nicip 200mg tablet - Nimesulide (200mg) medicine

Nimesulide 200mg Tablet: Complete Guide to Uses, Side Effects, and Safety

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🏭 Cipla Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 21, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 🤰 Pregnancy Category Not established from the available information. However, this medicine is generally not recommended during pregnancy, especially in the third trimester, due to potential risks to the fetus. Consult your doctor for alternative options. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for short-term use in acute pain; limited for long-term use due to safety concerns.
Reviewed by
SaathiMed Expert Panel | Oct 21, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Black or tarry stools
  • Vomiting blood or material that looks like coffee grounds
  • Severe abdominal pain
  • Yellowing of the skin or eyes
  • Decreased urine output or swelling in legs
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Swelling of the face, lips, or throat

If experiencing severe symptoms, call emergency services immediately.

What is nicip 200mg tablet used for?

This medicine contains Nimesulide 200mg, an NSAID used for short-term relief of acute pain, inflammation, and fever in adults. It works by blocking COX-2 enzymes. It should not be used for more than 15 days and is contraindicated in people with stomach ulcers, severe liver or kidney disease, and during pregnancy.

  • Generic Name: Nimesulide (200mg)
  • Manufacturer: Cipla Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 nicip 200mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा नाइमेसुलाइड 200 मिलीग्राम युक्त एक दर्द निवारक और सूजन कम करने वाली दवा है। इसका उपयोग अल्पकालिक दर्द, सूजन और बुखार के इलाज के लिए किया जाता है। यह जोड़ों के दर्द, दांत के दर्द, मांसपेशियों के दर्द और मासिक धर्म के दर्द में राहत देती है। यह दवा केवल डॉक्टर की सलाह पर ही लेनी चाहिए और 15 दिनों से अधिक नहीं लेनी चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, दस्त, पेट दर्द, चक्कर आना और सिरदर्द शामिल हैं। गंभीर दुष्प्रभावों में पेट या आंतों में रक्तस्राव, लिवर की समस्या, गुर्दे की समस्या और एलर्जी प्रतिक्रियाएं हो सकती हैं। यदि आपको काला मल, खून की उल्टी, पेट में तेज दर्द, आंखों या त्वचा का पीलापन, या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को हमेशा डॉक्टर के बताए अनुसार ही लें। इसे भोजन या दूध के साथ लें ताकि पेट में जलन न हो। इस दवा के साथ शराब का सेवन न करें। यदि आपको पेट के अल्सर, लिवर या गुर्दे की गंभीर बीमारी है, तो इस दवा का उपयोग न करें। गर्भवती या स्तनपान कराने वाली महिलाएं इस दवा का उपयोग न करें। यदि आपको चक्कर आते हैं तो वाहन न चलाएं। दवा को ठंडी और सूखी जगह पर रखें।

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 nicip 200mg tablet Uses & Benefits

[{"condition":"Acute pain","description":"This medicine is used for short-term relief of acute pain such as musculoskeletal pain, dental pain, and post-operative pain.","evidence":"Well-established"},{"condition":"Osteoarthritis","description":"It helps reduce pain and inflammation in osteoarthritis, improving joint mobility, but is typically used for short courses.","evidence":"Established"},{"condition":"Fever","description":"This medicine has antipyretic properties and can reduce fever, though it is not a first-line choice for this purpose.","evidence":"Established"},{"condition":"Dysmenorrhea","description":"It may be prescribed for menstrual pain due to its anti-inflammatory and analgesic effects.","evidence":"Established"}]

Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks, but evidence is limited and other treatments are preferred.","evidence":"Limited"},{"condition":"Soft tissue injuries","description":"May be used for pain and swelling in sprains and strains, though not a standard first-line option.","evidence":"Limited"}]

Primary treatment for: Acute pain and inflammation

Also treats: Osteoarthritis, Dysmenorrhea, Fever

📋 Drug Information

Generic Name(s)Nimesulide (200mg)
Brand Namenicip 200mg tablet
ManufacturerCipla Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action ClassNSAID's-Non-Selective COX 1&2 Inhibitors (Others)
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a cool, dry place. Protect from direct sunlight and moisture. Keep out of reach of children.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Prescribe this medicine only for short-term use, not exceeding 15 days.
2
Always advise patients to take it with food to minimize gastrointestinal irritation.
3
Assess liver and kidney function before starting treatment, especially in at-risk patients.
4
Avoid concomitant use with other NSAIDs, corticosteroids, or anticoagulants.
5
Warn patients about the signs of gastrointestinal bleeding and liver toxicity.
6
Consider alternative analgesics in elderly patients and those with cardiovascular risk factors.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Acute joint pain
This medicine is commonly prescribed for short-term relief of joint pain.
Likely Use
✅
Fever
It has antipyretic properties but is not a first-line choice.
Likely Use
❌
Chronic pain
Not recommended for long-term use due to safety concerns.
Not Primary
❌
Headache
Not a primary treatment for headache; other options are preferred.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionThis medicine is rapidly absorbed from the gastrointestinal tract after oral administration. Food may delay the rate but not the extent of absorption.
DistributionIt is widely distributed throughout the body, with a volume of distribution of approximately 0.2 L/kg. It crosses the placental barrier and may be excreted in breast milk.
Protein BindingNimesulide is highly bound to plasma proteins, primarily albumin, with a binding rate of about 99%.
MetabolismThis medicine is extensively metabolized in the liver, primarily by cytochrome P450 enzymes, including CYP2C9. The main metabolite is 4-hydroxynimesulide, which is pharmacologically active.
Half-LifeThe elimination half-life of this medicine is approximately 2 to 5 hours, but the active metabolite has a longer half-life of about 6 to 8 hours.
ExcretionThis medicine and its metabolites are excreted primarily through the kidneys (about 70%) and in feces (about 30%).
BioavailabilityThe oral bioavailability of this medicine is approximately 80% to 90%.
Onset of ActionThe onset of pain relief typically occurs within 30 to 60 minutes after oral administration.
Peak Plasma TimePeak plasma concentrations are reached approximately 1.5 to 3 hours after oral intake.
Duration of ActionThe analgesic and anti-inflammatory effects last for about 6 to 8 hours, requiring dosing two to three times daily.

How It Works

This medicine works by selectively inhibiting the cyclooxygenase-2 (COX-2) enzyme, which is responsible for producing prostaglandins that mediate pain, inflammation, and fever. By blocking COX-2, it reduces the synthesis of these prostaglandins, thereby alleviating pain and swelling. It has a weaker effect on COX-1, which is why it may cause fewer gastrointestinal side effects compared to non-selective NSAIDs, but it still carries risks.

Mechanism Steps

1
Selective COX-2 inhibition: This medicine binds to and inhibits the COX-2 enzyme, preventing the conversion of arachidonic acid to prostaglandin H2.
2
Reduced prostaglandin synthesis: The inhibition of COX-2 leads to decreased production of prostaglandins, which are key mediators of pain, inflammation, and fever.
3
Analgesic and anti-inflammatory effects: Lower prostaglandin levels result in reduced pain sensitivity and less swelling at the site of inflammation.
4
Antipyretic effect: Prostaglandins also play a role in fever; their reduction helps normalize body temperature.

💡 How to Take nicip 200mg tablet

Strength: Nimesulide 200 mg immediate-release tablet

1Take this medicine exactly as prescribed by your doctor.
2Swallow the tablet whole with a glass of water.
3Take it with food or milk to reduce stomach upset.
4Do not crush, chew, or break the tablet unless instructed.
5Follow the prescribed dosing schedule and duration.
6Do not take more than the recommended dose.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 100 mg twice daily, but for this 200 mg strength, it is typically taken once daily or as directed by the physician. The maximum recommended duration is 15 days. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients (above 65 years) are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor kidney and liver function closely. Dose must be individualized by a qualified clinician.
Renal ImpairmentUse with caution in patients with kidney impairment. In patients with severe kidney impairment (creatinine clearance <30 mL/min), this medicine is contraindicated. For mild to moderate impairment, dose reduction may be necessary. Consult a doctor for individualized dosing.
Hepatic ImpairmentUse with caution in patients with liver impairment. In severe liver impairment, this medicine is contraindicated. For mild to moderate impairment, dose reduction may be necessary. Monitor liver function regularly. Consult a doctor for individualized dosing.
Maximum Daily DoseThe maximum recommended daily dose is 200 mg. Do not exceed this dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset and risk of ulcers.
Alcohol
Avoid
Increases risk of gastrointestinal bleeding and liver toxicity.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of nicip 200mg tablet

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food or milk to reduce nausea. If it persists, consult your doctor.
Diarrhea (Common (5-10%))
Stay hydrated. If diarrhea is severe or persistent, seek medical advice.
Stomach pain (Common (5-10%))
Take with food. If pain is severe or accompanied by black stools, seek immediate medical attention.
Dizziness (Common (5-10%))
Avoid driving or operating machinery until you know how this medicine affects you.
Headache (Common (5-10%))
Usually resolves on its own. If persistent, consult your doctor.

🚨 Serious Side Effects

Gastrointestinal bleeding (Rare (<0.1%))
Seek immediate medical attention if you notice black or tarry stools, vomiting blood, or severe abdominal pain.
Liver toxicity (Rare (<0.1%))
Report yellowing of skin or eyes, dark urine, or unexplained fatigue to your doctor immediately.
Kidney impairment (Rare (<0.1%))
Consult your doctor if you experience decreased urine output or swelling in your legs or feet.
Severe allergic reaction (Rare (<0.1%))
Seek emergency help if you develop swelling of the face, lips, or throat, or difficulty breathing.
Cardiovascular events (Rare (<0.1%))
Seek immediate medical attention if you experience chest pain, shortness of breath, or weakness on one side of the body.

⚠️ Rare Side Effects

Severe skin reactions (e.g., Stevens-Johnson syndrome)
Stop the medicine and seek immediate medical help if you develop a rash with blisters or peeling skin.
Aseptic meningitis
Seek immediate medical attention if you experience severe headache, stiff neck, or sensitivity to light.
Pancreatitis
Seek immediate medical attention if you have severe upper abdominal pain that radiates to your back.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Other NSAIDs Major
Corticosteroids Major
ACE inhibitors Major
Diuretics Major
Lithium Moderate
Methotrexate Moderate
SSRIs Moderate
Antidiabetic drugs Moderate
Antacids Minor

🚨 Major Interactions

  • Warfarin
  • Other NSAIDs (e.g., ibuprofen, diclofenac)
  • Corticosteroids
  • ACE inhibitors and ARBs
  • Diuretics

⚡ Moderate Interactions

  • Lithium
  • Methotrexate
  • SSRIs
  • Antidiabetic drugs (sulfonylureas)

🍷 Alcohol Interaction

Avoid consuming alcohol while taking this medicine. Alcohol can increase the risk of stomach bleeding, ulcers, and liver damage. It may also worsen dizziness and drowsiness.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to Nimesulide or any component of the formulation.","Active or history of peptic ulcer, gastrointestinal bleeding, or perforation.","Severe liver impairment.","Severe kidney impairment (e.g., creatinine clearance

⚠️ Warnings & Precautions

["Use the lowest effective dose for the shortest possible duration to minimize risks.","Avoid concomitant use with other NSAIDs or corticosteroids.","Monitor for signs of gastrointestinal bleeding, especially in the elderly.","Use with caution in patients with hypertension, heart failure, or cardiovascular risk factors.","Avoid in patients with dehydration or hypovolemia due to increased risk of kidney injury.","Do not use for pain relief before or after coronary artery bypass graft surgery.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Inform your doctor if you have a history of liver or kidney disease.","Alcohol consumption should be avoided during treatment."]

🤱 Lactation Safety

This medicine may pass into breast milk. It is not recommended during breastfeeding due to potential risks to the infant. Consult your doctor for safer alternatives.

💊 Overdose Management

Overdose of this medicine may cause symptoms such as nausea, vomiting, abdominal pain, drowsiness, and gastrointestinal bleeding. In severe cases, it can lead to liver or kidney failure. If you suspect an overdose, seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Activated charcoal may be administered if the patient presents early. Monitor vital signs, liver and kidney function, and manage complications accordingly.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Always take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine as it can increase the risk of stomach bleeding. Do not use this medicine if you have a history of stomach ulcers, bleeding disorders, or severe kidney or liver disease. Inform your doctor about all other medications you are taking, especially blood thinners, other NSAIDs, or corticosteroids. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine. Do not drive or operate heavy machinery if you feel dizzy or drowsy after taking it. Store this medicine in a cool, dry place away from direct sunlight and out of reach of children. If you experience any signs of a serious reaction such as black stools, vomiting blood, severe abdominal pain, or yellowing of the eyes, seek immediate medical help.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor kidney and liver function closely. Avoid use in frail elderly patients unless clearly necessary.

🤰 Pregnancy Planning (TTC)

This medicine is not recommended during pregnancy or when planning pregnancy. Consult your doctor for safer alternatives for pain relief. If you become pregnant while taking this medicine, stop it and inform your doctor immediately.

🏥 Post-Surgery Considerations

This medicine may be used for post-operative pain, but it should be used with caution due to the risk of bleeding and kidney impairment. Follow your surgeon's instructions and do not use it for prolonged periods.

🦷 Dental Procedures

This medicine can be used for dental pain, but inform your dentist if you are taking it before any dental procedure, as it may increase bleeding risk. It is not a substitute for dental treatment.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce stress on joints.
🥗
Engage in regular low-impact exercises like walking or swimming.
😴
Practice good posture to prevent musculoskeletal pain.
💧
Include anti-inflammatory foods like fruits, vegetables, and omega-3 fatty acids in your diet.
🧘
Get adequate sleep to help your body recover.
🌞
Avoid smoking and limit alcohol consumption.

🏋️ Exercise Considerations

While taking this medicine, you can continue light exercises as tolerated. However, avoid strenuous activities that may worsen pain or cause injury. If you experience dizziness, avoid activities that require balance or coordination.

🥗 Diet Recommendations

Include omega-3 rich foods such as fish, flaxseeds, and walnuts.
Reduce intake of processed and fried foods.
Stay well hydrated by drinking plenty of water.
Eat a balanced diet rich in fruits and vegetables.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue desk work, but take breaks and stay hydrated.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor immediately if you experience any signs of a serious side effect, such as black stools, vomiting blood, severe abdominal pain, yellowing of the eyes or skin, decreased urine output, or severe allergic reactions. Do not stop taking it without consulting your doctor if you are on a prescribed course, but do not exceed the recommended duration.

📅 Long-Term Use Effects

Long-term use of this medicine is not recommended due to the risk of serious side effects such as liver toxicity, kidney impairment, gastrointestinal bleeding, and cardiovascular events. If long-term pain management is needed, consult your doctor for safer alternatives and regular monitoring of liver and kidney function.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can help strengthen muscles and improve joint mobility for chronic pain conditions.

Evidence: Well-established
Topical analgesics

Creams or gels containing NSAIDs or capsaicin can provide local pain relief with fewer systemic side effects.

Evidence: Established
Heat and cold therapy

Applying heat or cold packs can help reduce pain and inflammation.

Evidence: Established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medications you are taking.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it in a cool, dry place away from direct sunlight. If crossing time zones, adjust dosing times gradually as advised by your doctor. Check local customs regulations regarding prescription medicines. Always carry enough supply for your trip and keep it in your carry-on luggage.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old man with acute knee pain due to osteoarthritis
He was prescribed this medicine for 7 days. He took it with food as directed and experienced significant pain relief within 2 days. He was advised not to take it for more than a week and to follow up if pain persisted.
💡 Lesson: Short-term use with food is effective and minimizes stomach upset. Prolonged use should be avoided.
👤 A 60-year-old woman with fever and body ache
She took this medicine for fever but developed nausea and stomach pain after the first dose. She consulted her doctor, who advised her to take it with milk and reduced the dose. Her symptoms improved, and she completed the short course without further issues.
💡 Lesson: Taking this medicine with food or milk can reduce gastrointestinal side effects. Always report side effects to your doctor.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts relieving pain within 30 to 60 minutes after taking it.

Q: Can I take it on an empty stomach?

A: It is best taken with food or milk to reduce stomach upset.

Q: Is it safe for long-term use?

A: No, it is only recommended for short-term use, up to 15 days, due to risks of liver, kidney, and gastrointestinal side effects.

Q: Can I take it with other painkillers?

A: Do not take it with other NSAIDs unless advised by your doctor, as it increases the risk of side effects.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for nicip 200mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine is completely safe for long-term use.
    Fact: This medicine is only recommended for short-term use (up to 15 days) due to risks of liver, kidney, and gastrointestinal side effects.
  • Myth: This medicine can be taken on an empty stomach.
    Fact: It should be taken with food or milk to reduce stomach upset and risk of ulcers.
  • Myth: This medicine is safe for children.
    Fact: It is not recommended for children under 12 years of age.

🔄 Alternative Options

Generic Alternatives

  • Nimesulide 100 mg tablet
  • Nimesulide 50 mg tablet

Brand Alternatives

  • Nise 200 mg tablet
  • Nimulid 200 mg tablet
  • Nimed 200 mg tablet

📊 Comparison with Similar Medicines

[{"medicine":"Nimesulide 200 mg","class":"Preferential COX-2 inhibitor","common_use":"Acute pain, inflammation","duration":"Short-term (up to 15 days)","gi_risk":"Moderate","liver_risk":"High"},{"medicine":"Paracetamol 500 mg","class":"Analgesic, antipyretic","common_use":"Pain, fever","duration":"Short-term","gi_risk":"Low","liver_risk":"High in overdose"},{"medicine":"Ibuprofen 400 mg","class":"Non-selective NSAID","common_use":"Pain, inflammation, fever","duration":"Short-term","gi_risk":"High","liver_risk":"Low"}]

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