E Grain Tablet: Complete Guide to Uses, Dosage, Side Effects, and Safety
When to Call Your Doctor IMMEDIATELY
- Chest pain, pressure, or tightness
- Shortness of breath or difficulty breathing
- Cold, pale, blue, or painful fingers or toes
- Severe abdominal pain or vomiting blood
- Sudden weakness, confusion, or difficulty speaking
- Swelling of the face, lips, or throat
- Severe headache that is different from usual migraine
- Decreased urine output or blood in urine
If experiencing severe symptoms, call emergency services immediately.
What is mygrain tablet used for?
This medicine is a combination of caffeine and ergotamine used to treat acute migraine attacks. It works by narrowing dilated blood vessels in the brain and reducing inflammation. It is taken at the first sign of a migraine, usually one tablet, and must not be used daily or in people with heart or circulation problems.
- Generic Name: Caffeine (100mg) + Ergotamine (1mg)
- Manufacturer: Sunlife Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 mygrain tablet के बारे में (Hindi Summary)
उपयोग: यह दवा कैफीन और एर्गोटामाइन का संयोजन है, जिसका उपयोग माइग्रेन के तीव्र दौरे के इलाज के लिए किया जाता है। यह माइग्रेन के दर्द, मतली, और रोशनी तथा आवाज के प्रति संवेदनशीलता को कम करने में मदद करती है। इसे माइग्रेन के लक्षण शुरू होते ही लेना चाहिए। यह दवा सिरदर्द की रोकथाम के लिए नहीं है और इसे रोज नहीं लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट में असहजता, चक्कर आना, और उंगलियों या पैर की उंगलियों में झुनझुनी या ठंडक महसूस होना शामिल है। गंभीर दुष्प्रभावों में छाती में दर्द, हाथ-पैरों का ठंडा और नीला पड़ना, और गंभीर एलर्जी प्रतिक्रिया शामिल हैं। अगर ऐसे लक्षण दिखें तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें और मात्रा या बार-बार लेने की संख्या न बढ़ाएं। इसे रोज न लें, क्योंकि इससे दवा-अति प्रयोग सिरदर्द और रक्त संचार की गंभीर समस्याएं हो सकती हैं। शराब और ग्रेपफ्रूट जूस से बचें। अगर आपको छाती में दर्द, सांस लेने में तकलीफ, या हाथ-पैर ठंडे और नीले पड़ रहे हैं, तो तुरंत आपातकालीन चिकित्सा लें।
💊 mygrain tablet Uses & Benefits
- [{"condition":"Acute migraine attack","description":"This medicine is used to relieve the pain and other symptoms of a migraine attack once it has started.
- It is most effective when taken early in the attack.","evidence":"Well-established"},{"condition":"Migraine-associated nausea and vomiting","description":"The combination may help reduce migraine-related nausea and vomiting in some patients, although caffeine can sometimes worsen stomach upset.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Cluster headache","description":"Ergotamine has been used in some cases for cluster headache attacks, but this is not a first-line treatment and requires specialist supervision.","evidence":"Limited"},{"condition":"Medication-overuse headache withdrawal","description":"In some specialist settings, ergotamine has been used as part of a withdrawal protocol, but this is not a standard or recommended practice.","evidence":"Limited"}]
Primary treatment for: Migraine
Also treats: Cluster headache (off-label), Medication-overuse headache (withdrawal, specialist use only)
📋 Drug Information
| Generic Name(s) | Caffeine (100mg) + Ergotamine (1mg) |
| Brand Name | mygrain tablet |
| Manufacturer | Sunlife Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from direct sunlight, heat, and moisture. Do not store in the bathroom. Keep in the original container with the lid tightly closed. |
| Shelf Life | The shelf life is typically 24 months from the date of manufacture, but refer to the expiry date printed on the pack. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary actions. Ergotamine is a non-selective ergot alkaloid that binds to serotonin 5-HT1B/1D receptors and to alpha-adrenergic receptors, causing constriction of dilated cranial blood vessels and inhibiting the release of inflammatory neuropeptides. Caffeine is a xanthine derivative that blocks adenosine receptors, leading to mild vasoconstriction and enhanced absorption of ergotamine. Together, they produce vasoconstriction of cranial vessels and reduce neurogenic inflammation, which helps relieve migraine pain.
Mechanism Steps
💡 How to Take mygrain tablet
Strength: Each immediate-release tablet contains caffeine 100 mg and ergotamine 1 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken at the first sign of a migraine attack, as prescribed by your doctor. The dose may be repeated after 30 to 60 minutes if needed, but the total daily dose must not exceed the limit set by your doctor, usually no more than 2 to 3 tablets in 24 hours and no more than 10 tablets in a week. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and cardiovascular risk. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of ergotamine and caffeine. Use with caution and at the lowest effective dose. Dose must be individualized by a qualified clinician based on renal and hepatic function and cardiovascular status. |
| Renal Impairment | Use with caution in patients with kidney impairment. Caffeine elimination may be prolonged. Dose adjustment may be needed based on the degree of impairment. Consult your doctor. |
| Hepatic Impairment | Use with caution in patients with mild to moderate liver impairment. Severe liver disease is a contraindication. Dose reduction may be necessary. Consult your doctor. |
| Maximum Daily Dose | The maximum daily dose is usually 2 to 3 tablets in 24 hours, but this must be confirmed by your doctor. Do not exceed the prescribed limit. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of mygrain tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Erythromycin | Major | |
| Ritonavir | Major | |
| Sumatriptan | Major | |
| Propranolol | Moderate | |
| Ciprofloxacin | Moderate | |
| Oral contraceptives | Moderate | |
| Ketoconazole | Major | |
| Pseudoephedrine | Major | |
| Cimetidine | Minor | |
| Fluconazole | Minor |
🚨 Major Interactions
- Macrolide antibiotics (e.g., erythromycin, clarithromycin)
- Protease inhibitors (e.g., ritonavir, indinavir)
- Azole antifungals (e.g., ketoconazole, itraconazole)
- Triptans (e.g., sumatriptan)
- Vasoconstrictors (e.g., pseudoephedrine, phenylephrine)
⚡ Moderate Interactions
- Beta-blockers (e.g., propranolol)
- Oral contraceptives
- CYP1A2 inhibitors (e.g., ciprofloxacin, fluvoxamine)
- Nicotine
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol can worsen migraine and may increase the risk of dizziness, drowsiness, and stomach upset. It can also add to the vasoconstrictive effects and increase the risk of cardiovascular complications.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Coronary artery disease or history of heart attack","Peripheral vascular disease","Uncontrolled hypertension","Severe liver disease","Severe kidney disease","Pregnancy","Breastfeeding","Sepsis","Hypersensitivity to ergotamine, caffeine, or any component of this medicine","Concurrent use with potent CYP3A4 inhibitors (e.g., ritonavir, ketoconazole, erythromycin)","Concurrent use with triptans within 24 hours"]
⚠️ Warnings & Precautions
["Do not exceed the prescribed dose or frequency. Overuse can lead to medication-overuse headache and dependence.","Use with caution in the elderly, who may be more sensitive to the effects of ergotamine.","Avoid in people with risk factors for cardiovascular disease unless specifically approved by a cardiologist.","Do not use for migraine prevention; this medicine is only for acute attacks.","Inform your doctor if you have a history of Raynaud's phenomenon or other circulatory problems.","Stop the medicine and seek medical help if you experience chest pain, cold or blue fingers or toes, or severe abdominal pain.","Avoid alcohol and grapefruit juice while taking this medicine.","Do not drive or operate machinery if you feel dizzy or drowsy."]
🤱 Lactation Safety
Ergotamine passes into breast milk and can cause vomiting, diarrhea, and weakness in a nursing infant. Caffeine also passes into breast milk and may cause irritability or poor sleep in the baby. This medicine is not recommended during breastfeeding. Consult your doctor for alternative migraine treatments that are safer while nursing.
💊 Overdose Management
Overdose of this medicine can cause severe vasoconstriction, nausea, vomiting, chest pain, confusion, seizures, and coma. If you suspect an overdose, seek emergency medical care immediately. Treatment is supportive and may include medications to dilate blood vessels, control seizures, and manage complications. Do not try to treat an overdose at home.
⏰ Missed Dose
This medicine is taken only when needed for an acute migraine attack, so a missed dose is not applicable in the usual sense. If you are on a scheduled regimen prescribed by your doctor and miss a dose, take it as soon as you remember unless it is almost time for the next dose. Do not double the dose to catch up. Follow your doctor's specific instructions.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, and never exceed the recommended dose or frequency. Do not use it for more than the number of days your doctor advises, because daily use can cause medication-overuse headache and serious circulation problems. Avoid alcohol, grapefruit juice, and other migraine medicines unless your doctor approves. Tell your doctor about all other medicines you take, especially antibiotics, antifungals, and antidepressants, because they can interact dangerously. Do not drive or operate heavy machinery if you feel dizzy or weak. If you have chest pain, cold or blue fingers or toes, severe stomach pain, or sudden weakness, stop the medicine and seek emergency care immediately. Keep this medicine out of reach of children and store it in its original packaging.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the effects of ergotamine and caffeine. They are also more likely to have heart and circulation problems, which increase the risk of serious side effects. Use this medicine with caution, at the lowest effective dose, and only after a thorough cardiovascular assessment.
🤰 Pregnancy Planning (TTC)
This medicine is contraindicated during pregnancy and should not be used if you are planning to become pregnant. Ergotamine can cause uterine contractions and harm the fetus. Consult your doctor for safer migraine treatments before trying to conceive.
🏥 Post-Surgery Considerations
This medicine should be used with caution after surgery, especially if you have had cardiovascular or vascular surgery. Ergotamine can cause vasoconstriction and may interfere with blood flow. Consult your surgeon and doctor before using this medicine after any surgery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. Ergotamine can interact with certain medicines used during dental procedures, such as vasoconstrictors in local anesthetics. Your dentist may need to adjust the anesthetic used.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise during a migraine attack. If you experience chest pain, dizziness, or cold extremities after taking this medicine, do not exercise and seek medical advice. Regular moderate exercise between attacks can help reduce migraine frequency.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause dizziness, drowsiness, and nausea, which may affect your ability to drive or operate machinery. Avoid driving or operating heavy machinery until you know how this medicine affects you. It is best to rest in a quiet, dark room after taking it during a migraine attack.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor immediately if you experience chest pain, cold or blue fingers or toes, severe abdominal pain, or any signs of an allergic reaction. Do not stop a prescribed regimen without consulting your doctor, but this medicine is not for daily use. If you are using it more than twice a week, consult your doctor to review your migraine treatment plan.
📅 Long-Term Use Effects
Long-term or frequent use of this medicine can lead to medication-overuse headache, where headaches become more frequent and severe. It can also cause dependence and serious circulatory problems, including ergotism and cardiovascular complications. Regular monitoring of headache frequency, blood pressure, and circulation is recommended if long-term use is unavoidable. This medicine is not intended for long-term use.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A class of medicines specifically designed for acute migraine with a different mechanism of action.
Evidence: Well-establishedCan be effective for mild to moderate migraine attacks.
Evidence: Well-establishedHelp relieve nausea and vomiting associated with migraine.
Evidence: Well-establishedNon-drug techniques that can help reduce migraine frequency and severity.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are not feeling well due to a migraine, it may be better to postpone vaccination until you feel better. Consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in the original container with the lid tightly closed
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom cabinet
✅ DO
Keep out of reach of children and pets
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label clearly visible. Bring a copy of your prescription or a letter from your doctor, especially for international travel, as ergotamine may be a controlled substance in some countries. Store it at room temperature and protect it from extreme heat or cold. If crossing time zones, take the medicine only when you have a migraine attack, not on a fixed schedule. Keep it in your carry-on luggage to avoid loss or temperature extremes.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts to relieve migraine symptoms within 30 to 60 minutes after taking it. It works best when taken at the first sign of a migraine.
A: No. This medicine is only for acute migraine attacks and should not be taken daily. Daily use can cause medication-overuse headache and serious circulation problems.
A: Stop taking the medicine and seek emergency medical care immediately. Chest pain may be a sign of a serious heart problem.
A: Do not take this medicine with triptans such as sumatriptan within 24 hours of each other. Always inform your doctor about all medicines you take.
A: No. This medicine is contraindicated during pregnancy because it can cause uterine contractions and reduce blood flow to the fetus. Consult your doctor for safer alternatives.
🤔 Common Patient Concerns
🔄 Substitutes for mygrain tablet
View AllAlternative brands with exact same active ingredient:
-
neuromol plus tabletBilcare Ltd ₹26.25 60% CHEAPER
-
nt grain tabletIntas Pharmaceuticals Ltd ₹37.97 42.1% CHEAPER
-
e grain tabletElixir Life Care Pvt Ltd ₹42.19 35.7% CHEAPER
-
livigrain tabletLividus Pharmaceuticals Pvt Ltd ₹46.88 28.6% CHEAPER
-
migrarest tabletInnovative Pharmaceuticals ₹55.78 15% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken daily to prevent migraines.
Fact: This medicine is only for acute migraine attacks. Daily use can cause medication-overuse headache and serious circulation problems. - Myth: This medicine is safe for everyone with a headache.
Fact: It is not safe for people with heart disease, circulation problems, uncontrolled high blood pressure, or pregnant women. - Myth: Taking more tablets will relieve a migraine faster.
Fact: Taking more than the prescribed dose increases the risk of severe side effects and does not improve relief. - Myth: This medicine is a simple painkiller like paracetamol.
Fact: It contains ergotamine, a powerful vasoconstrictor that requires medical supervision and has significant risks.
🔄 Alternative Options
Generic Alternatives
- Caffeine 100 mg + Ergotamine 1 mg tablet
Brand Alternatives
- E grain tablet