Nebivolol + Amlodipine 5mg/5mg Tablet: Complete Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe dizziness or fainting
- Slow or irregular heartbeat
- Chest pain or shortness of breath
- Swelling of face, lips, tongue, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Severe headache with visual changes
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is nebinex am 5 mg/5 mg tablet used for?
This medicine is a combination of Nebivolol and Amlodipine used to treat high blood pressure. It works by relaxing blood vessels and slowing the heart rate. Take it once daily as prescribed.
- Generic Name: Nebivolol (5mg) + Amlodipine (5mg)
- Manufacturer: Glenmark Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nebinex am 5 mg/5 mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा नेबिवोलोल और एम्लोडिपिन का संयोजन है, जिसका उपयोग उच्च रक्तचाप (हाइपरटेंशन) के इलाज के लिए किया जाता है। यह रक्त वाहिकाओं को आराम देकर और हृदय की गति को धीमा करके रक्तचाप को कम करती है। यह उन वयस्कों के लिए है जिनका रक्तचाप अकेले एक दवा से नियंत्रित नहीं हो पाता। यह दवा हृदयाघात, स्ट्रोक और गुर्दे की क्षति के जोखिम को कम करने में मदद करती है। इसे डॉक्टर के निर्देशानुसार ही लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, चक्कर आना, थकान, मतली, पैरों में सूजन और चेहरे पर लालिमा शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर दुष्प्रभावों में धीमी हृदय गति, हृदय रुकावट, गंभीर निम्न रक्तचाप, और सांस लेने में कठिनाई शामिल हैं। यदि आपको बेहोशी, सीने में दर्द, या सांस लेने में तकलीफ हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे अचानक बंद न करें, क्योंकि इससे एनजाइना या दिल का दौरा पड़ सकता है। शराब का सेवन न करें क्योंकि इससे चक्कर आ सकते हैं। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन न चलाएं। यदि आप गर्भवती हैं या स्तनपान करा रही हैं, तो डॉक्टर से सलाह लें। नियमित रूप से रक्तचाप और हृदय गति की जांच कराएं।
💊 nebinex am 5 mg/5 mg tablet Uses & Benefits
- [{"condition":"Essential hypertension","description":"This medicine is used to lower high blood pressure in adults when monotherapy is insufficient.
- It reduces both systolic and diastolic blood pressure, thereby decreasing cardiovascular risk.","evidence":"Well-established"},{"condition":"Hypertension with concomitant angina","description":"The combination may be beneficial in patients with both hypertension and stable angina due to the anti-anginal effects of Nebivolol and vasodilation from Amlodipine.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Heart failure with reduced ejection fraction","description":"Nebivolol, a component of this medicine, has been studied in heart failure, but the combination with Amlodipine is not standard for this indication.","evidence":"Limited"},{"condition":"Migraine prophylaxis","description":"Beta-blockers like Nebivolol are sometimes used off-label to prevent migraines, but this combination is not routinely recommended for that purpose.","evidence":"Limited"}]
Primary treatment for: Essential hypertension
Also treats: Angina pectoris, Heart failure with reduced ejection fraction (off-label)
📋 Drug Information
| Generic Name(s) | Nebivolol (5mg) + Amlodipine (5mg) |
| Brand Name | nebinex am 5 mg/5 mg tablet |
| Manufacturer | Glenmark Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antihypertensive agents with complementary mechanisms. Nebivolol is a cardioselective beta-1 adrenergic receptor blocker that also causes vasodilation by increasing nitric oxide bioavailability. Amlodipine is a dihydropyridine calcium channel blocker that inhibits the influx of calcium ions into vascular smooth muscle and cardiac muscle, leading to relaxation of peripheral arterioles and reduced peripheral vascular resistance. The combined effect results in reduced heart rate, decreased myocardial contractility, and vasodilation, effectively lowering blood pressure.
Mechanism Steps
💡 How to Take nebinex am 5 mg/5 mg tablet
Strength: Tablet containing Nebivolol 5 mg and Amlodipine 5 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet (Nebivolol 5 mg + Amlodipine 5 mg) taken orally once daily, with or without food. The dose may be adjusted by your doctor based on your blood pressure response and tolerability. Do not exceed the prescribed dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially dizziness and hypotension. Start with a lower dose and monitor closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with renal impairment, dose adjustment may be necessary. Nebivolol is primarily excreted in urine, and Amlodipine is metabolized in the liver. Monitor renal function closely. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | In patients with hepatic impairment, dose adjustment is required. Nebivolol is extensively metabolized in the liver, and Amlodipine is also metabolized hepatically. Use with caution and monitor liver function. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose is one tablet (Nebivolol 5 mg + Amlodipine 5 mg) once daily. Do not exceed this dose unless directed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nebinex am 5 mg/5 mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Fluoxetine | Major | |
| Ketoconazole | Major | |
| Verapamil | Major | |
| Ibuprofen | Moderate | |
| Prazosin | Moderate | |
| Antacids | Minor | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)
- CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir)
- Beta-blockers (e.g., metoprolol, propranolol)
- Calcium channel blockers (non-dihydropyridine, e.g., verapamil, diltiazem)
⚡ Moderate Interactions
- Alpha-blockers (e.g., prazosin, terazosin)
- NSAIDs (e.g., ibuprofen, naproxen)
- Corticosteroids
🍷 Alcohol Interaction
Alcohol may enhance the blood pressure-lowering effects of this medicine, leading to dizziness, lightheadedness, and increased risk of fainting. It is advisable to avoid or limit alcohol consumption while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe bradycardia","Heart block greater than first degree","Cardiogenic shock","Severe hypotension","Decompensated heart failure","Known hypersensitivity to Nebivolol or Amlodipine","Severe hepatic impairment","Pregnancy (especially second and third trimesters)"]
⚠️ Warnings & Precautions
["Do not abruptly discontinue this medicine, especially in patients with coronary artery disease, as it may worsen angina or precipitate a heart attack.","Use with caution in patients with asthma or COPD due to risk of bronchospasm.","May mask symptoms of hypoglycemia in diabetic patients.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Use with caution in patients with peripheral vascular disease or Raynaud's phenomenon.","May worsen psoriasis.","Monitor for signs of heart failure; dose adjustment may be needed.","Avoid alcohol consumption as it may enhance hypotensive effects."]
🤱 Lactation Safety
Nebivolol and Amlodipine are excreted in breast milk. Breastfeeding is not recommended while taking this medicine unless the potential benefit outweighs the risk. Consult your doctor for guidance.
💊 Overdose Management
Overdose may cause severe hypotension, bradycardia, heart failure, and bronchospasm. Treatment is supportive and symptomatic. If overdose is suspected, seek immediate medical attention. Gastric lavage may be considered if ingestion is recent. Administer intravenous fluids, atropine for bradycardia, and vasopressors for hypotension as needed. Glucagon may be used for beta-blocker overdose. Hemodialysis is not effective for removing Nebivolol or Amlodipine.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not stop or change the dose without medical advice, as abrupt discontinuation of Nebivolol can worsen angina or precipitate a heart attack. Avoid alcohol while taking this medicine, as it can enhance blood pressure-lowering effects and cause dizziness. Do not drive or operate heavy machinery until you know how this medicine affects you. Inform your doctor if you have asthma, chronic obstructive pulmonary disease, diabetes, liver disease, or kidney disease. Regular monitoring of blood pressure, heart rate, and renal function is advised. This medicine is not recommended during pregnancy or breastfeeding without consulting your doctor. Keep this medicine out of reach of children and store it in its original packaging at room temperature.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the blood pressure-lowering effects of this medicine and are at higher risk of dizziness, falls, and electrolyte imbalances. Start with a lower dose and monitor closely. Regular assessment of renal function and blood pressure is essential.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before conception. This medicine is generally not recommended during pregnancy. Your doctor may switch you to a safer alternative, such as labetalol or nifedipine, which are considered safer during pregnancy.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with anesthetic agents and affect blood pressure and heart rate during surgery. Your doctor may advise temporary discontinuation or dose adjustment before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may cause dry mouth or increase the risk of bleeding during dental procedures. Your dentist may take precautions and monitor your blood pressure during the procedure.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe while taking this medicine. However, avoid sudden strenuous activities, especially in hot weather, as they may cause dizziness or low blood pressure. Stay hydrated and rise slowly from sitting or lying positions. If you experience chest pain, severe shortness of breath, or dizziness during exercise, stop and seek medical attention.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue, especially when you first start taking it. Avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their normal work and daily activities with dose adjustment. Inform your employer if your job involves operating machinery or working at heights.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects like severe bradycardia, heart block, or angioedema, seek immediate medical attention and your doctor may advise discontinuation. If your blood pressure is well controlled for a long period, your doctor may consider dose reduction or alternative therapy, but this must be done under medical supervision.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe and effective for managing high blood pressure. Regular monitoring of blood pressure, heart rate, kidney function, and electrolytes is recommended. Prolonged use may increase the risk of new-onset diabetes, especially with beta-blockers, but Nebivolol has a more favorable metabolic profile. Periodic eye exams and foot checks are advised for diabetic patients. Do not stop the medicine without medical advice.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet, exercise, weight loss, and stress reduction can help lower blood pressure and may reduce the need for medication.
Evidence: Well-establishedARBs, ACE inhibitors, or thiazide diuretics may be used in combination with calcium channel blockers or beta-blockers based on patient profile.
Evidence: Well-establishedAn interventional procedure for resistant hypertension, but not widely available.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, always inform your healthcare provider about all medicines you are taking before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss. Store at room temperature and protect from extreme heat or moisture. If traveling across time zones, consult your doctor about adjusting the dosing schedule. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts lowering blood pressure within a few hours, but the full effect may take 1 to 2 weeks. Continue taking it regularly as prescribed.
A: Yes, you can take it with or without food. Taking it with food may help reduce stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: No, do not stop taking this medicine without consulting your doctor. High blood pressure is a chronic condition, and stopping suddenly can cause dangerous rebound effects.
A: This medicine is generally not recommended during pregnancy, especially in the second and third trimesters. Consult your doctor for alternative treatment options.
🤔 Common Patient Concerns
🔄 Substitutes for nebinex am 5 mg/5 mg tablet
View AllAlternative brands with exact same active ingredient:
-
amoline-nb tabletZeelab Pharmacy Pvt Ltd ₹30.00 50.8% CHEAPER
-
davaindia nebivolol+amlodipine 5mg/5mg tabletDavaindia Generic Pharmacy ₹34.00 44.2% CHEAPER
-
nebiwin am 5mg/5mg tabletDocwin Healthcare ₹59.00 3.2% CHEAPER
-
nevy a 5mg/5mg tabletIntas Pharmaceuticals Ltd ₹59.63 2.1% CHEAPER
-
cardilol am 5mg/5mg tabletWelkind Pharma ₹80.00 31.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be stopped once blood pressure is normal.
Fact: High blood pressure is a chronic condition. This medicine controls it but does not cure it. Stopping suddenly can cause dangerous rebound hypertension or angina. - Myth: This medicine causes kidney damage.
Fact: This medicine is used to protect the kidneys from damage caused by high blood pressure. However, regular monitoring is needed, especially if you have kidney disease. - Myth: You can take this medicine without a prescription.
Fact: This medicine is a prescription-only drug. It should only be taken under the supervision of a qualified doctor.
🔄 Alternative Options
Generic Alternatives
- Nebivolol 5 mg + Amlodipine 5 mg tablet (various manufacturers)
Brand Alternatives
- Not established from the available information.