Metart 25mg/6.25mg Tablet ER: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe dizziness or fainting
- Heart rate below 50 beats per minute
- Difficulty breathing or wheezing
- Swelling of face, lips, tongue, or throat
- Chest pain or palpitations
- Severe muscle cramps or weakness
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is metart 25mg/6.25mg tablet er used for?
This medicine is a combination of metoprolol succinate and chlorthalidone used to treat high blood pressure. It works by slowing the heart rate and removing excess fluid from the body.
- Generic Name: Metoprolol Succinate (25mg) + Chlorthalidone (6.25mg)
- Manufacturer: Precise Lifescience
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 metart 25mg/6.25mg tablet er के बारे में (Hindi Summary)
उपयोग: यह दवा उच्च रक्तचाप (हाई ब्लड प्रेशर) के इलाज के लिए इस्तेमाल की जाती है। इसमें मेटोप्रोलोल सक्सिनेट और क्लोर्थालिडोन दो सक्रिय तत्व हैं। मेटोप्रोलोल दिल की धड़कन को धीमा करता है और रक्तचाप को कम करता है, जबकि क्लोर्थालिडोन शरीर से अतिरिक्त नमक और पानी को बाहर निकालता है। यह दवा उन वयस्कों के लिए है जिनका रक्तचाप एक दवा से नियंत्रित नहीं हो पाता। इसे डॉक्टर के निर्देशानुसार ही लें।
साइड इफेक्ट्स: आम दुष्प्रभावों में चक्कर आना, थकान, सिरदर्द, और धड़कन का धीमा होना शामिल है। कुछ लोगों को ठंडे हाथ-पैर, पेट खराब, या बार-बार पेशाब आना महसूस हो सकता है। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें गंभीर धड़कन का धीमा होना, सांस लेने में कठिनाई, और एलर्जी प्रतिक्रिया शामिल हो सकती है। यदि आपको असामान्य लक्षण दिखें तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। अचानक बंद न करें, क्योंकि इससे दिल की समस्या बढ़ सकती है। शराब से बचें, क्योंकि इससे चक्कर और निम्न रक्तचाप बढ़ सकता है। अगर चक्कर आए तो धीरे-धीरे उठें। नियमित रूप से रक्तचाप और रक्त परीक्षण कराएं। गर्भवती होने या होने की योजना बनाने पर डॉक्टर से सलाह लें।
💊 metart 25mg/6.25mg tablet er Uses & Benefits
- [{"condition":"Hypertension","description":"Used to lower blood pressure in adults when a single agent is not effective.
- The combination provides complementary blood pressure-lowering effects.","evidence":"Well-established"},{"condition":"Heart failure with reduced ejection fraction","description":"Metoprolol succinate is indicated to reduce the risk of cardiovascular death and hospitalization in patients with stable, symptomatic heart failure.
- The chlorthalidone component may be used for additional blood pressure control.","evidence":"Well-established for metoprolol component"},{"condition":"Angina pectoris","description":"Metoprolol succinate is used for long-term management of angina due to coronary artery disease.
- Chlorthalidone may be added for blood pressure control.","evidence":"Well-established for metoprolol component"}]
Off-label uses: [{"condition":"Migraine prophylaxis","description":"Beta-blockers like metoprolol are sometimes used off-label to prevent migraines, but this combination is not specifically approved for that purpose.","evidence":"Limited"},{"condition":"Performance anxiety","description":"Beta-blockers may be used off-label to reduce symptoms of anxiety, but this combination is not standard for this use.","evidence":"Limited"}]
Primary treatment for: Hypertension
Also treats: Heart failure with reduced ejection fraction, Angina pectoris
📋 Drug Information
| Generic Name(s) | Metoprolol Succinate (25mg) + Chlorthalidone (6.25mg) |
| Brand Name | metart 25mg/6.25mg tablet er |
| Manufacturer | Precise Lifescience |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C. Protect from moisture and light. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with distinct mechanisms. Metoprolol succinate selectively blocks beta-1 adrenergic receptors in the heart, reducing heart rate, contractility, and cardiac output. It also suppresses renin release from the kidneys. Chlorthalidone inhibits the sodium-chloride symporter in the distal convoluted tubule of the kidney, increasing excretion of sodium, chloride, and water. This reduces plasma volume and peripheral vascular resistance. The combined effect lowers blood pressure through both cardiac and renal mechanisms.
Mechanism Steps
💡 How to Take metart 25mg/6.25mg tablet er
Strength: Tablet containing metoprolol succinate 25 mg and chlorthalidone 6.25 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet of metoprolol succinate 25 mg and chlorthalidone 6.25 mg taken orally once daily, preferably in the morning. The dose may be adjusted by your doctor based on your blood pressure response and tolerance. Do not exceed the prescribed dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially dizziness and electrolyte imbalances. Start with a low dose and monitor closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with renal impairment. Chlorthalidone may accumulate and cause electrolyte disturbances. Dose adjustment may be required based on creatinine clearance. Consult your doctor. |
| Hepatic Impairment | Metoprolol is metabolized in the liver; hepatic impairment may require dose reduction. Chlorthalidone is not significantly affected by hepatic impairment. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is one tablet of metoprolol succinate 25 mg and chlorthalidone 6.25 mg. Do not exceed without medical advice. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of metart 25mg/6.25mg tablet er
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Verapamil | Major | |
| Clonidine | Major | |
| MAOIs | Major | |
| Digoxin | Major | |
| Lithium | Major | |
| NSAIDs | Moderate | |
| Corticosteroids | Moderate | |
| Oral hypoglycemics | Moderate | |
| Fluoxetine | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Verapamil or diltiazem
- Clonidine
- Monoamine oxidase inhibitors (MAOIs)
- Digoxin
- Lithium
⚡ Moderate Interactions
- NSAIDs
- Corticosteroids
- Oral hypoglycemics
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine)
🍷 Alcohol Interaction
Alcohol may enhance the blood pressure-lowering and dizzy effects of this medicine. It is advisable to avoid or limit alcohol consumption while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe bradycardia","Second- or third-degree heart block","Cardiogenic shock","Decompensated heart failure","Severe asthma or COPD with bronchospasm","Anuria","Hypersensitivity to metoprolol, chlorthalidone, or sulfonamide-derived drugs"]
⚠️ Warnings & Precautions
["Do not stop this medicine abruptly; taper gradually under medical supervision.","May mask symptoms of hypoglycemia in diabetic patients.","May worsen symptoms of peripheral vascular disease.","Can cause electrolyte imbalances; monitor potassium and sodium levels.","May increase sensitivity to allergens.","Use with caution in patients with hepatic or renal impairment.","May cause dizziness; avoid driving or operating machinery until you know how it affects you."]
🤱 Lactation Safety
Metoprolol and chlorthalidone are excreted in breast milk. Breastfeeding is not recommended while taking this medicine unless the potential benefit outweighs the risk. Consult your doctor.
💊 Overdose Management
Overdose can cause severe bradycardia, hypotension, heart failure, bronchospasm, and electrolyte disturbances. Seek emergency medical attention immediately. Treatment is supportive and may include activated charcoal, atropine, vasopressors, and electrolyte correction.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed. Do not stop taking it suddenly, as abrupt withdrawal can worsen heart conditions. Avoid alcohol, as it can increase dizziness and low blood pressure. Stand up slowly to prevent falls if you feel dizzy. Keep all follow-up appointments for blood pressure and blood tests. Inform your doctor if you have diabetes, asthma, kidney disease, or gout. Do not use potassium supplements without medical advice. If you become pregnant or plan to become pregnant, talk to your doctor immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the effects of this medicine, especially dizziness, electrolyte imbalances, and slow heart rate. Start with a low dose and monitor closely. Regular follow-up is essential.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before conceiving. This medicine may not be suitable during pregnancy, and alternative treatments may be recommended. Use effective contraception while taking this medicine unless otherwise advised.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with anesthetic agents and affect heart rate and blood pressure during surgery. Your doctor may adjust the dose before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine, as it may cause dry mouth or interact with local anesthetics containing epinephrine. Your dentist may take precautions to monitor your blood pressure and heart rate during the procedure.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise is generally safe and beneficial, but avoid strenuous activities initially as this medicine may cause dizziness or fatigue. Stay hydrated and monitor your heart rate during exercise. Consult your doctor before starting a new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue, especially when you first start taking it. Avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their normal activities with some adjustments. Inform your employer if your job involves operating machinery.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience severe side effects or your doctor decides to discontinue it, they will gradually reduce the dose to prevent withdrawal effects. Always follow your doctor's instructions.
📅 Long-Term Use Effects
Long-term use of this medicine requires regular monitoring of blood pressure, heart rate, electrolytes, and kidney function. It can effectively control hypertension and reduce the risk of cardiovascular events. However, it may cause electrolyte imbalances and increased blood sugar levels. Periodic check-ups are essential to adjust the dose and manage any side effects.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet, exercise, and stress reduction can help lower blood pressure and may reduce the need for medication.
Evidence: Well-establishedACE inhibitors, ARBs, or calcium channel blockers may be used as alternatives based on individual needs.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are established. However, maintain routine vaccinations as recommended by your doctor. Inform your healthcare provider about this medicine before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If traveling across time zones, consult your doctor about adjusting the timing of your dose. Check local customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The blood pressure-lowering effect begins within a few hours, but full benefits may take 2 to 4 weeks of regular use.
A: No, do not stop without consulting your doctor. High blood pressure often requires long-term treatment, and stopping suddenly can be dangerous.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
🤔 Common Patient Concerns
🔄 Substitutes for metart 25mg/6.25mg tablet er
View AllAlternative brands with exact same active ingredient:
-
clovet m 25mg/6.25mg tabletAjanta Pharma Ltd ₹56.78 26.1% CHEAPER
-
telma-mct 25/6.25 tablet erGlenmark Pharmaceuticals Ltd ₹121.00 57.4% COSTLIER
-
ctd-m 6.25/25 tablet erIpca Laboratories Ltd ₹124.27 61.6% COSTLIER
-
revelol-ch 25mg/6.25mg tabletIpca Laboratories Ltd ₹124.27 61.6% COSTLIER
-
vinicor-d 25 tablet erIpca Laboratories Ltd ₹124.27 61.6% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be stopped once blood pressure is normal.
Fact: High blood pressure often requires long-term treatment. Stopping suddenly can cause serious heart problems. Always consult your doctor before stopping. - Myth: This medicine causes kidney damage in everyone.
Fact: Chlorthalidone can affect kidney function in some people, but with regular monitoring, the risk is manageable. It is often used to protect kidneys in the long run. - Myth: You can take this medicine without any dietary changes.
Fact: A low-sodium diet and healthy lifestyle are important for controlling blood pressure and reducing the risk of complications.
🔄 Alternative Options
Generic Alternatives
- Metoprolol succinate and chlorthalidone combination tablets from other manufacturers.
Brand Alternatives
- Metart 25mg/6.25mg Tablet ER