Pregabid NT Tablet: Comprehensive Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Thoughts of harming yourself or others
- Severe allergic reaction (swelling of face, lips, throat, difficulty breathing)
- Irregular or rapid heartbeat
- Severe skin rash with blisters or peeling
- Yellowing of eyes or skin, dark urine
- Severe abdominal pain or persistent vomiting
- Sudden weight gain or swelling in legs
If experiencing severe symptoms, call emergency services immediately.
What is mecoxing n 75mg/10mg/1500mcg tablet used for?
This medicine is a combination of Pregabalin and Nortriptyline used to treat neuropathic pain. It works by reducing pain signals in the nervous system and enhancing mood. It is taken orally, usually once or twice daily, and should not be stopped suddenly.
- Generic Name: Pregabalin (75mg) + Nortriptyline (10mg)
- Manufacturer: Sannova Biotech Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 mecoxing n 75mg/10mg/1500mcg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा न्यूरोपैथिक दर्द (नसों से जुड़ा दर्द) के इलाज के लिए इस्तेमाल की जाती है। यह मधुमेह से होने वाले नसों के दर्द, दाद के बाद होने वाले दर्द, और फाइब्रोमायल्जिया जैसी स्थितियों में राहत देती है। यह दवा दर्द के संकेतों को कम करके और मूड को बेहतर बनाकर काम करती है।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में चक्कर आना, नींद आना, मुँह सूखना, धुंधली दृष्टि, वजन बढ़ना और हाथ-पैरों में सूजन शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें आत्महत्या के विचार, गंभीर एलर्जी, अनियमित दिल की धड़कन और त्वचा पर गंभीर प्रतिक्रियाएँ हो सकती हैं। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे अचानक बंद न करें, क्योंकि इससे घबराहट, अनिद्रा और मतली जैसे लक्षण हो सकते हैं। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन न चलाएँ और मशीनरी न चलाएँ। इस दवा के साथ शराब न पिएँ। अपने डॉक्टर को अन्य सभी दवाओं के बारे में बताएँ जो आप ले रहे हैं।
💊 mecoxing n 75mg/10mg/1500mcg tablet Uses & Benefits
[{"condition":"Diabetic peripheral neuropathy","description":"This medicine helps relieve burning, shooting, and tingling pain in the feet and hands caused by nerve damage from diabetes.","evidence":"Well-established"},{"condition":"Postherpetic neuralgia","description":"It reduces persistent nerve pain that can occur after a shingles infection.","evidence":"Well-established"},{"condition":"Neuropathic pain","description":"This medicine is used for various types of nerve pain, including that from spinal cord injuries or multiple sclerosis.","evidence":"Moderate"},{"condition":"Fibromyalgia","description":"It may help reduce widespread muscle pain and improve sleep in some patients with fibromyalgia.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Migraine prophylaxis","description":"Sometimes prescribed off-label to prevent migraines, especially when other treatments fail.","evidence":"Limited"},{"condition":"Generalized anxiety disorder","description":"Pregabalin component may be used off-label for anxiety, but the combination is not standard.","evidence":"Limited"}]
Primary treatment for: Neuropathic pain
Also treats: Diabetic peripheral neuropathy, Postherpetic neuralgia, Fibromyalgia
📋 Drug Information
| Generic Name(s) | Pregabalin (75mg) + Nortriptyline (10mg) |
| Brand Name | mecoxing n 75mg/10mg/1500mcg tablet |
| Manufacturer | Sannova Biotech Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, reducing the release of excitatory neurotransmitters such as glutamate, norepinephrine, and substance P. This leads to decreased neuronal excitability and pain transmission. Nortriptyline, a tricyclic antidepressant, inhibits the reuptake of serotonin and norepinephrine in the brain, enhancing descending inhibitory pain pathways and modulating pain perception. Together, they provide synergistic relief for neuropathic pain.
Mechanism Steps
💡 How to Take mecoxing n 75mg/10mg/1500mcg tablet
Strength: Tablet containing Pregabalin 75 mg and Nortriptyline 10 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally once or twice daily, or as directed by your doctor. The dose may be adjusted based on your response and tolerability. Do not exceed the prescribed dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine. Start with a lower dose and titrate slowly. Monitor renal function and for signs of confusion or falls. |
| Renal Impairment | Dose adjustment is required in patients with renal impairment. Pregabalin dose should be reduced based on creatinine clearance. Consult your doctor for specific dosing. |
| Hepatic Impairment | Nortriptyline dose may need reduction in patients with hepatic impairment. Monitor liver function. Consult your doctor for specific dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is 2 tablets (Pregabalin 150 mg + Nortriptyline 20 mg) per day, but this may vary based on individual clinical judgment. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of mecoxing n 75mg/10mg/1500mcg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAO inhibitors | Major | |
| Opioids | Major | |
| Tramadol | Major | |
| SSRIs | Moderate | |
| Anticholinergics | Moderate | |
| Beta-blockers | Moderate | |
| Antacids | Minor | |
| Cimetidine | Minor |
🚨 Major Interactions
- MAO inhibitors
- CNS depressants (e.g., opioids, benzodiazepines)
- Tramadol
⚡ Moderate Interactions
- SSRIs (e.g., fluoxetine)
- Anticholinergics (e.g., oxybutynin)
- Beta-blockers
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol can increase drowsiness, dizziness, and the risk of central nervous system depression. It may also worsen the side effects of Nortriptyline.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to Pregabalin, Nortriptyline, or any component of the formulation","Recent myocardial infarction","Uncontrolled narrow-angle glaucoma","Concurrent use with MAO inhibitors","Severe liver disease"]
⚠️ Warnings & Precautions
["May cause dizziness and drowsiness; avoid driving or operating machinery until you know how it affects you.","Do not stop abruptly; taper gradually under medical supervision to avoid withdrawal symptoms.","May increase suicidal thoughts; monitor mood closely, especially in young adults.","Use with caution in elderly patients due to increased risk of falls and confusion.","May cause peripheral edema; monitor for swelling.","Avoid alcohol and other CNS depressants.","Inform your doctor if you have kidney or liver disease, heart problems, or glaucoma."]
🤱 Lactation Safety
Pregabalin and Nortriptyline are excreted in breast milk. Breastfeeding is not recommended while taking this medicine unless advised by a doctor.
💊 Overdose Management
Overdose may cause severe drowsiness, confusion, tachycardia, hypotension, and respiratory depression. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if within 1-2 hours of ingestion. Monitor vital signs and cardiac rhythm.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not stop taking it suddenly, as this can cause withdrawal symptoms such as anxiety, insomnia, and nausea. Avoid driving or operating heavy machinery until you know how this medicine affects you. Do not consume alcohol while taking this medicine, as it can increase drowsiness and dizziness. Inform your doctor about all other medications you are taking, especially pain relievers, antidepressants, and blood thinners. Keep this medicine out of reach of children and store it in a cool, dry place.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of dizziness, confusion, and falls. Start with a lower dose and monitor closely. Renal function should be checked regularly.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor. This medicine may not be suitable during pregnancy. Effective contraception should be used while taking this medicine unless otherwise advised.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with anesthetic agents and affect pain management. Do not stop without medical advice.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may cause dry mouth, increasing the risk of dental problems. Maintain good oral hygiene and stay hydrated.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid high-impact exercises that may worsen nerve pain. Consult your doctor before starting any new exercise regimen. If you experience dizziness, stop and rest.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness and dizziness, affecting your ability to drive or operate machinery. Avoid these activities until you know how it affects you. Inform your employer if your job involves such tasks.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience serious side effects, contact your doctor immediately. A gradual dose reduction is usually recommended to prevent withdrawal symptoms.
📅 Long-Term Use Effects
Long-term use may lead to weight gain, peripheral edema, and dependence. Regular monitoring of renal function, mood, and weight is advised. Do not stop abruptly; taper gradually under medical supervision.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain.
Evidence: Well-establishedHelps manage chronic pain and improve coping skills.
Evidence: ModerateMay provide pain relief for some patients.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, consult your doctor before receiving any live vaccines while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. If traveling across time zones, adjust dosing times gradually under medical advice. Store in a cool, dry place away from direct sunlight. Check customs regulations for controlled substances before traveling internationally.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling some relief within a few days, but full effects can take 2-4 weeks.
A: No, do not stop suddenly. Consult your doctor for a gradual taper to avoid withdrawal symptoms.
A: Inform your doctor about all medicines you take. Some combinations may increase side effects.
🤔 Common Patient Concerns
🔄 Substitutes for mecoxing n 75mg/10mg/1500mcg tablet
View AllAlternative brands with exact same active ingredient:
-
megaseep nt 75mg/10mg tabletSeepi Pharma Pvt Ltd ₹18.00 87.2% CHEAPER
-
nervzone np tabletZeelab Pharmacy Pvt Ltd ₹30.00 78.7% CHEAPER
-
davaindia pregabalin+nortriptyline 75mg/10mg tabletDavaindia Generic Pharmacy ₹35.00 75.1% CHEAPER
-
stayhappi pregabalin+nortriptyline 75mg/10mg tabletSarvagunaushdhi Pvt Ltd ₹56.25 60% CHEAPER
-
ezinuro nt 75mg/10mg tabletDR Best pharmaceuticals Pvt Ltd ₹60.94 56.7% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a sleeping pill.
Fact: It is primarily for nerve pain, though it may cause drowsiness as a side effect. - Myth: It is addictive.
Fact: It is not addictive in the traditional sense, but it can cause dependence and withdrawal if stopped abruptly. - Myth: It can be taken for any type of pain.
Fact: It is specifically for neuropathic pain, not for ordinary headaches or muscle strains.
🔄 Alternative Options
Generic Alternatives
- Pregabalin 75 mg + Nortriptyline 10 mg tablet (various manufacturers)
Brand Alternatives
- Pregabid NT Tablet