befsul 1.5gm injection - Cefepime (1000mg) + Sulbactam (500mg) medicine

Befsul 1.5gm Injection: Complete Medicine Guide

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🏭 Bayberry Pharmaceuticals Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 22, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for approved indications.
Reviewed by
SaathiMed Expert Panel | Oct 22, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Difficulty breathing or swelling of the face, lips, or throat
  • Severe or bloody diarrhea
  • Seizures or confusion
  • Rash with blisters or peeling skin
  • Decreased urine output or swelling in legs
  • Yellowing of skin or eyes
  • Unusual bleeding or bruising

If experiencing severe symptoms, call emergency services immediately.

What is befsul 1.5gm injection used for?

This medicine is a combination antibiotic injection containing cefepime and sulbactam. It is used to treat serious bacterial infections in hospitals. It works by killing bacteria and is given intravenously by a healthcare professional.

  • Generic Name: Cefepime + Sulbactam
  • Manufacturer: Bayberry Pharmaceuticals Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 befsul 1.5gm injection के बारे में (Hindi Summary)

उपयोग: यह दवा सेफेपाइम और सल्बैक्टम का संयोजन है, जिसे गंभीर बैक्टीरियल संक्रमणों के इलाज के लिए नस के माध्यम से दिया जाता है। यह अस्पताल में होने वाले निमोनिया, मूत्र मार्ग के जटिल संक्रमण, त्वचा और मुलायम ऊतकों के संक्रमण, और पेट के अंदर के संक्रमणों के लिए उपयोग किया जाता है। यह दवा बैक्टीरिया को मारती है और संक्रमण को फैलने से रोकती है। यह केवल डॉक्टर की देखरेख में ही दी जानी चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में इंजेक्शन की जगह पर दर्द, लालिमा या सूजन, दस्त, मतली, उल्टी, सिरदर्द, चकत्ते और बुखार शामिल हैं। गंभीर दुष्प्रभावों में एलर्जी की प्रतिक्रिया, गंभीर दस्त, दौरे, और रक्त विकार हो सकते हैं। यदि आपको सांस लेने में कठिनाई, चेहरे या गले में सूजन, या गंभीर दस्त हो, तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: यह दवा केवल योग्य स्वास्थ्य पेशेवर द्वारा ही दी जानी चाहिए। इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी एलर्जी, गुर्दे या यकृत की समस्याओं, और दौरे के इतिहास के बारे में बताएं। इलाज के दौरान पर्याप्त पानी पिएं। शराब का सेवन न करें। यदि आप गर्भवती हैं या स्तनपान करा रही हैं, तो डॉक्टर से सलाह लें। दवा का कोर्स पूरा करें, बीच में न छोड़ें।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 befsul 1.5gm injection Uses & Benefits

[{"condition":"Complicated urinary tract infections","description":"This medicine is used to treat serious kidney and bladder infections caused by susceptible bacteria, including those producing beta-lactamases.","evidence":"Well-established"},{"condition":"Hospital-acquired pneumonia","description":"It is effective against many gram-negative and gram-positive bacteria that cause lung infections in hospitalized patients.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"This medicine treats severe skin infections, including cellulitis and abscesses, when caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"It is used in combination with other antibiotics for complicated intra-abdominal infections such as peritonitis.","evidence":"Well-established"},{"condition":"Febrile neutropenia","description":"This medicine is often used as empiric therapy for fever in patients with low white blood cell counts.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Meningitis","description":"Sometimes used off-label for bacterial meningitis when other options are not suitable, but dosing and monitoring must be specialized.","evidence":"Limited"},{"condition":"Endocarditis","description":"May be used off-label for certain cases of heart valve infection, but usually in combination with other antibiotics.","evidence":"Limited"}]

Primary treatment for: Bacterial infections

Also treats: Complicated urinary tract infections, Hospital-acquired pneumonia, Skin and soft tissue infections, Intra-abdominal infections, Febrile neutropenia

📋 Drug Information

Generic Name(s)Cefepime + Sulbactam
Brand NameBefsul 1.5gm Injection
ManufacturerBayberry Pharmaceuticals Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI INFECTIVES
Action ClassCephalosporin + Beta-lactamase inhibitor
Route of AdministrationIntravenous (IV) infusion over 30 minutes to 2 hours, depending on the dose and clinical setting. It must be administered by a qualified healthcare professional
StorageStore the unreconstituted vial at controlled room temperature between 20°C and 25°C (68°F to 77°F). Protect from light and moisture. Once reconstituted or diluted, the solution should be used within the time specified by the manufacturer, typically within 24 hours if refrigerated. Do not freeze.
Shelf LifeThe shelf life of the unreconstituted product is typically 24 to 36 months from the date of manufacture. Check the expiration date on the vial before use. Do not use if expired.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always administer this medicine in a healthcare setting where emergency equipment is available.
2
Adjust the dose based on the patient's kidney function to prevent neurotoxicity.
3
Monitor for signs of allergic reactions during and after infusion.
4
Watch for severe diarrhea that may indicate C. difficile infection.
5
Ensure the full course is completed to prevent resistance.
6
Educate patients to report any unusual symptoms immediately.
7
Avoid concurrent use with other nephrotoxic drugs if possible.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Fever with chills
This medicine is used for serious bacterial infections that cause fever.
Likely Use
✅
Burning urination
It is used for complicated urinary tract infections.
Likely Use
✅
Cough with yellow sputum
It is used for hospital-acquired pneumonia.
Likely Use
❌
Runny nose
This medicine is not for viral infections like the common cold.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionThis medicine is administered intravenously, so absorption is not applicable. It is directly delivered into the bloodstream.
DistributionCefepime and sulbactam distribute widely into body tissues and fluids, including the lungs, skin, urine, and bile. Both agents achieve therapeutic concentrations in many sites of infection.
Protein BindingCefepime is approximately 20% bound to plasma proteins. Sulbactam is about 38% bound to plasma proteins.
MetabolismCefepime is minimally metabolized and is primarily excreted unchanged. Sulbactam undergoes limited metabolism, with most of the drug excreted unchanged in the urine.
Half-LifeThe elimination half-life of cefepime is approximately 2 hours in adults with normal kidney function. Sulbactam has a half-life of about 1 hour. Both are prolonged in patients with renal impairment.
ExcretionCefepime and sulbactam are primarily excreted unchanged in the urine by glomerular filtration and tubular secretion. Dosage adjustment is required in patients with reduced kidney function.
BioavailabilityBioavailability is 100% because this medicine is given intravenously.
Onset of ActionThe onset of antibacterial action begins within 30 minutes to 1 hour after intravenous administration, as drug levels rise in the blood and tissues.
Peak Plasma TimePeak plasma concentrations are achieved immediately at the end of the intravenous infusion.
Duration of ActionThe antibacterial effect typically lasts for about 8 to 12 hours after a dose, depending on the dose and the susceptibility of the bacteria. Dosing intervals are usually every 8 to 12 hours.

How It Works

This medicine combines two active ingredients. Cefepime is a fourth-generation cephalosporin that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, leading to bacterial lysis and death. Sulbactam is a beta-lactamase inhibitor that irreversibly binds to certain beta-lactamase enzymes, protecting cefepime from degradation and extending its spectrum against beta-lactamase-producing bacteria. Together, they provide broad-spectrum antibacterial activity.

Mechanism Steps

1
Cefepime binds to penicillin-binding proteins: Cefepime attaches to specific PBPs on the bacterial cell membrane, blocking the cross-linking of peptidoglycan chains.
2
Inhibition of cell wall synthesis: This blockade prevents the formation of a stable bacterial cell wall, causing the bacterium to weaken and burst.
3
Sulbactam inhibits beta-lactamases: Sulbactam binds to and inactivates certain beta-lactamase enzymes that would otherwise destroy cefepime.
4
Enhanced antibacterial spectrum: By protecting cefepime, sulbactam extends its activity against bacteria that produce beta-lactamases.
5
Bacterial cell death: The combined action leads to lysis and death of susceptible bacteria, resolving the infection.

💡 How to Take befsul 1.5gm injection

Strength: This medicine is available as a sterile powder for injection in a vial containing 1000 mg cefepime and 500 mg sulbactam, total 1.5 grams. It is reconstituted with a suitable diluent before intravenous infusion.

1This medicine is given by a healthcare professional as an intravenous infusion.
2The vial is reconstituted with sterile water or a suitable diluent as directed.
3The solution is then further diluted in an appropriate intravenous fluid.
4The infusion is administered over 30 minutes to 2 hours, depending on the dose.
5Vital signs and injection site are monitored during and after infusion.
6Do not self-administer; always seek professional administration.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 1.5 grams (1000 mg cefepime + 500 mg sulbactam) administered intravenously every 8 to 12 hours, depending on the type and severity of infection. For complicated urinary tract infections, 1.5 grams every 12 hours may be used. For severe infections such as pneumonia or intra-abdominal infections, 1.5 grams every 8 hours is common. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Treatment duration varies from 7 to 14 days or longer for complicated infections.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children.
Elderly DosageElderly patients may have reduced kidney function, which can increase the risk of side effects. Dosage should be adjusted based on renal function. Close monitoring for neurological effects and kidney function is recommended. Dose must be individualized by a qualified clinician.
Renal ImpairmentDosage adjustment is required in patients with renal impairment. For adults with a creatinine clearance (CrCl) of 30-60 mL/min, the usual dose is 1.5 grams every 12 hours. For CrCl 11-29 mL/min, 1.5 grams every 24 hours is recommended. For CrCl ≤10 mL/min, 1.5 grams every 48 hours or as guided by dialysis. Patients on hemodialysis should receive a dose after each dialysis session. Dose must be individualized by a qualified clinician based on renal function.
Hepatic ImpairmentNo specific dosage adjustment is required for hepatic impairment alone. However, patients with combined hepatic and renal impairment should be monitored closely. Dose must be individualized by a qualified clinician.
Maximum Daily DoseThe maximum recommended daily dose is 6 grams of cefepime (e.g., 2 grams every 8 hours) in adults with normal renal function. For this specific combination product, the maximum daily dose would be 6 grams of cefepime plus 3 grams of sulbactam. Doses above these are not recommended and must be determined by a qualified clinician.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

No specific food interactions
No dietary restrictions
This medicine is given intravenously and does not interact with food.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Contact your healthcare provider to reschedule the dose as soon as possible.
💡 Do not self-administer; a professional will determine the best timing.
📌 More than half the dosing interval has passed
→ Skip the missed dose and continue with the next scheduled dose.
💡 Do not double the dose to catch up.

⚠️ Side Effects of befsul 1.5gm injection

✅ Common Side Effects

Injection site pain or inflammation (Common (1-10%))
Apply a warm compress if advised by your nurse. Report if severe or worsening.
Diarrhea (Common (1-10%))
Stay hydrated. If diarrhea is severe or bloody, contact your doctor immediately.
Nausea (Common (1-10%))
Eat small, bland meals. Inform your doctor if it persists.
Rash (Common (1-10%))
Report any rash to your doctor. Stop the infusion if advised.
Headache (Common (1-10%))
Rest and stay hydrated. Consult your doctor if it becomes severe.

🚨 Serious Side Effects

Anaphylaxis (Rare (<0.1%))
Seek emergency medical help immediately if you experience difficulty breathing, swelling of the face or throat, or a severe rash.
Clostridioides difficile-associated diarrhea (Uncommon (0.1-1%))
Contact your doctor if you develop severe, persistent, or bloody diarrhea, even weeks after treatment.
Seizures (Rare (<0.1%))
Seek immediate medical attention if you have a seizure, especially if you have kidney problems.
Severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis) (Very rare (<0.01%))
Stop the medicine and get emergency care if you develop a painful rash, blisters, or peeling skin.
Blood disorders (neutropenia, thrombocytopenia) (Rare (<0.1%))
Report unusual bruising, bleeding, or signs of infection to your doctor. Blood tests may be needed.

⚠️ Rare Side Effects

Liver enzyme elevation
Your doctor may monitor liver function. Report yellowing of eyes or skin.
Kidney impairment
Report decreased urine output or swelling. Kidney function tests may be needed.
Encephalopathy
Seek medical attention if you experience confusion, hallucinations, or extreme drowsiness.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Aminoglycosides Major
Loop diuretics Major
Warfarin Major
Probenecid Moderate
Other beta-lactams Moderate
Oral contraceptives Minor
Alcohol Minor

🚨 Major Interactions

  • Aminoglycosides (e.g., gentamicin, tobramycin)
  • Loop diuretics (e.g., furosemide)
  • Warfarin

⚡ Moderate Interactions

  • Probenecid
  • Other beta-lactam antibiotics

🍷 Alcohol Interaction

Alcohol should be avoided while receiving this medicine because it may increase the risk of liver strain and worsen gastrointestinal side effects such as nausea and diarrhea. It can also impair your ability to fight infection and recover. Consult your doctor for personalized advice.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known severe hypersensitivity to cefepime, sulbactam, or other beta-lactam antibiotics","Previous anaphylactic reaction to penicillins or cephalosporins","Use in patients with a history of serious beta-lactam-associated allergic reactions"]

⚠️ Warnings & Precautions

["Serious allergic reactions, including anaphylaxis, can occur. Discontinue immediately if suspected.","Clostridioides difficile-associated diarrhea may develop during or after treatment. Monitor for severe diarrhea.","Seizures have been reported, particularly in patients with renal impairment. Adjust dose in kidney disease.","Use with caution in patients with a history of seizures or central nervous system disorders.","May cause false-positive results in certain urine glucose tests.","Prolonged use may lead to overgrowth of non-susceptible organisms, including fungi.","Do not use in patients with known severe beta-lactam allergy."]

🤱 Lactation Safety

Cefepime and sulbactam are excreted in human milk in low amounts. Caution is advised when administering this medicine to a breastfeeding woman. Consult your doctor to weigh the benefits and risks; temporary interruption of breastfeeding may be considered.

💊 Overdose Management

Overdose with this medicine can cause severe neurological effects, including seizures and encephalopathy, especially in patients with kidney impairment. There is no specific antidote. Treatment is supportive and symptomatic. Hemodialysis may be considered to remove cefepime and sulbactam from the blood in severe cases. Contact a poison control center or emergency department immediately if overdose is suspected.

⏰ Missed Dose

This medicine is given by a healthcare professional, so missed doses are unlikely. If you miss a scheduled dose, contact your healthcare provider as soon as possible. Do not attempt to self-administer a double dose. Your provider will determine the best course of action based on the timing of the next dose.

Additional Safety Advice

General Safety

This medicine must be given only by a qualified healthcare professional in a setting where emergency equipment is available. Before receiving this medicine, inform your doctor about all your allergies, especially to antibiotics, and about any kidney or liver problems, seizure history, or gastrointestinal conditions such as colitis. Do not attempt to self-administer this injection. While receiving this medicine, stay well hydrated unless your doctor advises otherwise. Report any new symptoms such as severe diarrhea, rash, difficulty breathing, or unusual bleeding immediately. Do not skip doses or stop treatment early, even if you feel better, as this can lead to resistance and relapse. Avoid alcohol during treatment to reduce the risk of liver strain and interactions. If you are pregnant, planning pregnancy, or breastfeeding, discuss the risks and benefits with your doctor before starting this medicine.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more likely to have reduced kidney function, which can increase the risk of side effects such as seizures and kidney toxicity. Dosage adjustment based on renal function is essential. Close monitoring is recommended.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, discuss with your doctor before starting this medicine. It is classified as Pregnancy Category B, meaning animal studies show no risk but human data are limited. Use only if clearly needed, as determined by your healthcare provider.

🏥 Post-Surgery Considerations

This medicine is often used to prevent or treat surgical site infections. It may be given before, during, or after surgery. Follow your surgeon's instructions regarding dosing and duration. Report any signs of infection such as redness, swelling, or fever.

🦷 Dental Procedures

Inform your dentist if you are receiving this medicine. It may be used prophylactically for dental procedures in patients at risk of infective endocarditis. However, routine use for dental prophylaxis is not recommended unless specified by your doctor.

💚 Lifestyle Tips for Better Results

🏃
Stay well hydrated to help your kidneys flush out the medicine.
🥗
Get plenty of rest to support your immune system.
😴
Eat a balanced diet rich in fruits and vegetables.
💧
Avoid alcohol during treatment.
🧘
Practice good hand hygiene to prevent new infections.
🌞
Complete the full course of treatment as prescribed.

🏋️ Exercise Considerations

While receiving this medicine, you may feel tired or weak. Avoid strenuous exercise until you have recovered. Light activity such as walking is fine if you feel up to it. Consult your doctor before resuming intense workouts.

🥗 Diet Recommendations

Drink plenty of water and fluids.
Eat small, frequent meals if you have nausea.
Include probiotic-rich foods like yogurt if approved by your doctor.
Avoid spicy and greasy foods that may upset your stomach.
Ensure adequate protein intake for healing.

💼 Impact on Daily Work & Life

This medicine is given in a hospital or clinic, so you may need to take time off work or arrange for transportation. You may feel tired or have mild side effects that affect your daily activities. Driving is generally not recommended if you feel dizzy or unwell. Discuss with your doctor when you can return to work.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. Stopping early can lead to incomplete treatment and resistance. Your doctor will determine when to stop based on your clinical response and test results. If you experience severe side effects, contact your doctor immediately; they will decide whether to stop or change the medicine.

📅 Long-Term Use Effects

Long-term use of this medicine may lead to antibiotic resistance, fungal overgrowth, and rarely, blood disorders or kidney impairment. Prolonged therapy requires regular monitoring of kidney function, liver function, and blood counts. It should only be used for as long as necessary.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Other antibiotics

Depending on the bacteria and sensitivity, other antibiotics such as piperacillin-tazobactam or meropenem may be used.

Evidence: Well-established
Oral antibiotics

Once stabilized, patients may be switched to oral antibiotics if appropriate.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no specific vaccine interactions with this medicine. However, it is important to stay up to date with recommended vaccinations, especially pneumococcal and influenza vaccines, to prevent infections. Consult your doctor for personalized advice.

📦 Storage Guide

✅ DO

Store at room temperature (20-25°C)

❌ DON'T

Do not freeze the vial

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Protect from light and moisture

❌ DON'T

Do not store in bathroom cabinet

✅ DO

Use reconstituted solution within the specified time

❌ DON'T

Do not use if expired or discolored

✈️ Traveling with This Medicine

This medicine is given in a healthcare setting, so travel is not applicable. If you are prescribed this medicine as an outpatient, carry your prescription and medical records. Store the vials in their original packaging at room temperature, away from direct sunlight. If traveling by air, keep them in your carry-on luggage with a doctor&#039;s note. Check customs regulations for carrying prescription injectables.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 65-year-old man with hospital-acquired pneumonia
He was started on this medicine intravenously. His fever subsided within 48 hours, and his breathing improved over 5 days. He completed a 10-day course and recovered fully. His kidney function was monitored closely due to his age.
💡 Lesson: This medicine is effective for serious lung infections when given promptly and monitored appropriately.
👤 A 45-year-old woman with complicated urinary tract infection
She received this medicine every 12 hours for 7 days. Her symptoms improved significantly by day 3. She experienced mild nausea, which was managed with antiemetics. She was advised to stay hydrated.
💡 Lesson: Adherence to the prescribed schedule and hydration helps manage side effects and ensures recovery.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Improvement in symptoms may begin within 24 to 48 hours, but full recovery depends on the infection and may take several days to weeks.

Q: Can I take this medicine at home?

A: No, this medicine must be given by a healthcare professional in a supervised setting.

Q: What should I do if I experience side effects?

A: Report any side effects to your doctor immediately. Do not ignore severe symptoms.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine if I have kidney problems?
  • Will this medicine interact with my other medications?
  • How long will I need to stay in the hospital?
  • Can I breastfeed while on this medicine?
  • What if I miss a dose?
  • Is this medicine safe for elderly patients?

🔄 Substitutes for befsul 1.5gm injection

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure viral infections like the flu.
    Fact: This medicine is an antibiotic and only works against bacterial infections. It is not effective against viruses.
  • Myth: You can stop this medicine as soon as you feel better.
    Fact: You must complete the full course as prescribed to prevent resistance and relapse, even if symptoms improve.
  • Myth: This medicine is safe to self-administer at home.
    Fact: This medicine must be given by a healthcare professional in a supervised setting due to risks of allergic reactions and other complications.

🔄 Alternative Options

Generic Alternatives

  • Cefepime 1000 mg + Sulbactam 500 mg injection (generic versions may be available)

Brand Alternatives

  • Befsul 1.5gm injection

📊 Comparison with Similar Medicines

[{"medicine":"Cefepime + Sulbactam","class":"4th gen cephalosporin + beta-lactamase inhibitor","route":"Intravenous","spectrum":"Broad-spectrum including Pseudomonas","typical_use":"Serious hospital-acquired infections"},{"medicine":"Cefoperazone + Sulbactam","class":"3rd gen cephalosporin + beta-lactamase inhibitor","route":"Intravenous","spectrum":"Broad-spectrum including Pseudomonas","typical_use":"Intra-abdominal, gynecological infections"},{"medicine":"Piperacillin + Tazobactam","class":"Ureidopenicillin + beta-lactamase inhibitor","route":"Intravenous","spectrum":"Broad-spectrum including Pseudomonas","typical_use":"Nosocomial infections, febrile neutropenia"}]

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