Nimeka Plus 100mg/325mg Tablet: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Yellowing of skin or eyes
- Dark urine or decreased urine output
- Severe headache with visual changes
- Swelling of face, lips, or throat
- Difficulty breathing
- Unusual bruising or bleeding
- Persistent fever or pain lasting more than 3 days
If experiencing severe symptoms, call emergency services immediately.
What is nimeka plus 100mg/325mg tablet used for?
This medicine is a combination of nimesulide and paracetamol used for short-term relief of acute pain, inflammation, and fever. It works by reducing prostaglandins that cause pain and swelling. It should be taken with food and not for more than 7-10 days.
- Generic Name: Information coming soon
- Manufacturer: Multiple manufacturers
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nimeka plus 100mg/325mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा नाइमेसुलाइड और पैरासिटामोल का संयोजन है, जिसका उपयोग अल्पकालिक दर्द, सूजन और बुखार से राहत के लिए किया जाता है। यह मांसपेशियों के दर्द, दांत दर्द, सर्जरी के बाद के दर्द और मासिक धर्म के दर्द में प्रभावी है। यह दवा केवल 7-10 दिनों तक ही लेनी चाहिए और डॉक्टर की सलाह के बिना नहीं लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त, सिरदर्द और चक्कर आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें पेट में अल्सर या रक्तस्राव, लीवर की क्षति, गुर्दे की समस्या और गंभीर एलर्जी प्रतिक्रिया शामिल हो सकती है। यदि आपको काला मल, खून की उल्टी, पीलिया, या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। इसे भोजन के साथ लें ताकि पेट में जलन न हो। शराब का सेवन न करें क्योंकि इससे लीवर और पेट की समस्या बढ़ सकती है। अन्य दर्द निवारक दवाओं के साथ इसका सेवन न करें। यदि आप गर्भवती हैं, स्तनपान करा रही हैं, या आपको लीवर/किडनी की बीमारी है, तो डॉक्टर से सलाह लें। 7-10 दिनों से अधिक इसका उपयोग न करें।
💊 nimeka plus 100mg/325mg tablet Uses & Benefits
[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in muscles, joints, and soft tissues, such as back pain, sprains, and strains.","evidence":"Well-established for short-term use"},{"condition":"Dental pain","description":"Provides relief from toothache and pain following dental procedures.","evidence":"Well-established for short-term use"},{"condition":"Post-operative pain","description":"Used for short-term management of pain after minor surgeries.","evidence":"Well-established for short-term use"},{"condition":"Fever","description":"Reduces fever due to the paracetamol component, though nimesulide also has antipyretic properties.","evidence":"Well-established for short-term use"},{"condition":"Primary dysmenorrhea","description":"Relieves menstrual cramps and associated pain.","evidence":"Well-established for short-term use"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks, but not a first-line treatment.","evidence":"Limited"},{"condition":"Osteoarthritis flare-ups","description":"May be used short-term for pain relief during flare-ups, but not for long-term management.","evidence":"Limited"}]
Primary treatment for: Acute pain and inflammation
Also treats: Fever, Dental pain, Musculoskeletal pain, Post-operative pain, Dysmenorrhea
📋 Drug Information
| Generic Name(s) | Information coming soon |
| Brand Name | nimeka plus 100mg/325mg tablet |
| Manufacturer | Multiple manufacturers |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with different mechanisms. Nimesulide is a non-steroidal anti-inflammatory drug that selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, reducing the production of prostaglandins, which are chemicals that cause pain, inflammation, and fever. Paracetamol works primarily in the central nervous system to relieve pain and reduce fever, although its exact mechanism is not fully understood. It may inhibit prostaglandin synthesis in the brain and affect pain perception. Together, they provide additive pain relief and anti-inflammatory effects.
Mechanism Steps
💡 How to Take nimeka plus 100mg/325mg tablet
Strength: Each tablet contains nimesulide 100 mg and paracetamol 325 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally every 6 to 8 hours as needed for pain and fever, not exceeding 3 tablets in 24 hours. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. This medicine should be used for the shortest duration possible, typically not more than 7 to 10 days. Do not exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. This medicine is not recommended for children under 12 years of age. Consult a pediatrician for appropriate alternatives. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the side effects of this medicine, especially gastrointestinal bleeding and kidney problems. Use with caution and at the lowest effective dose for the shortest duration. Monitor renal and hepatic function. Consult a doctor for dose adjustments. |
| Renal Impairment | Use with caution in patients with kidney disease. Dose reduction may be necessary. Consult a doctor for individualized dosing. This medicine is contraindicated in severe kidney disease. |
| Hepatic Impairment | Use with caution in patients with liver disease. Dose reduction may be necessary. This medicine is contraindicated in severe liver disease. Consult a doctor for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose is 3 tablets in 24 hours. Do not exceed this dose. Each tablet contains nimesulide 100 mg and paracetamol 325 mg. The total daily paracetamol dose should not exceed 3250 mg from all sources. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nimeka plus 100mg/325mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Corticosteroids | Major | |
| Methotrexate | Major | |
| ACE inhibitors | Major | |
| Diuretics | Moderate | |
| Lithium | Moderate | |
| SSRIs | Moderate | |
| Antacids | Minor | |
| Cholestyramine | Minor |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., ibuprofen, diclofenac)
- Corticosteroids
- Methotrexate
- ACE inhibitors and ARBs
⚡ Moderate Interactions
- Diuretics (e.g., furosemide)
- Lithium
- SSRIs
- Antihypertensives (e.g., beta-blockers)
🍷 Alcohol Interaction
Avoid consuming alcohol while taking this medicine. Alcohol increases the risk of liver damage, especially from paracetamol, and can worsen stomach irritation and bleeding caused by nimesulide. If you consume alcohol regularly, consult your doctor before taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to nimesulide, paracetamol, or any component of the formulation","Active or history of peptic ulcer or gastrointestinal bleeding","Severe liver disease or severe kidney disease","Heart failure or severe cardiovascular disease","Children under 12 years of age","Pregnancy, especially third trimester","Breastfeeding without medical advice","Concurrent use with other NSAIDs or anticoagulants"]
⚠️ Warnings & Precautions
["Use the lowest effective dose for the shortest possible duration.","Take with food to reduce gastrointestinal irritation.","Avoid alcohol during treatment.","Do not use if you have a history of stomach ulcers or bleeding.","Consult your doctor if you have liver or kidney disease.","Do not exceed the recommended dose of paracetamol from all sources.","Stop and seek medical help if you experience signs of liver or kidney problems.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Not recommended for children under 12 years.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding."]
🤱 Lactation Safety
Not established from the available information. It is not known if nimesulide passes into breast milk. Paracetamol is considered safe during breastfeeding. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose of this medicine can cause severe liver damage, especially due to paracetamol. Symptoms of overdose may include nausea, vomiting, abdominal pain, confusion, and yellowing of skin or eyes. If you suspect an overdose, seek emergency medical help immediately. Treatment may include activated charcoal, N-acetylcysteine (for paracetamol toxicity), and supportive care. Do not wait for symptoms to appear.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not take more than the recommended dose or for longer than advised. Always take it with food or milk to reduce stomach irritation. Avoid drinking alcohol while taking this medicine, as it can increase the risk of stomach bleeding and liver damage. Do not take other medicines containing paracetamol or other NSAIDs without consulting your doctor, as this can lead to overdose or increased side effects. If you have a history of stomach ulcers, liver disease, kidney disease, or heart problems, inform your doctor before taking this medicine. Do not use this medicine if you are pregnant, planning to become pregnant, or breastfeeding without medical advice. Keep this medicine out of reach of children. Store it at room temperature, away from moisture and direct sunlight. If you miss a dose, take it as soon as you remember, but if it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients (above 65 years) are at higher risk of gastrointestinal bleeding, kidney problems, and liver toxicity from this medicine. Use the lowest effective dose for the shortest duration. Monitor renal and hepatic function regularly. Avoid concurrent use with other NSAIDs or anticoagulants.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended for women who are planning to become pregnant or are pregnant. It may increase the risk of complications. Consult your doctor for safer alternatives for pain relief before and during pregnancy.
🏥 Post-Surgery Considerations
This medicine may be used for short-term pain relief after surgery, but it should be used with caution due to the risk of bleeding and kidney problems. Follow your surgeon's instructions and do not exceed the recommended dose or duration.
🦷 Dental Procedures
This medicine can be used for short-term relief of dental pain, including after dental procedures. However, inform your dentist that you are taking this medicine, especially if you are scheduled for a procedure that may cause bleeding. It is not a substitute for dental treatment.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may experience dizziness or drowsiness. Avoid strenuous exercise or activities that require alertness until you know how the medicine affects you. If you have pain, gentle stretching and low-impact exercises may be beneficial, but consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue desk work, but take breaks and maintain good posture. If your job involves physical labor, consult your doctor about modifications.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor immediately if you experience any signs of serious side effects, such as black or tarry stools, vomiting blood, severe abdominal pain, yellowing of skin or eyes, dark urine, decreased urine output, severe headache, or allergic reactions. Do not stop taking this medicine without consulting your doctor if you are using it for a prescribed condition, but do not continue beyond the recommended duration without medical advice.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended due to the risk of serious side effects such as liver damage, kidney problems, gastrointestinal bleeding, and cardiovascular events. If long-term pain management is needed, consult your doctor for safer alternatives and regular monitoring of liver and kidney function.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve mobility.
Evidence: Well-establishedApplying heat or cold packs can help reduce pain and inflammation.
Evidence: Well-establishedMay provide pain relief for some individuals.
Evidence: ModerateRelaxation, meditation, and yoga can help manage pain.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled to receive a vaccine, inform your healthcare provider that you are taking this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If crossing time zones, continue taking the medicine as prescribed, but adjust the timing gradually to the new local schedule. Do not pack it in checked luggage; keep it in your carry-on bag. Check the customs regulations of your destination country regarding prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 30 to 60 minutes after taking it.
A: This medicine should only be used for short-term relief, typically not more than 7 to 10 days, unless your doctor advises otherwise.
A: This medicine can cause liver damage, especially with high doses, long-term use, or alcohol consumption. It should be used with caution in people with liver disease.
A: No, you should avoid alcohol while taking this medicine as it increases the risk of liver damage and stomach bleeding.
A: Common side effects include nausea, stomach pain, heartburn, diarrhea, headache, and dizziness. These are usually mild and temporary.
A: This medicine is not recommended during pregnancy, especially in the third trimester. Consult your doctor for safer alternatives.
A: You should not take this medicine with other NSAIDs or paracetamol-containing products without consulting your doctor, as it can increase the risk of side effects.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: Drowsiness is not a common side effect, but some people may experience dizziness. Avoid driving or operating machinery until you know how it affects you.
A: This medicine may relieve headache, but it is not specifically intended for headache treatment. Consult your doctor for appropriate headache management.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine is safe for long-term use.
Fact: This medicine is only for short-term use. Long-term use can cause serious liver, kidney, and stomach problems. - Myth: It is safe to take this medicine without a prescription.
Fact: This medicine is a prescription drug in many countries. It should only be taken under medical supervision. - Myth: Taking this medicine with alcohol is safe.
Fact: Alcohol increases the risk of liver damage and stomach bleeding. Avoid alcohol while taking this medicine. - Myth: This medicine can be taken for any type of pain.
Fact: This medicine is for specific types of acute pain and fever. It is not for all pain conditions and should be used as directed.
🔄 Alternative Options
Generic Alternatives
- Nimesulide 100 mg + Paracetamol 325 mg tablet
Brand Alternatives
- Nimeka Plus 100mg/325mg Tablet