Nive-p Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Yellowing of the skin or eyes (jaundice)
- Dark urine or pale stools
- Severe abdominal pain or persistent vomiting
- Black, tarry stools or blood in vomit
- Decreased urine output or swelling in legs
- Difficulty breathing or swelling of face, lips, or throat
- Unusual bruising or bleeding
- Severe headache with visual disturbances
If experiencing severe symptoms, call emergency services immediately.
What is nive-p tablet used for?
This medicine is a combination of nimesulide and paracetamol used for short-term relief of acute pain and inflammation. It should be taken with food and only under medical supervision due to the risk of liver and gastrointestinal side effects.
- Generic Name: Information coming soon
- Manufacturer: Multiple manufacturers
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nive-p tablet के बारे में (Hindi Summary)
उपयोग: यह दवा निमेसुलाइड और पैरासिटामोल का संयोजन है, जिसका उपयोग अल्पकालिक दर्द और सूजन के इलाज के लिए किया जाता है। यह मांसपेशियों की चोट, दांत दर्द, ऑपरेशन के बाद के दर्द, और गठिया जैसी स्थितियों में राहत देती है। इसे डॉक्टर की सलाह के अनुसार ही लें और लंबे समय तक न लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट में दर्द, जलन, दस्त और चक्कर आना शामिल हैं। गंभीर दुष्प्रभावों में लिवर की क्षति, पेट में रक्तस्राव, और किडनी की समस्या हो सकती है। अगर आपको पीलिया, गहरे रंग का पेशाब, या पेट में तेज दर्द हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को हमेशा भोजन के साथ लें ताकि पेट में जलन न हो। शराब का सेवन न करें क्योंकि इससे लिवर और पेट की समस्या बढ़ सकती है। डॉक्टर की सलाह के बिना खुराक न बढ़ाएं और न ही लंबे समय तक लें। अगर आपको पेप्टिक अल्सर, लिवर या किडनी की बीमारी है, तो इस दवा का सेवन न करें। गर्भवती और स्तनपान कराने वाली महिलाओं को इससे बचना चाहिए।
💊 nive-p tablet Uses & Benefits
[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in conditions such as sprains, strains, and sports injuries.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides short-term relief from toothache and post-dental procedure pain.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of pain after minor surgical procedures.","evidence":"Moderate"},{"condition":"Osteoarthritis","description":"Reduces pain and improves joint function in osteoarthritis, but only for short-term use due to safety concerns.","evidence":"Moderate"},{"condition":"Rheumatoid arthritis","description":"May be used short-term to alleviate pain and stiffness, but not as a first-line treatment.","evidence":"Limited"}]
Off-label uses: [{"condition":"Fever","description":"Sometimes used to reduce fever, but paracetamol alone is preferred due to safer profile.","evidence":"Limited"},{"condition":"Migraine","description":"May be used off-label for acute migraine attacks, but not routinely recommended.","evidence":"Limited"}]
Primary treatment for: Acute pain and inflammation
Also treats: Osteoarthritis, Rheumatoid arthritis, Dental pain, Post-operative pain, Musculoskeletal injuries
📋 Drug Information
| Generic Name(s) | Information coming soon |
| Brand Name | nive-p tablet |
| Manufacturer | Multiple manufacturers |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. Nimesulide is not approved in many countries due to safety concerns, and its use is restricted. Always follow local guidelines. |
| ICMR Guideline | Not established from the available information. Consult local guidelines for pain management. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Nimesulide is a non-steroidal anti-inflammatory drug that selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, reducing the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. Paracetamol acts primarily in the central nervous system, where it inhibits prostaglandin synthesis and may also modulate pain perception through other pathways. Together, they provide analgesic and anti-inflammatory effects.
Mechanism Steps
💡 How to Take nive-p tablet
Strength: Immediate-release oral tablet containing nimesulide 100 mg and paracetamol 325 mg (strength not specified in identity; typical fixed-dose combination).
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally every 6 to 8 hours as needed for pain, not exceeding 3 tablets in 24 hours. It should be taken with food or milk to reduce stomach upset. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose or duration of treatment without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the side effects of this medicine, especially gastrointestinal bleeding, kidney problems, and liver toxicity. Use with caution and at the lowest effective dose for the shortest duration. Close monitoring is recommended. |
| Renal Impairment | Use with caution in patients with mild to moderate renal impairment. Dose reduction may be necessary. Avoid in severe renal impairment (creatinine clearance <30 mL/min). Consult a doctor for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with mild to moderate hepatic impairment. Dose reduction and close monitoring of liver function are recommended. Avoid in severe hepatic impairment. |
| Maximum Daily Dose | Maximum 3 tablets in 24 hours. Do not exceed the recommended dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nive-p tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Methotrexate | Major | |
| ACE inhibitors | Moderate | |
| Diuretics | Moderate | |
| Corticosteroids | Moderate | |
| SSRIs | Moderate | |
| Alcohol | Moderate | |
| Antacids | Minor | |
| Cholestyramine | Minor |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., ibuprofen, aspirin)
- Methotrexate
- ACE inhibitors and ARBs
- Diuretics
⚡ Moderate Interactions
- Corticosteroids
- SSRIs
- Alcohol
🍷 Alcohol Interaction
Avoid consuming alcohol while taking this medicine. Alcohol increases the risk of liver damage, especially with paracetamol, and can worsen gastrointestinal irritation and bleeding risk associated with nimesulide.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to nimesulide, paracetamol, or any component of the formulation.","History of allergic reactions to NSAIDs (e.g., asthma, urticaria, angioedema).","Active peptic ulcer disease or history of recurrent ulcers.","Severe liver impairment (e.g., cirrhosis, active hepatitis).","Severe kidney impairment (e.g., creatinine clearance
⚠️ Warnings & Precautions
["Use the lowest effective dose for the shortest possible duration.","Avoid concomitant use with other NSAIDs or paracetamol-containing products.","Monitor liver function closely, especially if used for more than 7 days.","Caution in patients with dehydration, heart failure, or kidney disease.","Avoid alcohol consumption during treatment.","May cause drowsiness or dizziness; avoid driving if affected.","Not recommended for children under 12 years.","Consult a doctor if symptoms persist beyond 3-5 days."]
🤱 Lactation Safety
Not established from the available information. It is not known whether nimesulide is excreted in human breast milk. Paracetamol is excreted in breast milk in small amounts. Due to potential risks, this medicine should be avoided during breastfeeding unless specifically advised by a doctor.
💊 Overdose Management
Overdose of this medicine can cause severe liver damage, especially due to paracetamol and nimesulide. Symptoms of overdose may include nausea, vomiting, abdominal pain, confusion, and jaundice. If overdose is suspected, seek immediate medical attention. Treatment may include activated charcoal, N-acetylcysteine for paracetamol toxicity, and supportive care. Do not induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Always take this medicine with food or milk to reduce the risk of stomach upset. Do not exceed the recommended dose or duration of treatment. Avoid consuming alcohol while taking this medicine as it can increase the risk of liver damage and gastrointestinal bleeding. Do not use this medicine if you have a history of peptic ulcer, severe liver or kidney disease, or if you are allergic to nimesulide, paracetamol, or other NSAIDs. Inform your doctor about all other medications you are taking, especially blood thinners, other pain relievers, or antidepressants. This medicine is not recommended during pregnancy, especially in the third trimester, and should be avoided while breastfeeding. Keep out of reach of children. Store at room temperature away from moisture and heat.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and liver toxicity from this medicine. Use with caution, at the lowest effective dose, and for the shortest duration. Regular monitoring of liver and kidney function is advised.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended for use during pregnancy or when planning pregnancy. Consult your doctor for safer alternatives for pain relief. Avoid use, especially in the third trimester, due to potential risks to the fetus.
🏥 Post-Surgery Considerations
This medicine may be used for short-term post-operative pain relief, but it should be prescribed with caution due to the risk of bleeding and kidney problems. Follow your surgeon's instructions carefully and do not exceed the recommended dose.
🦷 Dental Procedures
This medicine can be used for short-term relief of dental pain, but it is not a substitute for dental treatment. Inform your dentist if you are taking this medicine before any dental procedure, as it may increase bleeding risk.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, avoid strenuous activities that could increase the risk of bleeding or injury. Listen to your body and rest if you feel dizzy or fatigued. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some individuals. Avoid driving or operating heavy machinery until you know how it affects you. It is advisable to take it when you can rest if needed.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor immediately if you experience symptoms of liver injury (jaundice, dark urine), gastrointestinal bleeding (black stools, vomiting blood), or severe allergic reactions. Do not stop abruptly if you are on a prescribed regimen without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended due to the risk of serious liver injury, gastrointestinal bleeding, and kidney damage. If long-term pain management is needed, consult your doctor for safer alternatives and regular monitoring of liver and kidney function.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain management.
Evidence: Well-establishedMay provide localized pain relief with fewer systemic side effects.
Evidence: Well-establishedSafer alternative for mild to moderate pain, especially for those at risk of NSAID side effects.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information. There are no known interactions between this medicine and vaccines. However, consult your doctor before receiving any vaccine while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it in a cool, dry place away from direct sunlight. If crossing time zones, continue with your regular dosing schedule as advised by your doctor. Check local customs regulations regarding prescription medications before traveling internationally.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 30 to 60 minutes after taking it orally.
A: It should only be used for short-term relief, typically not exceeding 5-7 days, unless otherwise directed by your doctor.
A: No, combining with other NSAIDs or paracetamol-containing products can increase the risk of serious side effects. Always consult your doctor before combining.
A: It is best taken with food or milk to reduce the risk of stomach upset and gastrointestinal irritation.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine is completely safe for long-term use.
Fact: This medicine is associated with serious liver and gastrointestinal risks and should only be used short-term under medical supervision. - Myth: It can be taken on an empty stomach without any issues.
Fact: Taking this medicine with food reduces the risk of stomach upset and gastrointestinal irritation. - Myth: It is safe to take with other pain relievers.
Fact: Combining with other NSAIDs or paracetamol can increase the risk of side effects and should be avoided unless advised by a doctor.
🔄 Alternative Options
Generic Alternatives
- Nimesulide + Paracetamol combination (generic)