Nefspas 10mg/250mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Yellowing of skin or eyes (jaundice)
- Dark urine or pale stools
- Severe abdominal pain or vomiting blood
- Black, tarry stools
- Swelling of face, lips, or throat
- Difficulty breathing or severe rash
- Decreased urine output or swelling in legs
- Unusual bleeding or bruising
- Persistent fever or pain worsening despite treatment
If experiencing severe symptoms, call emergency services immediately.
What is nefspas 10mg/250mg tablet used for?
This medicine is a combination of nimesulide and paracetamol used for short-term relief of acute pain, inflammation, and fever. It should not be used for more than 5-7 days without medical advice.
- Generic Name: Information coming soon
- Manufacturer: Multiple manufacturers
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nefspas 10mg/250mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा नाइमेसुलाइड और पैरासिटामोल का संयोजन है, जिसका उपयोग दर्द, सूजन और बुखार के अल्पकालिक उपचार के लिए किया जाता है। यह मांसपेशियों के दर्द, दांत दर्द, सर्जरी के बाद के दर्द और मासिक धर्म के दर्द में राहत देती है। इसे 5-7 दिनों से अधिक नहीं लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त, चक्कर आना और सिरदर्द शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इसमें लिवर की क्षति, पेट में रक्तस्राव, और एलर्जी प्रतिक्रियाएं हो सकती हैं। यदि आपको पीलिया, काला मल, या सांस लेने में कठिनाई हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को हमेशा डॉक्टर के निर्देशानुसार ही लें। इसे भोजन के साथ लें ताकि पेट की परेशानी कम हो। शराब का सेवन न करें। अन्य दर्द निवारक दवाओं के साथ इसका सेवन न करें। यदि आप गर्भवती हैं या स्तनपान करा रही हैं तो डॉक्टर से सलाह लें। 5-7 दिनों से अधिक इसका उपयोग न करें।
💊 nefspas 10mg/250mg tablet Uses & Benefits
[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in conditions such as sprains, strains, and low back pain.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides short-term relief from toothache and post-dental procedure pain.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of mild to moderate pain after surgery.","evidence":"Moderate"},{"condition":"Fever","description":"Reduces fever due to its paracetamol component, though nimesulide also has antipyretic effects.","evidence":"Well-established"},{"condition":"Primary dysmenorrhea","description":"Relieves menstrual cramps and associated pain.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Osteoarthritis flare-up","description":"Sometimes used for short-term relief of osteoarthritis pain, but not for long-term management due to safety concerns.","evidence":"Limited"},{"condition":"Acute gouty arthritis","description":"May be used for short-term pain relief during acute gout attacks, but other treatments are preferred.","evidence":"Limited"}]
Primary treatment for: Acute pain and inflammation
Also treats: Fever, Dental pain, Musculoskeletal pain, Post-operative pain, Dysmenorrhea
📋 Drug Information
| Generic Name(s) | Information coming soon |
| Brand Name | nefspas 10mg/250mg tablet |
| Manufacturer | Multiple manufacturers |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Nimesulide is a non-steroidal anti-inflammatory drug that selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, leading to decreased production of prostaglandins, which are mediators of inflammation, pain, and fever. Paracetamol (acetaminophen) acts primarily in the central nervous system, where it inhibits prostaglandin synthesis and modulates pain perception, and also acts on the hypothalamus to reduce fever. The combination provides both peripheral anti-inflammatory and central analgesic/antipyretic effects.
Mechanism Steps
💡 How to Take nefspas 10mg/250mg tablet
Strength: Each tablet contains nimesulide 100 mg and paracetamol 325 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet (nimesulide 100 mg + paracetamol 325 mg) taken orally every 8 to 12 hours as needed for pain and fever, not exceeding 3 tablets in 24 hours. The maximum duration of treatment should not exceed 5 to 7 days. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) may be more susceptible to the side effects of this medicine, especially gastrointestinal bleeding, kidney impairment, and liver toxicity. Use with caution, at the lowest effective dose, and for the shortest duration. Monitor renal and hepatic function closely. |
| Renal Impairment | Use with caution in patients with mild to moderate renal impairment. In severe renal impairment (eGFR <30 mL/min), this medicine is contraindicated. Dose adjustment may be required; consult a clinician. |
| Hepatic Impairment | Use with caution in patients with mild to moderate hepatic impairment. In severe hepatic impairment, this medicine is contraindicated. Dose reduction and close monitoring of liver function are advised. |
| Maximum Daily Dose | Maximum daily dose is 3 tablets (nimesulide 300 mg + paracetamol 975 mg) in 24 hours. Do not exceed the recommended dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nefspas 10mg/250mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Corticosteroids | Major | |
| Methotrexate | Major | |
| ACE inhibitors/ARBs | Moderate | |
| Diuretics | Moderate | |
| Lithium | Moderate | |
| SSRIs | Moderate | |
| Antidiabetics | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., ibuprofen, diclofenac)
- Corticosteroids
- Methotrexate
- ACE inhibitors and ARBs
⚡ Moderate Interactions
- Diuretics (e.g., furosemide)
- Lithium
- SSRIs
- Antidiabetics (sulfonylureas)
🍷 Alcohol Interaction
Avoid consuming alcohol while taking this medicine. Alcohol increases the risk of liver damage, especially with paracetamol, and can worsen gastrointestinal irritation and bleeding caused by nimesulide.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to nimesulide, paracetamol, or any component of the formulation.","Active peptic ulcer or history of recurrent peptic ulcers.","Severe liver impairment or active liver disease.","Severe kidney impairment (eGFR
⚠️ Warnings & Precautions
["Use the lowest effective dose for the shortest possible duration, not exceeding 5-7 days.","Avoid concomitant use with other NSAIDs or paracetamol-containing products.","Caution in patients with a history of gastrointestinal bleeding or ulcers.","Caution in patients with cardiovascular risk factors.","Monitor liver function during treatment, especially if used for more than a few days.","Avoid alcohol consumption.","Not recommended for patients with severe dehydration or hypovolemia.","May impair ability to drive or operate machinery; caution advised."]
🤱 Lactation Safety
This medicine is not recommended during breastfeeding as both nimesulide and paracetamol are excreted in breast milk. Consult your doctor for alternative treatments.
💊 Overdose Management
Overdose of this medicine can cause severe liver damage, especially due to paracetamol. Symptoms of overdose may include nausea, vomiting, abdominal pain, confusion, and jaundice. If overdose is suspected, seek immediate medical attention. Treatment may include activated charcoal, N-acetylcysteine for paracetamol toxicity, and supportive care. There is no specific antidote for nimesulide; management is symptomatic and supportive.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Take it with food or milk to reduce the risk of stomach upset. Avoid drinking alcohol while taking this medicine, as it can increase the risk of liver damage and gastrointestinal bleeding. Do not take other medicines containing paracetamol or other NSAIDs without consulting your doctor, as this can lead to overdose or increased side effects. Inform your doctor if you have a history of liver disease, kidney disease, stomach ulcers, or bleeding disorders. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before taking this medicine. Do not use this medicine for more than 5 to 7 days unless directed by a doctor. If your pain or fever does not improve or worsens, seek medical advice. Keep this medicine out of reach of children. Store it in a cool, dry place away from direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and liver toxicity from this medicine. Use with caution, at the lowest effective dose, and for the shortest duration. Regular monitoring of renal and hepatic function is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. It is not recommended during pregnancy, especially in the third trimester, due to potential risks to the fetus. Discuss safer alternatives for pain relief.
🏥 Post-Surgery Considerations
This medicine may be used for short-term post-operative pain relief, but it should be used with caution due to the risk of bleeding and kidney impairment. Follow your surgeon's instructions and do not exceed the recommended dose or duration.
🦷 Dental Procedures
This medicine can be used for short-term relief of dental pain, including after dental procedures. However, inform your dentist if you are taking this medicine, as it may increase bleeding risk during dental surgery. Do not take it for more than 5-7 days without consulting your dentist.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may experience dizziness or drowsiness. Avoid strenuous exercise or activities that require alertness until you know how the medicine affects you. If you have pain, gentle stretching and low-impact exercises may be beneficial, but consult your doctor before starting any new exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue desk work, but take regular breaks and maintain good posture. If your job involves physical labor, consult your doctor about modifications.
🛑 When to Stop This Medicine
Stop taking this medicine if you experience any signs of liver problems (yellowing of eyes or skin, dark urine, fatigue), severe stomach pain, black stools, or allergic reactions. Do not stop abruptly if you are on a prescribed course without consulting your doctor. If your pain or fever persists beyond 5-7 days, consult your doctor before continuing.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended due to the risk of serious liver injury, kidney damage, and gastrointestinal bleeding. If prolonged use is necessary, regular monitoring of liver and kidney function is essential. Patients should be reviewed periodically to assess the need for continued treatment.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help manage musculoskeletal pain and improve mobility.
Evidence: Well-establishedApplying heat or cold packs can reduce pain and inflammation.
Evidence: ModerateMay provide pain relief for some individuals.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you have a fever, consult your doctor before receiving any vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from extreme heat or moisture. If crossing time zones, continue your dosing schedule as prescribed, but do not exceed the maximum daily dose. Check customs regulations for carrying prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain and fever within 30 to 60 minutes after taking it.
A: It should not be taken for more than 5 to 7 days without medical advice due to the risk of liver and kidney damage.
A: It is best taken with food or milk to reduce the risk of stomach upset.
A: It is not recommended during pregnancy, especially in the third trimester. Consult your doctor for safer alternatives.
A: No, alcohol should be avoided as it increases the risk of liver damage and gastrointestinal bleeding.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine is safe for long-term use.
Fact: This medicine is only for short-term use (up to 5-7 days) due to the risk of liver and kidney damage. - Myth: This medicine can be taken on an empty stomach.
Fact: It should be taken with food to reduce the risk of stomach upset and bleeding. - Myth: This medicine is safe for children.
Fact: It is not recommended for children under 12 years of age. - Myth: This medicine can be combined with other painkillers.
Fact: Combining with other NSAIDs or paracetamol can increase the risk of side effects.
🔄 Alternative Options
Generic Alternatives
- Nimesulide + Paracetamol (generic)
Brand Alternatives
- Nefspas 10mg/250mg Tablet