nacpo tablet - Chlormezanone (250mg) + Paracetamol (325mg) medicine

Nacpo Tablet: Complete Guide to Uses, Side Effects, and Safety

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🏭 Helax Healthcare Pvt. Ltd. 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 24, 2026
⚠️ Hepatotoxicity Risk 🤰 Pregnancy Category Not established from the available information. This medicine should be avoided during pregnancy unless clearly needed and advised by a doctor. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Limited
Reviewed by
SaathiMed Expert Panel | Sep 24, 2026

When to Call Your Doctor IMMEDIATELY

  • Rash, blisters, or peeling skin
  • Fever with sore throat or mouth sores
  • Unusual bleeding or bruising
  • Yellowing of eyes or skin
  • Severe abdominal pain
  • Difficulty breathing or swelling of face, lips, or throat
  • Decreased urine output

If experiencing severe symptoms, call emergency services immediately.

What is nacpo tablet used for?

This medicine is a combination of chlormezanone and paracetamol used for short-term relief of painful muscle spasms and mild to moderate pain. It works by relaxing muscles and reducing pain. It should be taken exactly as prescribed and avoided in pregnancy, severe liver or kidney disease, and with alcohol.

  • Generic Name: Chlormezanone (250mg) + Paracetamol (325mg)
  • Manufacturer: Helax Healthcare Pvt. Ltd.
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 nacpo tablet के बारे में (Hindi Summary)

उपयोग: यह दवा क्लोरमेज़ानोन और पैरासिटामोल का संयोजन है, जिसका उपयोग मांसपेशियों में ऐंठन और हल्के से मध्यम दर्द के अल्पकालिक उपचार के लिए किया जाता है। यह मांसपेशियों को आराम देकर और दर्द को कम करके काम करती है। इसका उपयोग केवल डॉक्टर की सलाह से और सीमित समय के लिए ही करना चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, मुँह सूखना, जी मिचलाना और कमजोरी शामिल हैं। गंभीर दुष्प्रभावों में त्वचा पर गंभीर दाने, बुखार, खून की कमी और लीवर की समस्या हो सकती है। अगर कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसके साथ शराब बिल्कुल न लें। दवा लेने के बाद गाड़ी चलाने या मशीन चलाने से बचें। पैरासिटामोल वाली अन्य दवाएं साथ में न लें। अगर आप गर्भवती हैं, स्तनपान करा रही हैं, या आपको लीवर या किडनी की बीमारी है, तो डॉक्टर को बताएं।

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 nacpo tablet Uses & Benefits

[{"condition":"Musculoskeletal pain with muscle spasm","description":"This medicine is used for short-term relief of painful muscle spasms and tension associated with strains, sprains, and other musculoskeletal conditions.","evidence":"Limited"},{"condition":"Tension-type headache with muscle tightness","description":"Sometimes used for short-term relief of tension headaches when associated with muscle spasm, though evidence is limited.","evidence":"Limited"},{"condition":"Mild to moderate pain","description":"Paracetamol component provides relief of mild to moderate pain and fever, while chlormezanone adds muscle relaxant effect.","evidence":"Limited"}]

Off-label uses: [{"condition":"Anxiety-related muscle tension","description":"Chlormezanone has been used historically for anxiety and tension, but this is not a recommended use due to safety concerns.","evidence":"Limited"}]

Primary treatment for: Musculoskeletal pain with muscle spasm

Also treats: Tension headache, Mild to moderate pain

📋 Drug Information

Generic Name(s)Chlormezanone (250mg) + Paracetamol (325mg)
Brand Namenacpo tablet
ManufacturerHelax Healthcare Pvt. Ltd.
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action Class
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C in a dry place, away from direct sunlight and moisture. Keep in the original container.
Shelf LifeNot established from the available information. Refer to the packaging for the expiry date.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food or milk to reduce stomach upset.
2
Avoid alcohol completely while taking this medicine.
3
Do not drive or operate machinery until you know how this medicine affects you.
4
Do not take other paracetamol-containing products simultaneously.
5
Stop the medicine and seek immediate medical help if you develop a rash, fever, or mouth sores.
6
Use this medicine for the shortest duration possible, as recommended by your doctor.
7
Inform your doctor if you have liver or kidney disease before taking this medicine.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Muscle spasm
This medicine is commonly prescribed for this.
Likely Use
Mild to moderate pain
This medicine may be used for this.
Likely Use
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionChlormezanone is absorbed from the gastrointestinal tract after oral administration. Paracetamol is also rapidly absorbed from the gastrointestinal tract. Exact absorption parameters for this combination are not established from the available information.
DistributionChlormezanone is distributed throughout the body, including the central nervous system. Paracetamol distributes widely into most body tissues. Specific distribution data for this combination are not established from the available information.
Protein BindingChlormezanone is reported to be highly bound to plasma proteins. Paracetamol has low plasma protein binding. Exact values for this combination are not established from the available information.
MetabolismChlormezanone is metabolized in the liver. Paracetamol is metabolized primarily in the liver by conjugation and, to a small extent, by cytochrome P450 enzymes. The exact metabolic pathways for this combination are not established from the available information.
Half-LifeThe elimination half-life of chlormezanone is not established from the available information. Paracetamol has an elimination half-life of approximately 2 to 3 hours in adults with normal liver function.
ExcretionChlormezanone and its metabolites are excreted mainly in urine. Paracetamol metabolites are excreted primarily in urine. Exact excretion data for this combination are not established from the available information.
BioavailabilityNot established from the available information.
Onset of ActionOnset of muscle relaxant effect is usually within 30 to 60 minutes after oral administration. Analgesic effect of paracetamol begins within 30 to 60 minutes.
Peak Plasma TimePeak plasma concentration of paracetamol is typically reached within 30 to 60 minutes. Peak plasma time for chlormezanone is not established from the available information.
Duration of ActionThe muscle relaxant effect may last 4 to 6 hours. Paracetamol analgesia lasts about 4 to 6 hours. Exact duration for this combination is not established from the available information.

How It Works

This medicine combines two active ingredients with different mechanisms. Chlormezanone is a centrally acting agent that reduces muscle tone by depressing polysynaptic reflexes in the spinal cord and brainstem, likely through effects on the limbic system and reticular formation. Paracetamol reduces pain and fever mainly by inhibiting prostaglandin synthesis in the central nervous system and possibly by activating descending pain-inhibitory pathways. Together, they reduce muscle spasm and associated pain.

Mechanism Steps

1
Central nervous system depression: Chlormezanone acts on the central nervous system to reduce excessive muscle tone and spasm.
2
Inhibition of polysynaptic reflexes: It suppresses polysynaptic reflex pathways in the spinal cord and brainstem, leading to muscle relaxation.
3
Central prostaglandin inhibition: Paracetamol inhibits prostaglandin synthesis in the brain and spinal cord, reducing pain and fever.
4
Descending pain pathway activation: Paracetamol may enhance descending inhibitory pain pathways, contributing to analgesia.

💡 How to Take nacpo tablet

Strength: Chlormezanone 250 mg + Paracetamol 325 mg immediate-release tablet

1Take this medicine orally with a full glass of water.
2Take it with food or milk to reduce stomach upset.
3Swallow the tablet whole; do not crush or chew.
4Take it at the same times each day as prescribed.
5Do not take more than the prescribed dose.

Dosage Information

Adult DosageThe usual adult dose of this medicine is one tablet taken orally two to three times a day, as prescribed by your doctor. The exact dose and duration depend on your condition, age, liver and kidney function, and response to treatment. Do not exceed the recommended dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the sedative and muscle relaxant effects of this medicine. Use with caution and lower doses may be advised by the doctor. Dose must be individualized by a qualified clinician.
Renal ImpairmentUse with caution in patients with kidney disease. Dose adjustment may be needed. Consult your doctor.
Hepatic ImpairmentUse with caution in patients with liver disease. Paracetamol dose should be limited, and chlormezanone should be avoided in severe liver disease. Consult your doctor.
Maximum Daily DoseNot established from the available information. Do not exceed the dose prescribed by your doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Alcohol
Avoid
Increases risk of liver damage and drowsiness.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of nacpo tablet

✅ Common Side Effects

Drowsiness (Common (5-10%))
Avoid driving or operating machinery. Consult your doctor if it persists or interferes with daily activities.
Dizziness (Common (5-10%))
Rise slowly from sitting or lying position. Avoid alcohol. Consult your doctor if severe.
Dry mouth (Common (5-10%))
Sip water frequently. Chew sugar-free gum if needed. Consult your doctor if it becomes bothersome.
Nausea (Common (5-10%))
Take with food or milk. Consult your doctor if vomiting occurs.
Weakness (Common (5-10%))
Rest adequately. Consult your doctor if weakness is severe or persistent.

🚨 Serious Side Effects

Severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis) (Rare (<0.1%))
Stop this medicine immediately and seek emergency medical care if you develop rash, blisters, peeling skin, fever, or mouth sores.
Blood disorders (agranulocytosis, thrombocytopenia) (Rare (<0.1%))
Seek immediate medical attention if you develop fever, sore throat, unusual bleeding, or bruising.
Liver injury due to paracetamol (Rare (<0.1%))
Seek urgent care if you notice yellowing of eyes or skin, dark urine, or severe abdominal pain.
Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek emergency help if you experience swelling of face, lips, throat, difficulty breathing, or widespread rash.

⚠️ Rare Side Effects

Jaundice
Seek immediate medical attention.
Pancreatitis
Seek immediate medical attention if severe abdominal pain occurs.
Hypersensitivity reactions
Stop the medicine and consult a doctor immediately.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Alcohol Major
Benzodiazepines Major
Carbamazepine Moderate
Phenytoin Moderate
Rifampicin Moderate
Metoclopramide Minor
Activated charcoal Minor

🚨 Major Interactions

  • Warfarin
  • Alcohol
  • Other central nervous system depressants (e.g., benzodiazepines, opioids, antihistamines)

⚡ Moderate Interactions

  • Carbamazepine
  • Phenytoin
  • Rifampicin

🍷 Alcohol Interaction

Alcohol should be completely avoided while taking this medicine. Combining alcohol with paracetamol increases the risk of serious liver damage, and alcohol also adds to the sedative effects of chlormezanone, leading to excessive drowsiness and impaired coordination.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known allergy to chlormezanone or paracetamol","Severe liver disease","Severe kidney disease","History of blood disorders such as agranulocytosis or thrombocytopenia","Pregnancy and breastfeeding unless clearly advised by a doctor","Children unless specifically prescribed by a pediatrician"]

⚠️ Warnings & Precautions

["May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol completely.","Do not take other paracetamol-containing products.","Stop immediately and seek medical help if rash, fever, or mouth sores develop.","Use with caution in elderly patients and those with liver or kidney disease.","Do not use for longer than recommended without medical supervision."]

🤱 Lactation Safety

Not established from the available information. This medicine should be avoided during breastfeeding unless clearly advised by a doctor.

💊 Overdose Management

Overdose of this medicine can cause severe liver damage due to paracetamol and increased sedation due to chlormezanone. Seek emergency medical attention immediately. Treatment may include activated charcoal, acetylcysteine for paracetamol toxicity, and supportive care. Do not wait for symptoms to appear.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor and do not increase the dose or duration on your own. Avoid alcohol completely while taking this medicine because it increases the risk of liver damage and excessive drowsiness. Do not drive, operate heavy machinery, or perform activities requiring full alertness until you know how this medicine affects you. Do not take other products containing paracetamol at the same time, as this can lead to accidental overdose and liver injury. Inform your doctor if you have liver or kidney problems, blood disorders, or if you are pregnant, planning pregnancy, or breastfeeding. Stop this medicine and contact your doctor immediately if you develop a rash, fever, mouth sores, or any unusual bleeding or bruising. Keep this medicine out of reach of children and store it in its original packaging away from direct sunlight and moisture.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more likely to experience drowsiness, dizziness, and confusion with this medicine. Lower doses may be needed, and caution is advised while driving or operating machinery. Regular monitoring for side effects is recommended.

🤰 Pregnancy Planning (TTC)

This medicine should be avoided if you are planning pregnancy or are pregnant. Consult your doctor for safer alternatives for muscle spasm and pain.

🏥 Post-Surgery Considerations

This medicine may be used for post-surgical muscle spasm and pain, but only under medical supervision. It can add to the sedative effects of anesthesia and other pain medicines. Inform your surgeon and anesthesiologist if you are taking this medicine.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine before any dental procedure. It may interact with sedatives or anesthetics used during dental work, and it can cause drowsiness.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce strain on muscles and joints.
🥗
Practice regular stretching and low-impact exercises like walking or swimming.
😴
Ensure good posture while sitting and lifting.
💧
Get adequate sleep to help muscle recovery.
🧘
Stay well hydrated throughout the day.
🌞
Avoid heavy lifting and sudden jerky movements.

🏋️ Exercise Considerations

Avoid strenuous exercise or heavy lifting while taking this medicine, as it can cause drowsiness and muscle weakness. Gentle stretching and walking may be beneficial, but consult your doctor before starting any exercise routine.

🥗 Diet Recommendations

Include plenty of fruits and vegetables.
Choose whole grains and lean proteins.
Limit processed and fried foods.
Stay well hydrated.
Avoid alcohol completely.

💼 Impact on Daily Work & Life

This medicine can cause drowsiness and dizziness, which may affect your ability to drive, operate machinery, or perform tasks requiring alertness. It is best to avoid such activities until you know how the medicine affects you. Office work may be continued if you do not feel drowsy.

🛑 When to Stop This Medicine

Stop this medicine if you develop any serious side effects such as rash, fever, unusual bleeding, or yellowing of eyes. Do not stop abruptly if you have been taking it for a long time without consulting your doctor. Usually, this medicine is stopped when the muscle spasm and pain resolve, as advised by your doctor.

📅 Long-Term Use Effects

Long-term use of this medicine is not recommended. Prolonged use of chlormezanone may increase the risk of blood disorders and dependence, while long-term paracetamol use can affect the liver, especially with alcohol. Regular monitoring of liver function and blood counts may be needed if extended use is unavoidable.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can help strengthen muscles and reduce spasm.

Evidence: Well-established
Hot or cold packs

May help relieve muscle spasm and pain.

Evidence: Limited
Gentle stretching and yoga

Can improve flexibility and reduce tension.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

Not established from the available information. There are no known interactions between this medicine and vaccines.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from direct sunlight and moisture. If crossing time zones, continue your doses as prescribed, but do not double up. Check local customs regulations regarding prescription medicines before you travel.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old office worker with acute lower back pain and muscle spasm
He was prescribed this medicine for short-term relief. He took it with food as advised and avoided driving. His muscle spasm improved within a few days, and he stopped the medicine after one week as instructed by his doctor.
💡 Lesson: Taking this medicine with food and avoiding driving improves tolerability and safety. Short-term use as prescribed is important.
👤 A 60-year-old woman with neck muscle spasm and tension headache
She was started on this medicine but developed drowsiness and dizziness. Her doctor reduced the dose and advised her to take it at bedtime. She improved without serious side effects.
💡 Lesson: Elderly patients may be more sensitive to side effects. Dose adjustment and timing can help.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts working within 30 to 60 minutes after taking it.

Q: Can I take this medicine for a long time?

A: No, this medicine is for short-term use only. Prolonged use should be avoided unless specifically advised by your doctor.

Q: Is this medicine safe in pregnancy?

A: This medicine should be avoided during pregnancy unless clearly advised by a doctor.

Q: Can I drink alcohol while taking this medicine?

A: No, alcohol should be completely avoided as it increases the risk of liver damage and drowsiness.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for nacpo tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine is a general painkiller for all types of pain.
    Fact: This medicine is specifically for painful muscle spasms and is not recommended for all types of pain.
  • Myth: It is safe to take this medicine for long periods.
    Fact: This medicine is for short-term use only. Prolonged use can increase the risk of side effects.
  • Myth: You can drink alcohol while taking this medicine.
    Fact: Alcohol should be completely avoided as it increases the risk of liver damage and drowsiness.

📊 Comparison with Similar Medicines

[{"medicine":"Chlormezanone + Paracetamol","class":"Muscle relaxant + analgesic","main_use":"Muscle spasm and pain","sedation":"Moderate to high","liver_risk":"Moderate"},{"medicine":"Chlorzoxazone + Paracetamol","class":"Muscle relaxant + analgesic","main_use":"Muscle spasm and pain","sedation":"Moderate","liver_risk":"Moderate"},{"medicine":"Thiocolchicoside + Paracetamol","class":"Muscle relaxant + analgesic","main_use":"Muscle spasm and pain","sedation":"Low","liver_risk":"Low"}]

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