Nefroglad 500mg/150mg Tablet: Complete Guide To Uses, Side Effects, And Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bruising or bleeding
If experiencing severe symptoms, call emergency services immediately.
What is nefroglad 500mg/150mg tablet used for?
This medicine is a combination of aceclofenac and paracetamol used for short-term relief of acute pain and inflammation. It works by reducing prostaglandins that cause pain and swelling. Take it with food to avoid stomach upset and do not exceed the prescribed dose.
- Generic Name: Information coming soon
- Manufacturer: Multiple manufacturers
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nefroglad 500mg/150mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एसिटोक्लोफेनाक और पैरासिटामोल का संयोजन है, जिसका उपयोग दर्द और सूजन को कम करने के लिए किया जाता है। यह गठिया, कमर दर्द, दांत दर्द, और सर्जरी के बाद के दर्द में प्रभावी है। यह दवा सूजन पैदा करने वाले प्रोस्टाग्लैंडिन को कम करके काम करती है। इसे भोजन के साथ लें और डॉक्टर के बताए अनुसार ही सेवन करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, अपच, सिरदर्द, चक्कर आना और नींद आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें पेट में रक्तस्राव, एलर्जी, लीवर और किडनी की समस्या शामिल हो सकती है। यदि आपको कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खाली पेट न लें, भोजन के साथ लें। शराब का सेवन न करें। अन्य दर्द निवारक दवाओं के साथ इसका सेवन बिना डॉक्टर की सलाह के न करें। यदि आप गर्भवती हैं या स्तनपान करा रही हैं तो डॉक्टर से परामर्श लें। बच्चों से दूर रखें।
💊 nefroglad 500mg/150mg tablet Uses & Benefits
[{"condition":"Osteoarthritis","description":"Relieves pain and inflammation, improving joint mobility in knee, hip, and hand osteoarthritis.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Reduces joint pain, swelling, and stiffness in rheumatoid arthritis as an adjunct to disease-modifying therapy.","evidence":"Well-established"},{"condition":"Ankylosing spondylitis","description":"Helps alleviate back pain and stiffness associated with ankylosing spondylitis.","evidence":"Well-established"},{"condition":"Acute gout","description":"Provides short-term relief of pain and inflammation during acute gout attacks.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for the management of mild to moderate post-operative pain and inflammation.","evidence":"Well-established"},{"condition":"Dental pain","description":"Effective for relieving dental pain and inflammation following dental procedures.","evidence":"Well-established"},{"condition":"Musculoskeletal pain","description":"Used for acute musculoskeletal pain such as sprains, strains, and low back pain.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks, but evidence is limited.","evidence":"Limited"},{"condition":"Dysmenorrhea","description":"May be used off-label for menstrual pain, though other NSAIDs are more commonly recommended.","evidence":"Limited"}]
Primary treatment for: Acute pain and inflammation associated with musculoskeletal conditions
Also treats: Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis, Acute gout, Post-operative pain, Dental pain
📋 Drug Information
| Generic Name(s) | Information coming soon |
| Brand Name | nefroglad 500mg/150mg tablet |
| Manufacturer | Multiple manufacturers |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI DIABETIC |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Aceclofenac, an NSAID, inhibits the cyclooxygenase (COX) enzymes, particularly COX-2, leading to decreased synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. Paracetamol acts primarily in the central nervous system by inhibiting prostaglandin synthesis and possibly activating descending serotonergic pathways, producing analgesia and antipyresis with minimal anti-inflammatory activity. Together, they provide enhanced pain relief and anti-inflammatory effects.
Mechanism Steps
💡 How to Take nefroglad 500mg/150mg tablet
Strength: Each tablet contains aceclofenac 500 mg and paracetamol 150 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally two to three times daily, preferably after meals. The maximum daily dose should not exceed three tablets in 24 hours. The exact dose and duration of treatment must be individualized by a qualified clinician based on the indication, severity of symptoms, age, weight, and renal and hepatic function. Do not self-medicate or exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the side effects of this medicine, especially gastrointestinal bleeding and kidney impairment. Use the lowest effective dose for the shortest duration. Dose adjustment may be necessary based on renal and hepatic function. Consult a doctor for appropriate dosing. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose reduction may be necessary. Avoid use in severe renal impairment. Consult a doctor for appropriate dosing. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose reduction may be necessary. Avoid use in severe hepatic impairment. Consult a doctor for appropriate dosing. |
| Maximum Daily Dose | The maximum daily dose is three tablets in 24 hours. Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nefroglad 500mg/150mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Corticosteroids | Major | |
| Methotrexate | Major | |
| Lithium | Major | |
| Antihypertensives | Moderate | |
| SSRIs | Moderate | |
| Alcohol | Moderate | |
| Antacids | Minor | |
| Cholestyramine | Minor |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., ibuprofen, naproxen)
- Corticosteroids
- Methotrexate
- Lithium
⚡ Moderate Interactions
- Antihypertensives (e.g., ACE inhibitors, ARBs, diuretics)
- SSRIs
- Corticosteroids (inhaled or oral)
- Alcohol
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding, ulceration, and liver damage, especially with paracetamol. It may also enhance the sedative effects of the medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to aceclofenac, paracetamol, or any component of the formulation","History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs","Active peptic ulcer or history of recurrent peptic ulcer","Severe heart failure","Severe hepatic impairment","Severe renal impairment","Third trimester of pregnancy","Breastfeeding"]
⚠️ Warnings & Precautions
["Take with food or milk to reduce gastrointestinal irritation.","Avoid alcohol while taking this medicine.","Do not exceed the recommended dose or duration of treatment.","Use with caution in elderly patients due to increased risk of side effects.","Use with caution in patients with a history of gastrointestinal bleeding or ulcer.","Monitor liver and kidney function during prolonged use.","May cause dizziness or drowsiness; avoid driving or operating machinery until you know how it affects you.","Do not use in children without medical advice."]
🤱 Lactation Safety
This medicine is not recommended during breastfeeding as aceclofenac and paracetamol may pass into breast milk. Consult your doctor for alternative options.
💊 Overdose Management
Overdose of this medicine may cause severe nausea, vomiting, abdominal pain, liver damage, and kidney failure. Seek immediate medical attention. Treatment is supportive and symptomatic. For paracetamol overdose, N-acetylcysteine is the antidote and should be administered as soon as possible. Activated charcoal may be considered if the patient presents within 1-2 hours of ingestion.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine as it may increase the risk of stomach bleeding and liver damage. Do not take other pain relievers or NSAIDs without consulting your doctor. Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, heart problems, or asthma. Do not use this medicine for more than 7 days without medical advice. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before taking this medicine. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor renal and hepatic function regularly. Avoid concurrent use of other NSAIDs.
🤰 Pregnancy Planning (TTC)
This medicine should be avoided during pregnancy, especially in the third trimester, as it may harm the fetus. If you are planning pregnancy, consult your doctor to discuss safer alternatives for pain management.
🏥 Post-Surgery Considerations
This medicine may be used for post-operative pain management. However, it may increase the risk of bleeding and should be used with caution after surgery. Consult your surgeon before taking this medicine.
🦷 Dental Procedures
This medicine can be used for dental pain but may increase the risk of bleeding during dental procedures. Inform your dentist that you are taking this medicine before any dental work.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may experience dizziness or drowsiness. Avoid strenuous exercise or activities that require alertness until you know how the medicine affects you. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It is generally safe to continue desk work, but take regular breaks and maintain good posture.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if you experience severe side effects such as gastrointestinal bleeding, allergic reactions, or signs of liver or kidney problems. Do not stop abruptly if you have been on long-term therapy without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of gastrointestinal bleeding, kidney impairment, liver damage, and cardiovascular events. Regular monitoring of liver and kidney function, blood pressure, and complete blood count is recommended. Use the lowest effective dose for the shortest duration. Consult your doctor regularly to assess the need for continued therapy.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve joint function.
Evidence: Well-establishedApplying heat or cold packs can help reduce pain and inflammation.
Evidence: Well-establishedMay provide pain relief for some individuals with chronic pain.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing schedule as advised by your doctor. Check customs regulations for carrying prescription medicines. Keep enough supply for the entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 30-60 minutes after taking it.
A: It is best to take this medicine with food or milk to reduce the risk of stomach upset.
A: Long-term use should only be done under medical supervision with regular monitoring of liver and kidney function.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can cure arthritis permanently.
Fact: This medicine provides symptomatic relief but does not cure arthritis. It should be used as part of a comprehensive treatment plan. - Myth: It is safe to take this medicine for long periods without monitoring.
Fact: Long-term use requires regular monitoring of liver and kidney function and may increase the risk of cardiovascular events. - Myth: Taking this medicine with alcohol is safe.
Fact: Alcohol increases the risk of liver damage and gastrointestinal bleeding. Avoid alcohol while taking this medicine.
🔄 Alternative Options
Generic Alternatives
- Aceclofenac 500 mg + Paracetamol 150 mg tablet
Brand Alternatives
- Nefroglad 500mg/150mg tablet