Nock Sp 100mg/500mg/15mg Tablet: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is nock sp 100mg/500mg/15mg tablet used for?
This medicine is a combination of nimesulide, paracetamol, and serratiopeptidase used for short-term relief of pain, inflammation, and swelling in musculoskeletal conditions. It should be taken with food and not exceeding the prescribed dose.
- Generic Name: Information coming soon
- Manufacturer: Multiple manufacturers
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nock sp 100mg/500mg/15mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा नाइमसुलाइड, पैरासिटामोल और सेरेशियोपेप्टिडेज़ का संयोजन है, जिसका उपयोग दर्द, सूजन और जलन को कम करने के लिए किया जाता है। यह मांसपेशियों और जोड़ों के दर्द, ऑस्टियोआर्थराइटिस, सर्जरी के बाद की सूजन और दांतों के दर्द में प्रभावी है।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त और चक्कर आना शामिल हैं। गंभीर दुष्प्रभावों में पेट में रक्तस्राव, लीवर की क्षति, गुर्दे की समस्या और गंभीर त्वचा प्रतिक्रियाएं शामिल हो सकती हैं।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खाने के साथ लें ताकि पेट की जलन कम हो। शराब न लें। 7 दिनों से अधिक उपयोग न करें। यदि आपको पेट अल्सर, लीवर या गुर्दे की बीमारी है तो डॉक्टर को बताएं।
💊 nock sp 100mg/500mg/15mg tablet Uses & Benefits
[{"condition":"Musculoskeletal pain","description":"Relief of pain and inflammation in conditions such as sprains, strains, and back pain.","evidence":"Well-established"},{"condition":"Post-operative inflammation","description":"Reduction of swelling and pain after surgical procedures.","evidence":"Well-established"},{"condition":"Osteoarthritis","description":"Symptomatic relief of pain and stiffness in osteoarthritis.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Adjunctive therapy for pain and inflammation in rheumatoid arthritis.","evidence":"Moderate"},{"condition":"Dental pain","description":"Relief of pain and swelling following dental procedures.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks.","evidence":"Limited"},{"condition":"Dysmenorrhea","description":"May be used off-label for menstrual pain.","evidence":"Limited"}]
Primary treatment for: Musculoskeletal pain and inflammation
Also treats: Osteoarthritis, Rheumatoid arthritis, Post-operative inflammation, Dental pain
📋 Drug Information
| Generic Name(s) | Information coming soon |
| Brand Name | nock sp 100mg/500mg/15mg tablet |
| Manufacturer | Multiple manufacturers |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines three active ingredients with complementary mechanisms. Nimesulide selectively inhibits cyclooxygenase-2 (COX-2), reducing prostaglandin synthesis and thereby decreasing pain and inflammation. Paracetamol acts centrally to relieve pain and reduce fever, though its exact mechanism is not fully established. Serratiopeptidase is a proteolytic enzyme that may reduce swelling by breaking down fibrin and other proteins involved in inflammation.
Mechanism Steps
💡 How to Take nock sp 100mg/500mg/15mg tablet
Strength: Each tablet contains nimesulide 100 mg, paracetamol 500 mg, and serratiopeptidase 15 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally every 8 to 12 hours as needed for pain and inflammation, but the exact dose and duration must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. Use with caution and lower doses may be required. Consult a doctor. |
| Renal Impairment | Dose adjustment may be required in patients with kidney impairment. Consult a doctor. |
| Hepatic Impairment | Dose adjustment may be required in patients with liver impairment. Consult a doctor. |
| Maximum Daily Dose | The maximum daily dose should not exceed the prescribed amount. Typically, not more than 3 tablets in 24 hours, but must be individualized by a clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nock sp 100mg/500mg/15mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Methotrexate | Major | |
| ACE inhibitors | Moderate | |
| Diuretics | Moderate | |
| Corticosteroids | Moderate | |
| Antacids | Minor | |
| Alcohol | Minor |
🚨 Major Interactions
- Warfarin
- Other NSAIDs
- Methotrexate
⚡ Moderate Interactions
- ACE inhibitors
- Diuretics
- Corticosteroids
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine as it increases the risk of liver damage and gastrointestinal bleeding.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to any component","Active peptic ulcer disease","Severe liver impairment","Severe kidney impairment","Pregnancy","Breastfeeding","Children under 12 years"]
⚠️ Warnings & Precautions
["Take with food to reduce stomach upset.","Do not exceed recommended dose or duration.","Avoid alcohol.","Use with caution in elderly patients.","Use with caution in patients with asthma.","Use with caution in patients with bleeding disorders."]
🤱 Lactation Safety
Not recommended during breastfeeding as components may pass into breast milk. Consult your doctor.
💊 Overdose Management
Seek immediate medical attention. Symptoms of overdose may include nausea, vomiting, abdominal pain, and liver damage. Treatment is supportive and symptomatic.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration. Take it with food to reduce stomach upset. Avoid alcohol while taking this medicine. Do not use it for more than 7 days without medical advice. Inform your doctor if you have a history of stomach ulcers, liver or kidney disease, or bleeding disorders. Do not take other pain relievers or NSAIDs without consulting your doctor.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of side effects such as gastrointestinal bleeding and kidney problems. Use with caution and lower doses may be required.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy or when planning pregnancy. Consult your doctor for alternative treatment.
🏥 Post-Surgery Considerations
This medicine may be used for post-operative pain and swelling, but only under medical supervision. Inform your surgeon if you are taking this medicine before surgery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure, as it may increase the risk of bleeding.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise while taking this medicine as it may increase the risk of bleeding or injury. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how it affects you.
🛑 When to Stop This Medicine
Stop taking this medicine if you experience any serious side effects or if your doctor advises you to stop. Do not stop abruptly without consulting your doctor if you have been taking it for a long time.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of gastrointestinal bleeding, liver damage, and kidney problems. It is not recommended for extended use without medical supervision. Regular monitoring of liver and kidney function may be required.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain.
Evidence: Well-establishedMay help reduce inflammation and pain.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are established. Consult your doctor before vaccination if you are taking this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and avoid extreme heat. If traveling across time zones, adjust dosing as advised by your doctor. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Pain relief typically begins within 30-60 minutes after taking the tablet.
A: It is best taken with food to reduce stomach upset.
A: Take it as soon as you remember, but if it's almost time for your next dose, skip the missed dose and continue with your regular schedule.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can be taken long-term for chronic pain.
Fact: This medicine is for short-term use only. Long-term use may cause serious side effects. - Myth: It is safe to take without a prescription.
Fact: This medicine requires a prescription and should only be taken under medical supervision.
🔄 Alternative Options
Generic Alternatives
- Nimesulide + Paracetamol + Serratiopeptidase combination products