Nimphen Plus 100mg/325mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Yellowing of skin or eyes
- Decreased urine output
- Severe skin rash or blistering
- Swelling of face, lips, or throat
- Difficulty breathing
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is nimphen plus 100mg/325mg tablet used for?
This medicine is a combination of nimesulide and paracetamol used for short-term relief of acute pain, inflammation, and fever. It is taken orally, usually twice daily after meals, for up to 7 days.
- Generic Name: Information coming soon
- Manufacturer: Multiple manufacturers
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nimphen plus 100mg/325mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा निमेसुलाइड और पैरासिटामोल का संयोजन है, जिसका उपयोग तीव्र दर्द, सूजन और बुखार से राहत के लिए किया जाता है। यह मांसपेशियों के दर्द, दांत दर्द, सर्जरी के बाद के दर्द और जोड़ों के दर्द में प्रभावी है। इसे भोजन के बाद लेना चाहिए और 7 दिनों से अधिक नहीं लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त और चक्कर आना शामिल हैं। गंभीर दुष्प्रभावों में पेट में रक्तस्राव, लिवर की क्षति, गुर्दे की समस्या और एलर्जी प्रतिक्रियाएं हो सकती हैं। यदि काला मल, खून की उल्टी, त्वचा या आंखों का पीलापन, या सांस लेने में कठिनाई हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक या अवधि से अधिक न लें। इसे भोजन के साथ लें ताकि पेट की जलन कम हो। इस दवा के साथ शराब न लें क्योंकि इससे लिवर और पेट की समस्याएं बढ़ सकती हैं। यदि आपको पेट अल्सर, गुर्दे या लिवर की बीमारी, उच्च रक्तचाप या हृदय रोग है तो डॉक्टर को बताएं। 7 दिनों से अधिक उपयोग से पहले डॉक्टर से सलाह लें।
💊 nimphen plus 100mg/325mg tablet Uses & Benefits
[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in conditions such as sprains, strains, and back pain.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides relief from toothache and post-dental procedure pain.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of pain after minor surgeries.","evidence":"Moderate"},{"condition":"Fever","description":"Reduces fever due to its paracetamol component.","evidence":"Well-established"},{"condition":"Osteoarthritis","description":"Short-term relief of pain and stiffness in osteoarthritis flare-ups.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used for acute migraine attacks, but not first-line.","evidence":"Limited"},{"condition":"Dysmenorrhea","description":"May be used for menstrual pain, but other NSAIDs are preferred.","evidence":"Limited"}]
Primary treatment for: Acute pain and inflammation
Also treats: Musculoskeletal pain, Dental pain, Post-operative pain, Fever
📋 Drug Information
| Generic Name(s) | Information coming soon |
| Brand Name | nimphen plus 100mg/325mg tablet |
| Manufacturer | Multiple manufacturers |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Nimesulide selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, reducing the synthesis of prostaglandins that mediate pain, inflammation, and fever. Paracetamol acts primarily in the central nervous system by inhibiting prostaglandin synthesis and possibly activating descending serotonergic pathways, producing analgesia and antipyresis. Together, they provide enhanced pain relief and anti-inflammatory effects.
Mechanism Steps
💡 How to Take nimphen plus 100mg/325mg tablet
Strength: Each tablet contains nimesulide 100 mg and paracetamol 325 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet (nimesulide 100 mg + paracetamol 325 mg) taken orally twice daily, preferably after meals. The maximum recommended duration is 7 days. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. This medicine is not recommended for children under 12 years. Consult a pediatrician for appropriate alternatives. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the side effects, especially gastrointestinal bleeding and kidney impairment. Use the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician based on renal and hepatic function. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose reduction may be necessary. Avoid in severe renal impairment. Consult a doctor for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose reduction may be necessary. Avoid in severe hepatic impairment. Consult a doctor for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is 2 tablets (nimesulide 200 mg + paracetamol 650 mg). Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nimphen plus 100mg/325mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Corticosteroids | Major | |
| Methotrexate | Major | |
| ACE inhibitors/ARBs | Moderate | |
| Diuretics | Moderate | |
| Lithium | Moderate | |
| SSRIs | Moderate | |
| Alcohol | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., ibuprofen, aspirin)
- Corticosteroids
- Methotrexate
- ACE inhibitors and ARBs
⚡ Moderate Interactions
- Diuretics (e.g., furosemide)
- Lithium
- SSRIs
- Alcohol
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of liver damage, especially with paracetamol, and can worsen gastrointestinal irritation and bleeding caused by nimesulide.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to nimesulide, paracetamol, or any component","Active peptic ulcer or history of recurrent ulcers","Gastrointestinal bleeding or bleeding disorders","Severe liver impairment","Severe kidney impairment","Children under 12 years","Pregnancy (especially third trimester)","Breastfeeding","Severe heart failure","Concurrent use with other NSAIDs"]
⚠️ Warnings & Precautions
["Take with food to reduce stomach upset.","Do not exceed the recommended dose or duration.","Avoid alcohol while taking this medicine.","Use with caution in the elderly and those with kidney or liver disease.","May cause dizziness; avoid driving if affected.","Do not use for more than 7 days without medical advice.","Inform your doctor if you have a history of ulcers, bleeding, or cardiovascular disease.","Stop and seek medical help if you experience signs of liver damage or allergic reactions."]
🤱 Lactation Safety
Not recommended during breastfeeding. Nimesulide may pass into breast milk and could harm the infant. Paracetamol is considered safe, but the combination should be avoided. Consult your doctor for alternatives.
💊 Overdose Management
Overdose can cause severe liver damage, especially due to paracetamol. Symptoms include nausea, vomiting, abdominal pain, and confusion. Seek immediate medical attention. Treatment may include activated charcoal, N-acetylcysteine for paracetamol toxicity, and supportive care. Do not induce vomiting unless advised by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine as it increases the risk of liver damage and gastrointestinal bleeding. Do not take other pain relievers or NSAIDs without consulting your doctor. Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, high blood pressure, or heart disease. Do not use this medicine for more than 7 days without medical advice. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor renal and hepatic function regularly.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy or when planning pregnancy. Consult your doctor for safer alternatives for pain relief.
🏥 Post-Surgery Considerations
This medicine may be used for short-term post-operative pain, but it can increase bleeding risk. Inform your surgeon if you are taking it. It is usually stopped before surgery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure, as it may increase bleeding risk. It can be used for dental pain, but short-term only.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting while experiencing acute pain. Gradually return to activity as pain improves. Consult a physiotherapist for guided exercises.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue desk work, but take breaks and maintain good posture.
🛑 When to Stop This Medicine
Stop this medicine after the prescribed duration (usually up to 7 days) or as soon as pain subsides. If you experience any serious side effects like black stools, yellowing of eyes, or severe rash, stop immediately and seek medical help. Do not stop abruptly if you are on long-term therapy without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended due to increased risk of liver damage, kidney impairment, gastrointestinal bleeding, and cardiovascular events. If long-term pain management is needed, consult your doctor for safer alternatives and regular monitoring of liver and kidney function.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve mobility.
Evidence: Well-establishedMay help reduce localized pain and inflammation.
Evidence: ModerateSome evidence for pain relief in musculoskeletal conditions.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No known interactions with vaccines. However, if you have a fever, consult your doctor before vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, continue your regular dosing schedule as prescribed. Check customs regulations for carrying prescription medicines. Do not leave it in a hot car.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Pain relief typically begins within 30-60 minutes after taking the tablet.
A: It is best taken with food to reduce stomach upset.
A: No, this medicine is not recommended for children under 12 years.
A: Do not take with other NSAIDs or paracetamol without consulting your doctor.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can be taken long-term for chronic pain.
Fact: This medicine is only for short-term use (up to 7 days) due to risks of liver, kidney, and gastrointestinal side effects. - Myth: It is safe to take with other painkillers.
Fact: Combining with other NSAIDs or paracetamol can increase the risk of toxicity. Always consult a doctor. - Myth: It can be taken on an empty stomach.
Fact: It should be taken with food to reduce stomach upset and risk of ulcers.
🔄 Alternative Options
Generic Alternatives
- Nimesulide + Paracetamol combination (generic)
Brand Alternatives
- Nimphen Plus 100mg/325mg Tablet