Nimsa 100mg/325mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bruising or bleeding
- Persistent fever or sore throat
If experiencing severe symptoms, call emergency services immediately.
What is nimsa 100mg/325mg tablet used for?
This medicine is a combination of nimesulide and paracetamol used for short-term relief of acute pain and inflammation. It works by reducing prostaglandins. It should not be used for more than 7-10 days and is not recommended for children under 12 or during pregnancy.
- Generic Name: Information coming soon
- Manufacturer: Multiple manufacturers
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nimsa 100mg/325mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा नाइमसुलाइड और पैरासिटामोल का संयोजन है, जिसका उपयोग अल्पकालिक दर्द और सूजन के इलाज के लिए किया जाता है। यह मांसपेशियों के दर्द, दांत दर्द, सर्जरी के बाद के दर्द, और बुखार में राहत देती है। इसका उपयोग केवल 7 से 10 दिनों तक ही करना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त, चक्कर आना, और त्वचा पर दाने शामिल हैं। गंभीर दुष्प्रभावों में पेट में रक्तस्राव, लीवर की क्षति, गुर्दे की समस्या, और एलर्जी प्रतिक्रियाएं शामिल हो सकती हैं। यदि आपको काला मल, खून की उल्टी, पेट में तेज दर्द, या त्वचा का पीलापन दिखे तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खाने के साथ लें ताकि पेट की जलन कम हो। शराब का सेवन न करें। अन्य दर्द निवारक दवाओं के साथ न लें। 7-10 दिनों से अधिक उपयोग न करें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। बच्चों को न दें।
💊 nimsa 100mg/325mg tablet Uses & Benefits
[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in conditions such as muscle strain, back pain, and soft tissue injuries.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides relief from toothache and pain following dental procedures.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of pain after minor surgical procedures.","evidence":"Moderate"},{"condition":"Fever","description":"Reduces fever due to the paracetamol component, though nimesulide also has antipyretic properties.","evidence":"Well-established"},{"condition":"Primary dysmenorrhea","description":"Relieves menstrual cramps and associated pain.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks, but not first-line.","evidence":"Limited"},{"condition":"Osteoarthritis flare","description":"May be used short-term for osteoarthritis pain flares, but not for long-term management.","evidence":"Limited"}]
Primary treatment for: Acute pain and inflammation
Also treats: Musculoskeletal pain, Dental pain, Post-operative pain, Fever, Dysmenorrhea
📋 Drug Information
| Generic Name(s) | Information coming soon |
| Brand Name | nimsa 100mg/325mg tablet |
| Manufacturer | Multiple manufacturers |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Nimesulide is a non-steroidal anti-inflammatory drug that selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, reducing the production of prostaglandins, which are mediators of inflammation, pain, and fever. Paracetamol (acetaminophen) acts primarily in the central nervous system by inhibiting prostaglandin synthesis and possibly activating descending serotonergic pathways, producing analgesia and antipyresis with minimal anti-inflammatory effect. Together, they provide enhanced pain relief and anti-inflammatory action compared to either agent alone.
Mechanism Steps
💡 How to Take nimsa 100mg/325mg tablet
Strength: Each tablet contains nimesulide 100 mg and paracetamol 325 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally two to three times daily, preferably after meals. The maximum recommended duration of treatment is 7 to 10 days. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. This medicine is not recommended for children under 12 years of age. Consult a pediatrician for appropriate pain management in children. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the side effects of this medicine, especially gastrointestinal bleeding and kidney impairment. Use with caution and at the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with kidney impairment. Dose reduction may be necessary. This medicine is contraindicated in severe kidney impairment (creatinine clearance <30 mL/min). Consult a doctor for dose adjustment. |
| Hepatic Impairment | Use with caution in patients with liver impairment. Dose reduction and monitoring of liver function may be necessary. This medicine is contraindicated in severe liver impairment. Consult a doctor for dose adjustment. |
| Maximum Daily Dose | The maximum daily dose of this medicine is 3 tablets (nimesulide 300 mg and paracetamol 975 mg) per day. Do not exceed this dose. The maximum duration of use is 7 to 10 days. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nimsa 100mg/325mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Corticosteroids | Major | |
| Methotrexate | Major | |
| ACE inhibitors/ARBs | Moderate | |
| Diuretics | Moderate | |
| Lithium | Moderate | |
| SSRIs | Moderate | |
| Anticonvulsants | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., ibuprofen, diclofenac)
- Corticosteroids
- Methotrexate
- ACE inhibitors and ARBs
⚡ Moderate Interactions
- Diuretics (e.g., furosemide, hydrochlorothiazide)
- Lithium
- SSRIs
- Anticonvulsants (e.g., phenytoin, carbamazepine)
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of liver damage, especially with paracetamol, and can increase the risk of gastrointestinal bleeding due to nimesulide.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to nimesulide, paracetamol, or any component of the formulation.","Active peptic ulcer or history of recurrent peptic ulcer.","Severe liver impairment or active liver disease.","Severe kidney impairment (creatinine clearance
⚠️ Warnings & Precautions
["Use the lowest effective dose for the shortest possible duration.","Avoid alcohol consumption while taking this medicine.","Take with food to reduce gastrointestinal irritation.","Do not exceed the recommended dose of paracetamol from all sources.","Use with caution in elderly patients and those with kidney or liver disease.","Monitor for signs of gastrointestinal bleeding, especially with long-term use.","Discontinue immediately if signs of liver injury or severe skin reaction occur.","Inform your doctor if you have a history of asthma, kidney disease, liver disease, or bleeding disorders.","Do not use for more than 7-10 days without medical advice.","Keep out of reach of children."]
🤱 Lactation Safety
Nimesulide is not recommended during breastfeeding as it may pass into breast milk and harm the infant. Paracetamol is considered safe during breastfeeding. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose of this medicine can cause severe liver damage due to paracetamol and gastrointestinal bleeding due to nimesulide. Symptoms of overdose may include nausea, vomiting, abdominal pain, confusion, and yellowing of skin or eyes. If overdose is suspected, seek immediate medical attention. Treatment may include activated charcoal, N-acetylcysteine for paracetamol toxicity, and supportive care. Do not induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine as it can increase the risk of liver damage and gastrointestinal bleeding. Do not take other medicines containing paracetamol or other NSAIDs without consulting your doctor, as this can lead to overdose or increased side effects. Inform your doctor if you have a history of stomach ulcers, liver disease, kidney disease, asthma, or bleeding disorders. Do not use this medicine for more than 7 to 10 days unless directed by your doctor. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before taking this medicine. Keep this medicine out of reach of children. Store it at room temperature, away from direct sunlight and moisture.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and liver toxicity. Use the lowest effective dose for the shortest duration. Monitor renal and hepatic function regularly. Avoid concurrent use with other NSAIDs or anticoagulants.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Nimesulide is not recommended during pregnancy, especially in the third trimester. Paracetamol is generally considered safe, but always consult your doctor for appropriate pain management.
🏥 Post-Surgery Considerations
This medicine may be used for short-term post-operative pain relief. However, consult your surgeon before taking it, as it may interact with other medications or affect healing. Do not use for prolonged periods after surgery without medical supervision.
🦷 Dental Procedures
This medicine can be used for short-term relief of dental pain. Inform your dentist if you are taking this medicine before any dental procedure, as it may increase bleeding risk. Do not take it for more than 3 days for dental pain without consulting your dentist.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may experience dizziness or fatigue. Avoid strenuous exercise or activities that require alertness until you know how the medicine affects you. If you have musculoskeletal pain, gentle stretching and low-impact exercises may be beneficial, but consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue desk work, but take regular breaks and maintain good posture. If your job involves physical labor, consult your doctor about modifications.
🛑 When to Stop This Medicine
Stop taking this medicine after the prescribed duration, usually 7 to 10 days, or as directed by your doctor. If your pain persists or worsens, consult your doctor before continuing. Do not stop abruptly if you have been on long-term therapy without medical advice.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended due to the risk of liver damage, kidney impairment, gastrointestinal bleeding, and cardiovascular events. If long-term pain management is needed, consult your doctor for safer alternatives and regular monitoring of liver and kidney function.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain management.
Evidence: Well-establishedMay help relieve localized pain and inflammation.
Evidence: ModerateMay provide pain relief for some conditions.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you have a fever, consult your doctor before vaccination. There is no need to postpone vaccination solely due to this medicine unless advised by your doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If crossing time zones, adjust dosing times gradually to maintain consistent intervals. Check local customs regulations regarding prescription medicines before traveling internationally. Do not pack it in checked luggage; keep it in your carry-on bag.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 30 to 60 minutes after taking it orally.
A: It should not be used for more than 7 to 10 days without medical advice due to safety concerns.
A: It is best taken with food or milk to reduce stomach upset.
A: It is not recommended during pregnancy, especially in the third trimester. Consult your doctor.
A: No, alcohol increases the risk of liver damage and gastrointestinal bleeding.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine is safe for long-term use.
Fact: This medicine is only for short-term use (up to 7-10 days) due to risks of liver and kidney damage, and gastrointestinal bleeding. - Myth: This medicine can be taken on an empty stomach.
Fact: It should be taken with food to reduce stomach upset and risk of ulcers. - Myth: This medicine is safe for children.
Fact: It is not recommended for children under 12 years of age. - Myth: This medicine can be taken with other painkillers.
Fact: Taking it with other NSAIDs or paracetamol-containing products can increase the risk of side effects.
🔄 Alternative Options
Generic Alternatives
- Nimesulide + Paracetamol combination (generic)
Brand Alternatives
- Nimsa 100mg/325mg Tablet