Aceclofenac 100mg + Paracetamol 500mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual tiredness or weakness
If experiencing severe symptoms, call emergency services immediately.
What is nanofenac p 100mg/500mg tablet used for?
This medicine is a combination of aceclofenac and paracetamol used for short-term relief of acute pain and inflammation. It works by reducing prostaglandins that cause pain. Take it with food, and do not exceed the prescribed dose.
- Generic Name: Information coming soon
- Manufacturer: Multiple manufacturers
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nanofenac p 100mg/500mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एसिफेनाक और पैरासिटामोल का संयोजन है, जिसका उपयोग दर्द और सूजन को कम करने के लिए किया जाता है। यह मुख्य रूप से जोड़ों के दर्द, मांसपेशियों के दर्द, दांतों के दर्द, और सर्जरी के बाद के दर्द में राहत के लिए दी जाती है। यह दवा शरीर में प्रोस्टाग्लैंडिन नामक रसायन को कम करती है, जो दर्द और सूजन का कारण बनता है। इसे डॉक्टर की सलाह के अनुसार ही लें, और खाने के बाद लें ताकि पेट में जलन न हो।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, अपच, सिरदर्द, चक्कर आना और नींद आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन पेट में रक्तस्राव, एलर्जी, सांस लेने में कठिनाई, और गुर्दे की समस्या हो सकती है। यदि आपको कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खाने के बाद लें ताकि पेट में जलन न हो। शराब का सेवन न करें क्योंकि इससे पेट में रक्तस्राव और लीवर की समस्या हो सकती है। अन्य दर्द निवारक दवाओं के साथ इसका सेवन न करें। यदि आपको पेट में अल्सर, गुर्दे या लीवर की बीमारी, या दमा है, तो डॉक्टर को बताएं। 7 दिनों से अधिक इसका उपयोग न करें।
💊 nanofenac p 100mg/500mg tablet Uses & Benefits
[{"condition":"Osteoarthritis","description":"Relieves pain and improves joint mobility in knee, hip, and hand osteoarthritis.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Reduces pain and inflammation in rheumatoid arthritis as an adjunct to disease-modifying therapy.","evidence":"Well-established"},{"condition":"Acute musculoskeletal pain","description":"Provides short-term relief for strains, sprains, and other soft tissue injuries.","evidence":"Well-established"},{"condition":"Dental pain","description":"Effective for relief of post-extraction pain and other acute dental pain.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of mild to moderate post-surgical pain.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks, but evidence is limited.","evidence":"Limited"},{"condition":"Dysmenorrhea","description":"May be used off-label for menstrual pain, though other NSAIDs are more commonly recommended.","evidence":"Limited"}]
Primary treatment for: Pain and inflammation
Also treats: Osteoarthritis, Rheumatoid arthritis, Acute musculoskeletal pain, Dental pain, Post-operative pain
📋 Drug Information
| Generic Name(s) | Information coming soon |
| Brand Name | nanofenac p 100mg/500mg tablet |
| Manufacturer | Multiple manufacturers |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines aceclofenac, a non-steroidal anti-inflammatory drug, and paracetamol, an analgesic and antipyretic. Aceclofenac selectively inhibits cyclooxygenase-2 (COX-2) and to a lesser extent COX-1, reducing prostaglandin synthesis at sites of inflammation. Paracetamol acts primarily in the central nervous system, inhibiting prostaglandin synthesis and modulating pain perception, with minimal anti-inflammatory effects. Together, they provide synergistic pain relief.
Mechanism Steps
💡 How to Take nanofenac p 100mg/500mg tablet
Strength: Each tablet contains aceclofenac 100 mg and paracetamol 500 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally two to three times daily, preferably after meals, or as directed by your doctor. The maximum daily dose should not exceed three tablets in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-medicate or exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine. Use the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician based on renal and hepatic function. |
| Renal Impairment | Use with caution in patients with mild to moderate renal impairment. Avoid in severe renal impairment (creatinine clearance <30 mL/min). Dose adjustment may be required. Consult your doctor. |
| Hepatic Impairment | Use with caution in patients with mild to moderate hepatic impairment. Avoid in severe hepatic impairment. Dose adjustment may be required. Consult your doctor. |
| Maximum Daily Dose | The maximum daily dose is three tablets (aceclofenac 300 mg and paracetamol 1500 mg) in 24 hours. Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nanofenac p 100mg/500mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Methotrexate | Major | |
| ACE inhibitors | Moderate | |
| Diuretics | Moderate | |
| Corticosteroids | Moderate | |
| Antacids | Minor | |
| Cholestyramine | Minor |
🚨 Major Interactions
- Warfarin
- Other NSAIDs
- Methotrexate
⚡ Moderate Interactions
- ACE inhibitors
- Diuretics
- Corticosteroids
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding and can potentiate liver toxicity, especially with paracetamol.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to aceclofenac, paracetamol, or any component of the formulation.","Active peptic ulcer or history of recurrent peptic ulcer.","Severe heart failure.","Severe kidney impairment (e.g., creatinine clearance
⚠️ Warnings & Precautions
["Use with caution in elderly patients due to increased risk of side effects.","Avoid in patients with asthma, as NSAIDs may precipitate bronchospasm.","Use with caution in patients with hypertension, as NSAIDs may increase blood pressure.","Do not exceed recommended dose of paracetamol to avoid liver toxicity.","Discontinue if signs of gastrointestinal bleeding occur.","Use with caution in patients with dehydration or volume depletion."]
🤱 Lactation Safety
Aceclofenac and paracetamol are excreted in breast milk in small amounts. Consult your doctor before using this medicine while breastfeeding. Short-term use of paracetamol is generally considered safe, but aceclofenac should be avoided unless prescribed.
💊 Overdose Management
Overdose may cause nausea, vomiting, abdominal pain, liver damage (from paracetamol), and kidney impairment. Seek immediate medical attention. Treatment includes activated charcoal if within 1-2 hours, and acetylcysteine for paracetamol toxicity. Supportive care and monitoring of liver and kidney function are essential.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine as it can increase the risk of stomach bleeding and liver damage. Do not take other NSAIDs or paracetamol-containing products simultaneously without consulting your doctor. Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, heart problems, or asthma. Do not use this medicine for more than 7 days without medical advice. Keep out of reach of children. Store in a cool, dry place away from direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration and monitor closely.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy, especially in the third trimester. If you are planning pregnancy, consult your doctor for alternative pain relief options.
🏥 Post-Surgery Considerations
This medicine may be used for post-operative pain, but it can increase bleeding risk. Inform your surgeon if you are taking it before surgery.
🦷 Dental Procedures
This medicine can be used for dental pain, but it may increase bleeding during dental procedures. Inform your dentist if you are taking it.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise if you have acute pain or injury. Consult your doctor before starting any exercise program while on this medicine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how it affects you. It may affect your ability to perform tasks requiring alertness.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if you experience severe side effects, or if your pain persists beyond 7 days. Do not stop abruptly if you have been on long-term therapy without medical advice.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of gastrointestinal bleeding, kidney impairment, liver toxicity, and cardiovascular events. Regular monitoring of liver and kidney function is advised. Use the lowest effective dose for the shortest duration.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain.
Evidence: Well-establishedMay help relieve localized pain and inflammation.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No known interactions with vaccines. However, if you have a fever, consult your doctor before vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. If traveling across time zones, adjust dosing intervals as advised by your doctor. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Pain relief typically begins within 30 to 60 minutes after taking the tablet.
A: It is best taken with food or milk to reduce stomach upset.
A: Do not take other NSAIDs or paracetamol-containing products without consulting your doctor.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can be taken on an empty stomach.
Fact: It should be taken with food to reduce stomach upset. - Myth: It is safe to take this medicine for long periods without monitoring.
Fact: Long-term use requires monitoring of liver and kidney function. - Myth: This medicine is safe during pregnancy.
Fact: It should be avoided during pregnancy, especially in the third trimester.
🔄 Alternative Options
Generic Alternatives
- Aceclofenac 100 mg + Paracetamol 500 mg tablet