Nazolex Plus Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Seizures or convulsions
- Severe abdominal pain
- Blood in stool or vomit
- Signs of severe allergic reaction (swelling of face, lips, throat, difficulty breathing)
- Numbness or tingling in hands or feet
- Unusual bruising or bleeding
- Yellowing of skin or eyes
If experiencing severe symptoms, call emergency services immediately.
What is nazolex plus tablet used for?
Nazolex Plus Tablet is a combination antibiotic and antiprotozoal medicine used to treat infectious diarrhoea and dysentery. It contains nalidixic acid and metronidazole, which work together to kill bacteria and protozoa. It should be taken as prescribed by a doctor, with food, and alcohol must be avoided.
- Generic Name: Information coming soon
- Manufacturer: Multiple manufacturers
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nazolex plus tablet के बारे में (Hindi Summary)
उपयोग: यह दवा नालिडिक्सिक एसिड और मेट्रोनिडाजोल का संयोजन है, जिसका उपयोग संक्रामक दस्त और पेचिश के इलाज के लिए किया जाता है। यह बैक्टीरिया और प्रोटोजोआ को मारती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त, सिरदर्द, चक्कर आना और मुँह में धातु जैसा स्वाद शामिल हैं। गंभीर दुष्प्रभावों में दौरे, तंत्रिका क्षति, और गंभीर एलर्जी प्रतिक्रियाएँ हो सकती हैं।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। शराब का सेवन बिल्कुल न करें। यदि आपको मिर्गी, लीवर की समस्या या रक्त विकार है तो डॉक्टर को बताएं। गाड़ी चलाते समय सावधानी बरतें।
💊 nazolex plus tablet Uses & Benefits
[{"condition":"Infectious diarrhoea","description":"Used to treat diarrhoea caused by susceptible bacteria and protozoa.","evidence":"Established"},{"condition":"Amoebic dysentery","description":"Effective against Entamoeba histolytica infections.","evidence":"Established"},{"condition":"Giardiasis","description":"Used to treat Giardia lamblia infections.","evidence":"Established"},{"condition":"Bacterial gastroenteritis","description":"Covers a range of gram-negative bacteria causing gut infections.","evidence":"Limited"}]
Off-label uses: [{"condition":"Diverticulitis","description":"Sometimes used in combination regimens for diverticulitis.","evidence":"Limited"}]
Primary treatment for: Infectious diarrhoea
Also treats: Amoebic dysentery, Giardiasis, Bacterial gastroenteritis
📋 Drug Information
| Generic Name(s) | Information coming soon |
| Brand Name | nazolex plus tablet |
| Manufacturer | Multiple manufacturers |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antimicrobial agents with different mechanisms. Nalidixic acid inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair, leading to bacterial cell death. Metronidazole enters anaerobic organisms and is reduced to reactive intermediates that bind to DNA, causing strand breakage and inhibiting nucleic acid synthesis, which results in cell death.
Mechanism Steps
💡 How to Take nazolex plus tablet
Strength: Nazolex Plus Tablet: Nalidixic acid 500 mg + Metronidazole 200 mg (example; actual strength may vary).
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally two to three times daily, depending on the severity of the infection and your doctor's prescription. The exact dose and duration must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function. Always complete the full course as prescribed. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may require dose adjustment based on renal and hepatic function. Consult your doctor. |
| Renal Impairment | Dose adjustment may be needed in patients with renal impairment. Consult your doctor. |
| Hepatic Impairment | Dose adjustment may be needed in patients with hepatic impairment. Consult your doctor. |
| Maximum Daily Dose | The maximum daily dose should not exceed the prescribed amount. Do not take more than directed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nazolex plus tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Alcohol | Major | |
| Phenytoin | Major | |
| Cimetidine | Moderate | |
| Lithium | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin
- Alcohol
- Phenytoin
⚡ Moderate Interactions
- Cimetidine
- Lithium
🍷 Alcohol Interaction
Avoid alcohol completely while taking this medicine and for at least 48 hours after the last dose. Alcohol can cause a disulfiram-like reaction with metronidazole, leading to severe nausea, vomiting, flushing, and rapid heartbeat.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to nalidixic acid, metronidazole, or any component of the formulation.","History of seizures.","Severe liver disease.","Blood dyscrasias.","Pregnancy (especially first trimester) unless clearly needed.","Breastfeeding."]
⚠️ Warnings & Precautions
["May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol during and for 48 hours after treatment.","Use with caution in patients with epilepsy or CNS disorders.","May cause peripheral neuropathy with prolonged use.","Monitor blood counts during prolonged therapy.","Use with caution in elderly patients.","Not recommended for children under 12 years unless prescribed by a doctor."]
🤱 Lactation Safety
Metronidazole is excreted in breast milk. Nalidixic acid may also pass into breast milk. Consult your doctor before breastfeeding while taking this medicine.
💊 Overdose Management
Overdose may cause nausea, vomiting, dizziness, and seizures. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop early, even if you feel better. Avoid alcohol completely while taking this medicine and for at least 48 hours after the last dose, as it can cause severe nausea and vomiting. Inform your doctor if you have epilepsy, liver problems, or blood disorders. Use caution when driving or operating machinery until you know how this medicine affects you. Do not share this medicine with others. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to side effects like dizziness and blood dyscrasias. Dose adjustment may be needed based on renal and hepatic function.
🤰 Pregnancy Planning (TTC)
Consult your doctor before planning pregnancy. This medicine is generally avoided during pregnancy unless clearly needed.
🏥 Post-Surgery Considerations
Consult your surgeon before taking this medicine after surgery, as it may interact with other medications.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may interact with other drugs used during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise if you feel weak or dizzy. Resume gradually after recovery.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
You may feel dizzy or tired; avoid driving or operating heavy machinery until you know how this medicine affects you. Take rest as needed.
🛑 When to Stop This Medicine
Stop only after completing the full prescribed course. Do not stop early even if you feel better. Consult your doctor if you experience severe side effects.
📅 Long-Term Use Effects
Long-term use may lead to peripheral neuropathy, blood dyscrasias, and increased risk of resistance. Regular monitoring of blood counts and liver function is advised. Use only for the prescribed duration.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Essential for managing dehydration from diarrhoea.
Evidence: Well-establishedMay help restore gut flora after antibiotic treatment.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If crossing time zones, adjust dosing intervals as advised by your doctor. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 1-2 days, but complete the full course as prescribed.
A: Inform your doctor about all medicines you take, as interactions can occur.
A: Consult your doctor. It is generally avoided during pregnancy unless clearly needed.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: Nazolex Plus Tablet can cure any stomach upset.
Fact: It is only effective against specific bacterial and protozoal infections. It does not work for viral or non-infectious causes. - Myth: You can stop taking it once you feel better.
Fact: You must complete the full course to prevent recurrence and resistance.
🔄 Alternative Options
Generic Alternatives
- Nalidixic acid + Metronidazole combination tablets
Brand Alternatives
- Nazolex Plus Tablet