Nimupay 100mg/325mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit that looks like coffee grounds.
- Severe abdominal pain or persistent vomiting.
- Yellowing of the skin or eyes (jaundice).
- Decreased urine output or swelling in the legs.
- Severe headache with visual changes or confusion.
- Sudden swelling of the face, lips, or throat, or difficulty breathing.
- Unusual tiredness, pale skin, or frequent infections.
- Chest pain or shortness of breath.
If experiencing severe symptoms, call emergency services immediately.
What is nimupay 100mg/325mg tablet used for?
This medicine is a combination of nimesulide and paracetamol used for short-term relief of acute pain and inflammation. It works by reducing pain and fever through different mechanisms. It should be taken with food and not for more than 5-7 days without medical advice.
- Generic Name: Information coming soon
- Manufacturer: Multiple manufacturers
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nimupay 100mg/325mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा निमेसुलाइड और पैरासिटामोल का संयोजन है, जिसका उपयोग तीव्र दर्द और सूजन के अल्पकालिक उपचार के लिए किया जाता है। यह मांसपेशियों के दर्द, दांत दर्द, सर्जरी के बाद के दर्द और बुखार में राहत देती है। इसे भोजन के साथ लेना चाहिए और 5-7 दिनों से अधिक नहीं लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त और चक्कर आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन पेट में रक्तस्राव, लीवर और किडनी की समस्या हो सकती है। यदि आपको काला मल, खून की उल्टी, पीलिया या पेशाब में कमी दिखे तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। इसे भोजन के साथ लें ताकि पेट में जलन न हो। इस दवा के साथ शराब न पिएं। अन्य दर्द निवारक दवाओं के साथ इसका सेवन न करें। यदि आप गर्भवती हैं, स्तनपान करा रही हैं, या आपको लीवर या किडनी की बीमारी है, तो डॉक्टर को बताएं। 5-7 दिनों से अधिक इसका उपयोग न करें।
💊 nimupay 100mg/325mg tablet Uses & Benefits
[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in conditions such as muscle strains, sprains, and back pain.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides short-term relief from toothache and pain after dental procedures.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of pain after minor surgeries.","evidence":"Moderate"},{"condition":"Fever","description":"Reduces fever due to its paracetamol content, though not a first-line choice.","evidence":"Moderate"},{"condition":"Osteoarthritis flare-up","description":"Short-term relief of pain and stiffness during acute flare-ups.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used for acute migraine pain, but not a standard treatment.","evidence":"Limited"},{"condition":"Dysmenorrhea","description":"May be used for menstrual cramps, but other NSAIDs are preferred.","evidence":"Limited"}]
Primary treatment for: Acute pain and inflammation
Also treats: Musculoskeletal pain, Dental pain, Post-operative pain, Fever, Osteoarthritis flare-up
📋 Drug Information
| Generic Name(s) | Information coming soon |
| Brand Name | nimupay 100mg/325mg tablet |
| Manufacturer | Multiple manufacturers |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture, heat, and direct sunlight. Do not refrigerate unless specified. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with different mechanisms. Nimesulide is a non-steroidal anti-inflammatory drug that selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, reducing the production of prostaglandins, which are chemicals that cause pain, inflammation, and fever. Paracetamol works primarily in the central nervous system by inhibiting prostaglandin synthesis and possibly activating descending pain pathways, leading to pain relief and fever reduction. Together, they provide additive analgesic and antipyretic effects.
Mechanism Steps
💡 How to Take nimupay 100mg/325mg tablet
Strength: Each tablet contains nimesulide 100 mg and paracetamol 325 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally two to three times daily, with food. The maximum daily dose is generally 3 tablets in 24 hours. However, the exact dose and duration must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function, and response to treatment. Do not exceed the prescribed dose or duration. This medicine is intended for short-term use only, typically not exceeding 5 to 7 days. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the side effects of this medicine, especially gastrointestinal bleeding and kidney problems. Use the lowest effective dose for the shortest possible duration. Dose must be individualized by a qualified clinician based on renal and hepatic function. |
| Renal Impairment | Use with caution in patients with kidney disease. Dose reduction may be necessary. Avoid use in severe kidney disease. Dose must be individualized by a qualified clinician based on renal function. |
| Hepatic Impairment | Use with caution in patients with liver disease. Dose reduction may be necessary. Avoid use in severe liver disease. Dose must be individualized by a qualified clinician based on hepatic function. |
| Maximum Daily Dose | The maximum recommended daily dose is 3 tablets (300 mg nimesulide and 975 mg paracetamol) in 24 hours. Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nimupay 100mg/325mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Methotrexate | Major | |
| ACE inhibitors | Major | |
| Diuretics | Major | |
| Corticosteroids | Moderate | |
| SSRIs | Moderate | |
| Lithium | Moderate | |
| Phenytoin | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., ibuprofen, diclofenac)
- Methotrexate
- ACE inhibitors and ARBs
- Diuretics
⚡ Moderate Interactions
- Corticosteroids
- SSRIs
- Lithium
- Phenytoin
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of liver damage, especially from paracetamol, and increases the risk of stomach bleeding from nimesulide. It can also worsen drowsiness and dizziness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active peptic ulcer or history of recurrent ulcers.","Severe liver disease or liver failure.","Severe kidney disease or kidney failure.","Known allergy to nimesulide, paracetamol, or other NSAIDs.","Children under 12 years of age.","Pregnancy, especially third trimester.","Breastfeeding.","History of asthma, urticaria, or allergic reactions to aspirin or other NSAIDs.","Severe heart failure.","Alcoholism."]
⚠️ Warnings & Precautions
["Do not exceed the recommended dose or duration of treatment.","Take with food to reduce stomach upset.","Avoid alcohol while taking this medicine.","Do not use with other NSAIDs or paracetamol-containing products.","Use with caution in elderly patients and those with kidney or liver disease.","Stop the medicine and consult a doctor if you experience signs of liver or kidney problems.","Do not use for more than 5-7 days without medical advice.","Inform your doctor if you have a history of stomach ulcers, heart disease, or hypertension.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Keep out of reach of children."]
🤱 Lactation Safety
Not recommended during breastfeeding. Nimesulide may pass into breast milk and could harm the infant. Paracetamol is considered safe during breastfeeding, but the combination should be avoided unless advised by a doctor.
💊 Overdose Management
Overdose of this medicine can cause severe liver damage, especially due to paracetamol. Symptoms of overdose may include nausea, vomiting, abdominal pain, confusion, and yellowing of the skin or eyes. If you suspect an overdose, seek immediate medical attention or contact a poison control center. Treatment may include activated charcoal, N-acetylcysteine for paracetamol toxicity, and supportive care. Do not wait for symptoms to appear.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not take more than the recommended dose or for longer than the prescribed duration. Always take it with food or milk to reduce stomach irritation. Avoid drinking alcohol while taking this medicine because it can increase the risk of liver damage and stomach bleeding. Do not take other pain relievers or fever medicines containing paracetamol or other NSAIDs without consulting your doctor, as this can lead to overdose or increased side effects. If you have a history of stomach ulcers, kidney disease, liver disease, or heart problems, inform your doctor before taking this medicine. Do not use this medicine if you are pregnant, planning to become pregnant, or breastfeeding unless your doctor specifically advises it. Keep this medicine out of reach of children. Store it at room temperature, away from moisture and direct sunlight. If you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney problems, and liver toxicity. Use the lowest effective dose for the shortest duration. Monitor renal and hepatic function closely.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended if you are planning pregnancy or are pregnant. Consult your doctor for safe alternatives for pain relief.
🏥 Post-Surgery Considerations
This medicine may be used for short-term post-operative pain, but it should be prescribed by a surgeon. It can increase bleeding risk, so inform your surgeon if you are taking it before surgery.
🦷 Dental Procedures
This medicine can be used for dental pain, but inform your dentist if you are taking it before any dental procedure, as it may increase bleeding risk.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may feel drowsy or dizzy. Avoid heavy lifting or high-impact exercises until you know how it affects you. Listen to your body and do not push through severe pain.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is usually taken for a short duration, so work impact is minimal if used as prescribed.
🛑 When to Stop This Medicine
Stop taking this medicine if you experience any serious side effects such as stomach bleeding, liver problems, kidney problems, or allergic reactions. Also stop after the prescribed duration (usually 5-7 days) unless your doctor advises otherwise. Do not stop abruptly if you are on a tapering schedule, but this medicine is not typically tapered.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended due to the risk of liver damage, kidney problems, and gastrointestinal bleeding. If you need pain relief for more than a few days, consult your doctor for alternative treatments. Regular monitoring of liver and kidney function may be required if prolonged use is unavoidable.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve mobility.
Evidence: Well-establishedMay help reduce localized pain and inflammation.
Evidence: ModerateSome evidence for pain relief in musculoskeletal conditions.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you have a fever, consult your doctor before vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription or doctor's note, especially for international travel. Store it in a cool, dry place away from direct sunlight. If crossing time zones, adjust dosing times gradually, but do not take extra doses. Check local customs regulations for carrying prescription medicines. Always keep it in your carry-on luggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 30 to 60 minutes after taking it.
A: It should not be taken for more than 5 to 7 days without medical advice.
A: No, it should be taken with food or milk to reduce stomach upset.
A: It is not recommended during pregnancy, especially in the third trimester. Consult your doctor.
A: Take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine is safe for long-term use.
Fact: This medicine is only for short-term use. Long-term use can cause liver and kidney damage. - Myth: It is safe to take this medicine on an empty stomach.
Fact: It should be taken with food to reduce stomach upset and risk of ulcers. - Myth: This medicine can be taken with alcohol.
Fact: Alcohol increases the risk of liver damage and stomach bleeding. Avoid alcohol. - Myth: This medicine is safe for children.
Fact: It is not recommended for children under 12 years of age.
🔄 Alternative Options
Generic Alternatives
- Nimesulide 100 mg + Paracetamol 325 mg tablet
Brand Alternatives
- Nimupay 100mg/325mg tablet