Nacpain SP 100mg/325mg/15mg Tablet: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bruising or bleeding
- Severe skin rash with blisters or peeling
If experiencing severe symptoms, call emergency services immediately.
What is nacpain sp 100mg/325mg/15mg tablet used for?
This medicine is a combination of aceclofenac, paracetamol, and serratiopeptidase used for short-term relief of acute inflammatory pain. It works by reducing pain, inflammation, and swelling. It should be taken with food and only as prescribed by a doctor.
- Generic Name: Information coming soon
- Manufacturer: Multiple manufacturers
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nacpain sp 100mg/325mg/15mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एसिफेनाक, पैरासिटामोल और सेरेशियोपेप्टिडेज़ का संयोजन है, जिसका उपयोग तीव्र सूजन और दर्द के इलाज के लिए किया जाता है। यह दांतों की सर्जरी, चोट, ऑपरेशन के बाद के दर्द, गठिया और मांसपेशियों की समस्याओं में राहत देती है। यह दर्द, सूजन और जलन को कम करने में मदद करती है। इसका सेवन डॉक्टर के निर्देशानुसार ही करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, अपच, सिरदर्द, चक्कर आना और नींद आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन पेट में तेज दर्द, काला मल, खून की उल्टी, सांस लेने में कठिनाई, चेहरे या गले में सूजन, या त्वचा पर गंभीर दाने हो सकते हैं। ऐसे लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे भोजन के साथ लें ताकि पेट में जलन न हो। शराब का सेवन न करें। अन्य दर्द निवारक दवाओं का सेवन बिना डॉक्टर की सलाह के न करें। यदि आपको पेट की बीमारी, गुर्दे या लीवर की समस्या, दिल की बीमारी या अस्थमा है, तो डॉक्टर को बताएं। गर्भावस्था के दौरान इसका सेवन न करें। बच्चों से दूर रखें।
💊 nacpain sp 100mg/325mg/15mg tablet Uses & Benefits
[{"condition":"Acute inflammatory pain","description":"This medicine is used for short-term relief of acute pain associated with inflammation, such as after dental procedures, minor surgeries, or musculoskeletal injuries.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"It helps manage pain and swelling after surgical procedures, including orthopedic and dental surgeries.","evidence":"Well-established"},{"condition":"Osteoarthritis","description":"It provides symptomatic relief of pain and stiffness in osteoarthritis of the knee, hip, and hand.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"It is used to reduce pain and inflammation in rheumatoid arthritis as part of a comprehensive treatment plan.","evidence":"Well-established"},{"condition":"Ankylosing spondylitis","description":"It helps relieve pain and stiffness in ankylosing spondylitis.","evidence":"Well-established"},{"condition":"Soft tissue injuries","description":"It is used for pain and swelling associated with sprains, strains, and sports injuries.","evidence":"Well-established"},{"condition":"Dysmenorrhea","description":"It may be prescribed for painful menstrual cramps.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks, but evidence is limited.","evidence":"Limited"},{"condition":"Fever","description":"May be used off-label for fever reduction, but paracetamol alone is usually preferred.","evidence":"Limited"}]
Primary treatment for: Acute inflammatory pain
Also treats: Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis, Post-operative pain, Dental pain, Soft tissue injuries, Dysmenorrhea
📋 Drug Information
| Generic Name(s) | Information coming soon |
| Brand Name | nacpain sp 100mg/325mg/15mg tablet |
| Manufacturer | Multiple manufacturers |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a cool, dry place away from direct sunlight. Keep in the original container, tightly closed. Do not refrigerate unless specified. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture, unless otherwise stated on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines three active ingredients with complementary mechanisms. Aceclofenac, a non-steroidal anti-inflammatory drug, inhibits the cyclooxygenase enzymes (COX-1 and COX-2), leading to decreased synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. Paracetamol acts primarily in the central nervous system to reduce pain and fever, with weak anti-inflammatory effects. Serratiopeptidase is a proteolytic enzyme that breaks down fibrin and other inflammatory proteins, potentially reducing swelling and improving tissue repair. Together, these actions provide analgesic, anti-inflammatory, and anti-edema effects.
Mechanism Steps
💡 How to Take nacpain sp 100mg/325mg/15mg tablet
Strength: Each tablet contains aceclofenac 100 mg, paracetamol 325 mg, and serratiopeptidase 15 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally two to three times daily, preferably after meals, or as directed by your doctor. The dose and duration depend on the condition being treated, its severity, and your response to therapy. Do not exceed the recommended dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not use for more than 7 days without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the side effects of this medicine, especially gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician based on renal and hepatic function. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose reduction may be necessary. Not recommended in severe renal impairment (creatinine clearance <30 mL/min). Consult your doctor for dose adjustment. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose reduction may be necessary. Contraindicated in severe hepatic impairment. Consult your doctor for dose adjustment. |
| Maximum Daily Dose | The maximum daily dose should not exceed three tablets in 24 hours, unless otherwise prescribed by your doctor. Do not exceed the recommended dose of paracetamol (maximum 4 grams per day from all sources). |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nacpain sp 100mg/325mg/15mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Corticosteroids | Major | |
| Methotrexate | Major | |
| Lithium | Major | |
| ACE inhibitors | Major | |
| Diuretics | Major | |
| SSRIs | Moderate | |
| Antihypertensives | Moderate | |
| Phenytoin | Moderate |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., ibuprofen, naproxen)
- Corticosteroids
- Methotrexate
- Lithium
- ACE inhibitors and angiotensin receptor blockers
- Diuretics
⚡ Moderate Interactions
- Antihypertensives (beta-blockers, calcium channel blockers)
- SSRIs
- Oral hypoglycemics
- Phenytoin
- Probenecid
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding, ulceration, and liver damage, especially when combined with paracetamol and NSAIDs.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity or allergy to aceclofenac, paracetamol, serratiopeptidase, or any component of the formulation.","Active or history of peptic ulcer, gastrointestinal bleeding, or perforation.","Severe heart failure, ischemic heart disease, or cerebrovascular disease.","Severe hepatic impairment or active liver disease.","Severe renal impairment (creatinine clearance
⚠️ Warnings & Precautions
["Take with food or milk to minimize stomach upset.","Avoid alcohol and other NSAIDs during treatment.","Use with caution in the elderly due to increased risk of side effects.","Monitor for signs of gastrointestinal bleeding, especially with long-term use.","Do not exceed the recommended dose of paracetamol to avoid liver toxicity.","Use with caution in patients with asthma, as NSAIDs may trigger bronchospasm.","May cause dizziness or drowsiness; avoid driving or operating machinery until you know how it affects you.","Inform your doctor if you have a history of kidney or liver disease, heart failure, or hypertension.","Do not use for more than 7 days without medical advice.","Keep out of reach of children."]
🤱 Lactation Safety
This medicine may pass into breast milk. It is not recommended during breastfeeding unless clearly needed and prescribed by a doctor. Consult your doctor for guidance.
💊 Overdose Management
Overdose of this medicine can cause severe liver damage due to paracetamol and gastrointestinal bleeding due to aceclofenac. Symptoms of overdose may include nausea, vomiting, abdominal pain, confusion, and drowsiness. If you suspect an overdose, seek immediate medical attention. Treatment may include activated charcoal, N-acetylcysteine for paracetamol toxicity, and supportive care. Do not induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine, as it can increase the risk of stomach bleeding and liver problems. Do not take other pain relievers or anti-inflammatory medicines without consulting your doctor, as this may increase the risk of side effects. If you have a history of stomach ulcers, kidney disease, liver disease, heart disease, or asthma, inform your doctor before taking this medicine. Do not use this medicine during the third trimester of pregnancy. If you are breastfeeding, consult your doctor before use. Keep this medicine out of the reach of children. Store it in a cool, dry place away from direct sunlight. If you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients (above 65 years) are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor renal and hepatic function regularly. Avoid concurrent use with other NSAIDs or anticoagulants.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. NSAIDs may affect ovulation and are not recommended during pregnancy, especially in the third trimester. Discuss safer alternatives for pain management.
🏥 Post-Surgery Considerations
This medicine may be prescribed after surgery for pain and swelling. Take it exactly as directed by your surgeon. Inform your surgeon if you have any history of kidney, liver, or heart disease. Do not use it for prolonged periods without medical advice.
🦷 Dental Procedures
This medicine is commonly prescribed after dental procedures for pain and swelling. Take it as directed by your dentist. Inform your dentist about any medical conditions or other medicines you are taking. Avoid alcohol and maintain good oral hygiene.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may experience dizziness or drowsiness. Avoid strenuous exercise or activities that require alertness until you know how the medicine affects you. If you have pain, consult your doctor or physiotherapist before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It is generally safe to continue desk work, but take regular breaks and maintain good posture. Inform your employer if your job involves operating heavy machinery.
🛑 When to Stop This Medicine
Stop taking this medicine if you experience severe side effects such as stomach bleeding, allergic reactions, or signs of liver or kidney problems. Do not stop abruptly if you have been taking it for a long time without consulting your doctor. Always consult your doctor before stopping this medicine, especially if you have been on it for more than a few days.
📅 Long-Term Use Effects
Long-term use of this medicine can increase the risk of gastrointestinal bleeding, ulcers, kidney impairment, liver damage, and cardiovascular events. Regular monitoring of kidney and liver function, blood pressure, and signs of bleeding is recommended. Use the lowest effective dose for the shortest duration. Consult your doctor if you need pain relief for more than 7 days.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve mobility.
Evidence: Well-establishedApplying heat or cold packs can help reduce pain and swelling.
Evidence: Well-establishedMay provide pain relief for some individuals.
Evidence: ModerateYoga, meditation, and relaxation techniques can help manage chronic pain.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from direct sunlight and moisture. If crossing time zones, continue your regular dosing schedule as prescribed; consult your doctor if adjustments are needed. Check local customs regulations regarding prescription medicines before traveling internationally.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 30-60 minutes after taking it. The anti-inflammatory and anti-swelling effects may take a few hours to a few days to become noticeable.
A: It is best to take this medicine with food or milk to reduce the risk of stomach upset. Taking it on an empty stomach may increase the chance of nausea and stomach pain.
A: This medicine is intended for short-term use only. Long-term use can increase the risk of stomach bleeding, kidney problems, and cardiovascular events. Consult your doctor if you need pain relief for more than 7 days.
A: No, you should avoid alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding and liver damage.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: This medicine is not recommended during pregnancy, especially in the third trimester, as it may harm the fetus. Consult your doctor for safer alternatives.
A: Some people may experience drowsiness or dizziness. Avoid driving or operating machinery until you know how this medicine affects you.
A: Do not take other painkillers or NSAIDs without consulting your doctor, as it may increase the risk of side effects.
A: No, this medicine is not a steroid. It contains an NSAID, paracetamol, and an enzyme.
A: Store at room temperature (15-30°C) in a cool, dry place away from direct sunlight. Keep in the original container and out of reach of children.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine is a steroid.
Fact: This medicine is not a steroid. It contains an NSAID, paracetamol, and an enzyme. - Myth: This medicine can be taken long-term without any risk.
Fact: Long-term use can increase the risk of stomach bleeding, kidney problems, and heart issues. It should be used for the shortest duration necessary. - Myth: This medicine is safe to take with alcohol.
Fact: Alcohol increases the risk of stomach bleeding and liver damage. Avoid alcohol while taking this medicine. - Myth: This medicine can be taken on an empty stomach.
Fact: It should be taken with food or milk to reduce stomach upset. - Myth: This medicine is safe for children.
Fact: Safety and efficacy in children are not established. Consult a pediatrician.
🔄 Alternative Options
Generic Alternatives
- Aceclofenac + Paracetamol + Serratiopeptidase (generic versions available)