Nimdus P 100mg/500mg Tablet: Complete Guide To Uses, Side Effects, And Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in vomit or black, tarry stools
- Severe abdominal pain or persistent vomiting
- Yellowing of skin or eyes (jaundice)
- Dark urine or decreased urine output
- Severe skin rash, blisters, or peeling skin
- Difficulty breathing or swelling of face, lips, or throat
- Unusual bleeding or bruising
- Sudden severe headache with visual changes
If experiencing severe symptoms, call emergency services immediately.
What is nimdus p 100mg/500mg tablet used for?
This medicine is a combination of nimesulide and paracetamol used for short-term relief of acute pain, inflammation, and fever. It should be taken with food and not exceeding 2 tablets in 24 hours. It is not recommended for children under 12, pregnant women, or those with liver or kidney disease.
- Generic Name: Information coming soon
- Manufacturer: Multiple manufacturers
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nimdus p 100mg/500mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा नाइमसुलाइड और पैरासिटामोल का संयोजन है, जिसका उपयोग दर्द, सूजन और बुखार के अल्पकालिक उपचार के लिए किया जाता है। यह मांसपेशियों के दर्द, दांत दर्द, सर्जरी के बाद के दर्द और मासिक धर्म के दर्द में राहत देती है। इसे भोजन के साथ लेना चाहिए और 24 घंटे में 2 गोलियों से अधिक नहीं लेना चाहिए। यह 12 वर्ष से कम बच्चों, गर्भवती महिलाओं और स्तनपान कराने वाली महिलाओं के लिए नहीं है।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त और चक्कर आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें गंभीर त्वचा प्रतिक्रियाएं, जठरांत्र रक्तस्राव, यकृत क्षति और गुर्दे की समस्याएं शामिल हो सकती हैं। यदि आपको उल्टी में खून, काला मल, पेट में तेज दर्द, आंखों या त्वचा का पीलापन, या असामान्य रक्तस्राव दिखे तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को भोजन या दूध के साथ लें ताकि पेट की जलन कम हो। निर्धारित खुराक और अवधि से अधिक न लें। इस दवा के साथ शराब का सेवन बिल्कुल न करें क्योंकि इससे यकृत क्षति और जठरांत्र रक्तस्राव का खतरा बढ़ जाता है। पैरासिटामोल युक्त अन्य दवाओं के साथ एक साथ न लें। यदि आपको यकृत रोग, गुर्दा रोग, अस्थमा या रक्तस्राव विकार है तो अपने डॉक्टर को बताएं। बिना चिकित्सकीय सलाह के 5 दिन से अधिक इसका उपयोग न करें।
💊 nimdus p 100mg/500mg tablet Uses & Benefits
[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in muscles, joints, and soft tissues due to sprains, strains, or injuries.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides short-term relief from toothache and post-dental procedure pain.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of mild to moderate pain after surgery.","evidence":"Moderate"},{"condition":"Fever","description":"Reduces fever due to its paracetamol component.","evidence":"Well-established"},{"condition":"Primary dysmenorrhea","description":"Relieves menstrual cramps and associated pain.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used for acute migraine attacks, but not first-line.","evidence":"Limited"},{"condition":"Osteoarthritis flare-up","description":"May be used short-term for pain relief during flare-ups, but not for long-term management.","evidence":"Limited"}]
Primary treatment for: Acute pain and inflammation
Also treats: Musculoskeletal pain, Dental pain, Post-operative pain, Fever, Dysmenorrhea
📋 Drug Information
| Generic Name(s) | Information coming soon |
| Brand Name | nimdus p 100mg/500mg tablet |
| Manufacturer | Multiple manufacturers |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients. Nimesulide selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, reducing the production of prostaglandins that cause inflammation, pain, and fever. Paracetamol acts primarily in the central nervous system, where it inhibits prostaglandin synthesis and modulates pain perception, also producing antipyretic effects. Together, they provide both peripheral anti-inflammatory and central analgesic actions.
Mechanism Steps
💡 How to Take nimdus p 100mg/500mg tablet
Strength: Tablet containing nimesulide 100 mg and paracetamol 500 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet (nimesulide 100 mg + paracetamol 500 mg) taken orally every 8 to 12 hours as needed for pain and fever, not exceeding 2 tablets in 24 hours. The dose and duration must be individualized by a qualified clinician based on the indication, severity of symptoms, age, weight, renal and hepatic function. Do not take for more than 5 days without medical supervision. |
| Pediatric Dosage | Pediatric dosing is not established from available information. This medicine is not recommended for children under 12 years. Consult a pediatrician for appropriate pain relief in children. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the side effects, especially gastrointestinal bleeding and kidney impairment. Use the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician based on renal and hepatic function. |
| Renal Impairment | Use with caution in patients with kidney disease. Dose reduction or avoidance may be necessary. Consult a qualified clinician for individualized dosing based on renal function. |
| Hepatic Impairment | Contraindicated in severe liver impairment. In mild to moderate liver disease, use with caution and at reduced dose. Dose must be individualized by a qualified clinician based on hepatic function. |
| Maximum Daily Dose | Maximum 2 tablets (nimesulide 200 mg + paracetamol 1000 mg) in 24 hours. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nimdus p 100mg/500mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Methotrexate | Major | |
| ACE inhibitors | Major | |
| Diuretics | Major | |
| Corticosteroids | Moderate | |
| SSRIs | Moderate | |
| Alcohol | Moderate | |
| Carbamazepine | Moderate | |
| Phenytoin | Moderate |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., ibuprofen, diclofenac)
- Methotrexate
- ACE inhibitors and ARBs
- Diuretics
⚡ Moderate Interactions
- Corticosteroids
- SSRIs
- Alcohol
- Carbamazepine
- Phenytoin
🍷 Alcohol Interaction
Avoid alcohol completely while taking this medicine. Alcohol increases the risk of liver damage, especially due to the paracetamol component, and raises the risk of gastrointestinal bleeding from nimesulide.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to nimesulide, paracetamol, or any component","Active peptic ulcer or history of recurrent ulcers","Severe liver impairment","Severe kidney impairment","Children under 12 years","Pregnancy and breastfeeding","Patients with history of NSAID-induced asthma, urticaria, or allergic reactions","Concurrent use with other NSAIDs or anticoagulants"]
⚠️ Warnings & Precautions
["Take with food to reduce stomach upset.","Do not exceed the recommended dose or duration.","Avoid alcohol completely.","Do not use for more than 5 days without medical advice.","Use with caution in elderly patients and those with kidney or liver disease.","Stop immediately if you develop signs of liver injury, severe skin reaction, or gastrointestinal bleeding.","Do not take other paracetamol-containing products concurrently."]
🤱 Lactation Safety
Not recommended during breastfeeding. Nimesulide may pass into breast milk and could harm the infant. Paracetamol is considered safe during breastfeeding, but the combination should be avoided.
💊 Overdose Management
Overdose can cause severe liver damage, especially due to paracetamol. Symptoms may include nausea, vomiting, abdominal pain, and confusion. Seek emergency medical help immediately. Treatment may include activated charcoal, N-acetylcysteine for paracetamol toxicity, and supportive care. Do not induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine with food or milk to reduce stomach upset. Do not exceed the prescribed dose or duration. Avoid alcohol completely while taking this medicine because it increases the risk of liver damage and gastrointestinal bleeding. Do not take other paracetamol-containing products simultaneously to prevent overdose. Inform your doctor if you have a history of liver disease, kidney disease, asthma, or bleeding disorders. Do not use this medicine for more than 5 days without medical advice. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and liver toxicity. Use the lowest effective dose for the shortest duration. Monitor renal and hepatic function regularly.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended for women planning pregnancy or who are pregnant. Consult your doctor for safe alternatives for pain relief.
🏥 Post-Surgery Considerations
This medicine may be used for short-term post-operative pain relief as prescribed by your surgeon. Do not self-administer. Inform your surgeon if you have any liver or kidney disease.
🦷 Dental Procedures
This medicine can be used for short-term relief of dental pain. Inform your dentist if you are taking this medicine before any dental procedure, as it may increase bleeding risk.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting while experiencing acute pain. Gradually resume activities as pain improves. Consult a physiotherapist for appropriate exercises.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue desk work, but take breaks and maintain good posture.
🛑 When to Stop This Medicine
Stop taking this medicine if you develop signs of liver injury (yellowing of eyes or skin, dark urine), severe skin rash, gastrointestinal bleeding, or any other serious side effect. Do not stop abruptly if you are on a prescribed course without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended due to the risk of liver damage, kidney impairment, and gastrointestinal bleeding. If prolonged use is necessary, regular monitoring of liver and kidney function is advised. Consult your doctor if you need pain relief for more than 5 days.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve mobility.
Evidence: Well-establishedMay help reduce localized pain and inflammation.
Evidence: ModerateSome evidence for pain relief in musculoskeletal conditions.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No known interactions with vaccines. However, if you have a fever, consult your doctor before vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from extreme heat or moisture. If crossing time zones, continue your dosing schedule as prescribed, but do not exceed the maximum daily dose. Check local customs regulations for carrying prescription medicines. Always keep it in your carry-on luggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Pain relief typically begins within 30 to 60 minutes after taking the tablet.
A: It is best taken with food or milk to reduce stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: Do not take other NSAIDs or paracetamol-containing products without consulting your doctor, as it may increase the risk of side effects.
A: This medicine is not recommended during pregnancy, especially in the third trimester. Consult your doctor for alternative pain relief.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine is safe for long-term use.
Fact: This medicine is only for short-term use. Prolonged use can cause liver and kidney damage. - Myth: It is safe to take with alcohol.
Fact: Alcohol increases the risk of liver damage and gastrointestinal bleeding. Avoid alcohol completely. - Myth: It can be given to children.
Fact: This medicine is not recommended for children under 12 years. - Myth: It can be taken on an empty stomach.
Fact: Taking with food reduces stomach upset and gastrointestinal irritation.
🔄 Alternative Options
Generic Alternatives
- Nimesulide + Paracetamol generic tablets
Brand Alternatives
- Nimdus P 100mg/500mg Tablet