Microspan Infusion: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or shortness of breath
- Swelling of face, lips, or throat
- Severe drop in blood pressure
- Decreased urine output
- Chest pain or irregular heartbeat
- Unusual bleeding or bruising
- Severe allergic reaction with rash and itching
If experiencing severe symptoms, call emergency services immediately.
What is microspan infusion used for?
This medicine is a plasma volume expander used to treat hypovolemia (low blood volume) by drawing fluid into the bloodstream. It is given intravenously in hospital settings.
- Generic Name: Low Dextrans ( 50000 Daltons) (NA)
- Manufacturer: Claris Lifesciences Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 microspan infusion के बारे में (Hindi Summary)
उपयोग: यह दवा लो डेक्सट्रान इन्फ्यूजन है, जिसका उपयोग रक्त की मात्रा बढ़ाने के लिए किया जाता है। यह आमतौर पर गंभीर चोट, सर्जरी, या जलने के कारण होने वाले शॉक में दी जाती है। यह दवा अस्पताल में डॉक्टर की देखरेख में ही दी जाती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में त्वचा पर चकत्ते, खुजली, मतली, और हल्का बुखार शामिल हैं। गंभीर दुष्प्रभावों में एलर्जी, सांस लेने में कठिनाई, और गुर्दे की समस्या हो सकती है। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल अस्पताल में डॉक्टर की देखरेख में दी जानी चाहिए। इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी एलर्जी, हृदय, गुर्दे, और रक्त संबंधी समस्याओं के बारे में बताएं। इंफ्यूजन के दौरान और बाद में अपने महत्वपूर्ण संकेतों की निगरानी करवाएं।
💊 microspan infusion Uses & Benefits
[{"condition":"Hypovolemic shock","description":"Used to restore blood volume in patients with significant blood loss due to trauma, surgery, or burns.","evidence":"Well-established"},{"condition":"Plasma volume expansion","description":"Helps maintain blood pressure and tissue perfusion in emergency situations.","evidence":"Well-established"},{"condition":"Adjunct in cardiopulmonary bypass","description":"Sometimes used to prime the bypass circuit and maintain volume during surgery.","evidence":"Limited"}]
Off-label uses: [{"condition":"Improvement of microcirculation","description":"Occasionally used off-label to improve blood flow in conditions like peripheral vascular disease.","evidence":"Limited"}]
Primary treatment for: Hypovolemia
📋 Drug Information
| Generic Name(s) | Low Dextrans ( 50000 Daltons) (NA) |
| Brand Name | microspan infusion |
| Manufacturer | Claris Lifesciences Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | BLOOD RELATED |
| Action Class | Colloids (Plasma substitutes) |
| Route of Administration | Intravenous infusion only |
| Storage | Store at room temperature (15-30°C). Do not freeze. Keep in original container. Protect from light. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by exerting an oncotic effect. The dextran molecules are large enough to remain in the bloodstream for a period of time, drawing water from the interstitial space into the intravascular compartment. This increases plasma volume and reduces hemoconcentration, thereby improving cardiac output and tissue perfusion. Additionally, dextran can reduce blood viscosity and inhibit red blood cell aggregation, which may further enhance microcirculatory flow.
Mechanism Steps
💡 How to Take microspan infusion
Strength: Low Dextrans (50000 Daltons) infusion, strength not specified.
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on the patient's clinical condition, degree of hypovolemia, and response to therapy. Typically, 500 mL to 1000 mL of a 6% or 10% solution may be infused intravenously. The rate of infusion should be adjusted to maintain hemodynamic stability. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more susceptible to fluid overload and renal impairment. Use with caution and monitor closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose reduction may be necessary. Monitor renal function closely. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | No specific dosage adjustments are established for hepatic impairment. Use with caution. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum daily dose is determined by the clinical situation and patient response. Typically, up to 20 mL/kg/day of a 6% solution may be used, but this must be individualized by a qualified clinician. |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of microspan infusion
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Heparin | Major | |
| Diuretics | Moderate | |
| NSAIDs | Moderate | |
| Antihypertensives | Minor |
🚨 Major Interactions
- Warfarin
- Heparin
⚡ Moderate Interactions
- Diuretics
- NSAIDs
🍷 Alcohol Interaction
Alcohol may worsen dehydration and electrolyte imbalances. Avoid alcohol while receiving this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to dextran","Severe congestive heart failure","Severe renal impairment with oliguria or anuria","Severe bleeding disorders","Fluid overload states"]
⚠️ Warnings & Precautions
["Administer with caution in patients with impaired renal function.","Monitor for signs of fluid overload, especially in patients with cardiac or renal disease.","May interfere with blood cross-matching; inform blood bank if recent administration.","Use with caution in patients with a history of allergies.","Do not use if solution is cloudy or contains particulate matter.","Ensure adequate hydration before infusion."]
🤱 Lactation Safety
Not established from the available information. Consult your doctor before use if breastfeeding.
💊 Overdose Management
Overdose can lead to fluid overload, pulmonary edema, and heart failure. Treatment is supportive and symptomatic. Discontinue infusion immediately and manage fluid overload with diuretics as needed. Monitor vital signs and renal function.
⏰ Missed Dose
This medicine is given as a single infusion or as a continuous infusion in a hospital setting. Missed doses are not applicable. If a scheduled dose is missed, inform your healthcare provider immediately.
Additional Safety Advice
This medicine must only be given by a healthcare professional in a hospital setting. Before receiving this medicine, inform your doctor if you have a history of allergies, heart problems, kidney disease, or bleeding disorders. Your doctor will monitor your vital signs, urine output, and blood tests during and after the infusion. Do not attempt to self-administer this medicine. If you are pregnant or breastfeeding, discuss the risks and benefits with your doctor. Avoid activities that require mental alertness until you know how this medicine affects you. Report any signs of allergic reactions, such as rash, itching, or difficulty breathing, immediately. Do not use this medicine if the solution is cloudy or contains particles. Keep this medicine out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of fluid overload and kidney injury. Use with caution and monitor closely.
🤰 Pregnancy Planning (TTC)
Consult your doctor if you are planning pregnancy or are pregnant. The safety of this medicine in pregnancy is not well established.
🏥 Post-Surgery Considerations
This medicine may be used during or after surgery to maintain blood volume. Monitor for fluid overload and kidney function.
🦷 Dental Procedures
Inform your dentist if you have recently received this medicine, as it may affect bleeding risk.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise immediately after receiving this medicine. Gradually resume activity as advised by your doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital setting, so it may require a short hospital stay. You should not drive or operate machinery immediately after receiving it. Follow your doctor's advice on when to resume normal activities.
🛑 When to Stop This Medicine
This medicine is stopped when your clinical condition stabilizes or if you experience serious side effects. Only your healthcare provider can decide when to stop the infusion.
📅 Long-Term Use Effects
Long-term effects of this medicine are not well established, as it is typically used for short-term volume expansion. Prolonged use may increase the risk of fluid overload, kidney injury, and bleeding. Monitoring of renal function and coagulation is advised with extended use.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
For mild dehydration, oral rehydration solutions may be sufficient.
Evidence: Well-establishedFor severe blood loss, blood transfusion may be necessary.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are established. Consult your doctor before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not use if solution is cloudy or contains particles
✈️ Traveling with This Medicine
This medicine is given in a hospital setting, so travel advice is not applicable. If you are traveling after receiving this medicine, carry a copy of your prescription and medical records. Inform your doctor before traveling. Store any remaining medicine as directed.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The volume-expanding effect begins immediately after infusion, with peak effect within 30 minutes to 1 hour.
A: Common side effects include rash, itching, nausea, and mild fever. Serious side effects are rare but include severe allergic reactions and fluid overload.
A: Patients with known hypersensitivity to dextran, severe heart failure, severe kidney impairment, or bleeding disorders should not receive this medicine.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: Dextran is a blood substitute.
Fact: Dextran is a plasma volume expander, not a blood substitute. It does not carry oxygen. - Myth: Dextran can be taken orally.
Fact: Dextran must be given intravenously. Oral administration is not effective.