Epitril-Beta 0.5 Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe dizziness or fainting
- Heart rate below 50 beats per minute
- Difficulty breathing or wheezing
- Severe confusion or hallucinations
- Seizures or unusual movements
- Severe rash with blistering or peeling skin
- Yellowing of eyes or skin
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is neolol beta 20 tablet used for?
This medicine is a combination of clonazepam and propranolol used for short-term treatment of anxiety disorders with prominent physical symptoms. It works by calming the brain and reducing the physical effects of adrenaline. It must be taken exactly as prescribed and should not be stopped suddenly.
- Generic Name: Clonazepam (0.5mg) + Propranolol (20mg)
- Manufacturer: Zenberg Pharmaceutical Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 neolol beta 20 tablet के बारे में (Hindi Summary)
उपयोग: यह दवा क्लोनाज़ेपम और प्रोप्रानोलोल का संयोजन है, जिसका उपयोग चिंता विकार, पैनिक अटैक और घबराहट के इलाज में किया जाता है। यह मस्तिष्क को शांत करने और दिल की धड़कन, कंपन और पसीने जैसे शारीरिक लक्षणों को कम करने में मदद करती है। इसका उपयोग केवल डॉक्टर की सलाह पर ही करें।
साइड इफेक्ट्स: आम दुष्प्रभावों में नींद आना, चक्कर आना, थकान, हाथ-पैर ठंडे होना और दिल की धड़कन धीमी होना शामिल है। गंभीर दुष्प्रभावों में बहुत धीमी धड़कन, बेहोशी, सांस लेने में कठिनाई और गंभीर त्वचा प्रतिक्रियाएं हो सकती हैं। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे अचानक बंद न करें, क्योंकि इससे दौरे या चिंता बढ़ सकती है। शराब का सेवन बिल्कुल न करें। गाड़ी चलाने या मशीन चलाने से बचें जब तक कि आपको पता न चल जाए कि यह दवा आप पर कैसा असर करती है। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें।
💊 neolol beta 20 tablet Uses & Benefits
[{"condition":"Anxiety disorders with prominent physical symptoms","description":"Used for short-term relief of anxiety when both psychological worry and physical symptoms such as palpitations, tremor, and sweating are present.","evidence":"Moderate"},{"condition":"Panic disorder","description":"May help reduce the frequency and intensity of panic attacks, especially when autonomic symptoms are prominent.","evidence":"Moderate"},{"condition":"Situational anxiety","description":"Sometimes prescribed for short-term use before stressful events such as public speaking or examinations, but only under medical supervision.","evidence":"Limited"},{"condition":"Performance anxiety with tremor","description":"Propranolol component may reduce tremor and palpitations, while clonazepam reduces anticipatory anxiety.","evidence":"Limited"}]
Off-label uses: [{"condition":"Essential tremor with anxiety","description":"Propranolol is used for essential tremor, and the combination may be used when anxiety coexists.","evidence":"Limited"},{"condition":"Akathisia","description":"Sometimes used off-label to manage medication-induced restlessness, but this requires specialist supervision.","evidence":"Limited"},{"condition":"Insomnia with anxiety","description":"May be used short-term for sleep disturbance related to anxiety, but not as a first-line treatment.","evidence":"Limited"}]
Primary treatment for: Anxiety disorders
Also treats: Panic disorder, Situational anxiety, Essential tremor with anxiety
📋 Drug Information
| Generic Name(s) | Clonazepam (0.5mg) + Propranolol (20mg) |
| Brand Name | neolol beta 20 tablet |
| Manufacturer | Zenberg Pharmaceutical Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C in a dry place. Protect from light and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with different but complementary mechanisms. Clonazepam enhances the inhibitory neurotransmitter gamma-aminobutyric acid at GABA-A receptors in the brain, which reduces neuronal excitability and produces anxiolytic, sedative, and anticonvulsant effects. Propranolol blocks beta-1 and beta-2 adrenergic receptors throughout the body, which reduces heart rate, blood pressure, and the physical manifestations of anxiety such as tremor, palpitations, and sweating. The combination addresses both the central emotional component and the peripheral physical symptoms of anxiety.
Mechanism Steps
💡 How to Take neolol beta 20 tablet
Strength: Each tablet contains Clonazepam 0.5 mg and Propranolol 20 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally once or twice daily, or as directed by your physician. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and response to treatment. Do not self-adjust the dose. The maximum daily dose should not exceed what is prescribed by your doctor. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients are more sensitive to the effects of both clonazepam and propranolol. Start with a lower dose and titrate slowly. Monitor for falls, confusion, and cardiac effects. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose adjustment may be required based on clinical response and renal function. Consult your doctor. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose reduction may be necessary. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose is determined by your physician based on your condition and response. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of neolol beta 20 tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Fluoxetine | Major | |
| Verapamil | Major | |
| Digoxin | Major | |
| Clonidine | Major | |
| Morphine | Moderate | |
| Ibuprofen | Moderate | |
| Antacids | Moderate | |
| Cimetidine | Minor | |
| Rifampicin | Minor |
🚨 Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine)
- Calcium channel blockers (e.g., verapamil, diltiazem)
- Digoxin
- Clonidine
⚡ Moderate Interactions
- Opioid analgesics
- Antihypertensives
- NSAIDs
- Antacids
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine. Alcohol enhances the sedative effects of clonazepam and can cause dangerous respiratory depression. It also adds to the blood pressure-lowering effect of propranolol, increasing the risk of dizziness, fainting, and falls.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe bradycardia","Second or third-degree heart block","Uncontrolled heart failure","Cardiogenic shock","Severe asthma or COPD","Acute narrow-angle glaucoma","Myasthenia gravis","Severe liver disease","Known hypersensitivity to benzodiazepines or beta-blockers","Pregnancy and breastfeeding unless specifically advised"]
⚠️ Warnings & Precautions
["May cause drowsiness and impair ability to drive or operate machinery.","Do not stop abruptly; taper gradually to avoid withdrawal seizures.","Avoid alcohol and other CNS depressants.","Use with caution in elderly patients due to increased risk of falls.","May mask symptoms of hypoglycemia in diabetics.","Can worsen respiratory conditions such as asthma.","May cause dependence and tolerance with long-term use.","Inform your doctor if you have kidney or liver disease."]
🤱 Lactation Safety
Clonazepam and propranolol are excreted in breast milk. Breastfeeding is not recommended while taking this medicine unless specifically advised by your doctor. Consult your doctor for guidance.
💊 Overdose Management
Overdose of this medicine can cause severe drowsiness, confusion, respiratory depression, bradycardia, hypotension, and coma. Seek emergency medical attention immediately. Treatment is supportive and may include activated charcoal, gastric lavage, intravenous fluids, and medications to support heart rate and blood pressure. Flumazenil may be used cautiously for benzodiazepine toxicity but can precipitate seizures in dependent patients.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not increase, decrease, or stop the dose on your own, because sudden withdrawal of clonazepam can cause seizures, anxiety rebound, or insomnia. Avoid alcohol completely while taking this medicine, as it can dangerously increase sedation and lower blood pressure. Do not drive or operate machinery until you know how this medicine affects you. Inform your doctor if you have asthma, diabetes, heart problems, liver disease, or kidney disease. Tell your doctor about all other medicines you take, especially blood pressure medicines, antidepressants, antipsychotics, and painkillers. If you are pregnant, planning pregnancy, or breastfeeding, speak to your doctor before using this medicine. Keep this medicine out of reach of children and store it in a cool, dry place away from direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the sedative and cardiac effects of this medicine. They are at higher risk of falls, confusion, and bradycardia. Lower doses are recommended, and close monitoring is required.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. Both clonazepam and propranolol may pose risks to the fetus. Your doctor may switch you to a safer alternative or adjust the dose.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with anesthetic agents and affect heart rate and blood pressure during surgery. Your doctor may advise temporary discontinuation or dose adjustment.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may interact with local anesthetics containing adrenaline and affect blood pressure and heart rate. Your dentist may take precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting until you know how this medicine affects you, as it can cause dizziness and low blood pressure. Light to moderate exercise like walking or yoga is generally safe. Stay hydrated.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and slow your reaction time, which may affect your ability to drive, operate machinery, or perform tasks requiring alertness. It is best to avoid these activities until you know how the medicine affects you. Discuss with your doctor if your work requires such activities.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Your doctor will gradually reduce the dose over time to prevent withdrawal symptoms. If you experience severe side effects, contact your doctor immediately for guidance.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to tolerance, dependence, and withdrawal symptoms. It may also cause cognitive impairment, memory problems, and increased risk of falls, especially in the elderly. Regular monitoring by a doctor is essential. The dose should be tapered gradually when discontinuing.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A first-line treatment for anxiety disorders that can be used alone or with medication.
Evidence: Well-establishedCan help reduce anxiety and improve emotional regulation.
Evidence: ModerateCan reduce anxiety symptoms and improve overall well-being.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are established from the available information. However, inform your doctor about this medicine before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. If traveling across time zones, adjust dosing times gradually under medical advice. Store it in a cool, dry place away from direct sunlight. Check customs regulations for controlled substances before international travel. Always carry enough supply for the entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 30 to 60 minutes after taking a dose. However, the full benefits for anxiety may take a few days to weeks of regular use.
A: No, you should never stop this medicine suddenly. It must be tapered gradually under medical supervision to avoid withdrawal symptoms and rebound anxiety.
A: Yes, the clonazepam component can cause dependence and tolerance with long-term use. It should be used for the shortest duration possible and under strict medical supervision.
A: You must inform your doctor about all other medicines you take, as this medicine can interact with many drugs, including blood pressure medicines, antidepressants, and painkillers.
🤔 Common Patient Concerns
🔄 Substitutes for neolol beta 20 tablet
View AllAlternative brands with exact same active ingredient:
-
lonafest p 0.5mg/20mg tabletArinna Lifescience Pvt Ltd ₹26.25 60% CHEAPER
-
closax 0.5mg/20mg tabletCortina Laboratories Pvt Ltd ₹32.81 50% CHEAPER
-
netril beta 0.5mg/20mg tabletNV Pharmaceuticals ₹32.81 50% CHEAPER
-
paxam forte 0.5mg/20mg tabletDefiner Pharmaceuticals Pvt Ltd ₹33.75 48.6% CHEAPER
-
bocker-c tabletPsychocare Health Pvt Ltd ₹35.63 45.7% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a permanent cure for anxiety.
Fact: This medicine provides symptomatic relief but is not a cure. It is usually used short-term along with other treatments. - Myth: It is safe to stop this medicine suddenly once you feel better.
Fact: Stopping suddenly can cause withdrawal symptoms and rebound anxiety. Always taper under medical supervision. - Myth: This medicine can be taken with alcohol to enhance relaxation.
Fact: Alcohol with this medicine can cause dangerous sedation and low blood pressure. It should be strictly avoided.
🔄 Alternative Options
Generic Alternatives
- Clonazepam 0.5 mg + Propranolol 20 mg tablet (generic)
Brand Alternatives
- Epitril-Beta 0.5 tablet