Nexflam Sp 50mg/325mg/15mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is nexflam sp 50mg/325mg/15mg tablet used for?
This medicine is a combination of aceclofenac, paracetamol, and serratiopeptidase used for short-term relief of acute pain and inflammation. It is taken orally with food, usually once or twice daily, and should not be used for more than 7 days without medical advice.
- Generic Name: Information coming soon
- Manufacturer: Multiple manufacturers
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nexflam sp 50mg/325mg/15mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एसिफ्लोफेनाक, पैरासिटामोल और सेरेशियोपेप्टिडेज़ का संयोजन है, जिसका उपयोग तीव्र दर्द और सूजन के इलाज के लिए किया जाता है। यह मांसपेशियों के दर्द, जोड़ों के दर्द, दांतों के दर्द, सर्जरी के बाद के दर्द और सूजन, और चोट लगने पर होने वाले दर्द और सूजन में राहत देती है। यह दवा दर्द को कम करने, सूजन को कम करने और बुखार को कम करने में मदद करती है। इसे भोजन के साथ लेना चाहिए और डॉक्टर के निर्देशानुसार ही सेवन करना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, अपच, सिरदर्द, चक्कर आना और नींद आना शामिल हैं। कुछ लोगों को त्वचा पर चकत्ते या खुजली भी हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन इनमें पेट या आंतों में रक्तस्राव, गंभीर एलर्जी प्रतिक्रिया, गुर्दे की समस्या और यकृत की क्षति शामिल हो सकती है। यदि आपको काला मल, खून की उल्टी, गंभीर पेट दर्द, आंखों या त्वचा का पीलापन, या पेशाब में कमी महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। अनुशंसित खुराक से अधिक न लें। इसे हमेशा भोजन या दूध के साथ लें ताकि पेट में जलन न हो। इस दवा के सेवन के दौरान शराब न पिएं क्योंकि इससे पेट में रक्तस्राव और यकृत की क्षति का खतरा बढ़ सकता है। बिना डॉक्टर की सलाह के अन्य दर्द निवारक दवाएं न लें। यदि आप गर्भवती हैं, स्तनपान करा रही हैं, या गुर्दे/यकृत की बीमारी है, तो डॉक्टर से परामर्श करें। चक्कर आने पर वाहन न चलाएं।
💊 nexflam sp 50mg/325mg/15mg tablet Uses & Benefits
[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in conditions such as sprains, strains, and back pain.","evidence":"Well-established"},{"condition":"Post-operative pain and swelling","description":"Reduces pain and edema following surgical procedures.","evidence":"Well-established"},{"condition":"Dental pain and inflammation","description":"Used for relief of pain and swelling after dental extractions or other dental procedures.","evidence":"Well-established"},{"condition":"Osteoarthritis","description":"Provides symptomatic relief of pain and stiffness in osteoarthritis.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Helps reduce pain and inflammation in rheumatoid arthritis as an adjunct to disease-modifying therapy.","evidence":"Moderate"},{"condition":"Soft tissue injuries","description":"Used for pain and swelling associated with sports injuries, contusions, and tendinitis.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine relief due to analgesic and anti-inflammatory effects.","evidence":"Limited"},{"condition":"Dysmenorrhea","description":"May be used off-label for menstrual pain and associated inflammation.","evidence":"Limited"}]
Primary treatment for: Acute musculoskeletal pain and inflammation
Also treats: Osteoarthritis, Rheumatoid arthritis, Post-operative pain, Dental pain, Soft tissue injuries
📋 Drug Information
| Generic Name(s) | Information coming soon |
| Brand Name | nexflam sp 50mg/325mg/15mg tablet |
| Manufacturer | Multiple manufacturers |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a cool, dry place away from direct sunlight. Keep in the original container, tightly closed. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines three active ingredients with complementary mechanisms. Aceclofenac, an NSAID, inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis and thereby decreasing pain, inflammation, and fever. Paracetamol acts primarily in the central nervous system to produce analgesia and antipyresis, with weak peripheral anti-inflammatory effects. Serratiopeptidase, a proteolytic enzyme, is thought to reduce inflammation and edema by breaking down fibrin and other inflammatory mediators, although its exact mechanism in humans is not fully established.
Mechanism Steps
💡 How to Take nexflam sp 50mg/325mg/15mg tablet
Strength: Each tablet contains aceclofenac 50 mg, paracetamol 325 mg, and serratiopeptidase 15 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally once or twice daily after meals, or as prescribed by your doctor. The dose may vary depending on the condition being treated, its severity, and your response to therapy. Do not exceed the recommended dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially gastrointestinal and kidney side effects. Use the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician based on renal and hepatic function. |
| Renal Impairment | Use with caution in patients with kidney impairment. Dose reduction may be necessary. Consult your doctor for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with liver impairment. Dose reduction may be necessary. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is two tablets (aceclofenac 100 mg, paracetamol 650 mg, serratiopeptidase 30 mg). Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nexflam sp 50mg/325mg/15mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Corticosteroids | Major | |
| Methotrexate | Major | |
| ACE inhibitors/ARBs | Major | |
| Diuretics | Moderate | |
| Lithium | Moderate | |
| SSRIs | Moderate | |
| Anticoagulants | Moderate | |
| Zidovudine | Moderate |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., ibuprofen, naproxen)
- Corticosteroids
- Methotrexate
- ACE inhibitors and angiotensin receptor blockers
⚡ Moderate Interactions
- Diuretics (e.g., furosemide, hydrochlorothiazide)
- Lithium
- Selective serotonin reuptake inhibitors (SSRIs)
- Anticoagulants (e.g., apixaban, rivaroxaban)
- Zidovudine
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding, ulceration, and liver damage, especially when combined with paracetamol and aceclofenac.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to aceclofenac, paracetamol, serratiopeptidase, or any component.","History of asthma, urticaria, or allergic reaction to NSAIDs.","Active peptic ulcer or history of recurrent peptic ulcer.","Severe heart failure, severe kidney impairment, or severe liver impairment.","Third trimester of pregnancy.","Children under 12 years (safety not established).","Concurrent use with other NSAIDs."]
⚠️ Warnings & Precautions
["Take with food to reduce stomach upset.","Avoid alcohol during treatment.","Do not exceed recommended dose or duration.","Use with caution in elderly patients due to increased risk of side effects.","Monitor for signs of gastrointestinal bleeding.","Consult doctor before use if you have kidney, liver, or heart disease.","Do not use for fever without consulting a doctor.","May cause dizziness; avoid driving if affected."]
🤱 Lactation Safety
Aceclofenac and paracetamol are excreted in breast milk in small amounts. Serratiopeptidase safety in lactation is not established. Consult your doctor before use if breastfeeding.
💊 Overdose Management
Overdose of this medicine can cause severe liver damage due to paracetamol, and gastrointestinal bleeding or kidney failure due to aceclofenac. Seek immediate medical attention. Treatment includes activated charcoal if within 1-2 hours, N-acetylcysteine for paracetamol toxicity, and supportive care. Do not induce vomiting unless advised by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Always take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine as it can increase the risk of stomach bleeding and liver damage. Do not take other pain relievers or NSAIDs without consulting your doctor. Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, heart problems, or asthma. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine. Do not drive or operate heavy machinery if you feel dizzy or drowsy. Store this medicine in a cool, dry place away from direct sunlight and out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor kidney and liver function regularly. Consult your doctor before use.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. NSAIDs may affect ovulation and are generally avoided during pregnancy, especially in the third trimester. Paracetamol is considered relatively safe, but serratiopeptidase safety is not established.
🏥 Post-Surgery Considerations
This medicine may be prescribed for post-operative pain and swelling. Follow your surgeon's instructions carefully. Inform your surgeon if you have any bleeding disorders or are taking blood thinners. Do not take additional painkillers without consulting your doctor.
🦷 Dental Procedures
This medicine is commonly prescribed after dental extractions or other dental procedures to relieve pain and swelling. Take it as prescribed, usually with food. Inform your dentist if you have any medical conditions or are taking other medications.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities that may increase pain while taking this medicine. Gentle stretching and low-impact exercises are generally safe. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue desk work, but take breaks and stay hydrated.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if you experience severe side effects such as gastrointestinal bleeding, allergic reactions, or if your pain does not improve within 7 days. Do not stop abruptly if you have been taking it for a long time without medical advice.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of gastrointestinal bleeding, kidney impairment, liver damage, and cardiovascular events. Regular monitoring of liver and kidney function is advised. Use the lowest effective dose for the shortest duration. Consult your doctor if you need to take it for more than 7 days.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve mobility.
Evidence: Well-establishedApplying heat or ice packs can help reduce pain and swelling.
Evidence: Well-establishedMay provide pain relief for some chronic pain conditions.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are established. However, if you are scheduled for vaccination, inform your doctor about this medicine. There is no need to postpone vaccination unless advised by your doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing schedule as advised by your doctor. Check customs regulations for carrying prescription medicines. Keep enough supply for your trip and carry it in your hand luggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Aceclofenac and paracetamol start relieving pain within 30-60 minutes. Serratiopeptidase may take several hours to days for noticeable anti-inflammatory effect.
A: No, it should be taken with food or milk to reduce stomach upset.
A: Do not take other NSAIDs or pain relievers without consulting your doctor, as it may increase the risk of side effects.
A: Consult your doctor before use. NSAIDs are generally avoided in the third trimester.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can be taken on an empty stomach.
Fact: It should be taken with food to reduce stomach upset. - Myth: This medicine is safe to take for any type of pain.
Fact: It is intended for specific inflammatory and painful conditions and should be used only as prescribed. - Myth: More tablets mean faster relief.
Fact: Taking more than the recommended dose can cause serious side effects and does not improve efficacy.
🔄 Alternative Options
Generic Alternatives
- Aceclofenac + Paracetamol + Serratiopeptidase combination tablets from various manufacturers.
Brand Alternatives
- Nexflam SP 50mg/325mg/15mg Tablet