can cause a dangerous drop in blood pressure and is contraindicated. - Myth: Once you feel better, you can stop taking this medicine.
Fact: You should not stop taking this medicine without consulting your doctor, as it may increase the risk of angina attacks.
🔄 Alternative Options
Generic Alternatives
- Nicorandil 5 mg and 10 mg immediate-release tablets are available as generic products.
Brand Alternatives
- Not established from the available information.