Defrost Tablet: Complete Guide to Uses, Dosage, and Safety
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bruising or bleeding
- Seizures
- Severe dizziness or fainting
If experiencing severe symptoms, call emergency services immediately.
What is maxcold 2mg/325mg/5mg tablet used for?
This medicine is a combination of Chlorpheniramine Maleate (an antihistamine) and Paracetamol (a pain reliever and fever reducer). It is used to treat symptoms of common cold and allergies such as runny nose, sneezing, watery eyes, and mild fever. It is usually taken every 4-6 hours as needed, but do not exceed 6 tablets in 24 hours. It may cause drowsiness, so avoid driving. Consult a doctor before use.
- Generic Name: Chlorpheniramine Maleate (2mg) + Paracetamol (325mg)
- Manufacturer: Roussel Laboratories Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 maxcold 2mg/325mg/5mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा क्लोरफेनिरामाइन मेलिएट और पैरासिटामोल का संयोजन है। इसका उपयोग सर्दी-जुकाम, एलर्जी, नाक बहना, छींक आना, आंखों में पानी आना और हल्के बुखार व दर्द से राहत के लिए किया जाता है। यह दवा एलर्जी के लक्षणों को कम करने में मदद करती है। इसे डॉक्टर की सलाह के अनुसार ही लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, मुंह सूखना, धुंधली दृष्टि, जी मिचलाना और कब्ज शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, सांस लेने में कठिनाई, या यकृत की क्षति हो सकती है। यदि कोई असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खुराक से अधिक न लें। दवा लेने के बाद वाहन चलाने या मशीन चलाने से बचें क्योंकि इससे नींद आ सकती है। शराब का सेवन न करें। यदि आप गर्भवती हैं या स्तनपान करा रही हैं तो डॉक्टर से सलाह लें। बच्चों को डॉक्टर की सलाह के बिना न दें।
💊 maxcold 2mg/325mg/5mg tablet Uses & Benefits
[{"condition":"Common cold","description":"Relieves runny nose, sneezing, watery eyes, and mild fever associated with common cold.","evidence":"Well-established"},{"condition":"Allergic rhinitis","description":"Reduces sneezing, rhinorrhea, and itching of nose and eyes due to allergies.","evidence":"Well-established"},{"condition":"Urticaria","description":"Provides symptomatic relief from itching and rash in allergic skin conditions.","evidence":"Moderate"},{"condition":"Mild pain and fever","description":"Paracetamol component helps reduce mild to moderate pain and fever.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Insomnia","description":"Sometimes used off-label for its sedative effects to promote sleep, but not recommended due to side effects.","evidence":"Limited"},{"condition":"Motion sickness","description":"Chlorpheniramine may be used off-label for motion sickness, but other agents are preferred.","evidence":"Limited"}]
Primary treatment for: Common cold and allergic rhinitis
Also treats: Urticaria, Allergic conjunctivitis, Mild pain and fever
📋 Drug Information
| Generic Name(s) | Chlorpheniramine Maleate (2mg) + Paracetamol (325mg) |
| Brand Name | maxcold 2mg/325mg/5mg tablet |
| Manufacturer | Roussel Laboratories Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in a cool, dry place. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients. Chlorpheniramine Maleate is a first-generation antihistamine that competitively blocks histamine H1 receptors, reducing allergic responses such as sneezing, runny nose, and itching. It also has anticholinergic properties that contribute to dry mouth and drowsiness. Paracetamol (acetaminophen) acts primarily in the central nervous system by inhibiting prostaglandin synthesis, which helps reduce fever and relieve mild to moderate pain. The combination provides symptomatic relief from cold and allergy symptoms.
Mechanism Steps
💡 How to Take maxcold 2mg/325mg/5mg tablet
Strength: Each tablet contains Chlorpheniramine Maleate 2 mg and Paracetamol 325 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 1 tablet taken orally every 4 to 6 hours as needed for symptoms, not to exceed 6 tablets in 24 hours. However, the dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose. Use for the shortest duration necessary. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. This medicine is not recommended for children under 12 years of age unless directed by a doctor. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of chlorpheniramine, especially drowsiness, dizziness, and anticholinergic effects. Use with caution and consider lower doses. Consult a doctor for appropriate dosing. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose adjustment may be necessary. Consult a doctor. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Paracetamol dose should be reduced or avoided in severe liver disease. Consult a doctor. |
| Maximum Daily Dose | Maximum daily dose: Chlorpheniramine Maleate 24 mg (12 tablets) and Paracetamol 3900 mg (12 tablets) in 24 hours. However, do not exceed 6 tablets in 24 hours unless directed by a doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of maxcold 2mg/325mg/5mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | |
| Alcohol | Major | |
| Warfarin | Major | |
| CNS depressants | Moderate | |
| Anticholinergics | Moderate | |
| Enzyme inducers | Moderate | |
| Antihypertensives | Minor | |
| Diuretics | Minor |
🚨 Major Interactions
- Monoamine oxidase inhibitors (MAOIs)
- Alcohol
- Warfarin
⚡ Moderate Interactions
- CNS depressants (e.g., benzodiazepines, opioids, sedatives)
- Anticholinergic drugs (e.g., atropine, tricyclic antidepressants)
- Enzyme inducers (e.g., carbamazepine, phenytoin, rifampin)
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can increase drowsiness, dizziness, and the risk of liver damage from paracetamol. Combining alcohol with paracetamol can lead to severe hepatotoxicity, especially with chronic use or overdose.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to chlorpheniramine, paracetamol, or any component of the formulation","Newborns and premature infants","Nursing mothers","Severe liver disease or severe active liver disease","Severe kidney disease","Narrow-angle glaucoma","Urinary retention","Severe asthma","MAOI therapy within 14 days"]
⚠️ Warnings & Precautions
["May cause drowsiness; avoid driving or operating machinery.","Avoid alcohol and other CNS depressants.","Do not exceed recommended dose of paracetamol; risk of severe liver damage.","Use with caution in elderly and children; may cause paradoxical excitation.","Consult doctor if symptoms persist beyond 7 days or worsen.","Do not use for self-medication in pregnancy or breastfeeding without medical advice.","May cause dry mouth, constipation, and urinary retention; caution in patients with benign prostatic hyperplasia.","May interfere with allergy skin tests; discontinue 4 days before testing."]
🤱 Lactation Safety
Chlorpheniramine and paracetamol are excreted in breast milk. Chlorpheniramine may cause drowsiness in nursing infants. Use with caution and consult a doctor before use. Paracetamol is generally considered safe during breastfeeding.
💊 Overdose Management
Overdose of this medicine can cause severe liver damage due to paracetamol and anticholinergic toxicity from chlorpheniramine. Symptoms include nausea, vomiting, abdominal pain, drowsiness, confusion, seizures, and arrhythmias. Seek immediate medical attention. Treatment includes gastric lavage if within 1-2 hours, administration of activated charcoal, and acetylcysteine as antidote for paracetamol toxicity. Supportive care for chlorpheniramine overdose includes management of seizures, arrhythmias, and anticholinergic effects. Monitor liver and renal function.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose. Avoid driving or operating heavy machinery until you know how this medicine affects you. Do not consume alcohol while taking this medicine as it can increase drowsiness and the risk of liver damage. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Do not use this medicine for longer than directed without consulting your doctor. Keep out of reach of children. If you have liver or kidney disease, use with caution and only under medical supervision. Do not take other products containing paracetamol while on this medicine to avoid overdose.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the side effects of chlorpheniramine, such as drowsiness, dizziness, confusion, and anticholinergic effects like dry mouth, constipation, and urinary retention. Use with caution and consider lower doses. Consult a doctor for appropriate dosing.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Chlorpheniramine and paracetamol are generally considered safe in pregnancy but should be used only if clearly needed and under medical supervision. Avoid use in the first trimester if possible.
🏥 Post-Surgery Considerations
After surgery, consult your doctor before taking this medicine. It may interact with anesthetics and other medications. Paracetamol may be used for pain relief but follow your surgeon's advice.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It may cause dry mouth and interact with other medications used during dental work.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause drowsiness and dizziness. Avoid strenuous exercise or activities requiring alertness until you know how the medicine affects you. If you exercise, do so with caution and stay hydrated.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness, which may affect your ability to drive, operate machinery, or perform tasks requiring mental alertness. It is advisable to avoid such activities until you know how the medicine affects you. Inform your employer if your work involves operating heavy machinery.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your symptoms do not improve within 7 days, if they worsen, or if you experience any serious side effects. Do not stop abruptly if you have been taking it regularly for a long time without medical advice.
📅 Long-Term Use Effects
Long-term use of this medicine should be avoided unless prescribed by a doctor. Prolonged use of chlorpheniramine may lead to tolerance, dependence, and anticholinergic side effects. Chronic paracetamol use can increase the risk of liver and kidney damage, especially with alcohol or other hepatotoxic drugs. Regular monitoring of liver and kidney function may be required. Consult your doctor if you need to use this medicine for more than 7 days.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Helps relieve nasal congestion and runny nose without medication.
Evidence: Well-establishedCan help loosen mucus and ease breathing.
Evidence: LimitedAlternative for allergic rhinitis with fewer systemic side effects.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you are scheduled for allergy skin testing, discontinue this medicine at least 4 days before the test as it may interfere with results.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from light and moisture. If crossing time zones, adjust dosing schedule accordingly, but do not exceed the maximum daily dose. Check customs regulations for carrying medications. Keep a list of your medications with you in case of emergency.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 30-60 minutes after oral administration.
A: It is best taken with food or milk to reduce stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: This medicine is not recommended for children under 12 years unless directed by a doctor. Consult a pediatrician for appropriate dosing.
A: No, alcohol should be avoided as it increases drowsiness and the risk of liver damage from paracetamol.
🤔 Common Patient Concerns
🔄 Substitutes for maxcold 2mg/325mg/5mg tablet
View AllAlternative brands with exact same active ingredient:
-
zukarest tabletAlkem Laboratories Ltd ₹7.03 75% CHEAPER
-
alril tabletMedoz Pharmaceutical Pvt. Ltd ₹13.45 52.2% CHEAPER
-
elzico new tabletElder Pharmaceuticals Ltd ₹14.41 48.8% CHEAPER
-
Tharmal S 2mg/325mg/5mg TabletApex Laboratories Pvt Ltd ₹23.11 17.8% CHEAPER
-
codylex plus 2 mg/325 mg tabletAnglo-French Drugs & Industries Ltd ₹23.21 17.5% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure the common cold.
Fact: This medicine only relieves symptoms; it does not cure the underlying viral infection. - Myth: It is safe to take this medicine with alcohol.
Fact: Alcohol increases drowsiness and the risk of liver damage from paracetamol. - Myth: This medicine is safe for children under 12.
Fact: It is not recommended for children under 12 unless directed by a doctor. - Myth: You can take this medicine long-term for allergies.
Fact: Long-term use should be under medical supervision due to potential side effects.
🔄 Alternative Options
Generic Alternatives
- Chlorpheniramine Maleate + Paracetamol tablet
Brand Alternatives
- Defrost Tablet