Nitrest 5 Tablet (Zolpidem 5 mg): Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Sleepwalking, sleep-driving, or preparing food while not fully awake
- Severe allergic reaction with swelling of face, lips, or throat, or difficulty breathing
- Memory loss or confusion that does not resolve
- Mood changes including depression or suicidal thoughts
- Severe drowsiness with slowed breathing, especially after taking alcohol or other sedatives
- Yellowing of the eyes or skin, or severe abdominal pain
- Falls or fractures, especially in elderly patients
If experiencing severe symptoms, call emergency services immediately.
What is nitrest 5 tablet used for?
This medicine contains Zolpidem 5 mg, a non-benzodiazepine hypnotic used for the short-term treatment of insomnia where the main problem is difficulty falling asleep. It works by enhancing the calming effect of GABA in the brain. It is usually taken once at bedtime and should not be used for more than two to four weeks without medical review.
- Generic Name: Zolpidem (5mg)
- Manufacturer: Sun Pharmaceutical Industries Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nitrest 5 tablet के बारे में (Hindi Summary)
उपयोग: यह दवा ज़ोलपिडेम 5 मिलीग्राम युक्त एक टैबलेट है, जिसका उपयोग नींद न आने की समस्या (अनिद्रा) के अल्पकालिक इलाज के लिए किया जाता है। यह मुख्य रूप से उन लोगों के लिए है जिन्हें सोने में कठिनाई होती है। यह दवा दिमाग में एक प्राकृतिक रसायन GABA के प्रभाव को बढ़ाकर नींद लाने में मदद करती है। यह आमतौर पर 2 से 4 सप्ताह से अधिक समय तक नहीं लेनी चाहिए। इसका सेवन केवल डॉक्टर के परामर्श से ही करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, सिरदर्द, जी मिचलाना और मुँह सूखना शामिल हैं। कुछ लोगों को याददाश्त में कमी, भ्रम, या नींद में चलने जैसी गंभीर समस्याएँ भी हो सकती हैं। अगर आपको ऐसी कोई असामान्य बात महसूस हो, तो तुरंत डॉक्टर से संपर्क करें। शराब के साथ इस दवा का सेवन बिल्कुल न करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें, अपनी मर्जी से मात्रा न बढ़ाएँ। इसे सोने से ठीक पहले लें और सुनिश्चित करें कि आपको कम से कम 7 से 8 घंटे की नींद मिले। शराब या अन्य नींद लाने वाली दवाओं के साथ इसका सेवन न करें। सुबह उठने के बाद गाड़ी चलाने या मशीन चलाने से बचें जब तक कि आप पूरी तरह सतर्क न हों। लंबे समय तक सेवन के बाद अचानक बंद न करें, डॉक्टर से सलाह लें।
💊 nitrest 5 tablet Uses & Benefits
- [{"condition":"Short-term management of insomnia characterised by difficulty falling asleep","description":"This medicine helps reduce the time taken to fall asleep in adults with sleep-onset insomnia.
- It is intended for short-term use, usually for two to four weeks, along with sleep hygiene measures.","evidence":"Well-established"},{"condition":"Insomnia associated with transient stressful situations","description":"Sometimes prescribed for a few nights during acute stress, travel, or shift changes when sleep onset is significantly disturbed.
- Use should remain short-term and supervised.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Adjunct in certain parasomnias","description":"Rarely used off-label in selected sleep disorders, but evidence is limited and specialist supervision is required.","evidence":"Limited"},{"condition":"Catatonia","description":"Occasionally reported in small case series as an add-on treatment, but this is not a standard approved use.","evidence":"Limited"}]
Primary treatment for: Insomnia characterised by difficulty falling asleep
Also treats: Transient insomnia due to stress or travel, Sleep-onset insomnia in shift workers
📋 Drug Information
| Generic Name(s) | Zolpidem (5mg) |
| Brand Name | nitrest 5 tablet |
| Manufacturer | Sun Pharmaceutical Industries Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Non-benzodiazepine hypnotics (Z Compounds) |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C in a dry place, away from direct sunlight and moisture. Keep the tablets in their original container with the lid tightly closed. |
| Shelf Life | Typically 24 months from the date of manufacture. Check the expiry date on the pack before use. |
| WHO Guideline | Not established from the available information. Guidelines generally recommend short-term use of hypnotics like this medicine only when sleep hygiene measures have failed, and for the shortest possible duration. |
| ICMR Guideline | Not established from the available information. Consult your doctor for guidance specific to your condition. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by binding selectively to the benzodiazepine site on GABA-A receptors in the brain. GABA is the main inhibitory neurotransmitter that calms nerve activity. By enhancing GABA's effect, this medicine increases the flow of chloride ions into nerve cells, making them less excitable. The result is a calming effect that helps initiate sleep. Unlike older benzodiazepines, this medicine has relatively greater selectivity for receptors involved in sedation rather than those involved in muscle relaxation or anxiety, which is why it is mainly used for sleep onset problems.
Mechanism Steps
💡 How to Take nitrest 5 tablet
Strength: Immediate-release tablet containing Zolpidem 5 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 5 mg to 10 mg taken once daily immediately before bedtime. The 5 mg strength is often used in women, elderly patients, and those with liver problems because they may clear the medicine more slowly. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not take more than the prescribed dose. This medicine is intended for short-term use only, usually not more than two to four weeks. |
| Pediatric Dosage | Pediatric dosing is not established from available information. This medicine is not recommended for children and adolescents under 18 years of age. Consult a pediatrician for safe alternatives. |
| Elderly Dosage | Elderly patients above 65 years are more sensitive to the effects of this medicine. The recommended starting dose is 5 mg once daily at bedtime. The dose should not exceed 5 mg per day in most elderly patients unless your doctor advises otherwise. Use the lowest effective dose for the shortest possible time to reduce the risk of falls, confusion, and dependence. |
| Renal Impairment | No specific dose adjustment is usually needed for mild to moderate kidney disease. In severe kidney disease, this medicine should be used with caution and the dose may need to be reduced. Your doctor will decide the appropriate dose based on your kidney function. |
| Hepatic Impairment | In mild to moderate liver disease, the starting dose should be 5 mg once daily at bedtime. This medicine should not be used in severe liver disease. Your doctor will monitor you closely and adjust the dose if needed. |
| Maximum Daily Dose | The maximum recommended daily dose is 10 mg taken once at bedtime. In elderly patients and those with liver disease, the maximum daily dose is 5 mg. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nitrest 5 tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Alcohol | Major | |
| Opioid pain medicines | Major | |
| Benzodiazepines | Major | |
| Ketoconazole | Major | |
| Ritonavir | Major | |
| Clarithromycin | Major | |
| Sertraline | Moderate | |
| Diphenhydramine | Moderate | |
| Rifampicin | Moderate | |
| Caffeine | Minor |
🚨 Major Interactions
- Alcohol
- Opioid pain medicines
- Other sedative-hypnotics including benzodiazepines
- Strong CYP3A4 inhibitors such as ketoconazole, itraconazole, clarithromycin, ritonavir
⚡ Moderate Interactions
- Antidepressants such as sertraline or fluoxetine
- Antihistamines that cause drowsiness
- Muscle relaxants
- Rifampicin
🍷 Alcohol Interaction
Alcohol must be strictly avoided while taking this medicine. Combining them can cause excessive sedation, slowed breathing, impaired coordination, memory problems, and dangerous falls. In severe cases, the combination can lead to coma or death. If you have consumed alcohol, do not take this medicine and inform your doctor.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Allergy to Zolpidem or any ingredient in the tablet","Severe liver disease","History of complex sleep behaviours after taking this medicine or similar medicines","Children and adolescents under 18 years of age","Severe breathing problems such as sleep apnoea","Myasthenia gravis","Severe kidney disease without medical supervision"]
⚠️ Warnings & Precautions
["This medicine can cause dependence and withdrawal symptoms if used for a long time. Use for the shortest possible duration.","Do not take this medicine with alcohol or other sedatives.","Avoid driving or operating machinery the morning after taking this medicine until you feel fully alert.","Elderly patients are more sensitive to the effects and should use the lowest effective dose.","Tell your doctor if you have liver or kidney disease, breathing problems, or a history of depression or substance abuse.","Do not stop this medicine suddenly after long-term use without medical advice.","Keep this medicine out of reach of children and do not share it with others."]
🤱 Lactation Safety
This medicine passes into breast milk in small amounts and may cause drowsiness in a breastfed baby. It is generally not recommended during breastfeeding. If it must be used, take it immediately after feeding and avoid breastfeeding for several hours afterwards. Discuss with your doctor.
💊 Overdose Management
Overdose of this medicine can cause excessive drowsiness, confusion, slowed breathing, and loss of consciousness. If you suspect an overdose, seek emergency medical help immediately. Do not try to induce vomiting. Treatment is supportive and may include monitoring of breathing and heart function. Flumazenil, a benzodiazepine antidote, may be used in severe cases under medical supervision, but it should be used with caution because it can trigger seizures.
⏰ Missed Dose
This medicine is usually taken only once at bedtime. If you miss a dose, take it only if you can still get at least 7 to 8 hours of sleep. If it is already morning or you need to wake up soon, skip the missed dose and do not take a double dose. Never take two doses to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, and never increase the dose on your own. Take it just before going to bed, and only when you can get at least seven to eight hours of sleep. Do not take it with alcohol or with other medicines that make you sleepy, as this can cause dangerous sedation. Avoid driving or operating heavy machinery the morning after taking this medicine, because you may still feel drowsy. Do not stop this medicine suddenly after long-term use without talking to your doctor, as withdrawal symptoms such as anxiety, tremors, and rebound insomnia can occur. Keep this medicine in a safe place away from children, and do not share it with anyone else. Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding. If you experience unusual sleep behaviours, memory loss, or mood changes, stop the medicine and seek medical advice immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the sedative effects of this medicine. They are at higher risk of falls, confusion, and memory problems. The recommended starting dose is 5 mg once daily at bedtime, and it should not exceed this dose unless advised by a doctor. Use for the shortest possible time and consider non-drug treatments for sleep.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before taking this medicine. It is generally not recommended during pregnancy. Your doctor may suggest non-drug approaches for sleep or alternative treatments that are safer during pregnancy.
🏥 Post-Surgery Considerations
After surgery, this medicine may be used for short-term sleep problems, but it should be used with caution because it can increase drowsiness and affect recovery. Inform your surgeon and anaesthetist if you are taking this medicine, as it can interact with anaesthetic agents. Do not take it without your doctor's advice after surgery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It can cause drowsiness and may interact with sedatives used during dental work. Your dentist may advise you to skip the dose on the day of the procedure or adjust the timing.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause drowsiness and dizziness, which may affect your coordination. Avoid exercising or doing any activity that requires balance or alertness soon after taking it. The morning after, wait until you feel fully awake before exercising. If you feel dizzy or unsteady, do not exercise and consult your doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause next-morning drowsiness, which may affect your ability to drive, operate machinery, or concentrate at work. You should not drive or perform hazardous tasks until you know how this medicine affects you. It may also cause memory problems, which can affect work performance. Discuss with your doctor if your work requires alertness, and avoid taking this medicine on nights before important work commitments if possible.
🛑 When to Stop This Medicine
You should stop this medicine if you experience unusual sleep behaviours, severe allergic reactions, mood changes, or memory problems. Do not stop suddenly after long-term use without consulting your doctor, as withdrawal symptoms can occur. Your doctor will guide you on gradual tapering. If your insomnia persists after the prescribed course, consult your doctor for further evaluation rather than continuing the medicine on your own.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to tolerance, meaning the same dose becomes less effective over time. It can also cause dependence and withdrawal symptoms such as anxiety, tremors, and rebound insomnia when stopped suddenly. There may be persistent memory problems and an increased risk of falls, especially in elderly patients. Long-term use should be avoided, and if needed, it should be under regular medical supervision with gradual tapering.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A structured programme that addresses thoughts and behaviours affecting sleep. It is considered the first-line treatment for chronic insomnia.
Evidence: Well-establishedPractical steps such as fixed sleep schedule, limiting caffeine, and creating a good sleep environment.
Evidence: Well-establishedProgressive muscle relaxation, deep breathing, and meditation can help reduce sleep-onset latency.
Evidence: ModerateMay help with certain sleep disorders and jet lag, but evidence for general insomnia is mixed.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. You can receive vaccinations while taking this medicine, but inform your healthcare provider about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in the original container with the lid tightly closed
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom cabinet
✅ DO
Keep out of reach of children and pets
❌ DON'T
Do not share this medicine with others
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your hand luggage if you need it during the flight, but only take it if you can get a full night's sleep at your destination. Adjust the timing if you are crossing time zones, and avoid taking it if you will need to be alert soon. Store it at room temperature and away from direct sunlight. Check the customs rules of your destination country for prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts to work within 15 to 30 minutes after taking it on an empty stomach. It is important to take it immediately before going to bed.
A: This medicine is intended for short-term use, usually not more than two to four weeks. Taking it every night for a long time can lead to dependence. Discuss with your doctor if you need it for longer.
A: Alcohol combined with this medicine can cause dangerous sedation, slowed breathing, memory problems, and even death. You must avoid alcohol completely while taking this medicine.
A: Elderly people are more sensitive to the effects. The recommended starting dose is 5 mg, and it should be used for the shortest possible time to reduce the risk of falls and confusion.
A: You should not drive or operate machinery the morning after taking this medicine until you feel fully alert. Drowsiness can persist and impair your ability to drive safely.
A: If you remember before going to bed and can still get 7 to 8 hours of sleep, take the missed dose. If it is already late or morning, skip the missed dose and do not double dose.
A: Yes, this medicine can cause dependence and withdrawal symptoms if used for a long time. It should be used for the shortest possible duration and stopped gradually under medical supervision.
A: This medicine is generally not recommended during pregnancy unless clearly needed. Consult your doctor if you are pregnant or planning pregnancy.
🤔 Common Patient Concerns
🔄 Substitutes for nitrest 5 tablet
View AllAlternative brands with exact same active ingredient:
-
zappy 5mg tabletAbbott ₹10.58 84.1% CHEAPER
-
benzopam 5mg tabletAchemic ₹14.34 78.4% CHEAPER
-
dactive 5mg tabletZydus Cadila ₹20.00 69.9% CHEAPER
-
zolnex 5mg tabletNexus Biotech ₹27.90 57.9% CHEAPER
-
isodem 5mg tabletSolitaire Pharmacia Pvt Ltd ₹28.00 57.8% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a natural sleep aid and is completely safe for long-term use.
Fact: This medicine is a prescription hypnotic that can cause dependence and withdrawal. It is meant for short-term use only. - Myth: You can take this medicine with alcohol to sleep better.
Fact: Alcohol combined with this medicine can cause dangerous sedation, breathing problems, and even death. Never mix them. - Myth: This medicine can be taken whenever you feel like sleeping during the day.
Fact: This medicine should only be taken at bedtime when you can get a full night's sleep. Taking it during the day can cause severe drowsiness and impair your ability to function. - Myth: Once you start this medicine, you can never stop it.
Fact: This medicine can be stopped, but it should be tapered gradually under medical supervision, especially after long-term use.
🔄 Alternative Options
Generic Alternatives
- Zolpidem 5 mg tablet
Brand Alternatives
- Nitrest 5 Tablet