nefspas 10mg/250mg tablet - Information coming soon medicine

Nefspas 10mg/250mg Tablet: Complete Medicine Guide

No reviews yet
Information coming soon
🏭 Generic 📦 Varies by brand 💊 Allopathy 📅 Updated: Nov 1, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
12 min read
Evidence: Moderate for short-term use in acute pain; limited for long-term use due to safety concerns.
Reviewed by
SaathiMed Expert Panel | Nov 01, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Yellowing of skin or eyes (jaundice)
  • Dark urine or pale stools
  • Severe abdominal pain or vomiting blood
  • Black, tarry stools
  • Swelling of face, lips, or throat
  • Difficulty breathing or severe rash
  • Decreased urine output or swelling in legs
  • Unusual bleeding or bruising
  • Persistent fever or pain worsening despite treatment

If experiencing severe symptoms, call emergency services immediately.

What is nefspas 10mg/250mg tablet used for?

This medicine is a combination of nimesulide and paracetamol used for short-term relief of acute pain, inflammation, and fever. It should not be used for more than 5-7 days without medical advice.

  • Generic Name: Information coming soon
  • Manufacturer: Multiple manufacturers
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 nefspas 10mg/250mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा नाइमेसुलाइड और पैरासिटामोल का संयोजन है, जिसका उपयोग दर्द, सूजन और बुखार के अल्पकालिक उपचार के लिए किया जाता है। यह मांसपेशियों के दर्द, दांत दर्द, सर्जरी के बाद के दर्द और मासिक धर्म के दर्द में राहत देती है। इसे 5-7 दिनों से अधिक नहीं लेना चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त, चक्कर आना और सिरदर्द शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इसमें लिवर की क्षति, पेट में रक्तस्राव, और एलर्जी प्रतिक्रियाएं हो सकती हैं। यदि आपको पीलिया, काला मल, या सांस लेने में कठिनाई हो तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को हमेशा डॉक्टर के निर्देशानुसार ही लें। इसे भोजन के साथ लें ताकि पेट की परेशानी कम हो। शराब का सेवन न करें। अन्य दर्द निवारक दवाओं के साथ इसका सेवन न करें। यदि आप गर्भवती हैं या स्तनपान करा रही हैं तो डॉक्टर से सलाह लें। 5-7 दिनों से अधिक इसका उपयोग न करें।

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 nefspas 10mg/250mg tablet Uses & Benefits

[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in conditions such as sprains, strains, and low back pain.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides short-term relief from toothache and post-dental procedure pain.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of mild to moderate pain after surgery.","evidence":"Moderate"},{"condition":"Fever","description":"Reduces fever due to its paracetamol component, though nimesulide also has antipyretic effects.","evidence":"Well-established"},{"condition":"Primary dysmenorrhea","description":"Relieves menstrual cramps and associated pain.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Osteoarthritis flare-up","description":"Sometimes used for short-term relief of osteoarthritis pain, but not for long-term management due to safety concerns.","evidence":"Limited"},{"condition":"Acute gouty arthritis","description":"May be used for short-term pain relief during acute gout attacks, but other treatments are preferred.","evidence":"Limited"}]

Primary treatment for: Acute pain and inflammation

Also treats: Fever, Dental pain, Musculoskeletal pain, Post-operative pain, Dysmenorrhea

📋 Drug Information

Generic Name(s)Information coming soon
Brand Namenefspas 10mg/250mg tablet
ManufacturerMultiple manufacturers
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always prescribe this medicine for the shortest duration possible, not exceeding 5-7 days.
2
Advise patients to take it with food to minimize gastrointestinal side effects.
3
Warn patients about the risk of liver toxicity and advise them to report symptoms like jaundice or dark urine immediately.
4
Avoid concomitant use with other NSAIDs or paracetamol-containing products.
5
Monitor liver function tests if treatment is extended beyond a few days.
6
Caution patients about driving or operating machinery if they experience dizziness.
7
Consider alternative analgesics in elderly patients or those with liver/kidney disease.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Acute musculoskeletal pain
This medicine is commonly prescribed for this.
Likely Use
✅
Dental pain
This medicine can provide short-term relief.
Likely Use
✅
Fever
This medicine has antipyretic effects.
Likely Use
❌
Chronic pain
This medicine is not for long-term use.
Not Primary
❌
Headache
This medicine is not a primary headache treatment.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionNimesulide is rapidly absorbed from the gastrointestinal tract after oral administration, with peak plasma concentrations reached in 1.5 to 3 hours. Paracetamol is also rapidly and completely absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 0.5 to 2 hours. Food may slightly delay the absorption of both components but does not significantly affect the extent of absorption.
DistributionNimesulide is highly bound to plasma proteins and is widely distributed to tissues, including synovial fluid. Paracetamol is distributed throughout most body tissues, with a volume of distribution of approximately 0.9 L/kg. Both drugs cross the placenta and are excreted in breast milk.
Protein BindingNimesulide is approximately 99% bound to plasma proteins, primarily albumin. Paracetamol is only about 10-25% bound to plasma proteins.
MetabolismNimesulide is extensively metabolized in the liver, primarily by cytochrome P450 2C9 (CYP2C9) to its major metabolite, 4-hydroxynimesulide, which is pharmacologically inactive. Paracetamol is metabolized in the liver via glucuronidation and sulfation, and a small fraction is oxidized by CYP2E1 to a toxic metabolite, N-acetyl-p-benzoquinone imine (NAPQI), which is normally detoxified by glutathione.
Half-LifeThe elimination half-life of nimesulide is approximately 1.8 to 4.7 hours. The elimination half-life of paracetamol is about 2 to 3 hours in adults with normal liver function.
ExcretionNimesulide and its metabolites are excreted primarily in the urine (about 70%) and feces (about 20%). Paracetamol is excreted in the urine mainly as glucuronide and sulfate conjugates, with less than 5% excreted unchanged.
BioavailabilityThe oral bioavailability of nimesulide is approximately 80-90%. Paracetamol has an oral bioavailability of about 80-100%.
Onset of ActionThe onset of analgesic and antipyretic effects is typically within 30 to 60 minutes after oral administration.
Peak Plasma TimePeak plasma concentrations are reached in about 1.5 to 3 hours for nimesulide and 0.5 to 2 hours for paracetamol.
Duration of ActionThe duration of pain relief and fever reduction is approximately 4 to 6 hours, and dosing is usually repeated every 6 to 8 hours as needed.

How It Works

This medicine combines two active ingredients with complementary mechanisms. Nimesulide is a non-steroidal anti-inflammatory drug that selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, leading to decreased production of prostaglandins, which are mediators of inflammation, pain, and fever. Paracetamol (acetaminophen) acts primarily in the central nervous system, where it inhibits prostaglandin synthesis and modulates pain perception, and also acts on the hypothalamus to reduce fever. The combination provides both peripheral anti-inflammatory and central analgesic/antipyretic effects.

Mechanism Steps

1
COX-2 inhibition by nimesulide: Nimesulide selectively binds to and inhibits the COX-2 enzyme, reducing the conversion of arachidonic acid to prostaglandin H2.
2
Reduced prostaglandin synthesis: Decreased prostaglandin production leads to less inflammation, pain, and fever at peripheral sites.
3
Central action of paracetamol: Paracetamol acts on the central nervous system to inhibit prostaglandin synthesis and modulate pain pathways, and it also acts on the hypothalamus to reduce fever.
4
Combined analgesic and antipyretic effect: The two mechanisms together provide enhanced pain relief and fever reduction compared to either agent alone.

💡 How to Take nefspas 10mg/250mg tablet

Strength: Each tablet contains nimesulide 100 mg and paracetamol 325 mg.

1Take this medicine orally with a full glass of water.
2Take it with food or milk to reduce stomach upset.
3Swallow the tablet whole; do not crush or chew.
4Do not take more than the prescribed dose.
5Follow the dosing schedule as directed by your doctor.

Dosage Information

Adult DosageThe usual adult dose is one tablet (nimesulide 100 mg + paracetamol 325 mg) taken orally every 8 to 12 hours as needed for pain and fever, not exceeding 3 tablets in 24 hours. The maximum duration of treatment should not exceed 5 to 7 days. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients (above 65 years) may be more susceptible to the side effects of this medicine, especially gastrointestinal bleeding, kidney impairment, and liver toxicity. Use with caution, at the lowest effective dose, and for the shortest duration. Monitor renal and hepatic function closely.
Renal ImpairmentUse with caution in patients with mild to moderate renal impairment. In severe renal impairment (eGFR <30 mL/min), this medicine is contraindicated. Dose adjustment may be required; consult a clinician.
Hepatic ImpairmentUse with caution in patients with mild to moderate hepatic impairment. In severe hepatic impairment, this medicine is contraindicated. Dose reduction and close monitoring of liver function are advised.
Maximum Daily DoseMaximum daily dose is 3 tablets (nimesulide 300 mg + paracetamol 975 mg) in 24 hours. Do not exceed the recommended dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset and nausea.
Alcohol
Avoid
Increases risk of liver damage and gastrointestinal bleeding.
Caffeine
Moderate intake
May enhance pain relief but can increase stomach irritation.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of nefspas 10mg/250mg tablet

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food to reduce nausea. If it persists, consult your doctor.
Stomach pain (Common (5-10%))
Take with food or milk. Avoid alcohol. If pain is severe or persistent, seek medical advice.
Heartburn (Common (5-10%))
Take with food. Avoid lying down immediately after taking. Consult doctor if it continues.
Dizziness (Uncommon (1-5%))
Avoid driving or operating machinery until you know how it affects you. Consult doctor if it persists.
Headache (Uncommon (1-5%))
Usually resolves on its own. If severe or persistent, consult your doctor.

🚨 Serious Side Effects

Hepatotoxicity (liver injury) (Rare (<0.1%))
Seek immediate medical attention if you notice yellowing of skin or eyes, dark urine, or unexplained fatigue.
Gastrointestinal bleeding (Rare (<0.1%))
Seek immediate medical attention if you notice black or tarry stools, vomiting blood, or severe abdominal pain.
Severe allergic reaction (anaphylaxis) (Very rare (<0.01%))
Call emergency services immediately if you experience swelling of face, lips, or throat, difficulty breathing, or severe rash.
Acute kidney injury (Rare (<0.1%))
Seek medical attention if you notice decreased urine output, swelling in legs, or unexplained weight gain.
Severe skin reactions (Stevens-Johnson syndrome) (Very rare (<0.01%))
Stop the medicine and seek immediate medical help if you develop a painful rash with blisters or peeling skin.

⚠️ Rare Side Effects

Blood disorders (e.g., thrombocytopenia, anemia)
Report unusual bruising or bleeding to your doctor immediately.
Pancreatitis
Seek medical attention if you experience severe upper abdominal pain radiating to the back.
Aseptic meningitis
Seek immediate medical help if you develop severe headache, stiff neck, and fever.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Other NSAIDs Major
Corticosteroids Major
Methotrexate Major
ACE inhibitors/ARBs Moderate
Diuretics Moderate
Lithium Moderate
SSRIs Moderate
Antidiabetics Moderate
Antacids Minor

🚨 Major Interactions

  • Warfarin
  • Other NSAIDs (e.g., ibuprofen, diclofenac)
  • Corticosteroids
  • Methotrexate
  • ACE inhibitors and ARBs

⚡ Moderate Interactions

  • Diuretics (e.g., furosemide)
  • Lithium
  • SSRIs
  • Antidiabetics (sulfonylureas)

🍷 Alcohol Interaction

Avoid consuming alcohol while taking this medicine. Alcohol increases the risk of liver damage, especially with paracetamol, and can worsen gastrointestinal irritation and bleeding caused by nimesulide.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to nimesulide, paracetamol, or any component of the formulation.","Active peptic ulcer or history of recurrent peptic ulcers.","Severe liver impairment or active liver disease.","Severe kidney impairment (eGFR

⚠️ Warnings & Precautions

["Use the lowest effective dose for the shortest possible duration, not exceeding 5-7 days.","Avoid concomitant use with other NSAIDs or paracetamol-containing products.","Caution in patients with a history of gastrointestinal bleeding or ulcers.","Caution in patients with cardiovascular risk factors.","Monitor liver function during treatment, especially if used for more than a few days.","Avoid alcohol consumption.","Not recommended for patients with severe dehydration or hypovolemia.","May impair ability to drive or operate machinery; caution advised."]

🤱 Lactation Safety

This medicine is not recommended during breastfeeding as both nimesulide and paracetamol are excreted in breast milk. Consult your doctor for alternative treatments.

💊 Overdose Management

Overdose of this medicine can cause severe liver damage, especially due to paracetamol. Symptoms of overdose may include nausea, vomiting, abdominal pain, confusion, and jaundice. If overdose is suspected, seek immediate medical attention. Treatment may include activated charcoal, N-acetylcysteine for paracetamol toxicity, and supportive care. There is no specific antidote for nimesulide; management is symptomatic and supportive.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Always take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Take it with food or milk to reduce the risk of stomach upset. Avoid drinking alcohol while taking this medicine, as it can increase the risk of liver damage and gastrointestinal bleeding. Do not take other medicines containing paracetamol or other NSAIDs without consulting your doctor, as this can lead to overdose or increased side effects. Inform your doctor if you have a history of liver disease, kidney disease, stomach ulcers, or bleeding disorders. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before taking this medicine. Do not use this medicine for more than 5 to 7 days unless directed by a doctor. If your pain or fever does not improve or worsens, seek medical advice. Keep this medicine out of reach of children. Store it in a cool, dry place away from direct sunlight.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and liver toxicity from this medicine. Use with caution, at the lowest effective dose, and for the shortest duration. Regular monitoring of renal and hepatic function is advised.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. It is not recommended during pregnancy, especially in the third trimester, due to potential risks to the fetus. Discuss safer alternatives for pain relief.

🏥 Post-Surgery Considerations

This medicine may be used for short-term post-operative pain relief, but it should be used with caution due to the risk of bleeding and kidney impairment. Follow your surgeon's instructions and do not exceed the recommended dose or duration.

🦷 Dental Procedures

This medicine can be used for short-term relief of dental pain, including after dental procedures. However, inform your dentist if you are taking this medicine, as it may increase bleeding risk during dental surgery. Do not take it for more than 5-7 days without consulting your dentist.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce stress on joints and muscles.
🥗
Engage in regular low-impact exercises like walking or swimming.
😴
Practice good posture to prevent musculoskeletal pain.
💧
Include anti-inflammatory foods in your diet, such as fruits and vegetables.
🧘
Get adequate sleep to promote healing and pain relief.
🌞
Stay well hydrated throughout the day.
🚭
Avoid smoking and limit alcohol consumption.

🏋️ Exercise Considerations

While taking this medicine, you may experience dizziness or drowsiness. Avoid strenuous exercise or activities that require alertness until you know how the medicine affects you. If you have pain, gentle stretching and low-impact exercises may be beneficial, but consult your doctor before starting any new exercise routine.

🥗 Diet Recommendations

Include omega-3 rich foods like fish, flaxseeds, and walnuts.
Reduce intake of processed and fried foods.
Eat plenty of fruits and vegetables rich in antioxidants.
Stay well hydrated by drinking plenty of water.
Avoid alcohol and excessive caffeine.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue desk work, but take regular breaks and maintain good posture. If your job involves physical labor, consult your doctor about modifications.

🛑 When to Stop This Medicine

Stop taking this medicine if you experience any signs of liver problems (yellowing of eyes or skin, dark urine, fatigue), severe stomach pain, black stools, or allergic reactions. Do not stop abruptly if you are on a prescribed course without consulting your doctor. If your pain or fever persists beyond 5-7 days, consult your doctor before continuing.

📅 Long-Term Use Effects

Long-term use of this medicine is not recommended due to the risk of serious liver injury, kidney damage, and gastrointestinal bleeding. If prolonged use is necessary, regular monitoring of liver and kidney function is essential. Patients should be reviewed periodically to assess the need for continued treatment.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can help manage musculoskeletal pain and improve mobility.

Evidence: Well-established
Hot/cold therapy

Applying heat or cold packs can reduce pain and inflammation.

Evidence: Moderate
Acupuncture

May provide pain relief for some individuals.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, if you have a fever, consult your doctor before receiving any vaccination.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from extreme heat or moisture. If crossing time zones, continue your dosing schedule as prescribed, but do not exceed the maximum daily dose. Check customs regulations for carrying prescription medicines in your destination country.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old man with acute low back pain
He was prescribed this medicine for 5 days. He took it with food as advised and experienced significant pain relief within 2 days. He was cautioned not to take it longer than prescribed and to avoid alcohol. He recovered fully without side effects.
💡 Lesson: Short-term use with food and adherence to prescribed duration ensures safety and efficacy.
👤 A 50-year-old woman with dental pain
She took this medicine for a toothache but continued it for 10 days without consulting a doctor. She developed nausea and fatigue, and blood tests revealed elevated liver enzymes. She was advised to stop the medicine immediately and recovered with supportive care.
💡 Lesson: Prolonged use beyond the recommended duration can lead to serious liver toxicity. Always follow the prescribed duration.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts relieving pain and fever within 30 to 60 minutes after taking it.

Q: How long can I take this medicine?

A: It should not be taken for more than 5 to 7 days without medical advice due to the risk of liver and kidney damage.

Q: Can I take this medicine on an empty stomach?

A: It is best taken with food or milk to reduce the risk of stomach upset.

Q: Is this medicine safe during pregnancy?

A: It is not recommended during pregnancy, especially in the third trimester. Consult your doctor for safer alternatives.

Q: Can I drink alcohol while taking this medicine?

A: No, alcohol should be avoided as it increases the risk of liver damage and gastrointestinal bleeding.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?
  • Is it safe for my liver?
  • Can I take it with other painkillers?

🛑 Myths vs. Facts

  • Myth: This medicine is safe for long-term use.
    Fact: This medicine is only for short-term use (up to 5-7 days) due to the risk of liver and kidney damage.
  • Myth: This medicine can be taken on an empty stomach.
    Fact: It should be taken with food to reduce the risk of stomach upset and bleeding.
  • Myth: This medicine is safe for children.
    Fact: It is not recommended for children under 12 years of age.
  • Myth: This medicine can be combined with other painkillers.
    Fact: Combining with other NSAIDs or paracetamol can increase the risk of side effects.

🔄 Alternative Options

Generic Alternatives

  • Nimesulide + Paracetamol (generic)

Brand Alternatives

  • Nefspas 10mg/250mg Tablet

📊 Comparison with Similar Medicines

[{"medicine":"Nimesulide + Paracetamol","class":"NSAID + Analgesic","uses":"Acute pain, fever","duration":"Short-term (5-7 days)","liver_risk":"High"},{"medicine":"Ibuprofen + Paracetamol","class":"NSAID + Analgesic","uses":"Pain, fever, inflammation","duration":"Short-term","liver_risk":"Moderate"},{"medicine":"Diclofenac + Paracetamol","class":"NSAID + Analgesic","uses":"Pain, inflammation","duration":"Short-term","liver_risk":"Moderate"}]

😊 Was this information helpful?

Browse Medicines A-Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Back to Medicines Directory