Nismol 100mg/325mg Tablet: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Yellowing of skin or eyes
- Decreased urine output
- Severe skin rash or blistering
- Difficulty breathing or swelling of face/throat
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is nismol 100mg/325mg tablet used for?
This medicine is a combination of nimesulide and paracetamol used for short-term relief of acute pain and fever. It works by reducing inflammation and pain signals. It should be taken with food and not for more than 5-7 days.
- Generic Name: Information coming soon
- Manufacturer: Multiple manufacturers
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nismol 100mg/325mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा निमेसुलाइड और पैरासिटामोल का संयोजन है, जिसका उपयोग अल्पकालिक दर्द और बुखार के इलाज के लिए किया जाता है। यह मांसपेशियों के दर्द, दांत दर्द, सिरदर्द और सर्जरी के बाद के दर्द में राहत देती है। यह सूजन को भी कम करती है। इसका उपयोग केवल 5-7 दिनों तक ही करना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त और चक्कर आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें लिवर की क्षति, गंभीर त्वचा प्रतिक्रियाएं और गैस्ट्रोइंटेस्टाइनल रक्तस्राव शामिल हो सकते हैं। यदि आपको काला मल, खून की उल्टी, या त्वचा का पीलापन दिखे तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खाने के साथ लें ताकि पेट में जलन न हो। शराब का सेवन न करें क्योंकि इससे लिवर को नुकसान हो सकता है। 5-7 दिनों से अधिक इसका उपयोग न करें। यदि आप गर्भवती हैं या स्तनपान करा रही हैं तो डॉक्टर से सलाह लें। बच्चों को यह दवा न दें।
💊 nismol 100mg/325mg tablet Uses & Benefits
[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in conditions such as sprains, strains, and back pain.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides relief from toothache and post-dental procedure pain.","evidence":"Well-established"},{"condition":"Headache","description":"Effective for tension-type headaches and mild migraines.","evidence":"Well-established"},{"condition":"Fever","description":"Reduces elevated body temperature due to infections or other causes.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of pain after minor surgical procedures.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Osteoarthritis flare-up","description":"Sometimes used for short-term relief of osteoarthritis pain, but not recommended for long-term use due to safety concerns.","evidence":"Limited"},{"condition":"Dysmenorrhea","description":"May be used for menstrual cramps, but other NSAIDs are preferred.","evidence":"Limited"}]
Primary treatment for: Acute pain and fever
Also treats: Musculoskeletal pain, Dental pain, Headache, Post-operative pain
📋 Drug Information
| Generic Name(s) | Information coming soon |
| Brand Name | nismol 100mg/325mg tablet |
| Manufacturer | Multiple manufacturers |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Nimesulide selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, reducing the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. Paracetamol acts primarily in the central nervous system, where it inhibits prostaglandin synthesis and may also modulate pain perception through other pathways. The combination provides enhanced analgesic and antipyretic effects compared to either agent alone.
Mechanism Steps
💡 How to Take nismol 100mg/325mg tablet
Strength: Each tablet contains nimesulide 100 mg and paracetamol 325 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet (nimesulide 100 mg + paracetamol 325 mg) taken orally twice daily, preferably after meals. The maximum recommended duration is 5 to 7 days. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. This medicine is contraindicated in children below 12 years of age. Consult a pediatrician for appropriate alternatives. |
| Elderly Dosage | Elderly patients (above 65 years) may be more susceptible to the side effects of this medicine, especially gastrointestinal bleeding and kidney problems. Use with caution and at the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with mild to moderate renal impairment. Dose reduction may be necessary. Contraindicated in severe renal impairment. Consult a doctor for dose adjustment. |
| Hepatic Impairment | Use with caution in patients with mild to moderate hepatic impairment. Dose reduction may be necessary. Contraindicated in severe hepatic impairment. Consult a doctor for dose adjustment. |
| Maximum Daily Dose | The maximum daily dose is 2 tablets (nimesulide 200 mg + paracetamol 650 mg) per day. Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nismol 100mg/325mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Corticosteroids | Major | |
| Methotrexate | Major | |
| ACE inhibitors/ARBs | Major | |
| Diuretics | Moderate | |
| Lithium | Moderate | |
| SSRIs | Moderate | |
| Alcohol | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., ibuprofen, diclofenac)
- Corticosteroids
- Methotrexate
- ACE inhibitors and ARBs
⚡ Moderate Interactions
- Diuretics (e.g., furosemide)
- Lithium
- SSRIs
- Alcohol
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of liver damage, especially with paracetamol, and can increase the risk of gastrointestinal bleeding due to nimesulide.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to nimesulide, paracetamol, or any other NSAIDs.","Active peptic ulcer or history of recurrent peptic ulcers.","Gastrointestinal bleeding or perforation.","Severe liver impairment.","Severe kidney impairment.","Children below 12 years of age.","Pregnancy, especially third trimester.","Breastfeeding.","Concurrent use with other NSAIDs or anticoagulants."]
⚠️ Warnings & Precautions
["Take this medicine with food to reduce stomach upset.","Do not exceed the recommended dose or duration of treatment.","Avoid alcohol while taking this medicine.","Do not use for more than 5-7 days without medical advice.","Inform your doctor if you have a history of stomach ulcers, liver or kidney disease, asthma, or bleeding disorders.","Stop the medicine and seek medical help if you experience signs of an allergic reaction, severe skin rash, or gastrointestinal bleeding.","Use with caution in elderly patients due to increased risk of side effects.","Do not take other medicines containing paracetamol or NSAIDs without consulting your doctor."]
🤱 Lactation Safety
This medicine is not recommended during breastfeeding as nimesulide and paracetamol may pass into breast milk and could harm the infant. Consult your doctor for alternative treatments.
💊 Overdose Management
Overdose of this medicine can cause severe liver damage, especially due to paracetamol. Symptoms of overdose may include nausea, vomiting, abdominal pain, and confusion. Seek immediate medical attention. Treatment may include activated charcoal, N-acetylcysteine for paracetamol toxicity, and supportive care. Do not induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine as it can increase the risk of liver damage and gastrointestinal bleeding. Do not take other medicines containing paracetamol or other NSAIDs without consulting your doctor. Inform your doctor if you have a history of stomach ulcers, liver or kidney disease, asthma, or bleeding disorders. Do not use this medicine for more than 5-7 days unless directed by your doctor. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before taking this medicine. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney problems, and liver toxicity. Use the lowest effective dose for the shortest duration. Monitor renal and hepatic function regularly.
🤰 Pregnancy Planning (TTC)
This medicine is contraindicated during pregnancy and while trying to conceive. Consult your doctor for safer alternatives for pain relief.
🏥 Post-Surgery Considerations
This medicine may be used for short-term post-operative pain, but consult your surgeon before taking it, especially if you are on other medications or have underlying conditions.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It may increase bleeding risk during dental surgery.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting while taking this medicine, especially if you have musculoskeletal pain. Gentle stretching and low-impact activities are generally safe. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe for office work, but take regular breaks if you have pain.
🛑 When to Stop This Medicine
Stop taking this medicine after the prescribed duration (usually 5-7 days) or as advised by your doctor. If you experience any serious side effects, stop immediately and seek medical help. Do not stop abruptly if you are on long-term therapy without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended due to the risk of liver damage, kidney impairment, and gastrointestinal bleeding. If prolonged use is necessary, regular monitoring of liver and kidney function is advised. Consult your doctor for alternative treatments if pain persists.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain management.
Evidence: Well-establishedMay help relieve localized pain and inflammation.
Evidence: ModerateCan help manage stress-related pain.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are established. However, if you have a fever, consult your doctor before vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing times gradually. Check customs regulations for carrying prescription medicines. Do not leave in a hot car.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Pain relief typically begins within 30 to 60 minutes after taking the tablet.
A: It is best taken with food or milk to reduce stomach upset.
A: No, it is contraindicated in children below 12 years of age.
A: Do not take other NSAIDs or paracetamol-containing products without consulting your doctor.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine is safe for long-term use.
Fact: This medicine is only for short-term use (5-7 days) due to the risk of liver and kidney damage. - Myth: It can be taken on an empty stomach.
Fact: It should be taken with food to reduce stomach upset. - Myth: It is safe for children.
Fact: It is contraindicated in children below 12 years of age.
🔄 Alternative Options
Generic Alternatives
- Nimesulide + Paracetamol combination generics
Brand Alternatives
- Nise
- Nimulid
- Nimesulide + Paracetamol brands