Nemoshid P 100mg/325mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Yellowing of the skin or eyes
- Dark urine or decreased urine output
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of the face, lips, or throat
- Unusual bruising or bleeding
- Severe skin rash or blistering
If experiencing severe symptoms, call emergency services immediately.
What is nemoshid p 100mg/325mg tablet used for?
This medicine is a combination of nimesulide and paracetamol used for short-term relief of acute pain and inflammation. It works by reducing pain and swelling. It should be taken with food and not for more than 5-7 days without medical advice.
- Generic Name: Information coming soon
- Manufacturer: Multiple manufacturers
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nemoshid p 100mg/325mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा निमेसुलाइड और पैरासिटामोल का संयोजन है, जिसका उपयोग अल्पकालिक दर्द और सूजन से राहत के लिए किया जाता है। यह मांसपेशियों के दर्द, दांत दर्द, सर्जरी के बाद के दर्द, और मासिक धर्म के दर्द में प्रभावी है। यह दवा सूजन और दर्द पैदा करने वाले रसायनों को कम करके काम करती है। इसे भोजन के साथ लेना चाहिए और डॉक्टर की सलाह के बिना 5-7 दिनों से अधिक नहीं लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त, चक्कर आना और सिरदर्द शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें पेट में रक्तस्राव, लिवर की क्षति, गुर्दे की समस्या और गंभीर एलर्जी प्रतिक्रिया शामिल हो सकती है। यदि आपको काला मल, खून की उल्टी, आंखों या त्वचा का पीलापन, गंभीर पेट दर्द, या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। अनुशंसित खुराक से अधिक न लें। इसे भोजन या दूध के साथ लें ताकि पेट की जलन कम हो। इस दवा के साथ शराब न पिएं क्योंकि इससे पेट में रक्तस्राव और लिवर की समस्या का खतरा बढ़ सकता है। यदि आपको पेट के अल्सर, लिवर रोग, गुर्दे की बीमारी, हृदय रोग या अस्थमा है, तो डॉक्टर को बताएं। बिना डॉक्टर की सलाह के 5-7 दिनों से अधिक इसका उपयोग न करें।
💊 nemoshid p 100mg/325mg tablet Uses & Benefits
[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in muscles, joints, and soft tissues, such as back pain, sprains, and strains.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides short-term relief from toothache and pain after dental procedures.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of mild to moderate pain after surgery.","evidence":"Moderate"},{"condition":"Primary dysmenorrhea","description":"Helps relieve menstrual cramps and associated pain.","evidence":"Moderate"},{"condition":"Osteoarthritis flare-up","description":"Short-term relief of pain and stiffness during acute flare-ups of osteoarthritis.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks, but evidence is limited.","evidence":"Limited"},{"condition":"Fever","description":"May be used off-label for fever when other options are not suitable, but not a primary use.","evidence":"Limited"}]
Primary treatment for: Acute pain and inflammation
Also treats: Musculoskeletal pain, Dental pain, Post-operative pain, Dysmenorrhea, Osteoarthritis flare-up
📋 Drug Information
| Generic Name(s) | Information coming soon |
| Brand Name | nemoshid p 100mg/325mg tablet |
| Manufacturer | Multiple manufacturers |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture, heat, and direct sunlight. Do not refrigerate unless specified. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with different but complementary mechanisms. Nimesulide is a non-steroidal anti-inflammatory drug that selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, reducing the production of prostaglandins, which are chemicals that cause pain, inflammation, and fever. Paracetamol works primarily in the central nervous system by inhibiting prostaglandin synthesis and possibly activating descending pain pathways, providing analgesic and antipyretic effects. Together, they reduce pain and inflammation more effectively than either alone.
Mechanism Steps
💡 How to Take nemoshid p 100mg/325mg tablet
Strength: Each tablet contains nimesulide 100 mg and paracetamol 325 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally every 8 to 12 hours as needed for pain, not exceeding three tablets in 24 hours. The maximum duration of use is typically 5 to 7 days. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the side effects of this medicine, especially gastrointestinal bleeding and kidney problems. Use the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician based on renal and hepatic function. |
| Renal Impairment | Use with caution in patients with kidney disease. Dose reduction may be necessary. This medicine is contraindicated in severe kidney disease (creatinine clearance <30 mL/min). Consult a doctor for dose adjustment. |
| Hepatic Impairment | Use with caution in patients with liver disease. Dose reduction may be necessary. This medicine is contraindicated in severe liver disease. Consult a doctor for dose adjustment. |
| Maximum Daily Dose | The maximum daily dose is 3 tablets (300 mg nimesulide and 975 mg paracetamol) in 24 hours. Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nemoshid p 100mg/325mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Methotrexate | Major | |
| ACE inhibitors/ARBs | Major | |
| Diuretics | Major | |
| Corticosteroids | Moderate | |
| SSRIs | Moderate | |
| Lithium | Moderate | |
| Phenytoin | Moderate | |
| Carbamazepine | Moderate |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., ibuprofen, diclofenac)
- Methotrexate
- ACE inhibitors and angiotensin receptor blockers (ARBs)
- Diuretics (e.g., furosemide, hydrochlorothiazide)
⚡ Moderate Interactions
- Corticosteroids
- Selective serotonin reuptake inhibitors (SSRIs)
- Lithium
- Phenytoin
- Carbamazepine
🍷 Alcohol Interaction
Avoid drinking alcohol while taking this medicine. Alcohol increases the risk of stomach bleeding, ulcers, and liver damage, especially when combined with paracetamol and nimesulide.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to nimesulide, paracetamol, or other NSAIDs","Active or history of peptic ulcer or gastrointestinal bleeding","Severe liver disease or active liver disease","Severe kidney disease (e.g., creatinine clearance
⚠️ Warnings & Precautions
["Use the lowest effective dose for the shortest possible duration.","Avoid alcohol while taking this medicine.","Do not take other paracetamol-containing products to avoid overdose.","Use with caution in elderly patients, who are at higher risk of side effects.","Monitor for signs of gastrointestinal bleeding, especially if you have a history of ulcers.","Consult your doctor before use if you have liver or kidney disease, heart disease, or asthma.","Do not use for more than 5-7 days without medical advice.","Stop the medicine and seek medical help if you develop yellowing of the eyes or skin, dark urine, or severe abdominal pain."]
🤱 Lactation Safety
Nimesulide and paracetamol are excreted in breast milk in small amounts. This medicine is not recommended during breastfeeding unless the potential benefit outweighs the risk. Consult your doctor before use.
💊 Overdose Management
Overdose of this medicine can cause severe liver damage, especially due to paracetamol. Symptoms of overdose may include nausea, vomiting, abdominal pain, confusion, and yellowing of the skin or eyes. If you suspect an overdose, seek immediate medical attention. Treatment may include activated charcoal, N-acetylcysteine (for paracetamol toxicity), and supportive care. Do not wait for symptoms to appear.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Take it with food or milk to reduce stomach upset. Avoid drinking alcohol while taking this medicine because it can increase the risk of stomach bleeding and liver problems. Do not take other medicines containing paracetamol or other NSAIDs without consulting your doctor. Inform your doctor if you have a history of stomach ulcers, liver disease, kidney disease, heart disease, or asthma. Do not use this medicine for more than 5 to 7 days unless your doctor advises otherwise. Keep out of reach of children. Store at room temperature away from moisture and direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney problems, and liver toxicity from this medicine. Use the lowest effective dose for the shortest duration and monitor closely for side effects.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. It is not recommended during pregnancy, especially in the third trimester, due to the risk of premature closure of the ductus arteriosus.
🏥 Post-Surgery Considerations
This medicine may be used for short-term pain relief after surgery, but it should be used with caution due to the risk of bleeding and kidney problems. Follow your surgeon's instructions carefully.
🦷 Dental Procedures
This medicine can be used for pain relief after dental procedures, but inform your dentist about all medicines you are taking. Avoid taking it before dental surgery if you have a history of bleeding disorders.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you can continue with your regular exercise routine, but avoid strenuous activities that may worsen your pain. If you experience dizziness, avoid activities that require balance or coordination.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is usually safe to continue your daily activities, but listen to your body and rest if needed.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your pain does not improve within 5 to 7 days, if it worsens, or if you experience any serious side effects such as stomach bleeding, yellowing of the eyes, or severe allergic reactions. Do not stop abruptly if you have been taking it for a long time without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended due to the risk of serious side effects, including liver damage, kidney impairment, gastrointestinal bleeding, and cardiovascular events. If long-term pain management is needed, your doctor may prescribe safer alternatives and monitor your liver and kidney function regularly.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve mobility.
Evidence: Well-establishedApplying heat or cold packs can help reduce pain and inflammation.
Evidence: ModerateMay provide pain relief for some individuals.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from moisture and direct sunlight. If you are crossing time zones, continue taking it as prescribed, but do not exceed the maximum daily dose. Check the customs regulations of your destination country regarding prescription medicines. Always carry enough supply for your trip and keep it in your carry-on luggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 30 to 60 minutes after taking it.
A: It is intended for short-term use only, typically not more than 5 to 7 days, unless your doctor advises otherwise.
A: Yes, it should be taken with food or milk to reduce stomach upset.
A: No, alcohol should be avoided as it increases the risk of stomach bleeding and liver damage.
A: This medicine is not recommended during pregnancy, especially in the third trimester. Consult your doctor for safer alternatives.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine is safe for long-term use.
Fact: This medicine is intended for short-term use only. Long-term use increases the risk of liver, kidney, and stomach problems. - Myth: It is safe to take this medicine with other pain relievers.
Fact: Taking this medicine with other NSAIDs or paracetamol-containing products can increase the risk of side effects. Always consult your doctor. - Myth: This medicine can be taken on an empty stomach.
Fact: It should be taken with food or milk to reduce stomach upset.
🔄 Alternative Options
Generic Alternatives
- Nimesulide + Paracetamol 100 mg/325 mg tablet
Brand Alternatives
- Nemoshid P 100mg/325mg tablet