Endace 160 Tablet (Megestrol 160mg): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Sudden swelling or pain in one leg
- Chest pain or difficulty breathing
- Severe headache with vision changes
- Yellowing of skin or eyes
- Dark urine or severe abdominal pain
- Signs of allergic reaction: rash, itching, swelling of face, lips, or throat
- Persistent high blood sugar or increased thirst and urination
If experiencing severe symptoms, call emergency services immediately.
What is megatrust 160mg tablet used for?
This medicine is a synthetic progestin used to stimulate appetite and promote weight gain in patients with cancer or AIDS-related cachexia. It is also used in advanced breast and endometrial cancers. It works by acting on the brain's appetite centers and suppressing certain hormones.
- Generic Name: Megestrol (160mg)
- Manufacturer: Torion Labs
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 megatrust 160mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा मेजेस्ट्रोल नामक सक्रिय तत्व से बनी है और मुख्य रूप से कैंसर या एड्स से जुड़े वजन घटने और भूख न लगने की समस्या में भूख बढ़ाने और वजन बढ़ाने के लिए दी जाती है। इसके अलावा यह स्तन कैंसर और गर्भाशय के कैंसर के इलाज में भी उपयोग की जाती है। यह दवा मस्तिष्क में भूख को नियंत्रित करने वाले केंद्रों पर काम करती है और कुछ हार्मोनों को दबाकर कैंसर कोशिकाओं की वृद्धि को धीमा करती है। इसका सेवन डॉक्टर की सलाह के अनुसार ही करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, दस्त, कब्ज, पेट में असहजता, भूख बढ़ना, वजन बढ़ना, शरीर में पानी जमा होना और हल्का चक्कर आना शामिल हैं। कुछ रोगियों में मूड बदलना, नींद न आना या गर्म लहरें महसूस हो सकती हैं। गंभीर दुष्प्रभावों में खून के थक्के बनना, एड्रिनल ग्रंथि का दबना, मधुमेह का बढ़ना और रक्तचाप बढ़ना शामिल हैं। अगर आपको सीने में दर्द, सांस लेने में तकलीफ, एक पैर में सूजन या दृष्टि में बदलाव हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। अपनी मर्जी से खुराक न बदलें और न ही दवा बंद करें। गोली को पानी के साथ पूरा निगलें। इसे भोजन के साथ या बिना भोजन के लिया जा सकता है, लेकिन भोजन के साथ लेने से पेट की तकलीफ कम हो सकती है। इस दवा के सेवन के दौरान शराब न पिएं। अगर आपको खून के थक्के, मधुमेह, उच्च रक्तचाप या लीवर की समस्या है तो डॉक्टर को बताएं। नियमित रूप से ब्लड शुगर, ब्लड प्रेशर और लीवर फंक्शन की जांच कराएं। दवा को बच्चों से दूर रखें।
💊 megatrust 160mg tablet Uses & Benefits
[{"condition":"Cancer-related cachexia and anorexia","description":"This medicine is used to stimulate appetite and promote weight gain in patients with cancer who have significant weight loss and loss of appetite.","evidence":"Well-established"},{"condition":"AIDS-related cachexia","description":"It helps improve appetite and weight in patients with acquired immunodeficiency syndrome suffering from wasting syndrome.","evidence":"Well-established"},{"condition":"Advanced breast cancer","description":"Used as palliative hormonal therapy in postmenopausal women with advanced breast cancer.","evidence":"Well-established"},{"condition":"Endometrial cancer","description":"Sometimes used in the treatment of advanced or recurrent endometrial cancer, especially in patients not suitable for surgery or radiation.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Hot flushes","description":"Occasionally prescribed off-label to reduce hot flushes in men undergoing androgen deprivation therapy or in women with menopause-related symptoms.","evidence":"Limited"},{"condition":"Prostate cancer","description":"Rarely used off-label as a second-line hormonal therapy in advanced prostate cancer.","evidence":"Limited"}]
Primary treatment for: Cancer-related cachexia and anorexia
Also treats: AIDS-related cachexia, Advanced breast cancer, Endometrial cancer
📋 Drug Information
| Generic Name(s) | Megestrol (160mg) |
| Brand Name | megatrust 160mg tablet |
| Manufacturer | Torion Labs |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Progestins (First generation) |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture and direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Megestrol is a synthetic progestin that exerts its effects by binding to progesterone receptors in target tissues. In appetite stimulation, it is thought to act on the hypothalamus to increase neuropeptide Y, a potent appetite stimulant, and to modulate other central pathways that regulate food intake and energy balance. In hormone-sensitive cancers, it suppresses the production of luteinizing hormone and follicle-stimulating hormone, leading to reduced estrogen levels, and it also directly inhibits the growth of estrogen-dependent tumour cells. Additionally, megestrol has glucocorticoid-like activity that may contribute to its appetite-stimulating and anti-inflammatory effects.
Mechanism Steps
💡 How to Take megatrust 160mg tablet
Strength: 160 mg immediate-release tablet
Dosage Information
| Adult Dosage | The usual adult dose for appetite stimulation in cancer or AIDS-related cachexia is 160 mg to 800 mg per day, often given as a single daily dose or in divided doses. For advanced breast cancer, the typical dose is 160 mg once daily. For endometrial cancer, doses may range from 40 mg to 320 mg daily in divided doses. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and clinical response. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially fluid retention, dizziness, and adrenal suppression. Start with a lower dose and monitor closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | No specific dose adjustment is established for renal impairment. Use with caution and monitor fluid status and renal function. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose reduction may be necessary. Monitor liver function tests regularly. |
| Maximum Daily Dose | The maximum recommended daily dose is 800 mg, but doses above 400 mg do not appear to provide additional benefit and may increase side effects. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of megatrust 160mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Dexamethasone | Major | |
| Insulin | Moderate | |
| Metformin | Moderate | |
| Amlodipine | Moderate | |
| Rifampicin | Minor | |
| Ketoconazole | Minor | |
| Grapefruit juice | Moderate | |
| Alcohol | Moderate | |
| St. John's Wort | Minor |
🚨 Major Interactions
- Warfarin
- Corticosteroids (e.g., dexamethasone)
⚡ Moderate Interactions
- Insulin and oral antidiabetic drugs
- Antihypertensive drugs
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can increase dizziness, drowsiness, and the risk of liver problems. It may also worsen fluid retention and blood pressure.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to megestrol or any component of the formulation","History of blood clots (thrombophlebitis, pulmonary embolism)","Severe liver disease","Pregnancy","Undiagnosed vaginal bleeding"]
⚠️ Warnings & Precautions
["This medicine can cause fluid retention and may worsen heart failure or hypertension.","It may increase blood sugar levels and worsen diabetes control.","Prolonged use can suppress adrenal function; do not stop abruptly without medical advice.","It may increase the risk of blood clots; avoid in patients with a history of thromboembolic events.","Use with caution in patients with a history of depression or mood disorders.","It may cause drowsiness or dizziness; avoid driving or operating machinery until you know how it affects you.","Do not use in pregnancy as it may harm the fetus."]
🤱 Lactation Safety
Megestrol is excreted in breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the medicine, taking into account the importance of the medicine to the mother.
💊 Overdose Management
Overdose of this medicine may cause nausea, vomiting, dizziness, and fluid retention. There is no specific antidote. Treatment should be symptomatic and supportive. In case of suspected overdose, contact a poison control center or seek immediate medical attention.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without medical advice. Swallow the tablet whole with a glass of water; you may take it with or without food, but taking it with food may reduce stomach upset. Avoid alcohol while on this medicine as it can increase dizziness and liver stress. Inform your doctor if you have a history of blood clots, diabetes, high blood pressure, or liver problems. Regular monitoring of blood sugar, blood pressure, and liver function may be necessary. Do not share this medicine with others. Keep it out of reach of children. If you miss a dose, take it as soon as you remember, but skip it if it is almost time for the next dose; never double the dose. Store at room temperature away from moisture and heat.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to side effects such as fluid retention, dizziness, and adrenal suppression. Start with a lower dose and monitor closely for any adverse effects. Regular monitoring of blood sugar, blood pressure, and liver function is advised.
🤰 Pregnancy Planning (TTC)
This medicine is contraindicated during pregnancy as it may harm the fetus. Women of childbearing potential should use effective contraception while taking this medicine. If you are planning to become pregnant, consult your doctor to discuss alternative treatments and stop this medicine well in advance.
🏥 Post-Surgery Considerations
This medicine may increase the risk of blood clots after surgery. Inform your surgeon that you are taking this medicine. It may need to be temporarily stopped before surgery. Follow your doctor's instructions regarding perioperative management.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine, as it may affect healing and increase the risk of bleeding or infection. Your dentist may recommend postponing non-urgent procedures until your condition is stable.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may experience dizziness or fatigue. Avoid strenuous exercise until you know how the medicine affects you. Light activities like walking are generally safe, but consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also cause mood changes; inform your doctor if this interferes with your daily life.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as blood clots, severe allergic reactions, or liver problems, seek immediate medical attention and your doctor will decide whether to discontinue the medicine.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to adrenal suppression, fluid retention, weight gain, increased blood sugar, and an increased risk of blood clots. Regular monitoring of blood sugar, blood pressure, liver function, and adrenal function is recommended. Do not stop the medicine abruptly after prolonged use; taper gradually under medical supervision.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A dietitian can help create a high-calorie, high-protein meal plan to support weight gain.
Evidence: Well-establishedOther medicines may be used to stimulate appetite, but they have different side effect profiles.
Evidence: ModerateGentle exercise can help maintain muscle mass and improve overall well-being.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions reported with this medicine. However, consult your doctor before receiving any live vaccines while on this medicine, as it may affect immune response.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid temperature extremes. If crossing time zones, continue taking your doses at the same intervals as prescribed; consult your doctor for specific advice. Store at room temperature and avoid leaving it in a hot car. Check customs regulations for carrying prescription medicines internationally.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Appetite improvement may begin within a few days to weeks, but noticeable weight gain typically takes several weeks of consistent use.
A: No, do not stop suddenly, especially after long-term use, as it can cause adrenal insufficiency. Consult your doctor before stopping.
A: Take it as soon as you remember if it is not almost time for your next dose. Otherwise, skip it and continue your regular schedule. Do not double dose.
A: No, this medicine is contraindicated in pregnancy as it may harm the fetus. Use effective contraception while taking it.
A: Inform your doctor about all other medicines you take, especially blood thinners, diabetes medicines, and corticosteroids, as interactions may occur.
🤔 Common Patient Concerns
🔄 Substitutes for megatrust 160mg tablet
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megesta 160 tabletRencord Life Sciences Pvt Ltd ₹609.30 38.1% CHEAPER
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megacet 160mg tabletMediart Lifesciences Pvt Ltd ₹649.60 34% CHEAPER
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cravihenz tabletBiokindle Lifesciences Pvt Ltd ₹703.12 28.6% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Megestrol is a steroid that builds muscle.
Fact: Megestrol is a progestin, not an anabolic steroid. It increases appetite and fat deposition, not muscle mass. - Myth: Megestrol can be used for weight loss.
Fact: Megestrol is used for weight gain in cachexia, not for weight loss. - Myth: Megestrol is safe to take without a prescription.
Fact: Megestrol is a prescription medicine and should only be used under medical supervision.
🔄 Alternative Options
Generic Alternatives
- Megestrol acetate 160 mg tablet
Brand Alternatives
- Megace
- Megestrol acetate