natelide 120mg tablet - Nateglinide (120mg) medicine

Glinate 120 Tablet: Complete Medicine Guide

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🏭 Alembic Pharmaceuticals Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 26, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for type 2 diabetes mellitus.
Reviewed by
SaathiMed Expert Panel | Oct 26, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Severe low blood sugar with confusion, seizures, or loss of consciousness.
  • Swelling of the face, lips, tongue, or throat, or difficulty breathing.
  • Yellowing of the skin or eyes, dark urine, or severe tiredness.
  • Severe abdominal pain that may radiate to the back.
  • Unusual bleeding or bruising.
  • Chest pain, palpitations, or shortness of breath.
  • Signs of a severe skin reaction such as painful rash, blisters, or peeling skin.

If experiencing severe symptoms, call emergency services immediately.

What is natelide 120mg tablet used for?

This medicine contains nateglinide 120 mg, an oral antidiabetic tablet used in adults with type 2 diabetes to lower blood sugar after meals. It is taken within 30 minutes before each main meal. It can cause low blood sugar, so it should be taken with meals and the dose must be individualized by a doctor.

  • Generic Name: Nateglinide (120mg)
  • Manufacturer: Alembic Pharmaceuticals Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 natelide 120mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा नेटेग्लिनाइड 120 मिलीग्राम युक्त एक ओरल एंटीडायबिटिक टैबलेट है। इसका उपयोग टाइप 2 डायबिटीज वाले वयस्कों में खाने के बाद ब्लड शुगर को कंट्रोल करने के लिए किया जाता है। यह अग्न्याशय से इंसुलिन निकलने में मदद करती है, जिससे भोजन के बाद शुगर का स्तर कम होता है। इसे आमतौर पर हर मुख्य भोजन से 30 मिनट पहले लिया जाता है। यह दवा टाइप 1 डायबिटीज या डायबिटिक कीटोएसिडोसिस के लिए नहीं है। इसे डॉक्टर की सलाह के बिना शुरू या बंद न करें।

साइड इफेक्ट्स: इस दवा के सबसे आम साइड इफेक्ट्स में लो ब्लड शुगर (हाइपोग्लाइसीमिया) के लक्षण जैसे कंपकंपी, पसीना, भूख लगना, चक्कर आना और दिल की धड़कन तेज होना शामिल हैं। कुछ लोगों को पेट में हल्की परेशानी, जी मिचलाना या दस्त हो सकता है। लंबे समय तक उपयोग से वजन बढ़ सकता है। कभी-कभी गंभीर लो ब्लड शुगर या एलर्जी हो सकती है। अगर आपको बहुत ज्यादा कमजोरी, पीलिया, या सांस लेने में तकलीफ हो, तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें, आमतौर पर हर मुख्य भोजन से 30 मिनट पहले। अगर आप कोई भोजन छोड़ देते हैं, तो उस भोजन की दवा भी छोड़ दें। खाली पेट या उपवास के दौरान इस दवा को न लें। लो ब्लड शुगर के लिए हमेशा ग्लूकोज या मिठाई साथ रखें। शराब का सेवन सीमित करें क्योंकि इससे लो ब्लड शुगर का खतरा बढ़ सकता है। अगर आपको किडनी या लिवर की बीमारी है, तो डॉक्टर को बताएं। बिना डॉक्टर की सलाह के कोई अन्य दवा शुरू या बंद न करें।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 natelide 120mg tablet Uses & Benefits

[{"condition":"Type 2 diabetes mellitus","description":"Used as an adjunct to diet and exercise to improve blood sugar control in adults whose blood sugar is not controlled by lifestyle alone.","evidence":"Well-established"},{"condition":"Postprandial hyperglycemia","description":"Helps reduce the spike in blood sugar that occurs after meals by stimulating a rapid, short-lived release of insulin.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Impaired glucose tolerance","description":"Sometimes considered to delay progression to diabetes in people with prediabetes, but this is not a standard approved use.","evidence":"Limited"}]

Primary treatment for: Type 2 diabetes mellitus

Also treats: Postprandial hyperglycemia, Prediabetes (off-label)

📋 Drug Information

Generic Name(s)Nateglinide (120mg)
Brand Namenatelide 120mg tablet
ManufacturerAlembic Pharmaceuticals Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI DIABETIC
Action ClassMeglitinides (Insulin Secretogogues)
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C. Keep away from moisture, heat, and direct sunlight. Do not refrigerate unless specified. Keep in the original container and out of reach of children.
Shelf LifeThe shelf life is typically 24 months from the date of manufacture, but check the expiry date on the pack. Do not use after the expiry date.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine within 30 minutes before each main meal. If you skip a meal, skip the dose.
2
Always carry a fast-acting source of sugar, such as glucose tablets or candy, to treat low blood sugar.
3
Check your blood sugar regularly, especially if you change your diet, exercise routine, or other medicines.
4
Tell your doctor about all other medicines you take, including over-the-counter drugs and herbal supplements.
5
Avoid drinking alcohol heavily while taking this medicine, as it can increase the risk of low blood sugar.
6
If you have kidney or liver problems, your doctor may need to adjust your dose.
7
Do not drive or operate machinery if you feel dizzy or have symptoms of low blood sugar.
8
Keep a record of your blood sugar readings and bring it to your doctor visits.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
High blood sugar after meals
This medicine is commonly prescribed for this.
Likely Use
✅
Type 2 diabetes
This medicine is used to manage type 2 diabetes.
Likely Use
❌
Type 1 diabetes
This medicine is not for type 1 diabetes.
Not Primary
❌
Diabetic ketoacidosis
This medicine is not used for this emergency condition.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionThis medicine is rapidly absorbed after oral administration. Food can affect the speed and extent of absorption, so it is usually taken shortly before meals. The exact absorption characteristics may vary between individuals.
DistributionNot established from the available information.
Protein BindingThis medicine is highly bound to plasma proteins, mainly albumin. The exact percentage is not established from the available information.
MetabolismThis medicine is extensively metabolized in the liver, primarily by the CYP2C9 enzyme, with some contribution from CYP3A4. Several metabolites are formed, and some may have weak blood sugar-lowering activity.
Half-LifeThe elimination half-life is approximately 1.5 hours, but this can vary. Not established from the available information for all populations.
ExcretionThis medicine and its metabolites are mainly excreted in the urine and feces. The exact proportions are not established from the available information.
BioavailabilityThe absolute bioavailability is not established from the available information. It is rapidly absorbed, but food can reduce the peak concentration.
Onset of ActionThis medicine starts to lower blood sugar within 15 to 60 minutes after taking a dose, which is why it is taken shortly before meals.
Peak Plasma TimePeak plasma concentration is usually reached within 1 hour after taking a dose on an empty stomach. Food can delay the peak.
Duration of ActionThe blood sugar-lowering effect lasts for about 4 to 6 hours, covering the post-meal period.

How It Works

This medicine works by closing ATP-sensitive potassium channels on the surface of pancreatic beta cells. This closure causes the cell membrane to depolarize, which opens voltage-gated calcium channels. The resulting influx of calcium triggers the release of insulin from stored granules. Because the effect is rapid and short-lived, it mainly boosts insulin release during the meal, helping to lower post-meal blood sugar levels.

Mechanism Steps

1
Binding to beta-cell potassium channels: This medicine binds to the sulfonylurea receptor subunit of ATP-sensitive potassium channels on pancreatic beta cells.
2
Channel closure and membrane depolarization: Binding closes the potassium channels, which stops potassium from leaving the cell and causes the cell membrane to depolarize.
3
Calcium influx: Depolarization opens voltage-gated calcium channels, allowing calcium to enter the beta cell.
4
Insulin release: The rise in intracellular calcium triggers the release of insulin-containing granules from the beta cell into the bloodstream.
5
Lowering of post-meal blood sugar: The released insulin helps move glucose from the blood into muscle and fat cells, reducing the blood sugar spike after a meal.

💡 How to Take natelide 120mg tablet

Strength: Immediate-release tablet containing 120 mg of nateglinide.

1Take this medicine by mouth with a glass of water.
2Take it within 30 minutes before each main meal.
3If you skip a meal, skip the dose for that meal.
4Do not take it if you are not going to eat.
5Swallow the tablet whole; do not crush or chew it unless your doctor says it is okay.
6Follow your doctor's instructions exactly and do not change the dose on your own.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 120 mg taken orally within 30 minutes before each main meal. For people with mild to moderate liver disease or those at higher risk of low blood sugar, a lower starting dose of 60 mg before meals may be used. The dose must be individualized by a qualified clinician based on blood sugar levels, kidney and liver function, and other medicines you take. Do not change your dose without consulting your doctor.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageOlder adults may be more sensitive to the blood sugar-lowering effects of this medicine. Start with a lower dose and monitor blood sugar closely. The dose must be individualized by a qualified clinician.
Renal ImpairmentFor people with mild to moderate kidney disease, no dose adjustment is usually needed. For severe kidney disease, this medicine should be used with caution and the dose may need to be reduced. The dose must be individualized by a qualified clinician.
Hepatic ImpairmentFor people with mild to moderate liver disease, a lower starting dose of 60 mg before meals is recommended. This medicine is not recommended for people with severe liver disease. The dose must be individualized by a qualified clinician.
Maximum Daily DoseThe maximum recommended daily dose is 120 mg before each main meal, up to three times daily, but the exact maximum must be determined by a qualified clinician.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

Main meals
Take within 30 minutes before the meal.
To match insulin release with the rise in blood sugar after eating.
Skipped meals
Skip the dose.
Taking without food can cause low blood sugar.
Grapefruit
No specific restriction, but monitor blood sugar if consumed regularly.
Grapefruit can affect some medicines, but the effect on this medicine is not well established.

⏰ What to Do If You Miss a Dose

📌 You remember before the meal
→ Take the missed dose as soon as you remember, then eat your meal.
💡 Continue with your regular schedule.
📌 You remember after the meal
→ Skip the missed dose.
💡 Do not take a double dose. Take the next dose before your next meal.
📌 You are not going to eat a meal
→ Skip the dose for that meal.
💡 Never take this medicine without food.

⚠️ Side Effects of natelide 120mg tablet

✅ Common Side Effects

Hypoglycemia (low blood sugar) (Common (5-10%))
Treat with fast-acting sugar if mild. If severe or recurrent, contact your doctor.
Weight gain (Common (5-10%))
Follow a balanced diet and regular exercise. Discuss with your doctor if weight gain is significant.
Nausea (Uncommon (1-5%))
Take with food if possible. If nausea persists, consult your doctor.
Diarrhea (Uncommon (1-5%))
Stay hydrated. If diarrhea is severe or persistent, seek medical advice.
Dizziness (Uncommon (1-5%))
Avoid driving or operating machinery until you know how this medicine affects you.

🚨 Serious Side Effects

Severe hypoglycemia (Rare (<0.1%))
Seek emergency medical help if you have confusion, seizures, or loss of consciousness. Do not try to drive yourself.
Allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical attention if you have swelling of the face, lips, tongue, or throat, difficulty breathing, or a severe rash.
Liver injury (Rare (<0.1%))
Report yellowing of the skin or eyes, dark urine, or severe tiredness to your doctor immediately.
Severe skin reactions (Rare (<0.1%))
Stop the medicine and seek immediate medical help if you develop a painful rash, blisters, or peeling skin.

⚠️ Rare Side Effects

Hemolytic anemia
Report unusual tiredness, pale skin, or shortness of breath to your doctor.
Thrombocytopenia
Report easy bruising or bleeding to your doctor.
Pancreatitis
Seek immediate medical attention for severe abdominal pain that may radiate to the back.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Insulin Major
Sulfonylureas Major
Beta-blockers Major
MAOIs Major
NSAIDs Major
Fluconazole Moderate
Rifampin Moderate
Corticosteroids Moderate
Thiazide diuretics Moderate
Alcohol Minor

🚨 Major Interactions

  • Other antidiabetic medicines (insulin, sulfonylureas, metformin)
  • Beta-blockers
  • Monoamine oxidase inhibitors (MAOIs)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs)
  • Salicylates (high doses)

⚡ Moderate Interactions

  • CYP2C9 inhibitors (e.g., fluconazole, gemfibrozil)
  • CYP2C9 inducers (e.g., rifampin, carbamazepine)
  • Corticosteroids
  • Thiazide diuretics
  • Thyroid hormones

🍷 Alcohol Interaction

Drinking alcohol while taking this medicine can increase the risk of low blood sugar and may cause symptoms such as flushing, nausea, and rapid heartbeat. It is best to limit alcohol intake and never drink on an empty stomach. Talk to your doctor about safe alcohol limits.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Allergy to nateglinide or any ingredient of this medicine","Type 1 diabetes mellitus","Diabetic ketoacidosis","Severe liver disease","Pregnancy and breastfeeding (unless advised by doctor)"]

⚠️ Warnings & Precautions

["This medicine can cause low blood sugar. Always take it with meals and carry a source of fast-acting sugar.","Do not take this medicine if you are fasting or skipping a meal.","Tell your doctor if you have kidney or liver problems, as the dose may need adjustment.","Avoid drinking alcohol heavily while taking this medicine.","This medicine may interact with many other medicines. Always inform your doctor about all medicines you take.","Do not drive or operate machinery if you feel dizzy or have symptoms of low blood sugar.","This medicine is not for use in children. Safety and effectiveness have not been established.","Older adults may be more sensitive to the effects of this medicine, especially low blood sugar."]

🤱 Lactation Safety

It is not known whether this medicine passes into breast milk. Because many medicines can pass into breast milk, consult your doctor before breastfeeding. Your doctor will weigh the benefits and risks.

💊 Overdose Management

Overdose of this medicine can cause severe low blood sugar, which may lead to seizures, coma, or other serious complications. If you suspect an overdose, seek emergency medical help immediately. Treatment may include giving sugar by mouth if the person is conscious, or intravenous glucose if unconscious. Monitor blood sugar closely until stable.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember, but only if you are about to eat a meal. If you have already missed the meal, skip the missed dose and take the next dose at the next scheduled meal. Do not take a double dose to make up for a missed one. Never take this medicine without food.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed, usually within 30 minutes before each main meal. If you skip a meal, skip the dose for that meal to avoid low blood sugar. Do not take this medicine if you are fasting or if you are not going to eat. Carry a fast-acting source of sugar, such as glucose tablets or candy, to treat low blood sugar. Check your blood sugar regularly as advised by your doctor. Avoid drinking alcohol heavily because it can increase the risk of low blood sugar. Tell your doctor if you have kidney or liver problems, because the dose may need adjustment. Do not start or stop any other medicine without asking your doctor, especially other diabetes medicines, blood pressure medicines, or steroids. Keep this medicine out of reach of children. Store it at room temperature away from moisture and heat. Do not use it after the expiry date.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Older adults are at higher risk of low blood sugar and may be more sensitive to this medicine. Start with a lower dose and monitor blood sugar closely. Regular review of kidney and liver function is important.

🤰 Pregnancy Planning (TTC)

This medicine is not recommended during pregnancy. If you are planning pregnancy, talk to your doctor about switching to insulin, which is the preferred treatment for diabetes in pregnancy. Good blood sugar control before and during pregnancy is important for the health of both mother and baby.

🏥 Post-Surgery Considerations

After surgery, blood sugar levels can be unstable. Your doctor will decide if you should continue this medicine or switch to insulin. Monitor blood sugar closely and follow your healthcare team's instructions.

🦷 Dental Procedures

Inform your dentist that you take this medicine. Dental procedures can affect your eating schedule, so you may need to adjust your dose. Check with your doctor before the procedure.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight through balanced diet and regular exercise.
🥗
Eat meals at regular times and do not skip meals.
😴
Monitor your blood sugar regularly as advised by your doctor.
💧
Limit alcohol intake and avoid drinking on an empty stomach.
🧘
Stay physically active with at least 30 minutes of moderate exercise most days.
🌞
Get enough sleep and manage stress to help control blood sugar.
🚭
Keep a record of your blood sugar readings and bring it to your doctor visits.

🏋️ Exercise Considerations

Exercise can lower blood sugar. If you exercise, check your blood sugar before and after, and carry a source of fast-acting sugar. Adjust your meal and medicine timing with your doctor's advice.

🥗 Diet Recommendations

Eat regular meals with a good balance of carbohydrates, protein, and healthy fats.
Choose whole grains, fruits, vegetables, and lean proteins.
Limit sugary drinks and refined carbohydrates.
Stay well hydrated with water.
Avoid skipping meals, especially when taking this medicine.

💼 Impact on Daily Work & Life

This medicine may cause low blood sugar, which can affect your ability to drive or operate machinery. Do not drive if you feel dizzy or have symptoms of low blood sugar. Take regular breaks and eat meals on time at work. Inform your employer about your condition and emergency contacts.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or your blood sugar is well controlled with lifestyle changes, your doctor may adjust or stop the medicine. Always follow your doctor's advice.

📅 Long-Term Use Effects

Long-term use of this medicine may lead to weight gain and an increased risk of low blood sugar episodes. Regular monitoring of blood sugar, HbA1c, liver, and kidney function is important. Over time, diabetes may require additional medicines to maintain control. This medicine does not cure diabetes, and lifestyle changes remain essential.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Lifestyle modifications

Diet and exercise are the foundation of diabetes management and can reduce the need for medicines.

Evidence: Well-established
Other oral antidiabetic medicines

Metformin, sulfonylureas, DPP-4 inhibitors, SGLT2 inhibitors, and others may be alternatives depending on your condition.

Evidence: Well-established
Insulin therapy

May be needed if oral medicines do not control blood sugar adequately.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

People with diabetes should stay up to date with recommended vaccines, including influenza, pneumococcal, and hepatitis B vaccines. Discuss with your doctor about the best timing.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C).

❌ DON'T

Do not refrigerate unless specified.

✅ DO

Keep in the original container.

❌ DON'T

Do not transfer to unmarked containers.

✅ DO

Keep away from direct sunlight and moisture.

❌ DON'T

Do not store in the bathroom cabinet.

✅ DO

Keep out of reach of children.

❌ DON'T

Do not use after the expiry date.

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. If crossing time zones, adjust your meal times and take the medicine before meals as usual. Store it at room temperature and protect it from moisture and heat. Check customs regulations for carrying prescription medicines to your destination.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 52-year-old man with type 2 diabetes not controlled by metformin alone.
His doctor added this medicine to be taken before each meal. He initially had mild dizziness after starting, but it improved when he made sure to eat regular meals. His post-meal blood sugar levels came down significantly over a few weeks.
💡 Lesson: Taking this medicine with meals and monitoring blood sugar helps achieve good control and reduces side effects.
👤 A 65-year-old woman with type 2 diabetes and mild kidney disease.
She was started on a lower dose of this medicine because of her kidney function. She was advised to check her blood sugar more often. She experienced one episode of low blood sugar when she skipped breakfast, but recovered after taking glucose. She now never misses meals.
💡 Lesson: Older adults and those with kidney disease need careful dose adjustment and should never skip meals while on this medicine.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine starts to lower blood sugar within 15 to 60 minutes after taking a dose. It is taken shortly before meals to control the post-meal blood sugar spike.

Q: Can I take this medicine if I skip a meal?

A: No, you should skip the dose if you skip the meal. Taking this medicine without food can cause low blood sugar.

Q: What are the signs of low blood sugar?

A: Signs include shakiness, sweating, hunger, dizziness, rapid heartbeat, confusion, and blurred vision. If you experience these, take fast-acting sugar immediately.

Q: Can I take this medicine with other diabetes medicines?

A: It can be used with other diabetes medicines, but the dose may need adjustment. Always consult your doctor before combining.

Q: Is this medicine safe for my kidneys?

A: This medicine is not known to directly damage the kidneys, but it should be used with caution in people with kidney disease. Your doctor may adjust the dose.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?
  • Is this medicine safe in pregnancy?
  • Can I take it with other diabetes medicines?

🔄 Substitutes for natelide 120mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure diabetes.
    Fact: This medicine helps control blood sugar but does not cure diabetes. It must be used along with diet, exercise, and regular monitoring.
  • Myth: This medicine can be taken without food.
    Fact: This medicine should be taken with meals to reduce the risk of low blood sugar. Taking it without food can cause hypoglycemia.
  • Myth: This medicine is safe for everyone with diabetes.
    Fact: This medicine is not for people with type 1 diabetes or diabetic ketoacidosis. It should be used with caution in people with liver or kidney disease.
  • Myth: Once you start this medicine, you can eat anything.
    Fact: Diet and exercise remain essential. This medicine works best when combined with a healthy lifestyle.

🔄 Alternative Options

Generic Alternatives

  • Nateglinide 120 mg tablet

Brand Alternatives

  • Glinate 120 Tablet

📊 Comparison with Similar Medicines

[{"medicine":"Nateglinide","class":"Meglitinide","onset":"Rapid","duration":"Short","hypoglycemia_risk":"Moderate","weight_effect":"Weight gain possible","dosing":"Before each meal"},{"medicine":"Repaglinide","class":"Meglitinide","onset":"Rapid","duration":"Short","hypoglycemia_risk":"Moderate","weight_effect":"Weight gain possible","dosing":"Before each meal"},{"medicine":"Glimepiride","class":"Sulfonylurea","onset":"Slower","duration":"Long","hypoglycemia_risk":"Higher","weight_effect":"Weight gain","dosing":"Once daily"},{"medicine":"Metformin","class":"Biguanide","onset":"Slow","duration":"Long","hypoglycemia_risk":"Low","weight_effect":"Weight neutral or loss","dosing":"Once or twice daily"}]

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