Eberlin 500mcg/75mg Capsule: Complete Guide To Uses, Side Effects, And Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of face, lips, tongue, or throat
- Difficulty breathing or swallowing
- Suicidal thoughts or self-harm behavior
- Severe dizziness or fainting
- Unusual muscle pain, weakness, or dark urine
- Yellowing of skin or eyes
- Severe abdominal pain
If experiencing severe symptoms, call emergency services immediately.
What is nanocob-pg capsule used for?
This medicine is a combination of Methylcobalamin (500 mcg) and Pregabalin (75 mg) used to treat neuropathic pain. It works by reducing pain signals and supporting nerve health. It is taken orally, usually once or twice daily, and should be used under medical supervision.
- Generic Name: Methylcobalamin (500mcg) + Pregabalin (75mg)
- Manufacturer: Cheminnova Life Sciences
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nanocob-pg capsule के बारे में (Hindi Summary)
उपयोग: यह दवा मेथिलकोबालामिन 500 माइक्रोग्राम और प्रीगाबालिन 75 मिलीग्राम का संयोजन है। इसका उपयोग मुख्य रूप से न्यूरोपैथिक दर्द (तंत्रिका दर्द) के इलाज के लिए किया जाता है, जैसे कि मधुमेह के कारण होने वाला तंत्रिका दर्द, दाद के बाद का दर्द, और अन्य तंत्रिका संबंधी दर्द। यह दवा तंत्रिकाओं को स्वस्थ रखने और दर्द के संकेतों को कम करने में मदद करती है। यह मिर्गी के दौरे और चिंता विकार में भी कभी-कभी उपयोग की जाती है। इसका सेवन डॉक्टर के निर्देशानुसार ही करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में चक्कर आना, नींद आना, थकान, धुंधली दृष्टि, मुँह सूखना और हाथ-पैरों में सूजन शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी, सांस लेने में कठिनाई, आत्महत्या के विचार, या चेहरे-होंठों में सूजन हो सकती है। ऐसे लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी स्वास्थ्य स्थितियों के बारे में बताएं, विशेष रूप से गुर्दे की बीमारी, हृदय की समस्या, या श्वसन संबंधी समस्याएं। इस दवा के साथ शराब न पिएं। गाड़ी चलाने या मशीन चलाने से बचें जब तक कि आपको पता न चल जाए कि यह दवा आप पर कैसे असर करती है। दवा को डॉक्टर के बताए अनुसार ही लें, खुद से बंद न करें। यदि आप गर्भवती हैं या स्तनपान करा रही हैं, तो डॉक्टर से सलाह लें।
💊 nanocob-pg capsule Uses & Benefits
[{"condition":"Diabetic peripheral neuropathy","description":"This medicine helps relieve burning, tingling, and shooting pain associated with nerve damage due to diabetes.","evidence":"Well-established"},{"condition":"Postherpetic neuralgia","description":"Used to manage persistent nerve pain that can occur after a shingles infection.","evidence":"Well-established"},{"condition":"Neuropathic pain of other origins","description":"May be prescribed for nerve pain caused by spinal cord injury, multiple sclerosis, or chemotherapy.","evidence":"Moderate"},{"condition":"Adjunctive therapy for partial-onset seizures","description":"Pregabalin component is used as add-on treatment for certain types of epilepsy in adults.","evidence":"Well-established"},{"condition":"Generalized anxiety disorder","description":"Pregabalin may be used short-term for anxiety, though this combination is not first-line.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Fibromyalgia","description":"Sometimes prescribed off-label to reduce widespread musculoskeletal pain and improve sleep.","evidence":"Limited"},{"condition":"Chronic low back pain with neuropathic features","description":"May be used off-label when nerve involvement is suspected.","evidence":"Limited"},{"condition":"Restless legs syndrome","description":"Pregabalin has been studied off-label for reducing symptoms of restless legs syndrome.","evidence":"Limited"}]
Primary treatment for: Neuropathic pain
Also treats: Diabetic peripheral neuropathy, Postherpetic neuralgia, Epilepsy (partial-onset seizures), Generalized anxiety disorder
📋 Drug Information
| Generic Name(s) | Methylcobalamin (500mcg) + Pregabalin (75mg) |
| Brand Name | nanocob-pg capsule |
| Manufacturer | Cheminnova Life Sciences |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from moisture and light. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with distinct mechanisms. Methylcobalamin is a coenzyme form of vitamin B12 that participates in transmethylation reactions essential for myelin synthesis and nerve cell maintenance. It supports the regeneration of damaged peripheral nerves and improves nerve conduction. Pregabalin binds with high affinity to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This binding reduces the influx of calcium into presynaptic nerve terminals, thereby decreasing the release of excitatory neurotransmitters such as glutamate, norepinephrine, and substance P. The result is a reduction in neuronal excitability and pain signal transmission. Together, these actions provide symptomatic relief from neuropathic pain and may support nerve repair.
Mechanism Steps
💡 How to Take nanocob-pg capsule
Strength: Capsule containing Methylcobalamin 500 mcg and Pregabalin 75 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one capsule taken orally once or twice daily, or as directed by your physician. The exact dose and frequency depend on the indication, severity of symptoms, and your kidney function. For neuropathic pain, the typical starting dose is one capsule daily, which may be increased gradually based on response and tolerability. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially dizziness, drowsiness, and peripheral edema. Dose reduction may be necessary based on renal function. Start with a low dose and titrate slowly. Regular monitoring for falls and cognitive changes is advised. |
| Renal Impairment | Pregabalin is primarily excreted by the kidneys. In patients with renal impairment, dose adjustment is required. For creatinine clearance 30-60 mL/min, the dose may be reduced by 50%. For creatinine clearance 15-30 mL/min, the dose may be reduced by 75%. For creatinine clearance less than 15 mL/min, the dose should be reduced to once daily or as prescribed. Methylcobalamin does not require renal dose adjustment. Always consult your doctor for personalized dosing. |
| Hepatic Impairment | Pregabalin undergoes negligible hepatic metabolism, so no dose adjustment is typically required for hepatic impairment. Methylcobalamin is also not metabolized by the liver. However, in severe hepatic impairment, caution is advised and monitoring is recommended. |
| Maximum Daily Dose | The maximum recommended daily dose of Pregabalin is 600 mg per day, but for this combination, the dose should not exceed the prescribed amount. The maximum daily dose of Methylcobalamin in this combination is 500 mcg, but higher doses may be prescribed separately. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nanocob-pg capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Opioid analgesics | Major | |
| Benzodiazepines | Major | |
| ACE inhibitors | Major | |
| Thiazolidinediones | Moderate | |
| Loop diuretics | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- CNS depressants (e.g., opioids, benzodiazepines, alcohol)
- Angiotensin-converting enzyme (ACE) inhibitors
⚡ Moderate Interactions
- Thiazolidinediones (e.g., pioglitazone)
- Loop diuretics
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can potentiate the sedative and dizzying effects of Pregabalin, leading to increased impairment and risk of accidents. It may also worsen dizziness and drowsiness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to Pregabalin, Methylcobalamin, or any component of the formulation","Severe renal impairment (creatinine clearance
⚠️ Warnings & Precautions
["May cause dizziness and drowsiness; avoid driving or operating machinery until effects are known.","Risk of suicidal thoughts and behavior; monitor mood closely.","May cause peripheral edema; use with caution in patients with heart failure.","Potential for dependence and withdrawal symptoms; do not stop abruptly.","Use with caution in elderly patients due to increased risk of falls.","May impair respiratory function in patients with compromised respiratory status.","Not recommended for children unless prescribed by a specialist.","Avoid alcohol and other CNS depressants."]
🤱 Lactation Safety
Pregabalin is excreted in breast milk. Breastfeeding is not recommended during treatment due to potential risk of infant sedation. Methylcobalamin is safe in breast milk. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose of this medicine may cause excessive drowsiness, confusion, agitation, and in severe cases, respiratory depression, coma, or death. If overdose is suspected, seek emergency medical attention immediately. Treatment is supportive and symptomatic. There is no specific antidote for Pregabalin. Hemodialysis may be considered in severe cases, especially in patients with renal impairment. Methylcobalamin overdose is unlikely to cause serious effects due to its low toxicity.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Before starting this medicine, inform your doctor about all your medical conditions, especially kidney disease, heart failure, respiratory problems, or a history of substance abuse. Do not drink alcohol while taking this medicine, as it can increase drowsiness and dizziness. Avoid driving or operating heavy machinery until you know how this medicine affects you. Take this medicine exactly as prescribed; do not change the dose without consulting your doctor. If you miss a dose, take it as soon as you remember, but if it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double the dose. Keep this medicine out of reach of children. Store it at room temperature, away from moisture and heat. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine. Pregabalin may pass into breast milk and could affect a nursing infant. Regular monitoring of kidney function may be required during long-term therapy. Report any unusual side effects to your healthcare provider promptly.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of dizziness, drowsiness, and falls. Dose reduction may be necessary based on kidney function. Regular monitoring of renal function and mental status is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Pregabalin may harm the fetus. Effective contraception is recommended during treatment. Methylcobalamin is generally safe but should be used under medical guidance.
🏥 Post-Surgery Considerations
This medicine may be continued after surgery if prescribed for neuropathic pain. However, it can interact with anesthetics and opioids, increasing sedation. Inform your anesthesiologist about this medicine before surgery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may interact with sedatives or anesthetics used during dental procedures. It may also cause dry mouth, which can affect oral health.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities requiring high alertness until you know how this medicine affects you. Dizziness and drowsiness may increase the risk of falls or injuries. Start with gentle exercises and gradually increase as tolerated.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness and dizziness, which can affect your ability to drive, operate machinery, or perform tasks requiring mental alertness. It is advisable to avoid such activities until you know how the medicine affects you. Inform your employer if your job involves safety-sensitive tasks.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects or your condition improves, your doctor may gradually reduce the dose to prevent withdrawal symptoms. Abrupt discontinuation can cause anxiety, insomnia, nausea, and headache.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to tolerance, dependence, and withdrawal symptoms if stopped abruptly. Regular monitoring of kidney function, mood, and weight is recommended. Some patients may experience persistent peripheral edema or cognitive effects. Periodic reassessment of the need for continued therapy is advised.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help improve nerve function and reduce pain through targeted exercises.
Evidence: ModerateMay provide symptomatic relief for some patients with neuropathic pain.
Evidence: LimitedHelps manage chronic pain and associated anxiety.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, consult your doctor before receiving any vaccine while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. If crossing time zones, adjust dosing times gradually to avoid missed doses. Store at room temperature and protect from extreme heat or moisture. Keep it in your carry-on luggage. Check local customs regulations for controlled substances, as Pregabalin may be regulated in some countries.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling some relief within a few days, but full benefits for neuropathic pain may take 2 to 4 weeks.
A: No, do not stop abruptly. Consult your doctor first, as stopping suddenly can cause withdrawal symptoms.
A: Pregabalin has a potential for dependence. It should be used exactly as prescribed and not shared with others.
A: Inform your doctor about all medicines you take. Some combinations may increase side effects.
🤔 Common Patient Concerns
🔄 Substitutes for nanocob-pg capsule
View AllAlternative brands with exact same active ingredient:
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gabafit m 500mcg/75mg tabletGlenmark Pharmaceuticals Ltd ₹76.03 37.4% CHEAPER
-
premylin tabletZoic Lifesciences ₹79.69 34.4% CHEAPER
-
apinex nv 500mcg/75mg capsuleProceed Formulations ₹84.38 30.6% CHEAPER
-
mythin 500mcg/75mg tabletSeven Hills Life Sciences ₹84.38 30.6% CHEAPER
-
axinerve tabletAvis Lifecare Pvt Ltd ₹88.13 27.5% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a painkiller for all types of pain.
Fact: It is specifically for neuropathic pain and not effective for ordinary muscle or joint pain. - Myth: It is safe to stop this medicine abruptly.
Fact: Stopping suddenly can cause withdrawal symptoms like anxiety, insomnia, and nausea. Always taper under medical guidance. - Myth: This medicine can be taken without a prescription.
Fact: It is a prescription-only medicine and should only be taken under a doctor's supervision.
🔄 Alternative Options
Generic Alternatives
- Methylcobalamin 500 mcg + Pregabalin 75 mg capsule (generic)