maxiflo synchrobreathe 6mcg/250mcg inhaler - Formoterol (6mcg) + Fluticasone Propionate (250mcg) medicine

Avessa 6mcg/250mcg Capsule: Complete Medicine Guide

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🏭 Cipla Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for asthma and COPD maintenance.
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
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When to Call Your Doctor IMMEDIATELY

  • Sudden severe shortness of breath or wheezing that does not improve with rescue inhaler.
  • Chest pain, fast or irregular heartbeat, or fainting.
  • Swelling of face, lips, tongue, or throat, or difficulty swallowing.
  • Signs of infection such as fever, chills, increased cough, or change in sputum color.
  • Severe headache, vision changes, or eye pain.
  • Unusual tiredness, weakness, nausea, or dizziness (may indicate adrenal insufficiency).
  • White patches in the mouth or throat (oral thrush).

If experiencing severe symptoms, call emergency services immediately.

What is maxiflo synchrobreathe 6mcg/250mcg inhaler used for?

This medicine is a combination inhaler containing formoterol (a long-acting bronchodilator) and fluticasone propionate (an inhaled corticosteroid). It is used for the maintenance treatment of asthma and COPD. It should not be used for sudden breathing attacks.

  • Generic Name: Formoterol (6mcg) + Fluticasone Propionate (250mcg)
  • Manufacturer: Cipla Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 maxiflo synchrobreathe 6mcg/250mcg inhaler के बारे में (Hindi Summary)

उपयोग: यह दवा अस्थमा और क्रॉनिक ऑब्सट्रक्टिव पल्मोनरी डिजीज (सीओपीडी) के दीर्घकालिक उपचार के लिए उपयोग की जाती है। यह सांस की नली की मांसपेशियों को आराम देकर सांस लेना आसान बनाती है और सूजन को कम करती है। यह दवा अचानक होने वाले सांस के दौरे के लिए नहीं है। इसे डॉक्टर के बताए अनुसार नियमित रूप से लें।

साइड इफेक्ट्स: आम दुष्प्रभावों में गले में जलन, आवाज में भारीपन, सिरदर्द, और हाथ-पैर कांपना शामिल हैं। कुछ लोगों को धड़कन तेज होना या मांसपेशियों में ऐंठन महसूस हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, हृदय की अनियमित धड़कन, और अधिवृक्क ग्रंथि की समस्या हो सकती है। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा का उपयोग करने के बाद हमेशा मुँह को पानी से धोएं ताकि मुँह में फंगल संक्रमण न हो। अचानक सांस की तकलीफ के लिए इस दवा का उपयोग न करें; हमेशा एक तेज काम करने वाला रेस्क्यू इनहेलर साथ रखें। निर्धारित खुराक से अधिक न लें। यदि आपको हृदय रोग, उच्च रक्तचाप, मधुमेह, थायरॉइड या लीवर की समस्या है तो अपने डॉक्टर को बताएं। डॉक्टर की सलाह के बिना यह दवा अचानक बंद न करें।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 maxiflo synchrobreathe 6mcg/250mcg inhaler Uses & Benefits

[{"condition":"Asthma","description":"Used as maintenance therapy to prevent asthma symptoms and reduce the frequency of attacks in patients not adequately controlled on inhaled corticosteroids alone or with other controllers.","evidence":"Well-established"},{"condition":"Chronic Obstructive Pulmonary Disease (COPD)","description":"Used for long-term maintenance treatment to relieve symptoms and reduce exacerbations in patients with COPD who require combination therapy.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Exercise-induced bronchoconstriction","description":"Sometimes prescribed off-label for prevention of exercise-induced asthma symptoms, but not a first-line choice.","evidence":"Limited"}]

Primary treatment for: Asthma

Also treats: Chronic Obstructive Pulmonary Disease (COPD)

📋 Drug Information

Generic Name(s)Formoterol (6mcg) + Fluticasone Propionate (250mcg)
Brand Namemaxiflo synchrobreathe 6mcg/250mcg inhaler
ManufacturerCipla Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action Class
Route of AdministrationInhalation
StorageStore at room temperature (15-30°C) in a dry place. Protect from direct sunlight and moisture. Keep capsules in the original blister pack until immediately before use.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always rinse your mouth with water after using this medicine to prevent oral thrush.
2
Keep a fast-acting rescue inhaler with you at all times for sudden breathing problems.
3
Do not exceed the prescribed dose; serious heart-related side effects may occur.
4
Inform your doctor if you have heart disease, high blood pressure, diabetes, or thyroid problems.
5
Do not stop this medicine abruptly without consulting your doctor, as it can worsen your condition.
6
Use the correct inhalation technique; ask your doctor or pharmacist for a demonstration.
7
Store the capsules in their original blister pack and only remove one just before use.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Chronic wheezing and shortness of breath
This medicine is commonly prescribed for asthma and COPD.
Likely Use
❌
Sudden severe breathlessness
This medicine is not for acute attacks; use a rescue inhaler.
Not Primary
❌
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionFormoterol is rapidly absorbed from the lungs after inhalation, reaching peak plasma levels within 10-20 minutes. Fluticasone propionate is absorbed from the lungs and also from the gastrointestinal tract if swallowed; however, oral bioavailability is low due to first-pass metabolism.
DistributionFormoterol is widely distributed in the body with a volume of distribution of approximately 4 L/kg. Fluticasone propionate has a large volume of distribution (approximately 4.2 L/kg) and is highly bound to plasma proteins.
Protein BindingFormoterol is about 50% bound to plasma proteins. Fluticasone propionate is approximately 99% bound to plasma proteins, primarily albumin and corticosteroid-binding globulin.
MetabolismFormoterol is metabolized primarily by glucuronidation and O-demethylation. Fluticasone propionate is metabolized in the liver by cytochrome P450 3A4 to an inactive metabolite.
Half-LifeThe elimination half-life of formoterol is approximately 2-3 hours. Fluticasone propionate has a half-life of about 7.8 hours after inhalation.
ExcretionFormoterol is excreted mainly in urine and feces. Fluticasone propionate is excreted primarily in feces as metabolites, with less than 5% in urine.
BioavailabilityFormoterol: systemic bioavailability after inhalation is about 20-25%. Fluticasone propionate: systemic bioavailability after inhalation is approximately 10-30% due to low oral absorption and first-pass metabolism.
Onset of ActionFormoterol provides bronchodilation within 1-3 minutes after inhalation. Fluticasone propionate's anti-inflammatory effects begin within hours but full benefits may take days to weeks.
Peak Plasma TimeFormoterol reaches peak plasma concentration within 10-20 minutes after inhalation. Fluticasone propionate reaches peak plasma levels within 1-2 hours.
Duration of ActionFormoterol provides bronchodilation for up to 12 hours. Fluticasone propionate's anti-inflammatory effect lasts for 24 hours or more, allowing twice-daily dosing.

How It Works

This medicine combines two active ingredients with complementary actions. Formoterol is a long-acting beta-2 adrenergic agonist that selectively stimulates beta-2 receptors in the airways, causing relaxation of bronchial smooth muscle and rapid bronchodilation. Fluticasone propionate is a synthetic corticosteroid that binds to glucocorticoid receptors inside cells, reducing the production of inflammatory mediators and suppressing the migration of inflammatory cells into the airways. Together, they provide both immediate and sustained bronchodilation and anti-inflammatory effects.

Mechanism Steps

1
Beta-2 receptor stimulation: Formoterol binds to beta-2 adrenergic receptors on airway smooth muscle cells, activating adenylate cyclase and increasing cyclic AMP levels.
2
Smooth muscle relaxation: Increased cyclic AMP leads to relaxation of bronchial smooth muscle, widening the airways and easing breathing.
3
Glucocorticoid receptor binding: Fluticasone propionate enters cells and binds to glucocorticoid receptors, forming a complex that moves into the nucleus.
4
Anti-inflammatory gene regulation: The complex modifies gene transcription, reducing the production of inflammatory cytokines and chemokines, and decreasing inflammatory cell activity.
5
Combined clinical effect: The combined actions lead to immediate bronchodilation and long-term reduction of airway inflammation, improving overall asthma and COPD control.

💡 How to Take maxiflo synchrobreathe 6mcg/250mcg inhaler

Strength: Inhalation capsule containing formoterol 6 mcg and fluticasone propionate 250 mcg.

1Wash and dry your hands.
2Open the inhaler device as instructed.
3Remove one capsule from the blister pack just before use.
4Place the capsule into the capsule chamber.
5Close the device until you hear a click.
6Puncture the capsule by pressing the piercing button once.
7Breathe out fully away from the device.
8Place the mouthpiece in your mouth and inhale deeply and steadily.
9Hold your breath for about 10 seconds, then exhale slowly.
10Remove the device and check if the capsule is empty; if not, repeat inhalation.
11Rinse your mouth with water and spit it out.
12Clean the device as per instructions.

Dosage Information

Adult DosageThe usual adult dose is one inhalation capsule (6 mcg formoterol + 250 mcg fluticasone propionate) twice daily, morning and evening, using the provided inhaler device. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and response to therapy. Do not exceed the prescribed dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageNo specific dose adjustment is required for elderly patients, but use with caution due to increased risk of cardiovascular and metabolic effects. Individualize by a qualified clinician.
Renal ImpairmentNo specific dose adjustment is established for renal impairment. Use with caution in severe renal impairment and individualize by a qualified clinician.
Hepatic ImpairmentUse with caution in patients with severe hepatic impairment due to reduced metabolism of fluticasone propionate. Individualize by a qualified clinician.
Maximum Daily DoseThe maximum recommended daily dose is two inhalation capsules (12 mcg formoterol + 500 mcg fluticasone propionate) per day. Do not exceed this dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
No specific timing required
Inhalation route bypasses gastrointestinal absorption.
Grapefruit
Avoid
May increase fluticasone levels by inhibiting CYP3A4.

⏰ What to Do If You Miss a Dose

📌 Less than 6 hours since missed dose
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than 6 hours since missed dose
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of maxiflo synchrobreathe 6mcg/250mcg inhaler

✅ Common Side Effects

Throat irritation (Common (1-10%))
Rinse mouth with water after each use. If persists, consult your doctor.
Hoarseness (Common (1-10%))
Rinsing mouth may help. If it continues, speak to your doctor.
Headache (Common (1-10%))
Usually resolves on its own. If severe or persistent, consult your doctor.
Tremors (Common (1-10%))
Usually mild and transient. If bothersome, inform your doctor.
Palpitations (Common (1-10%))
If you feel your heart racing, sit down and rest. If it persists, seek medical advice.

🚨 Serious Side Effects

Severe allergic reactions (anaphylaxis) (Rare (<0.1%))
Seek emergency medical help immediately if you experience rash, swelling of face, lips, or throat, or difficulty breathing.
Adrenal insufficiency (Rare (<0.1%))
Symptoms include fatigue, weakness, nausea, and low blood pressure. Contact your doctor if these occur.
Increased risk of pneumonia (in COPD patients) (Uncommon (0.1-1%))
Report symptoms like fever, chills, increased cough, or difficulty breathing to your doctor promptly.
Cardiac arrhythmias (Rare (<0.1%))
Seek immediate medical attention if you experience irregular heartbeat, chest pain, or fainting.
Hyperglycemia (Uncommon (0.1-1%))
Monitor blood sugar if diabetic. Report persistent high readings to your doctor.

⚠️ Rare Side Effects

Glaucoma
Report eye pain or vision changes to your doctor.
Cataracts
Regular eye check-ups are advised for long-term users.
Osteoporosis
Ensure adequate calcium and vitamin D intake. Discuss bone health with your doctor.
Behavioral changes
Report mood swings, agitation, or sleep disturbances to your doctor.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Ketoconazole Major
Propranolol Major
Ritonavir Major
Furosemide Moderate
Theophylline Moderate
Prednisone Moderate
Diphenhydramine Minor
Montelukast Minor
Grapefruit juice Moderate
Alcohol Minor

🚨 Major Interactions

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
  • Beta-blockers (e.g., propranolol)
  • Monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants

⚡ Moderate Interactions

  • Diuretics (e.g., furosemide)
  • Xanthine derivatives (e.g., theophylline)
  • Other corticosteroids

🍷 Alcohol Interaction

Alcohol may increase the risk of dizziness and drowsiness. It is advisable to limit or avoid alcohol while using this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to formoterol, fluticasone propionate, or any component of the formulation.","Not for acute bronchospasm or status asthmaticus.","Not for children under 12 years unless specifically prescribed by a specialist."]

⚠️ Warnings & Precautions

["Do not use as a rescue inhaler; keep a short-acting beta-agonist available.","Rinse mouth after each use to prevent oral candidiasis.","Do not exceed prescribed dose; serious cardiovascular effects may occur.","Use with caution in patients with cardiovascular disorders, seizure disorders, thyroid disease, diabetes, and liver disease.","Do not stop abruptly; taper under medical supervision.","May cause adrenal insufficiency after prolonged use; monitor if switching from systemic steroids.","Increased risk of pneumonia in COPD patients; report symptoms promptly."]

🤱 Lactation Safety

Not established from the available information. Consult your doctor before breastfeeding.

💊 Overdose Management

Overdose may cause tachycardia, tremors, palpitations, and hypokalemia. Seek immediate medical attention. Treatment is supportive and symptomatic. Monitor cardiac function and electrolytes.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Additional Safety Advice

General Safety

Always rinse your mouth with water after using this medicine to prevent oral thrush. Do not use this medicine for sudden breathing problems; keep a fast-acting rescue inhaler with you at all times. Do not exceed the prescribed dose. Inform your doctor if you have heart disease, high blood pressure, diabetes, thyroid problems, or liver disease. Do not stop this medicine abruptly without medical advice, as it can worsen your condition. Store the capsules in their original blister pack and only remove one just before use. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more susceptible to cardiovascular and metabolic side effects. Monitor heart rate, blood pressure, and blood glucose regularly. Use with caution and individualize dosing.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, consult your doctor. This medicine should be used only if clearly needed. Your doctor will weigh the benefits and risks.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist about this medicine before surgery. It may need to be continued or adjusted perioperatively. Do not stop without medical advice.

🦷 Dental Procedures

Inform your dentist about this medicine. Rinsing with water after use helps prevent oral thrush, which can be exacerbated by dental procedures. No specific precautions are required.

💚 Lifestyle Tips for Better Results

🏃
Avoid triggers such as smoke, dust, and pollen.
🥗
Maintain a healthy weight to reduce strain on your lungs.
😴
Practice breathing exercises as advised by your doctor.
💧
Get vaccinated against influenza and pneumonia.
🧘
Keep your home clean and free from mold and dust mites.
🌞
Use air purifiers if you live in polluted areas.

🏋️ Exercise Considerations

Exercise may trigger asthma symptoms. Use your rescue inhaler before exercise if advised. Warm up slowly and avoid exercising in cold, dry air. Consult your doctor before starting any new exercise program.

🥗 Diet Recommendations

Eat a balanced diet rich in fruits and vegetables.
Include omega-3 fatty acids from fish or flaxseed.
Avoid foods that trigger your allergies.
Stay well hydrated.
Limit processed foods and excess salt.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or tremors in some people. Avoid driving or operating heavy machinery until you know how it affects you. It should not interfere with your daily activities once you are used to it.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. If you experience severe side effects or your condition worsens, contact your doctor immediately. Your doctor may adjust the dose or switch to another medicine.

📅 Long-Term Use Effects

Long-term use of this medicine may increase the risk of oral thrush, hoarseness, bone thinning (osteoporosis), eye problems like glaucoma or cataracts, and adrenal insufficiency. Regular monitoring of lung function, bone health, and eye health is recommended. Do not stop the medicine without medical advice.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Allergen avoidance

Reducing exposure to allergens can help control asthma symptoms.

Evidence: Well-established
Pulmonary rehabilitation

Exercise and education program for COPD patients to improve quality of life.

Evidence: Well-established
Breathing exercises

Techniques like pursed-lip breathing can help manage breathlessness.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

Annual influenza vaccination is recommended for patients with asthma and COPD. Pneumococcal vaccination may also be advised. Consult your doctor for personalized recommendations.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original blister pack

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight and moisture

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid temperature extremes in checked baggage. If traveling across time zones, continue with your regular twice-daily schedule, adjusting times gradually. Store at room temperature and protect from moisture. Check customs regulations for carrying prescription inhalers.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old woman with moderate persistent asthma
She was prescribed this medicine twice daily. Initially, she used it only when she felt breathless, which led to poor control. After counseling, she started using it regularly and noticed a significant reduction in nighttime awakenings and daytime symptoms. She also learned to rinse her mouth after each use, preventing oral thrush.
💡 Lesson: Regular use as prescribed is key to controlling asthma. This medicine is not for immediate relief but for long-term control.
👤 A 60-year-old man with COPD
He had frequent exacerbations requiring hospitalization. After starting this medicine, his exacerbations decreased, and his exercise tolerance improved. He was advised to continue using the inhaler even when feeling well, and to report any signs of pneumonia promptly.
💡 Lesson: Consistent use of maintenance inhalers reduces COPD flare-ups and improves quality of life. Always report new or worsening symptoms to your doctor.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Formoterol provides bronchodilation within 1-3 minutes, but the full anti-inflammatory benefits of fluticasone may take days to weeks.

Q: Can I use this medicine for sudden breathing problems?

A: No, this medicine is for maintenance only. Always use a short-acting rescue inhaler for sudden attacks.

Q: What should I do if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Q: Is it safe to use during pregnancy?

A: Consult your doctor. Use only if clearly needed. The benefits and risks will be evaluated by your healthcare provider.

Q: Can I stop taking this medicine when I feel better?

A: Do not stop without consulting your doctor. Stopping suddenly can worsen your condition.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my heart?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for maxiflo synchrobreathe 6mcg/250mcg inhaler

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be used as a rescue inhaler for sudden attacks.
    Fact: This medicine is for maintenance only. It should not be used for sudden breathing problems. Always keep a short-acting rescue inhaler available.
  • Myth: Once symptoms improve, the medicine can be stopped.
    Fact: Do not stop this medicine without consulting your doctor. Stopping suddenly can worsen your condition.
  • Myth: This medicine is addictive.
    Fact: This medicine is not addictive. It is a prescribed treatment for chronic respiratory conditions.

🔄 Alternative Options

Generic Alternatives

  • Formoterol + Fluticasone propionate inhalation capsule (generic versions may be available)

Brand Alternatives

  • Foracort
  • Formonide
  • Duolin
  • Budamate
  • Seretide

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","active_ingredients":"Formoterol + Fluticasone propionate","strength":"6 mcg + 250 mcg","dosage_form":"Inhalation capsule","frequency":"Twice daily"},{"medicine":"Budesonide + Formoterol","active_ingredients":"Budesonide + Formoterol","strength":"Varies","dosage_form":"Inhaler","frequency":"Twice daily"},{"medicine":"Salmeterol + Fluticasone propionate","active_ingredients":"Salmeterol + Fluticasone propionate","strength":"Varies","dosage_form":"Inhaler","frequency":"Twice daily"}]

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